Improving survival and preventing recurrence of diffuse large B-cell lymphoma in younger patients: Current strategies and future directions

OncoTargets and Therapy

Volumn 6, Issue , 2013, Pages 289-296

  Coiffier, Lionel Karlin Bertrand ^a  

^a CENTRE HOSPITALIER LYON SUD   (France)

Author keywords

Early FDG PET; Keywords:diffuse large B cell lymphoma; Novel agents; Prognostic markers; Risk adapted therapy; Targeted therapy

Indexed keywords

BLEOMYCIN; CD20 ANTIGEN; CYCLOPHOSPHAMIDE; CYTARABINE; DOXORUBICIN; ETOPOSIDE; FLUORODEOXYGLUCOSE F 18; IBRUTINIB; IFOSFAMIDE; LENALIDOMIDE; METHOTREXATE; OBINUTUZUMAB; PLACEBO; PREDNISONE; PROTEIN BCL 2; RITUXIMAB; VINCRISTINE; VINDESINE;

ARTICLE; AUTOLOGOUS STEM CELL TRANSPLANTATION; BCL2 GENE; CANCER CHEMOTHERAPY; CANCER PROGNOSIS; CANCER RECURRENCE; CHRONIC LYMPHATIC LEUKEMIA; CYTOPENIA; DISEASE FREE SURVIVAL; DRUG DOSE ESCALATION; DRUG MEGADOSE; DRUG TOLERABILITY; EVENT FREE SURVIVAL; FAILURE FREE SURVIVAL; FEBRILE NEUTROPENIA; HEMATOLOGIC DISEASE; HUMAN; INTERNATIONAL PROGNOSTIC INDEX; LARGE CELL LYMPHOMA; MULTIPLE CYCLE TREATMENT; MULTIPLE MYELOMA; NEUTROPENIA; NONHODGKIN LYMPHOMA; ONCOGENE MYC; OVERALL SURVIVAL; POSITRON EMISSION TOMOGRAPHY; PROGRESSION FREE SURVIVAL; RECOMMENDED DRUG DOSE; THROMBOCYTOPENIA; TUMOR LYSIS SYNDROME;

EID: 84875994233     PISSN: 11786930     EISSN: None     Source Type: Journal    
DOI: 10.2147/OTT.S42574     Document Type: Article

References (39)

1. Coiffier B. State-of-the-art therapeutics: diffuse large B-cell lymphoma. J Clin Oncol. 2005 Sep 10;23(26):6387-93.
2. Coiffier B, Lepage E, Briere J, et al. CHOP chemotherapy plus rituximab compared with CHOP alone in elderly patients with diffuse large-B-cell lymphoma. N Engl J Med. 2002;346(4):235-242.
3. Coiffier B, Thieblemont C, Van Den Neste E, et al. Long-term outcome of patients in the LNH-98.5 trial, the first randomized study comparing rituximab-CHOP to standard CHOP chemotherapy in DLBCL patients: a study by the Groupe d'Etudes des Lymphomes de l'Adulte. Blood. 2010;116(12):2040-2045.
4. Feugier P, Van Hoof A, Sebban C, et al. Long-term results of the R-CHOP study in the treatment of elderly patients with diffuse large B-cell lymphoma: a study by the Groupe d'Etude des Lymphomes de l'Adulte. J Clin Oncol. 2005;23(18):4117-4126.
5. Pfreundschuh M, Schubert J, Ziepert M, et al. Six versus eight cycles of bi-weekly CHOP-14 with or without rituximab in elderly patients with aggressive CD20+ B-cell lymphomas: a randomised controlled trial (RICOVER-60). Lancet Oncol. 2008;9(2):105-116.
6. Habermann TM, Weller EA, Morrison VA, et al. Rituximab-CHOP versus CHOP alone or with maintenance rituximab in older patients with diffuse large B-cell lymphoma. J Clin Oncol. 2006;24(19): 3121-3127.
7. Pfreundschuh M, Trumper L, Osterborg A, et al. CHOP-like chemotherapy plus rituximab versus CHOP-like chemotherapy alone in young patients with good-prognosis diffuse large-B-cell lymphoma: a randomised controlled trial by the MabThera International Trial (MInT) Group. Lancet Oncol. 2006;7(5):379-391.
8. Pfreundschuh M, Kuhnt E, Trumper L, et al. CHOP-like chemotherapy with or without rituximab in young patients with good-prognosis diffuse large-B-cell lymphoma: 6-year results of an open-label randomised study of the MabThera International Trial (MInT) Group. Lancet Oncol. 2011;12(11):1013-1022.
9. Tilly H, Dreyling M. Diffuse large B-cell non-Hodgkin's lymphoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and followup. Ann Oncol. 2010;21 Suppl 5:v172-v174.
10. Recher C, Coiffier B, Haioun C, et al. Intensified chemotherapy with ACVBP plus rituximab versus standard CHOP plus rituximab for the treatment of diffuse large B-cell lymphoma (LNH03-02B): an open-label randomised phase 3 trial. Lancet. 2011;378(9806): 1858-1867.
11. Fitoussi O, Belhadj K, Mounier N, et al. Survival impact of rituximab combined with ACVBP and upfront consolidation autotransplantation in high-risk diffuse large B-cell lymphoma for GELA. Haematologica. 2011;96(8):1136-1143.
12. Cortelazzo S, Tarella C, Gianni A. Chemoimmunotherapy with R-CHOP or high dose sequential therapy with ASCT for high-risk DLBCL patients: results of the randomized R-HDS0305 trial by Gruppo Italiano Terapie Innovative Nei Linfomi (GITIL). 54th ASH Annual Meeting and Exposition; December 8-11, 2012; Atlanta, GA, USA.
13. Le Gouill S, Milpied N, Lamy T. First-line rituximab high-dose therapy versus R-CHOP14 for young adults with diffuse large B-cell lymphoma: Preliminary results of the GOELAMS 075 prospective multicenter randomized trial. J Clin Oncol. 2011;29 Suppl:8003.
14. Rosenwald A, Wright G, Chan WC, et al. The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma. N Engl J Med. 2002;346(25):1937-1947.
15. Salles G, de Jong D, Xie W, et al. Prognostic significance of immunohistochemical biomarkers in diffuse large B-cell lymphoma: a study from the Lunenburg Lymphoma Biomarker Consortium. Blood. 2011;117(26):7070-7078.
16. Green TM, Young KH, Visco C, et al. Immunohistochemical doublehit score is a strong predictor of outcome in patients with diffuse large B-cell lymphoma treated with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone. J Clin Oncol. 2012;30(28): 3460-3467.
17. Johnson NA, Slack GW, Savage KJ, et al. Concurrent expression of MYC and BCL2 in diffuse large B-cell lymphoma treated with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone. J Clin Oncol. 2012;30(28):3452-3459.
18. Cuccuini W, Briere J, Mounier N, et al. MYC+ diffuse large B-cell lymphoma is not salvaged by classical R-ICE or R-DHAP followed by BEAM plus autologous stem cell transplantation. Blood. 2012;119(20): 4619-4624.
19. Xu-Monette ZY, Wu L, Visco C, et al. Mutational profile and prognostic significance of TP53 in diffuse large B-cell lymphoma patients treated with R-CHOP: report from an International DLBCL Rituximab-CHOP Consortium Program Study. Blood. 2012;120(19):3986-3996.
20. Jerusalem G, Beguin Y, Fassotte MF, et al. Persistent tumor 18F-FDG uptake after a few cycles of polychemotherapy is predictive of treatment failure in non-Hodgkin's lymphoma. Haematologica. 2000;85(6): 613-618.
21. Safar V, Dupuis J, Itti E, et al. Interim [18F]fluorodeoxyglucose positron emission tomography scan in diffuse large B-cell lymphoma treated with anthracycline-based chemotherapy plus rituximab. J Clin Oncol. 2012;30(2):184-190.
22. Miyazaki Y, Nawa Y, Miyagawa M, et al. Maximum standard uptake value of (18)F-fluorodeoxyglucose positron emission tomography is a prognostic factor for progression-free survival of newly diagnosed patients with diffuse large B cell lymphoma. Ann Hematol. 2013;92(2): 239-244.
23. Mössner E, Brünker P, Moser S, et al. Increasing the efficacy of CD20 antibody therapy through the engineering of a new type II anti-CD20 antibody with enhanced direct and immune effector cell-mediated B-cell cytotoxicity. Blood. 2010;115(22):4393-4402.
24. Robak T. GA-101, a third-generation, humanized and glyco-engineered anti-CD20 mAb for the treatment of B-cell lymphoid malignancies. Curr Opin Investig Drugs. 2009;10(6):588-596.
25. Ferrara C, Brünker P, Suter T, Moser S, Püntener U, Umaña P. Modulation of therapeutic antibody effector functions by glycosylation engineering: influence of Golgi enzyme localization domain and coexpression of heterologous beta1, 4-N-acetylglucosaminyltransferase III and Golgi alpha-mannosidase II. Biotechnol Bioeng. 2006;93(5): 851-861.
26. Cartron G, Thieblemont C, Solal-Celigny P. Results from a phase II study of RO5072759 (GA101) monotherapy in relapsed/refractory aggressive non-Hodgkin's lymphoma. Ann Oncol. 2011; 22:068.
27. Advani R, Lebovic D, Brunvand M. A phase I study of DCDT2980S, an antibody-drug conjugate targeting CD22, in relapsed or refractory B-cell NHL. 54th ASHAnnual Meeting and Exposition; December 8-11, 2012; Atlanta, GA, USA.
28. Palanca-Wessels M, Flinn I, Sehn LH. A phase I study of the anti-CD79b antibody-drug conjugate DCDS4501 A targeting CD79b in relapsed or refractory B-cell NHL. 54th ASH Annual Meeting and Exposition; December 8-11, 2012; Atlanta, GA, USA.
29. Gunnellini M, Falchi L. Therapeutic activity of lenalidomide in mantle cell lymphoma and indolent non-Hodgkin's lymphomas. Adv Hematol. 2012;2012:523842.
30. Mounier N, Gisselbrecht C. Relapses, treatments and new drugs. Best Pract Res Clin Haematol. 2012;25(1):49-60.
31. Dawar R, Hernandez-Ilizaliturri F. The emerging role of lenalidomide in the management of mantle cell lymphoma (MCL). Best Pract Res Clin Haematol. 2012;25(2):185-190.
32. Wiernik PH, Lossos IS, Tuscano JM, et al. Lenalidomide monotherapy in relapsed or refractory aggressive non-Hodgkin's lymphoma. J Clin Oncol. 2008;26(30):4952-4957.
33. Witzig TE, Vose JM, Zinzani PL, et al. An international phase II trial of single-agent lenalidomide for relapsed or refractory aggressive B-cell non-Hodgkin's lymphoma. Ann Oncol. 2011;22(7): 1622-1627.
34. Nowakowski GS, LaPlant B, Habermann TM, et al. Lenalidomide can be safely combined with R-CHOP (R2CHOP) in the initial chemotherapy for aggressive B-cell lymphomas: phase I study. Leukemia. 2011;25(12): 1877-1881.
35. Chiapella A, Franceschetti S, Castellino A. Rituximab-CHOP21 plus lenalidomide (LR-CHOP21) is effective and feasible in elderly untreated diffuse large B-cell lymphoma (DLBCL): results of phase II REAL07 study of the Fondazione Italiana Linfomi (FIL). 54th ASH Annual Meeting and Exposition; December 8-11, 2012; Atlanta, GA, USA.
36. Hernandez-Ilizaliturri F., Deeb G, Zinzani PL, et al. Higher response to lenalidomide in relapsed/refractory diffuse large B-cell lymphoma in nongerminal center B-cell-like than in germinal center B-cell-like phenotype. Cancer. 2011;117(22):5058-5066.
37. Reddy NM, Simmons R, Caldwell M. A phase II randomized study of lenalidomide or lenalidomide and Rituximab as maintenance therapy following R-CHOP chemotherapy for patients with high-risk diffuse large B-cell lymphoma. 54th ASH Annual Meeting and Exposition; December 8-11, 2012; Atlanta, GA, USA.
38. Advani R, Sharman J, Smith S. The btk inhibitor pci-32765 is highly active and well tolerated in patients with relapsed/refractory B cell malignancies: final results from a phase I study. Ann Oncol. 2011;22:144.
39. Wilson WH, Gerecitano J, Goy A. The Bruton's tyrosine kinase inhibitor, ibrutinib (PCI-32765), has preferential activity in the ABC subtype of relapsed/refractory de novo DLBCL: interim results of a multicenter, open-label, phase 2 study. 54th ASH Annual Meeting and Exposition; December 8-11, 2012; Atlanta, GA, USA.