α-Cyperone, isolated from the rhizomes of Cyperus rotundus, inhibits LPS-induced COX-2 expression and PGE2 production through the negative regulation of NFκB signalling in RAW 264.7 cells

Journal of Ethnopharmacology

Volumn 147, Issue 1, 2013, Pages 208-214

  Jung, Seung Hyun ^a   Kim, Su Jung ^a   Jun, Bo Gyu ^a   Lee, Kyung Tae ^a   Hong, Seon Pyo ^a   Oh, Myung Sook ^a   Jang, Dae Sik ^a   Choi, Jung Hye ^a  

^a Kyung Hee University   (South Korea)

Author keywords

cyperone; COX 2; Inflammation; NF B; PGE2; Rhizomes of Cyperus rotundus

Indexed keywords

ALPHA CYPERONE; ANTIINFLAMMATORY AGENT; CYCLOOXYGENASE 2; CYPERUS ROTUNDUS EXTRACT; HEXANE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 6; MESSENGER RNA; NITRIC OXIDE; PROSTAGLANDIN E2; TRANSCRIPTION FACTOR RELA; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; BINDING AFFINITY; CELL VIABILITY; CONTROLLED STUDY; CYPERUS ROTUNDUS; CYTOKINE PRODUCTION; CYTOTOXICITY; MACROPHAGE; PROSTAGLANDIN SYNTHESIS INHIBITION; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RHIZOME; SIGNAL TRANSDUCTION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; BLOTTING, WESTERN; CELL LINE; CYCLOOXYGENASE 2; CYPERUS; DINOPROSTONE; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; ETHANOL; GENES, REPORTER; HEXANES; IMMUNOENZYME TECHNIQUES; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; MACROPHAGES; MEDICINE, KOREAN TRADITIONAL; MICE; NAPHTHALENES; NF-KAPPA B; NITRIC OXIDE SYNTHASE TYPE II; PHYTOTHERAPY; PLANT EXTRACTS; PLANTS, MEDICINAL; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RHIZOME; RNA, MESSENGER; SIGNAL TRANSDUCTION; SOLVENTS; TRANSFECTION; TUMOR NECROSIS FACTOR-ALPHA;

CYPERACEAE; CYPERUS ROTUNDUS;

EID: 84876017815     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2013.02.034     Document Type: Article

References (22)

1. Y. Ben-Neriah Regulatory functions of ubiquitination in the immune system Nature Immunology 3 2002 20 26 (Pubitemid 34065613)
2. B. Beutler, and A. Cerami The biology of cachectin/TNF-a primary mediator of the host response Annual Review of Immunology 7 1989 625 655 (Pubitemid 19138027)
3. S. Biradar, V.A. Kangralkar, Y. Mandavkar, M. Thakur, and N. Chougule Anti-inflammatory, anti-artheritic, analgesic and anticuonvulsant activit of cyperus essential oils International Journal of Pharmacy and Pharmaceutical Sciences 2 2010 112 115
4. G.K. Dang, R.R. Parekar, S.K. Kamat, A.M. Scindia, and N.N. Rege Antiinflammatory activity of Phyllanthus emblica, Plumbago zeylanica and Cyperus rotundus in acute models of inflammation Phytotherapy Research 25 2011 904 908
5. M.C. Duarte, G.M. Figueira, A. Sartoratto, V.L. Rehder, and C. Delarmelina Anti-candida activity of Brazilian medicinal plants Journal of Ethnopharmacology 97 2005 305 311 (Pubitemid 40222034)
6. G. Endler, C. Marsik, C. Joukhadar, R. Marculescu, F. Mayr, C. Mannhalter, O.F. Wagner, and B. Jilma The interleukin-6 G(-174)C promoter polymorphism does not determine plasma interleukin-6 concentrations in experimental endotoxemia in humans Clinical Chemistry 50 2004 195 200 (Pubitemid 38125718)
7. M.B. Gupta, T.K. Palit, N. Singh, and K.P. Bhargava Pharmacological studies to isolate the active constituents from Cyperus rotundus possessing anti-inflammatory, anti-pyretic and analgesic activities Indian Journal of Medical Research 59 1971 76 82
8. W. Jia, X. Wang, D. Xu, A. Zhao, and Y. Zhang Common traditional Chinese medicinal herbs for dysmenorrhea Phytotherapy Research 20 2006 819 824 (Pubitemid 44606475)
9. J.H. Jin, D.U. Lee, Y.S. Kim, and H.P. Kim Anti-allergic activity of sesquiterpenes from the rhizomes of Cyperus rotundus Archives of Pharmacal Research 34 2011 223 228
10. M. Karin, and Y. Ben-Neriah Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity Annual Review of Immunology 18 2000 621 663 (Pubitemid 30365393)
11. S. Kilani, R. Ben Ammar, I. Bouhlel, A. Abdelwahed, N. Hayder, A. Mahmoud, K. Ghedira, and L. Chekir-Ghedira Investigation of extracts from (Tunisian) Cyperus rotundus as antimutagens and radical scavengers Environmental Toxicology and Pharmacology 20 2005 478 484 (Pubitemid 41318062)
12. S. Kilani, M. Ben Sghaier, I. Limem, I. Bouhlel, J. Boubaker, W. Bhouri, I. Skandrani, A. Neffatti, R. Ben Ammar, M.G. Dijoux-Franca, K. Ghedira, and L. Chekir-Ghedira In vitro evaluation of antibacterial, antioxidant, cytotoxic and apoptotic activities of the tubers infusion and extracts of Cyperus rotundus Bioresource Technology 99 2008 9004 9008
13. S.J. Kim, H.J. Kim, H.J. Kim, Y.P. Jang, M.S. Oh, and D.S. Jang New patchoulane-type sesquiterpenes from the rhizomes of Cyperus rotundus Bulletin of the Korean Chemical Society 33 2012 3115
14. O.A. Lawal, and A.O. Oyedeji Chemical composition of the essential oils of Cyperus rotundus L. from South Africa Molecules 14 2009 2909 2917
15. M. Luo, J. Qiu, Y. Zhang, J. Wang, J. Dong, H. Li, B. Leng, Q. Zhang, X. Dai, X. Niu, S. Zhao, and X. Deng alpha-cyperone alleviates lung cell injury caused by Staphylococcus aureus via attenuation of alpha-hemolysin expression Journal of Microbiolgy and Biotechnology 22 2012 1170 1176
16. J.M. Pezzuto Plant-derived anticancer agents Biochemical Pharmacology 53 1997 121 133 (Pubitemid 27013467)
17. S.M. Prescott, and F.A. Fitzpatrick Cyclooxygenase-2 and carcinogenesis Biochimica et Biophysica Acta 1470 2000 M69 78
18. N.A. Raut, and N.J. Gaikwad Antidiabetic activity of hydro-ethanolic extract of Cyperus rotundus in alloxan induced diabetes in rats Fitoterapia 77 2006 585 588 (Pubitemid 44755335)
19. W.G. Seo, H.O. Pae, G.S. Oh, K.Y. Chai, T.O. Kwon, Y.G. Yun, N.Y. Kim, and H.T. Chung Inhibitory effects of methanol extract of Cyperus rotundus rhizomes on nitric oxide and superoxide productions by murine macrophage cell line, RAW 264.7 cells Journal of Ethnopharmacology 76 2001 59 64
20. N. Singh, V.K. Kulshrestha, M.B. Gupta, and K.P. Bhargava A pharmacological study of Cyperus rotundus Indian Journal of Medical Research 58 1970 103 109
21. C.U. Tam, F.Q. Yang, Q.W. Zhang, J. Guan, and S.P. Li Optimization and comparison of three methods for extraction of volatile compounds from Cyperus rotundus evaluated by gas chromatography-mass spectrometry Journal of Pharmaceutical and Biomedical Analysis 44 2007 444 449 (Pubitemid 46880076)
22. R. Zamora, Y. Vodovotz, and T.R. Billiar Inducible nitric oxide synthase and inflammatory diseases Molecular Medicine 6 2000 347 373