Macrophages: Are they involved in endometriosis, Abortion and Preeclampsia and How?

Journal of Nippon Medical School

Volumn 80, Issue 2, 2013, Pages 97-103

  Hutter, Stefan ^a   Heublein, Sabine ^a   Knabl, Julia ^a   Andergassen, Ulrich ^a   Vrekoussis, Thomas ^a   Makrigiannakis, Antonis ^b   Friese, Klaus ^a   Mayr, Doris ^a   Jeschke, Udo ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF CRETE   (Greece)

Author keywords

Abortion; Endometriosis; Macrophages; Plasticity; Preeclampsia

Indexed keywords

CD68 ANTIGEN; CORTICOTROPIN RELEASING FACTOR; ESTROGEN; FAS LIGAND; G PROTEIN COUPLED RECEPTOR 30; STEROID RECEPTOR;

ABORTION; APOPTOSIS; CELL POPULATION; CYST; DEREGULATION; ENDOMETRIOSIS; HUMAN; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; INFLAMMATION; MACROPHAGE; PLACENTA; PLASTICITY; PREECLAMPSIA; REVIEW; SPONTANEOUS ABORTION; TROPHOBLAST; UPREGULATION;

ABORTION, SPONTANEOUS; ENDOMETRIOSIS; FEMALE; HUMANS; MACROPHAGES; PRE-ECLAMPSIA; PREGNANCY;

EID: 84876095642     PISSN: 13454676     EISSN: 13473409     Source Type: Journal    
DOI: 10.1272/jnms.80.97     Document Type: Review

References (28)

1. Sica A, Mantovani A: Macrophage plasticity and polarization: in vivo veritas. J Clin Invest 2012; 122: 787-795.
2. Khoufache K, Michaud N, Harir N, Kibangou Bondza P, Akoum A: Anomalies in the inflammatory response in endometriosis and possible consequences: a review. Minerva Endocrinol 2012; 37: 75-92.
3. Anger DL, Foster WG: The link between environmental toxicant exposure and endometriosis. Front Biosci 2008; 13: 1578-1593.
4. Khoufache K, Bazin S, Girard K, et al.: Macrophage migration inhibitory factor antagonist blocks the development of endometriosis in vivo. PLoS One 2012; 7: e37264.
5. Heublein S, Lenhard M, Vrekoussis T, et al.: The G- Protein coupled estrogen receptor (GPER) is expressed in normal human ovaries and is upregulated in ovarian endometriosis and pelvic inflammatory disease involving the ovary. Reprod Sci 2012; 19: 1197-1204.
6. Khan KN, Kitajima M, Hiraki K, et al.: Immunopathogenesis of pelvic endometriosis: role of hepatocyte growth factor, macrophages and ovarian steroids. Am J Reprod Immunol 2008; 60: 383-404.
7. Guenther S, Vrekoussis T, Heublein S, et al.: Decidual macrophages are significantly increased in spontaneous miscarriages and over-express FasL: A potential role for macrophages in trophoblast apoptosis. Int J Mol Sci 2012; 13: 9069-9080.
8. Nagamatsu T, Schust DJ: The contribution of macrophages to normal and pathological pregnancies. Am J Reprod Immunol 2010; 63: 460- 471.
9. Warning JC, McCracken SA, Morris JM: A balancing act: Mechanisms by which the fetus avoids rejection by the maternal immune system. Reproduction 2011; 141: 715-724.
10. Nagata S: Fas and Fas ligand: A death factor and its receptor. Adv Immunol 1994; 57: 129-144.
11. Minas V, Jeschke U, Kalantaridou SN, et al.: Abortion is associated with increased expression of FasL in decidual leukocytes and apoptosis of extravillous trophoblasts: a role for CRH and urocortin. Mol Hum Reprod 2007; 13: 663-673.
12. Wongweragiat S, Searle RF, Bulmer JN: Expression of Fas/Fas ligand by decidual leukocytesin hydatidiform mole. Biol Reprod 2001; 64: 784-789.
13. Cudihy D, Lee RV: The pathophysiology of preeclampsia: current clinical concepts. J Obstet Gynaecol 2009; 29: 576-582.
14. Ahn H, Park J, Gilman-Sachs A, Kwak-Kim J: Immunologic characteristics of preeclampsia, a comprehensive review. Am J Reprod Immunol 2011; 65: 377-394.
15. Working Group on High Blood Pressure in Pregnancy: Report of the National High Blood Pressure Education Program. Am J Obstet Gynecol 2000; 183: S1-S22.
16. Redman CW, Sargent IL: Placental debris, oxidative stress and pre-eclampsia. Placenta 2000; 21: 597-602.
17. Saito S, Shiozaki A, Nakashima A, Sakai M, Sasaki Y: The role of the immune system in preeclampsia. Mol Aspects Med 2007; 28: 192-209.
18. Petsas G, Jeschke U, Richter DU, et al.: Aberrant expression of corticotropin-releasing hormone in preeclampsia induces expression of FasL in maternal macrophages and extravillous trophoblast apoptosis. Mol Hum Reprod 2012 (in press).
19. Berbic M, Schulke L, Markham R, Tokushige N, Russell P, Fraser IS: Macrophage expression in endometrium of women with and without endometriosis. Hum Reprod 2009; 24: 325-332.
20. Diao J, Mikhailova A, Tang M, Gu H, Zhao J, Cattral MS: Immunostimulatory conventional dendritic cells evolve into regulatory macrophage-like cells. Blood 2012; 119: 4919-4927.
21. Kolkova Z, Noskova V, Ehinger A, Hansson S, Casslén B: G protein-coupled estrogen receptor 1 (GPER, GPR 30) in normal human endometrium and early pregnancy decidua. Mol Hum Reprod 2010; 16: 743-751.
22. Cutolo M, Sulli A, Straub RH: Estrogen metabolism and autoimmunity. Autoimmun Rev 2012; 11: A460- 464.
23. Vassiliadou N, Bulmer JN: Immunohistochemical evidence for increased numbers of 'classic' CD57+ natural killer cells in the endometrium of women suffering spontaneous early pregnancy loss. Hum Reprod 1996; 11: 1569-1574.
24. Quack KC, Vassiliadou N, Pudney J, Anderson DJ, Hill JA: Leukocyte activation in the decidua of chromosomally normal and abnormal fetuses from women with recurrent abortion. Hum Reprod 2001; 16: 949-955.
25. Renaud SJ, Postovit LM, Macdonald-Goodfellow SK, McDonald GT, Caldwell JD, Graham CH: Activated macrophages inhibit human cytotrophoblast invasiveness in vitro. Biol Reprod 2005; 73: 237-243.
26. Reister F, Frank HG, Kingdom JC, et al.: Macrophage-induced apoptosis limits endovascular trophoblast invasion in the uterine wall of preeclamptic women. Lab Invest 2001; 81: 1143-1152.
27. Clifton VL, Read MA, Leitch IM, Boura AL, Robinson PJ, Smith R: Corticotropin-releasing hormone-induced vasodilatation in the human fetal placental circulation. J Clin Endocrinol Metab 1994; 79: 666-669.
28. McLean M, Smith R: Corticotropin-releasing Hormone in Human Pregnancy and Parturition. Trends Endocrinol Metab 1999; 10: 174-178.