A study of the effect of ascorbic acid on the antiplasmodial activity of artemether in Plasmodium Berghei infected mice

Journal of Applied Pharmaceutical Science

Volumn 2, Issue 6, 2012, Pages 96-100

  Ganiyu, K A ^a   Akinleye, M O ^a   Tayo, Fola ^a  

^a UNIVERSITY OF LAGOS   (Nigeria)

Author keywords

Artemether; Ascorbic acid; Interaction; Plasmodium berghei

Indexed keywords

EID: 84876039781     PISSN: None     EISSN: 22313354     Source Type: Journal    
DOI: 10.7324/JAPS.2012.2614     Document Type: Article

References (14)

1. Awodele, O., Emeka, P.M., Akintonwa, A. and Aina, O. Antagonistic Effect of Vitamin E on the Efficacy of Artesunate against Plasmodium berghei infection in mice. Afr. J. Biol. Res., 2007; 10: 51-57.
2. Benakis A,Paris M, Plessas CT, Plessas ST. Pharmacokinetics of artemisinin and artesunate after oral adminstration in healthy volunteers. Am J Trop Med Hyg 1997; 56: 17-23
3. Ibrahim M. Elhassan, Gwiria H.M Satti, Abed-Elharim Ali, Insaf Fadul, Ali A Elkhalifa, Abedelrahim M Abedlrahim, Chien Ming, Thor G Theander. The efficacy of artemether in the treatment of plasmodium malaria in sudan. Transactions of the Royal Society of Tropical medicine and Hygiene. 1993; 87(6):685-686.
4. Krishna, S., Uhlemann, A and Haynes, R.K. Artemisinins:mechanism of action and potential for resistance. Drug Resistance Updates 7, 2004; 233-244.
5. Lavender, O.A., Ager, A.L., Morris, V.C. Quinghaosu dietary vitamin E, Selenium and cod liver oil. Effect on susceptibility of mice to the malarial parasite Plasmodium yoelli. American Journal of Clinical Nutrition. 1989; 5: 346-352.
6. Malenga G., Ayo P., Sarah S., Walter k., Theonest M., evelyne A., Karen I B. and Christopher J.M.W. Antimalarial treatment with artemisinin combination therapy in Africa. BMJ 2005; 331: 706-707.
7. Meshnick, S.R., Tsang, T.W., Lin, F.B., Pan, H.Z., Chang, C.N., Kuypers, F., Chiu D. and Lubin, B. Activated oxygen mediates the antimalarial activity of qinghaosu. Prog. Clin. Biol. Res.,1989; 313: 95- 104.
8. Micheal Makanga and Srivicha Krudsood. The clinical efficacy of artemether/lumefantrine (coartem®). Malaria Journal. 2009; 8(1):S5 DOI:10.1186/1475/-2875-8-S1-S5
9. Newton P, Suputtamongkol Y, Teja-Isavadharm P, Pukrittayakamee S, Navaratnam V, Bates I, White N. Antimalarial bioavailability and disposition of artesunate in acute falciparum malaria. Antimicrob Agents Chemother. 2000;44(4):972-977.
10. Oreagba, A.I. and Ashorobi, R.B. Interactions between retinol and some established antimalarials in Plasmdium nigeriensis infection in mice. Int. J. Pharmacol. 2007; 3: 270-274.
11. Sirima SB, Gansane A. Artesunate-amodiaquine for the treatment of uncomplicated malaria. Expert Opin Investig Drugs. 2007; 16(7): 1079-85.
12. Trampuz, A., Jereb, M., Muzlovic, I., Prabhu, R. Clinical review: severe malaria. Crit. Care. 2003; 7(4): 315-23.
13. WHO, (2005). World Malaria Report 2008.
14. WHO. (2006). Facts onACTs (Artemisinin-basedCombination Therapies). http://www.who.int/malaria. Retrieved Oct .3rd, 2010.