Chromogranin A and vesicular monoamine transporter 2 immunolocalization in protein bodies of human locus coeruleus neurons

Ultrastructural Pathology

Volumn 37, Issue 2, 2013, Pages 102-109

  Kloukina Pantazidou, Ismini ^a   Chrysanthou Piterou, Margarita ^a,b   Havaki, Sophia ^a,c   Issidorides, Marietta R ^a,b  

^a Theodor Theohari Cozzika Foundation   (Greece)

^b NATIONAL AND KAPODISTRIAN UNIVERSITY OF ATHENS   (Greece)

^c UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

Author keywords

Chromogranin A; Electron microscopy; Human locus coeruleus; Immunogold labeling; Protein bodies; Vesicular monoamine transporter 2

Indexed keywords

CHROMOGRANIN A; NERVE PROTEIN; NORADRENALIN; SLC18A2 PROTEIN, HUMAN; VESICULAR MONOAMINE TRANSPORTER;

ADULT; AGED; ARTICLE; CELL ORGANELLE; DENDRITIC CELL; FEMALE; HUMAN; LOCUS CERULEUS; MALE; METABOLISM; MIDDLE AGED; NERVE CELL; PATHOLOGY; ULTRASTRUCTURE; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; CHROMOGRANIN A; DENDRITIC CELLS; FEMALE; HUMANS; LOCUS COERULEUS; MALE; MIDDLE AGED; NERVE TISSUE PROTEINS; NEURONS; NOREPINEPHRINE; ORGANELLES; VESICULAR MONOAMINE TRANSPORT PROTEINS;

EID: 84876107851     PISSN: 01913123     EISSN: 15210758     Source Type: Journal    
DOI: 10.3109/01913123.2012.750410     Document Type: Article

References (30)

1. Eiden LE. The vesicular neurotransmitter transporters: Current perspectives and future prospects. FASEB J 2000; 14: 2396-400
2. Weihe E, Eiden LE. Chemical neuroanatomy of the vesicular amine transporters. FASEB J 2000;14: 2435-49
3. Issidorides MR, Havaki S, Arvanitis DL, Chrysanthou-Piterou M. Noradrenaline storage function of speciesspecific protein bodies, markers of monoamine neurons in human locus coeruleus demonstrated by dopaminebeta- hydroxylase immunogold localization. Prog Neuropsychopharmacol Biol Psychiatry 2004;28: 829-47
4. Issidorides MR, Kriho V, Pappas GD. The fine structure of large dense-core organelles in human locus coeruleus neurons. Neurol Res 1996;18: 57-63
5. Winkler H. The adrenal chromaffin granule: A model for large dense core vesicles of endocrine and nervous tissue. J Anat 1993;183: 237-52
6. Crivellato E, Nico B, Ribatti D. The chromaffin vesicle: Advances in understanding the composition of a versatile, multifunctional secretory organelle. Anat Rec (Hoboken) 2008;291: 1587-602
7. Machado JD, Díaz-Vera J, Domínguez N, et al. Chromogranins A and B as regulators of vesicle cargo and exocytosis. Cell Mol Neurobiol 2010;30: 1181-7
8. Helle KB, Reed RK, Pihl KE, Serck-Hanssen G. Osmotic properties of the chromogranins and relation to osmotic pressure in catecholamine storage granules. ActaPhysiol Scand 1985;123: 21-33
9. Schafer MK, Mahata SK, Stroth N, et al. Cellular distribution of chromogranin A in excitatory, inhibitory, aminergic and peptidergic neurons of the rodent central nervous system. RegulPept 2010;165: 36-44
10. Nirenberg MJ, Chan J, Liu Y, et al. Ultrastructural localization of the vesicular monoamine transporter-2 in midbrain dopaminergic neurons: Potential sites for somatodendritic storage and release of dopamine. J Neurosci 1996;16: 4135-45
11. Erickson JD, Schafer MK, Bonner TI, et al. Distinct pharmacological properties and distribution in neurons and endocrine cells of two isoforms of the human vesicular monoamine transporter. Proc NatlAcad Sci 1996;93: 5166-71
12. Ludwig M. Dendritic Neurotransmitter Release. New York: Springer-Verlag; 2004
13. Pudovkina OL, Kawahara Y, de Vries J, Westerink BH. The release of noradrenaline in the locus coeruleus and prefrontal cortex studied with dual-probe microdialysis. Brain Res 2001;906: 38-45
14. Huang HP, Wang SR, Yao W, et al. Long latency of evoked quantal transmitter release from somata oflocus coeruleus neurons in rat pontine slices. Proc Natl Acad Sci USA 2007; 104: 1401-6
15. Winkler H, Fischer-Colbrie R. The chromogranins A and B: The first 25 years and future perspectives. Neuroscience 1992;49: 497-528
16. Kobayashi S, Uchida T, Ohashi T, et al. Immunocytochemical demonstration of the co-storage of noradrenaline with Met-enkephalin-Arg6-Phe7 and Met-enkephalin-Arg6-Gly7-Leu8 in the carotid body chief cells of the dog. Arch Histol Jap 1983;46: 713-22
17. Causton B. The choice of resins for electron immunocytochemistry. In: Polak JM, Varndell IM, eds. Immunolabelling for Electron Microscopy, Amsterdam: Elsevier, 1984:29-36
18. Bendayan M, Zollinger M. Ultrastructural localization of antigenic sites on osmium-fixed tissues applying the protein A-gold technique. J Histochem Cytochem 1983;31: 101-9
19. Polak JM, Van Noorden S. Post-embedding immunocytochemistry for the transmission electron microscope. In: Polak JM, Van Noorden S, eds. Introduction to Immunocytochemistry, Oxford, UK: Bios Scientific, 1997:81-9
20. Havaki S, Dafni U, Sotiropoulou C, et al. Ultrastructural immunostaining of infiltrating ductal breast carcinomas with the monoclonal antibody H: A comparative study with cytokeratin 8. UltrastructPathol 2003;27: 393-407
21. Hökfelt T, Jonsson G. Studies on reaction and binding of monoamines after fixation and processing for electron microscopy with special reference to fixation with potassium permanganate. Histochemie 1968;16: 45-67
22. Munoz DG, Kobylinski L, Henry DD, George DH. Chromogranin A-like immunoreactivity in the human brain: Distribution in bulbar medulla and cerebral cortex. Neuroscience 1990;34: 533-43
23. Kato A, Kammen-Jolly K, Fischer-Colbie R, et al. Co-distribution patterns of chromogranin B-like immunoreactivity with chromogranin A and secretoneurin within the human brainstem. Brain Res 2000;852: 444-52
24. Wimalasena K. Vesicular monoamine transporters: Structure-function, pharmacology, and medicinal chemistry. Med Res Rev 2011;31: 483-519
25. Yoshida M, Muneyuki E, Hisabori T. ATP synthase - A marvelous rotary engine of the cell. Nat Rev Mol Cell Biol 2001;2: 669-77
26. Muench SP, Trinick J, Harrison MA. Structural divergence of the rotary ATPases. Q Rev Biophys 2011;44: 311-56
27. Li H, Waites CL, Staal RG, et al. Sorting of vesicular monoamine transporter 2 to the regulated secretory pathway confers the somatodendritic exocytosis of monoamines. Neuron 2005;48: 619-33
28. Eisenhofer G, Kopin IJ, Goldstein DS. Catecholamine metabolism: A contemporary view with implications for physiology and medicine. Pharmacol Rev 2004;56: 331-49
29. Swanson LW, Hartman BK. The central adrenergic system: An immunofluorescence study of the location of cell bodies and their efferent connections in the rat utilizing dopamine-beta-hydroxylase as a marker. J Comp Neurol 1975; 163: 467-505
30. Huang HP, Zhu FP, Chen XW, et al. Physiology of quantal norepinephrine release from somatodendritic sites of neurons in locus coeruleus. Front Mol Neurosci 2012;5: 29