-
1
-
-
33646371709
-
Multiple genetic and epigenetic interacting mechanisms contribute to clonally selection of drug-resistant tumors: Current views and new therapeutic prospective
-
Roberti A, La Sala D and Cinti C: Multiple genetic and epigenetic interacting mechanisms contribute to clonally selection of drug-resistant tumors: current views and new therapeutic prospective. J Cell Physiol 207: 571-581, 2006.
-
(2006)
J Cell Physiol
, vol.207
, pp. 571-581
-
-
Roberti, A.1
La Sala, D.2
Cinti, C.3
-
2
-
-
33646128506
-
Epigenetics as a mechanism driving polygenic clinical drug resistance
-
Glasspool RM, Teodoridis JM and Brown R: Epigenetics as a mechanism driving polygenic clinical drug resistance. Br J Cancer 94: 1087-1092, 2006.
-
(2006)
Br J Cancer
, vol.94
, pp. 1087-1092
-
-
Glasspool, R.M.1
Teodoridis, J.M.2
Brown, R.3
-
3
-
-
33646183071
-
Evolution of resistance during clonal expansion
-
Iwasa Y, Nowak MA and Michor F: Evolution of resistance during clonal expansion. Genetics 172: 2557-2566, 2006.
-
(2006)
Genetics
, vol.172
, pp. 2557-2566
-
-
Iwasa, Y.1
Nowak, M.A.2
Michor, F.3
-
4
-
-
0347444723
-
MicroRNAs: Genomics, biogenesis, mechanism, and function
-
Bartel DP: MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116: 281-297, 2004.
-
(2004)
Cell
, vol.116
, pp. 281-297
-
-
Bartel, D.P.1
-
5
-
-
77954265970
-
Expression of miRNA-106b in conventional renal cell carcinoma is a potential marker for prediction of early metastasis after nephrectomy
-
Slaby O, Jancovicova J, Lakomy R, et al: Expression of miRNA-106b in conventional renal cell carcinoma is a potential marker for prediction of early metastasis after nephrectomy. J Exp Clin Cancer Res 29: 90, 2010.
-
(2010)
J Exp Clin Cancer Res
, vol.29
, pp. 90
-
-
Slaby, O.1
Jancovicova, J.2
Lakomy, R.3
-
6
-
-
77952838399
-
Signatures of microRNAs and selected microRNA target genes in human melanoma
-
Philippidou D, Schmitt M, Moser D, et al: Signatures of microRNAs and selected microRNA target genes in human melanoma. Cancer Res 70: 4163-4173, 2010.
-
(2010)
Cancer Res
, vol.70
, pp. 4163-4173
-
-
Philippidou, D.1
Schmitt, M.2
Moser, D.3
-
7
-
-
84877263372
-
Lyberopoulou A, Polymeneas G and Voros D: Expression of microRNAs, miR-21, miR-31, miR-122, miR-145, miR-146a, miR-200c, miR-221, miR-222, and miR-223 in patients with hepatocellular carcinoma or intrahepatic cholangiocarcinoma and its prognostic significance
-
(Epub ahead of print). doi: 10.1002/mc.21864
-
Karakatsanis A, Papaconstantinou I, Gazouli M, Lyberopoulou A, Polymeneas G and Voros D: Expression of microRNAs, miR-21, miR-31, miR-122, miR-145, miR-146a, miR-200c, miR-221, miR-222, and miR-223 in patients with hepatocellular carcinoma or intrahepatic cholangiocarcinoma and its prognostic significance. Mol Carcinog Dec 27, 2011 (Epub ahead of print). doi: 10.1002/mc.21864.
-
(2011)
Mol Carcinog Dec
, pp. 27
-
-
Karakatsanis, A.1
Papaconstantinou, I.2
Gazouli, M.3
-
8
-
-
66849140943
-
MicroRNA-200c mitigates invasiveness and restores sensitivity to microtubule-targeting chemotherapeutic agents
-
Cochrane DR, Spoelstra NS, Howe EN, Nordeen SK and Richer JK: MicroRNA-200c mitigates invasiveness and restores sensitivity to microtubule-targeting chemotherapeutic agents. Mol Cancer Ther 8: 1055-1066, 2009.
-
(2009)
Mol Cancer Ther
, vol.8
, pp. 1055-1066
-
-
Cochrane, D.R.1
Spoelstra, N.S.2
Howe, E.N.3
Nordeen, S.K.4
Richer, J.K.5
-
9
-
-
77957280345
-
Loss of miR-200c expression induces an aggressive, invasive, and chemoresistant phenotype in non-small cell lung cancer
-
Ceppi P, Mudduluru G, Kumarswamy R, et al: Loss of miR-200c expression induces an aggressive, invasive, and chemoresistant phenotype in non-small cell lung cancer. Mol Cancer Res 8: 1207-1216, 2010.
-
(2010)
Mol Cancer Res
, vol.8
, pp. 1207-1216
-
-
Ceppi, P.1
Mudduluru, G.2
Kumarswamy, R.3
-
10
-
-
51049104524
-
Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin
-
Kovalchuk O, Filkowski J, Meservy J, et al: Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin. Mol Cancer Ther 7: 2152-2159, 2008.
-
(2008)
Mol Cancer Ther
, vol.7
, pp. 2152-2159
-
-
Kovalchuk, O.1
Filkowski, J.2
Meservy, J.3
-
11
-
-
34548851138
-
Restoring E-cadherin-mediated cell-cell adhesion increases PTEN protein level and stability in human breast carcinoma cells
-
Li Z, Wang L, Zhang W, et al: Restoring E-cadherin-mediated cell-cell adhesion increases PTEN protein level and stability in human breast carcinoma cells. Biochem Biophys Res Commun 363: 165-170, 2007.
-
(2007)
Biochem Biophys Res Commun
, vol.363
, pp. 165-170
-
-
Li, Z.1
Wang, L.2
Zhang, W.3
-
12
-
-
77954217891
-
Acquired resistance to cetuximab is mediated by increased PTEN instability and leads cross-resistance to gefitinib in HCC827 NSCLC cells
-
Kim SM, Kim JS, Kim JH, et al: Acquired resistance to cetuximab is mediated by increased PTEN instability and leads cross-resistance to gefitinib in HCC827 NSCLC cells. Cancer Lett 296: 150-159, 2010.
-
(2010)
Cancer Lett
, vol.296
, pp. 150-159
-
-
Kim, S.M.1
Kim, J.S.2
Kim, J.H.3
-
13
-
-
41649091906
-
The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2
-
Park SM, Gaur AB, Lengyel E and Peter ME: The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2. Genes Dev 22: 894-907, 2008.
-
(2008)
Genes Dev
, vol.22
, pp. 894-907
-
-
Park, S.M.1
Gaur, A.B.2
Lengyel, E.3
Peter, M.E.4
-
14
-
-
79958789619
-
E-cadherin inhibits tumor cell growth by suppressing PI3K/Akt signaling via β-catenin-Egr1-mediated PTEN expression
-
Lau MT, Klausen C and Leung PC: E-cadherin inhibits tumor cell growth by suppressing PI3K/Akt signaling via β-catenin-Egr1-mediated PTEN expression. Oncogene 30: 2753-2766, 2011.
-
(2011)
Oncogene
, vol.30
, pp. 2753-2766
-
-
Lau, M.T.1
Klausen, C.2
Leung, P.C.3
-
15
-
-
69749115434
-
Role of caveolin 1, E-cadherin, Enolase 2 and PKCalpha on resistance to methotrexate in human HT29 colon cancer cells
-
Selga E, Morales C, Noé V, Peinado MA and Ciudad CJ: Role of caveolin 1, E-cadherin, Enolase 2 and PKCalpha on resistance to methotrexate in human HT29 colon cancer cells. BMC Med Genomics 1: 35, 2008.
-
(2008)
BMC Med Genomics
, vol.1
, pp. 35
-
-
Selga, E.1
Morales, C.2
Noé, V.3
Peinado, M.A.4
Ciudad, C.J.5
-
16
-
-
34548565806
-
Overexpression of the microRNA hsa-miR-200c leads to reduced expression of transcription factor 8 and increased expression of E-cadherin
-
Hurteau GJ, Carlson JA, Spivack SD and Brock GJ: Overexpression of the microRNA hsa-miR-200c leads to reduced expression of transcription factor 8 and increased expression of E-cadherin. Cancer Res 67: 7972-7976, 2007.
-
(2007)
Cancer Res
, vol.67
, pp. 7972-7976
-
-
Hurteau, G.J.1
Carlson, J.A.2
Spivack, S.D.3
Brock, G.J.4
-
17
-
-
20144388095
-
DeltaEF1 is a transcriptional repressor of E-cadherin and regulates epithelial plasticity in breast cancer cells
-
Eger A, Aigner K, Sonderegger S, et al: DeltaEF1 is a transcriptional repressor of E-cadherin and regulates epithelial plasticity in breast cancer cells. Oncogene 24: 2375-2385, 2005.
-
(2005)
Oncogene
, vol.24
, pp. 2375-2385
-
-
Eger, A.1
Aigner, K.2
Sonderegger, S.3
-
18
-
-
77951248184
-
E-cadherin transcriptional down-regulation by epigenetic and microRNA-200 family alterations is related to mesenchymal and drug-resistant phenotypes in human breast cancer cells
-
Tryndyak VP, Beland FA and Pogribny IP: E-cadherin transcriptional down-regulation by epigenetic and microRNA-200 family alterations is related to mesenchymal and drug-resistant phenotypes in human breast cancer cells. Int J Cancer 126: 2575-2583, 2010.
-
(2010)
Int J Cancer
, vol.126
, pp. 2575-2583
-
-
Tryndyak, V.P.1
Beland, F.A.2
Pogribny, I.P.3
-
19
-
-
33748947308
-
Potential mRNA degradation targets of hsa-miR-200c, identified using informatics and qRT-PCR
-
Hurteau GJ, Spivack SD and Brock GJ: Potential mRNA degradation targets of hsa-miR-200c, identified using informatics and qRT-PCR. Cell Cycle 5: 1951-1956, 2006.
-
(2006)
Cell Cycle
, vol.5
, pp. 1951-1956
-
-
Hurteau, G.J.1
Spivack, S.D.2
Brock, G.J.3
-
20
-
-
77954855721
-
Double strand RNA-guided endogeneous E-cadherin up-regulation induces the apoptosis and inhibits proliferation of breast carcinoma cells in vitro and in vivo
-
Junxia W, Ping G, Yuan H, et al: Double strand RNA-guided endogeneous E-cadherin up-regulation induces the apoptosis and inhibits proliferation of breast carcinoma cells in vitro and in vivo. Cancer Sci 101: 1790-1796, 2010.
-
(2010)
Cancer Sci
, vol.101
, pp. 1790-1796
-
-
Junxia, W.1
Ping, G.2
Yuan, H.3
-
21
-
-
0034059172
-
Expression of E-cadherin reduces bcl-2 expression and increases sensitivity to etoposide-induced apoptosis
-
Sasaki CY, Lin HC and Passaniti A: Expression of E-cadherin reduces bcl-2 expression and increases sensitivity to etoposide-induced apoptosis. Int J Cancer 86: 660-666, 2000.
-
(2000)
Int J Cancer
, vol.86
, pp. 660-666
-
-
Sasaki, C.Y.1
Lin, H.C.2
Passaniti, A.3
-
22
-
-
25844493033
-
Loss of functional E-cadherin renders cells more resistant to the apoptotic agent taxol in vitro
-
Ferreira P, Oliveira MJ, Beraldi E, et al: Loss of functional E-cadherin renders cells more resistant to the apoptotic agent taxol in vitro. Exp Cell Res 310: 99-104, 2005.
-
(2005)
Exp Cell Res
, vol.310
, pp. 99-104
-
-
Ferreira, P.1
Oliveira, M.J.2
Beraldi, E.3
-
23
-
-
40949091867
-
Sensitivity to epidermal growth factor receptor inhibitor requires E-cadherin expression in urothelial carcinoma cells
-
Black PC, Brown GA, Inamoto T, et al: Sensitivity to epidermal growth factor receptor inhibitor requires E-cadherin expression in urothelial carcinoma cells. Clin Cancer Res 14: 1478-1486, 2008.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 1478-1486
-
-
Black, P.C.1
Brown, G.A.2
Inamoto, T.3
-
24
-
-
31544452076
-
Restoring E-cadherin expression increases sensitivity to epidermal growth factor receptor inhibitors in lung cancer cell lines
-
Witta SE, Gemmill RM, Hirsch FR, et al: Restoring E-cadherin expression increases sensitivity to epidermal growth factor receptor inhibitors in lung cancer cell lines. Cancer Res 66: 944-950, 2006.
-
(2006)
Cancer Res
, vol.66
, pp. 944-950
-
-
Witta, S.E.1
Gemmill, R.M.2
Hirsch, F.R.3
-
25
-
-
0036632368
-
The phosphatidylinositol 3-kinase AKT pathway in human cancer
-
Vivanco I and Sawyers CL: The phosphatidylinositol 3-kinase AKT pathway in human cancer. Nat Rev Cancer 2: 489-501, 2002.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 489-501
-
-
Vivanco, I.1
Sawyers, C.L.2
-
26
-
-
26444503696
-
Akt phosphorylation associates with LOH of PTEN and leads to chemoresistance for gastric cancer
-
Oki E, Baba H, Tokunaga E, et al: Akt phosphorylation associates with LOH of PTEN and leads to chemoresistance for gastric cancer. Int J Cancer 117: 376-380, 2005.
-
(2005)
Int J Cancer
, vol.117
, pp. 376-380
-
-
Oki, E.1
Baba, H.2
Tokunaga, E.3
-
27
-
-
23044445418
-
PED mediates AKT-dependent chemoresistance in human breast cancer cells
-
Stassi G, Garofalo M, Zerilli M, et al: PED mediates AKT-dependent chemoresistance in human breast cancer cells. Cancer Res 65: 6668-6675, 2005.
-
(2005)
Cancer Res
, vol.65
, pp. 6668-6675
-
-
Stassi, G.1
Garofalo, M.2
Zerilli, M.3
-
28
-
-
0032506011
-
The lipid phosphatase activity of PTEN is critical for its tumor supressor function
-
Myers MP, Pass I, Batty IH, et al: The lipid phosphatase activity of PTEN is critical for its tumor supressor function. Proc Natl Acad Sci USA 95: 13513-13518, 1998.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 13513-13518
-
-
Myers, M.P.1
Pass, I.2
Batty, I.H.3
-
29
-
-
15544369937
-
Activation of PI3K/Akt pathway by PTEN reduction and PIK3CA mRNA amplification contributes to cisplatin resistance in an ovarian cancer cell line
-
Lee S, Choi EJ, Jin C and Kim DH: Activation of PI3K/Akt pathway by PTEN reduction and PIK3CA mRNA amplification contributes to cisplatin resistance in an ovarian cancer cell line. Gynecol Oncol 97: 26-34, 2005.
-
(2005)
Gynecol Oncol
, vol.97
, pp. 26-34
-
-
Lee, S.1
Choi, E.J.2
Jin, C.3
Kim, D.H.4
|