Identification of Anziaic Acid, a Lichen Depside from Hypotrachyna sp., as a New Topoisomerase Poison Inhibitor

PLoS ONE

Volumn 8, Issue 4, 2013, Pages

  Cheng, Bokun ^a   Cao, Shugeng ^b   Vasquez, Victor ^c   Annamalai, Thirunavukkarasu ^a,d   Tamayo Castillo, Giselle ^c   Clardy, Jon ^b   Tse Dinh, Yuk Ching ^a,d  

^a NEW YORK MEDICAL COLLEGE   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c UNIVERSIDAD DE COSTA RICA   (Costa Rica)

^d FLORIDA INTERNATIONAL UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANZIAIC ACID; DEPSIDE; DNA; DNA TOPOISOMERASE; DNA TOPOISOMERASE (ATP HYDROLYSING); DNA TOPOISOMERASE INHIBITOR; MAGNESIUM ION; RECOMBINANT DNA TOPOISOMERASE; RECOMBINANT ENZYME; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACILLUS SUBTILIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DNA CLEAVAGE; DRUG IDENTIFICATION; DRUG ISOLATION; DRUG RESEARCH; DRUG STRUCTURE; ENDOTHELIUM CELL; ENZYME ASSAY; ENZYME INHIBITION; ENZYME SPECIFICITY; ESCHERICHIA COLI; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; HYPOTRACHYNA; IC 50; IN VITRO STUDY; LICHEN (ORGANISM); NONHUMAN; PULMONARY ARTERY; YERSINIA PESTIS;

ANTI-BACTERIAL AGENTS; ASCOMYCOTA; BIOLOGICAL AGENTS; CELL SURVIVAL; DEPSIDES; DETERGENTS; DNA TOPOISOMERASES, TYPE I; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; ESCHERICHIA COLI; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; HYDROXYBENZOATES; MAGNESIUM; SMALL MOLECULE LIBRARIES; TOPOISOMERASE INHIBITORS; YERSINIA PESTIS;

BACILLUS SUBTILIS; ESCHERICHIA COLI; HYPOTRACHYNA; YERSINIA PESTIS;

EID: 84876006881     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0060770     Document Type: Article

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