메뉴 건너뛰기




Volumn 7, Issue 5, 2013, Pages 1579-1584

MiRNA-200c increases the sensitivity of breast cancer cells to doxorubicin through the suppression of E-cadherin-mediated PTEN/Akt signaling

Author keywords

Akt; Breast cancer; Doxorubicin resistance; E cadherin; MiRNA 200c; PTEN

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; DOXORUBICIN; MICRORNA 200C; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; TRANSCRIPTION FACTOR ZEB1; UVOMORULIN;

EID: 84876004859     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2013.1403     Document Type: Article
Times cited : (75)

References (29)
  • 1
    • 33646371709 scopus 로고    scopus 로고
    • Multiple genetic and epigenetic interacting mechanisms contribute to clonally selection of drug-resistant tumors: Current views and new therapeutic prospective
    • Roberti A, La Sala D and Cinti C: Multiple genetic and epigenetic interacting mechanisms contribute to clonally selection of drug-resistant tumors: current views and new therapeutic prospective. J Cell Physiol 207: 571-581, 2006.
    • (2006) J Cell Physiol , vol.207 , pp. 571-581
    • Roberti, A.1    La Sala, D.2    Cinti, C.3
  • 2
    • 33646128506 scopus 로고    scopus 로고
    • Epigenetics as a mechanism driving polygenic clinical drug resistance
    • Glasspool RM, Teodoridis JM and Brown R: Epigenetics as a mechanism driving polygenic clinical drug resistance. Br J Cancer 94: 1087-1092, 2006.
    • (2006) Br J Cancer , vol.94 , pp. 1087-1092
    • Glasspool, R.M.1    Teodoridis, J.M.2    Brown, R.3
  • 3
    • 33646183071 scopus 로고    scopus 로고
    • Evolution of resistance during clonal expansion
    • Iwasa Y, Nowak MA and Michor F: Evolution of resistance during clonal expansion. Genetics 172: 2557-2566, 2006.
    • (2006) Genetics , vol.172 , pp. 2557-2566
    • Iwasa, Y.1    Nowak, M.A.2    Michor, F.3
  • 4
    • 0347444723 scopus 로고    scopus 로고
    • MicroRNAs: Genomics, biogenesis, mechanism, and function
    • Bartel DP: MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116: 281-297, 2004.
    • (2004) Cell , vol.116 , pp. 281-297
    • Bartel, D.P.1
  • 5
    • 77954265970 scopus 로고    scopus 로고
    • Expression of miRNA-106b in conventional renal cell carcinoma is a potential marker for prediction of early metastasis after nephrectomy
    • Slaby O, Jancovicova J, Lakomy R, et al: Expression of miRNA-106b in conventional renal cell carcinoma is a potential marker for prediction of early metastasis after nephrectomy. J Exp Clin Cancer Res 29: 90, 2010.
    • (2010) J Exp Clin Cancer Res , vol.29 , pp. 90
    • Slaby, O.1    Jancovicova, J.2    Lakomy, R.3
  • 6
    • 77952838399 scopus 로고    scopus 로고
    • Signatures of microRNAs and selected microRNA target genes in human melanoma
    • Philippidou D, Schmitt M, Moser D, et al: Signatures of microRNAs and selected microRNA target genes in human melanoma. Cancer Res 70: 4163-4173, 2010.
    • (2010) Cancer Res , vol.70 , pp. 4163-4173
    • Philippidou, D.1    Schmitt, M.2    Moser, D.3
  • 7
    • 84877263372 scopus 로고    scopus 로고
    • Lyberopoulou A, Polymeneas G and Voros D: Expression of microRNAs, miR-21, miR-31, miR-122, miR-145, miR-146a, miR-200c, miR-221, miR-222, and miR-223 in patients with hepatocellular carcinoma or intrahepatic cholangiocarcinoma and its prognostic significance
    • (Epub ahead of print). doi: 10.1002/mc.21864
    • Karakatsanis A, Papaconstantinou I, Gazouli M, Lyberopoulou A, Polymeneas G and Voros D: Expression of microRNAs, miR-21, miR-31, miR-122, miR-145, miR-146a, miR-200c, miR-221, miR-222, and miR-223 in patients with hepatocellular carcinoma or intrahepatic cholangiocarcinoma and its prognostic significance. Mol Carcinog Dec 27, 2011 (Epub ahead of print). doi: 10.1002/mc.21864.
    • (2011) Mol Carcinog Dec , pp. 27
    • Karakatsanis, A.1    Papaconstantinou, I.2    Gazouli, M.3
  • 8
    • 66849140943 scopus 로고    scopus 로고
    • MicroRNA-200c mitigates invasiveness and restores sensitivity to microtubule-targeting chemotherapeutic agents
    • Cochrane DR, Spoelstra NS, Howe EN, Nordeen SK and Richer JK: MicroRNA-200c mitigates invasiveness and restores sensitivity to microtubule-targeting chemotherapeutic agents. Mol Cancer Ther 8: 1055-1066, 2009.
    • (2009) Mol Cancer Ther , vol.8 , pp. 1055-1066
    • Cochrane, D.R.1    Spoelstra, N.S.2    Howe, E.N.3    Nordeen, S.K.4    Richer, J.K.5
  • 9
    • 77957280345 scopus 로고    scopus 로고
    • Loss of miR-200c expression induces an aggressive, invasive, and chemoresistant phenotype in non-small cell lung cancer
    • Ceppi P, Mudduluru G, Kumarswamy R, et al: Loss of miR-200c expression induces an aggressive, invasive, and chemoresistant phenotype in non-small cell lung cancer. Mol Cancer Res 8: 1207-1216, 2010.
    • (2010) Mol Cancer Res , vol.8 , pp. 1207-1216
    • Ceppi, P.1    Mudduluru, G.2    Kumarswamy, R.3
  • 10
    • 51049104524 scopus 로고    scopus 로고
    • Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin
    • Kovalchuk O, Filkowski J, Meservy J, et al: Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin. Mol Cancer Ther 7: 2152-2159, 2008.
    • (2008) Mol Cancer Ther , vol.7 , pp. 2152-2159
    • Kovalchuk, O.1    Filkowski, J.2    Meservy, J.3
  • 11
    • 34548851138 scopus 로고    scopus 로고
    • Restoring E-cadherin-mediated cell-cell adhesion increases PTEN protein level and stability in human breast carcinoma cells
    • Li Z, Wang L, Zhang W, et al: Restoring E-cadherin-mediated cell-cell adhesion increases PTEN protein level and stability in human breast carcinoma cells. Biochem Biophys Res Commun 363: 165-170, 2007.
    • (2007) Biochem Biophys Res Commun , vol.363 , pp. 165-170
    • Li, Z.1    Wang, L.2    Zhang, W.3
  • 12
    • 77954217891 scopus 로고    scopus 로고
    • Acquired resistance to cetuximab is mediated by increased PTEN instability and leads cross-resistance to gefitinib in HCC827 NSCLC cells
    • Kim SM, Kim JS, Kim JH, et al: Acquired resistance to cetuximab is mediated by increased PTEN instability and leads cross-resistance to gefitinib in HCC827 NSCLC cells. Cancer Lett 296: 150-159, 2010.
    • (2010) Cancer Lett , vol.296 , pp. 150-159
    • Kim, S.M.1    Kim, J.S.2    Kim, J.H.3
  • 13
    • 41649091906 scopus 로고    scopus 로고
    • The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2
    • Park SM, Gaur AB, Lengyel E and Peter ME: The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2. Genes Dev 22: 894-907, 2008.
    • (2008) Genes Dev , vol.22 , pp. 894-907
    • Park, S.M.1    Gaur, A.B.2    Lengyel, E.3    Peter, M.E.4
  • 14
    • 79958789619 scopus 로고    scopus 로고
    • E-cadherin inhibits tumor cell growth by suppressing PI3K/Akt signaling via β-catenin-Egr1-mediated PTEN expression
    • Lau MT, Klausen C and Leung PC: E-cadherin inhibits tumor cell growth by suppressing PI3K/Akt signaling via β-catenin-Egr1-mediated PTEN expression. Oncogene 30: 2753-2766, 2011.
    • (2011) Oncogene , vol.30 , pp. 2753-2766
    • Lau, M.T.1    Klausen, C.2    Leung, P.C.3
  • 15
    • 69749115434 scopus 로고    scopus 로고
    • Role of caveolin 1, E-cadherin, Enolase 2 and PKCalpha on resistance to methotrexate in human HT29 colon cancer cells
    • Selga E, Morales C, Noé V, Peinado MA and Ciudad CJ: Role of caveolin 1, E-cadherin, Enolase 2 and PKCalpha on resistance to methotrexate in human HT29 colon cancer cells. BMC Med Genomics 1: 35, 2008.
    • (2008) BMC Med Genomics , vol.1 , pp. 35
    • Selga, E.1    Morales, C.2    Noé, V.3    Peinado, M.A.4    Ciudad, C.J.5
  • 16
    • 34548565806 scopus 로고    scopus 로고
    • Overexpression of the microRNA hsa-miR-200c leads to reduced expression of transcription factor 8 and increased expression of E-cadherin
    • Hurteau GJ, Carlson JA, Spivack SD and Brock GJ: Overexpression of the microRNA hsa-miR-200c leads to reduced expression of transcription factor 8 and increased expression of E-cadherin. Cancer Res 67: 7972-7976, 2007.
    • (2007) Cancer Res , vol.67 , pp. 7972-7976
    • Hurteau, G.J.1    Carlson, J.A.2    Spivack, S.D.3    Brock, G.J.4
  • 17
    • 20144388095 scopus 로고    scopus 로고
    • DeltaEF1 is a transcriptional repressor of E-cadherin and regulates epithelial plasticity in breast cancer cells
    • Eger A, Aigner K, Sonderegger S, et al: DeltaEF1 is a transcriptional repressor of E-cadherin and regulates epithelial plasticity in breast cancer cells. Oncogene 24: 2375-2385, 2005.
    • (2005) Oncogene , vol.24 , pp. 2375-2385
    • Eger, A.1    Aigner, K.2    Sonderegger, S.3
  • 18
    • 77951248184 scopus 로고    scopus 로고
    • E-cadherin transcriptional down-regulation by epigenetic and microRNA-200 family alterations is related to mesenchymal and drug-resistant phenotypes in human breast cancer cells
    • Tryndyak VP, Beland FA and Pogribny IP: E-cadherin transcriptional down-regulation by epigenetic and microRNA-200 family alterations is related to mesenchymal and drug-resistant phenotypes in human breast cancer cells. Int J Cancer 126: 2575-2583, 2010.
    • (2010) Int J Cancer , vol.126 , pp. 2575-2583
    • Tryndyak, V.P.1    Beland, F.A.2    Pogribny, I.P.3
  • 19
    • 33748947308 scopus 로고    scopus 로고
    • Potential mRNA degradation targets of hsa-miR-200c, identified using informatics and qRT-PCR
    • Hurteau GJ, Spivack SD and Brock GJ: Potential mRNA degradation targets of hsa-miR-200c, identified using informatics and qRT-PCR. Cell Cycle 5: 1951-1956, 2006.
    • (2006) Cell Cycle , vol.5 , pp. 1951-1956
    • Hurteau, G.J.1    Spivack, S.D.2    Brock, G.J.3
  • 20
    • 77954855721 scopus 로고    scopus 로고
    • Double strand RNA-guided endogeneous E-cadherin up-regulation induces the apoptosis and inhibits proliferation of breast carcinoma cells in vitro and in vivo
    • Junxia W, Ping G, Yuan H, et al: Double strand RNA-guided endogeneous E-cadherin up-regulation induces the apoptosis and inhibits proliferation of breast carcinoma cells in vitro and in vivo. Cancer Sci 101: 1790-1796, 2010.
    • (2010) Cancer Sci , vol.101 , pp. 1790-1796
    • Junxia, W.1    Ping, G.2    Yuan, H.3
  • 21
    • 0034059172 scopus 로고    scopus 로고
    • Expression of E-cadherin reduces bcl-2 expression and increases sensitivity to etoposide-induced apoptosis
    • Sasaki CY, Lin HC and Passaniti A: Expression of E-cadherin reduces bcl-2 expression and increases sensitivity to etoposide-induced apoptosis. Int J Cancer 86: 660-666, 2000.
    • (2000) Int J Cancer , vol.86 , pp. 660-666
    • Sasaki, C.Y.1    Lin, H.C.2    Passaniti, A.3
  • 22
    • 25844493033 scopus 로고    scopus 로고
    • Loss of functional E-cadherin renders cells more resistant to the apoptotic agent taxol in vitro
    • Ferreira P, Oliveira MJ, Beraldi E, et al: Loss of functional E-cadherin renders cells more resistant to the apoptotic agent taxol in vitro. Exp Cell Res 310: 99-104, 2005.
    • (2005) Exp Cell Res , vol.310 , pp. 99-104
    • Ferreira, P.1    Oliveira, M.J.2    Beraldi, E.3
  • 23
    • 40949091867 scopus 로고    scopus 로고
    • Sensitivity to epidermal growth factor receptor inhibitor requires E-cadherin expression in urothelial carcinoma cells
    • Black PC, Brown GA, Inamoto T, et al: Sensitivity to epidermal growth factor receptor inhibitor requires E-cadherin expression in urothelial carcinoma cells. Clin Cancer Res 14: 1478-1486, 2008.
    • (2008) Clin Cancer Res , vol.14 , pp. 1478-1486
    • Black, P.C.1    Brown, G.A.2    Inamoto, T.3
  • 24
    • 31544452076 scopus 로고    scopus 로고
    • Restoring E-cadherin expression increases sensitivity to epidermal growth factor receptor inhibitors in lung cancer cell lines
    • Witta SE, Gemmill RM, Hirsch FR, et al: Restoring E-cadherin expression increases sensitivity to epidermal growth factor receptor inhibitors in lung cancer cell lines. Cancer Res 66: 944-950, 2006.
    • (2006) Cancer Res , vol.66 , pp. 944-950
    • Witta, S.E.1    Gemmill, R.M.2    Hirsch, F.R.3
  • 25
    • 0036632368 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-kinase AKT pathway in human cancer
    • Vivanco I and Sawyers CL: The phosphatidylinositol 3-kinase AKT pathway in human cancer. Nat Rev Cancer 2: 489-501, 2002.
    • (2002) Nat Rev Cancer , vol.2 , pp. 489-501
    • Vivanco, I.1    Sawyers, C.L.2
  • 26
    • 26444503696 scopus 로고    scopus 로고
    • Akt phosphorylation associates with LOH of PTEN and leads to chemoresistance for gastric cancer
    • Oki E, Baba H, Tokunaga E, et al: Akt phosphorylation associates with LOH of PTEN and leads to chemoresistance for gastric cancer. Int J Cancer 117: 376-380, 2005.
    • (2005) Int J Cancer , vol.117 , pp. 376-380
    • Oki, E.1    Baba, H.2    Tokunaga, E.3
  • 27
    • 23044445418 scopus 로고    scopus 로고
    • PED mediates AKT-dependent chemoresistance in human breast cancer cells
    • Stassi G, Garofalo M, Zerilli M, et al: PED mediates AKT-dependent chemoresistance in human breast cancer cells. Cancer Res 65: 6668-6675, 2005.
    • (2005) Cancer Res , vol.65 , pp. 6668-6675
    • Stassi, G.1    Garofalo, M.2    Zerilli, M.3
  • 28
    • 0032506011 scopus 로고    scopus 로고
    • The lipid phosphatase activity of PTEN is critical for its tumor supressor function
    • Myers MP, Pass I, Batty IH, et al: The lipid phosphatase activity of PTEN is critical for its tumor supressor function. Proc Natl Acad Sci USA 95: 13513-13518, 1998.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 13513-13518
    • Myers, M.P.1    Pass, I.2    Batty, I.H.3
  • 29
    • 15544369937 scopus 로고    scopus 로고
    • Activation of PI3K/Akt pathway by PTEN reduction and PIK3CA mRNA amplification contributes to cisplatin resistance in an ovarian cancer cell line
    • Lee S, Choi EJ, Jin C and Kim DH: Activation of PI3K/Akt pathway by PTEN reduction and PIK3CA mRNA amplification contributes to cisplatin resistance in an ovarian cancer cell line. Gynecol Oncol 97: 26-34, 2005.
    • (2005) Gynecol Oncol , vol.97 , pp. 26-34
    • Lee, S.1    Choi, E.J.2    Jin, C.3    Kim, D.H.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.