The changing face of renal cell carcinoma: The impact of systematic genetic sequencing on our understanding of this tumor's biology

European Urology

Volumn 63, Issue 5, 2013, Pages 855-857

  Catto, James W F ^a   Shariat, Shahrokh F ^b  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b NEW YORK PRESBYTERIAN HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRCA1 PROTEIN ASSOCIATED PROTEIN 1; CARBONATE DEHYDRATASE IX; ERYTHROPOIETIN; ESTRONE; HISTONE H3; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 2ALPHA; JARID1C PROTEIN; KDM5C PROTEIN; KDM6A PROTEIN; MLL2 PROTEIN; POLYBROMO 1 PROTEIN; PROTEIN; SCATTER FACTOR RECEPTOR; SET DOMAIN CONTAINING 2; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; VASCULOTROPIN; VON HIPPEL LINDAU PROTEIN;

ACETYLATION; ADVANCED CANCER; BIRT HOGG DUBE SYNDROME; CANCER STAGING; CANCER SUSCEPTIBILITY; CHROMATIN STRUCTURE; CHROMOSOME 3P; DEMETHYLATION; DNA METHYLATION; EDITORIAL; EPIGENETICS; FAMILIAL CANCER; GENE CONTROL; GENE LOCATION; GENE MUTATION; GENE REPRESSION; GENE SEQUENCE; GENETIC SCREENING; GENETIC TRANSCRIPTION; HISTONE METHYLATION; HUMAN; KARYOTYPING; KIDNEY CARCINOMA; PRIORITY JOURNAL; VON HIPPEL LINDAU DISEASE;

CARCINOMA, RENAL CELL; CHROMATIN ASSEMBLY AND DISASSEMBLY; FEMALE; GENES, TUMOR SUPPRESSOR; HUMANS; KIDNEY NEOPLASMS; MALE; MUTATION;

EID: 84876014450     PISSN: 03022838     EISSN: 18737560     Source Type: Journal    
DOI: 10.1016/j.eururo.2012.09.049     Document Type: Editorial

References (11)

1. J. Cairns Mutation and cancer: the antecedents to our studies of adaptive mutation Genetics 148 1998 1433 1440
2. F. Latif, K. Tory, and J. Gnarra Identification of the von Hippel-Lindau disease tumor suppressor gene Science 260 1993 1317 1320
3. E. Jonasch, P.A. Futreal, and I.J. Davis State of the science: an update on renal cell carcinoma Mol Cancer Res 10 2012 859 880
4. G. Sonpavde, T.K. Choueiri, and B. Escudier Sequencing of agents for metastatic renal cell carcinoma: can we customize therapy? Eur Urol 61 2012 307 316
5. G. van Haaften, G.L. Dalgliesh, and H. Davies Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer Nat Genet 41 2009 521 523
6. G.L. Dalgliesh, K. Furge, and C. Greenman Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes Nature 463 2010 360 363
7. E. Dudziec, A. Giogel-Doering, V. Cookson, W. Chew, and J.W. Catto Integrated epigenome profiling of repressive histone modifications, DNA methylation and gene expression in normal and malignant urothelial cells PLoS One 7 2012 e32750
8. I. Varela, P. Tarpey, and K. Raine Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma Nature 469 2011 539 542
9. S. Pena-Llopis, S. Vega-Rubin-de-Celis, and A. Liao BAP1 loss defines a new class of renal cell carcinoma Nature Genet 44 2012 751 759
10. M. Gerlinger, A.J. Rowan, and S. Horswell Intratumor heterogeneity and branched evolution revealed by multiregion sequencing N Engl J Med 366 2012 883 892
11. A.A. Hakimi, Y.-B. Chen, and J. Wren Clinical and pathologic impact of select chromatin-modulating tumor suppressors in clear cell renal cell carcinoma Eur Urol 63 2013 848 854