Investigation of inpatient probiotic use at an academic medical center

International Journal of Infectious Diseases

Volumn 17, Issue 5, 2013, Pages

  Simkins, Jacques ^a   Kaltsas, Anna ^a   Currie, Brian P ^a,b  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b Foundation for Applied Epidemiology   (United States)

Author keywords

Bloodstream infection; High risk patients; Lactobacillus; Probiotics; Safety

Indexed keywords

PROBIOTIC AGENT;

ARTICLE; BLOODSTREAM INFECTION; CLOSTRIDIUM DIFFICILE INFECTION; COLITIS; CONSTIPATION; CRYPTOSPORIDIOSIS; DIARRHEA; DRUG SAFETY; HEPATIC ENCEPHALOPATHY; HIGH RISK PATIENT; HOSPITAL PATIENT; HUMAN; INCIDENCE; INFECTION PREVENTION; INFECTION RISK; IRRITABLE COLON; ISCHEMIC COLITIS; LACTOBACILLUS ACIDOPHILUS INFECTION; LACTOBACILLUS BULGARICUS INFECTION; NONHUMAN; PEPTIC ULCER; PRESCRIPTION; RETROSPECTIVE STUDY;

ACADEMIC MEDICAL CENTERS; AGED; AGED, 80 AND OVER; BACTEREMIA; ENTEROCOLITIS, PSEUDOMEMBRANOUS; FEMALE; GRAM-POSITIVE BACTERIAL INFECTIONS; HUMANS; INCIDENCE; LACTOBACILLUS ACIDOPHILUS; LACTOBACILLUS DELBRUECKII; MALE; MIDDLE AGED; PROBIOTICS; RETROSPECTIVE STUDIES; RISK;

EID: 84876078328     PISSN: 12019712     EISSN: 18783511     Source Type: Journal    
DOI: 10.1016/j.ijid.2012.11.010     Document Type: Article

References (29)

1. Salminen S., Bouley C., Boutron-Ruault M.C., Cummings J.H., Franck A., Gibson G.R., et al. Functional food science and gastrointestinal physiology and function. Br J Nutr 1998, 80:147-171.
2. Goldin B.R., Gorbach S.L. Clinical indications for probiotics: an overview. Clin Infect Dis 2008, 46:96-100.
3. Venugopalan V., Shriner K.A., Wong-Beringer A. Regulatory oversight and safety of probiotic use. Emerg Infect Dis 2010, 16:1661-1665.
4. Hoffman F.A. Development of probiotics as biologic drugs. Clin Infect Dis 2008, 46:125-127.
5. Agency for Healthcare Research and Quality. Safety of probiotics to reduce risk and prevent or treat disease. Rockville, MD: AHRQ, US Department of Health and Human Services; 2011. Available at: (accessed July 11, 2012). http://www.ahrq.gov/downloads/pub/evidence/pdf/probiotics/probiotics.pdf.
6. World Health Organization/Food and Agriculture Organization of the United Nations. Guidelines for the evaluation of probiotics in food. Report of a Joint FAO/WHO Working Group. London, Ontario, Canada: WHOFAO; 2002. Available at: (accessed July 11, 2012). http://www.who.int/foodsafety/fs_management/en/probiotic_guidelines.pdf.
7. Grześkowiak Ł., Isolauri E., Salminen S., Gueimonde M. Manufacturing process influences properties of probiotic bacteria. Br J Nutr 2011, 105:887-894.
8. US Food and Drug Administration. Dietary Supplement and Nonprescription Drug Consumer Protection Act. Silver Spring, MD: FDA; 2009. Available at: (accessed July 11, 2012). http://www.fda.gov/RegulatoryInformation/Legislation/FederalFoodDrugandCos%20meticActFDCAct/SignificantAmendmentstotheFDCAct/ucm148035.htm.
9. Naidu A.S., Bidlack W.R., Clemens R.A. Probiotic spectra of lactic acid bacteria (LAB). Crit Rev Food Sci Nutr 1999, 39:13-126.
10. Salminen M.K., Tynkkynen S., Rautelin H., Saxelin M., Vaara M., Ruutu P., et al. Lactobacillus bacteremia during a rapid increase in probiotic use of Lactobacillus rhamnosus GG in Finland. Clin Infect Dis 2002, 35:1155-1160.
11. Sullivan A., Nord C.E. Probiotic lactobacilli and bacteraemia in Stockholm. Scand J Infect Dis 2006, 38:327-331.
12. Snydman D.R. The safety of probiotics. Clin Infect Dis 2008, 46:104-111.
13. Boyle R.J., Robins-Browne R.M., Tang M.L. Probiotic use in clinical practice: what are the risks?. Am J Clin Nutr 2006, 83:1256-1264.
14. Land M.H., Rouster-Stevens K., Woods C.R., Cannon M.L., Cnota J., Shetty A.K. Lactobacillus sepsis associated with probiotic therapy. Pediatrics 2005, 115:178-181.
15. Salminen M.K., Rautelin H., Tynkkynen S., Poussa T., Saxelin M., Valtonen V., et al. Lactobacillus bacteremia, clinical significance, and patient outcome, with special focus on probiotic L. rhamnosus GG. Clin Infect Dis 2004, 38:62-69.
16. Salvana E.M., Frank M. Lactobacillus endocarditis: case report and review of cases reported since 1992. J Infect 2006, 53:5-10.
17. Ledoux D., Labombardi V.J., Karter D. Lactobacillus acidophilus bacteraemia after use of a probiotic in a patient with AIDS and Hodgkin's disease. Int J STD AIDS 2006, 17:280-282.
18. Mackay A.D., Taylor M.B., Kibbler C.C., Hamilton-Miller J.M. Lactobacillus endocarditis caused by a probiotic organism. Clin Microbiol Infect 1999, 5:290-292.
19. Mego M., Koncekova R., Mikuskova E., Drgona L., Ebringer L., Demitrovicova L., et al. Prevention of febrile neutropenia in cancer patients by probiotic strain Enterococcus faecium M-74. Phase II study. Support Care Cancer 2006, 14:285-290.
20. Rayes N., Seehofer D., Hansen S., Boucsein K., Müller A.R., Serke S., et al. Early enteral supply of Lactobacillus and fiber versus selective bowel decontamination: a controlled trial in liver transplant recipients. Transplantation 2002, 74:123-127.
21. Wolf B.W., Wheeler K.B., Ataya D.G., Garleb K.A. Safety and tolerance of Lactobacillus reuteri supplementation to a population infected with the human immunodeficiency virus. Food Chem Toxicol 1998, 36:1085-1094.
22. Salminen M.K., Tynkkynen S., Rautelin H., Poussa T., Saxelin M., Ristola M., et al. The efficacy and safety of probiotic Lactobacillus rhamnosus GG on prolonged, noninfectious diarrhea in HIV patients on antiretroviral therapy: a randomized, placebo-controlled, crossover study. HIV Clin Trials 2004, 5:183-191.
23. Sanders M.E., Akkermans L.M., Haller D., Hammerman C., Heimbach J., Hörmannsperger G., et al. Safety assessment of probiotics for human use. Gut Microbes 2010, 1:164-185.
24. Cannon J.P., Lee T.A., Bolanos J.T., Danziger L.H. Pathogenic relevance of Lactobacillus: a retrospective review of over 200 cases. Eur J Clin Microb Infect Dis 2005, 24:31-40.
25. Seksik P., Dray X., Sokol H., Marteau P. Is there any place for alimentary probiotics, prebiotics or synbiotics, for patients with inflammatory bowel disease?. Mol Nutr Food Res 2008, 52:906-912.
26. Guarner C., Soriano G. Bacterial translocation and its consequences in patients with cirrhosis. Eur J Gastroenterol Hepatol 2005, 17:27-31.
27. Cohen S.H., Gerding D.N., Johnson S., Kelly C.P., Loo V.G., McDonald L.C., et al. Clinical practice guidelines for Clostridium difficile infection in adults: 2010 update by the Society for Healthcare Epidemiology of America (SHEA) and the Infectious Diseases Society of America (IDSA). Infect Control Hosp Epidemiol 2010, 31:431-455.
28. Patel R., Cockerill F.R., Porayko M.K., Osmon D.R., Ilstrup D.M., Keating M.R. Lactobacillemia in liver transplant patients. Clin Infect Dis 1994, 18:207-212.
29. Saxelin M., Chuang N.H., Chassy B., Rautelin H., Mäkelä P.H., Salminen S., et al. Lactobacilli and bacteremia in southern Finland, 1989-1992. Clin Infect Dis 1996, 22:564-566.