Efficacy and safety of MLC601 (NeuroAiD®), a traditional chinese medicine, in poststroke recovery: A systematic review

Cerebrovascular Diseases

Volumn 35, Issue SUPPL.1, 2013, Pages 8-17

  Siddiqui, Fahad Javaid ^a   Venketasubramanian, Narayanaswamy ^a   Chan, Edwin Shih Yen ^a   Chen, Christopher ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Barthel Index; Danqi Piantang Jiaonang; Functional independence; Meta analysis; MLC601; NeuroAiD; Randomized; Recovery; Stroke; Systematic review; Trial

Indexed keywords

MLC 601; NEUROAID; NEUROPROTECTIVE AGENT; PLACEBO; UNCLASSIFIED DRUG; CHINESE DRUG;

ABDOMINAL DISCOMFORT; BARTHEL INDEX; BRAIN BLOOD FLOW; CEREBROVASCULAR ACCIDENT; CHINESE MEDICINE; CONVALESCENCE; DRUG EFFICACY; DRUG SAFETY; DRUG WITHDRAWAL; FUNCTIONAL STATUS; HEADACHE; HUMAN; HYPOKALEMIA; JAUNDICE; MOTOR PERFORMANCE; NAUSEA; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SCORING SYSTEM; SEIZURE; SYSTEMATIC REVIEW; UNSPECIFIED SIDE EFFECT; VISUAL FIELD DEFECT; VOMITING; ARTICLE; DIZZINESS; DROWSINESS; DRUG INDUCED HEADACHE; FUNCTIONAL INDEPENDENCE MEASURE; META ANALYSIS; MULTICENTER STUDY (TOPIC); PERIANAL ABSCESS; RANKIN SCALE; SENSITIVITY ANALYSIS; SENSORIMOTOR FUNCTION; STROKE PATIENT; SYSTEMATIC REVIEW (TOPIC);

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; DATA INTERPRETATION, STATISTICAL; DOUBLE-BLIND METHOD; DRUGS, CHINESE HERBAL; FEMALE; HUMANS; INDEPENDENT LIVING; MALE; MEDICINE, CHINESE TRADITIONAL; MIDDLE AGED; MIDDLE CEREBRAL ARTERY; MOVEMENT; NEUROPROTECTIVE AGENTS; PUBLICATION BIAS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; RECOVERY OF FUNCTION; STROKE; SURVIVAL; TREATMENT OUTCOME; VISUAL FIELD TESTS; VISUAL FIELDS; YOUNG ADULT;

EID: 84875983565     PISSN: 10159770     EISSN: 14219786     Source Type: Journal    
DOI: 10.1159/000346231     Document Type: Review

References (22)

1. European Stroke Organisation (ESO) Executive Committee, ESO Writing Committee: Guidelines for management of ischaemic stroke and transient ischaemic attack 2008. Cerebrovasc Dis 2008; 25:457-450.
2. Wu B, Liu M, Liu H, Li W, Tan S, Zhang S, et al: Meta-analysis of traditional Chinese patent medicine for ischemic stroke. Stroke 2007; 38: 1973-1979.
3. Rausch WD, Liu S, Gille G, Radad K: Neuro-protective effects of ginsenosides. Acta Neu-robiol Exp 2006; 66:369-375.
4. Bei W, Peng W, Zang L, Xie Z, Hu D, Xu A: Neuroprotective effects of a standardized extract of Diospyros kaki leaves on MCAO transient focal cerebral ischemic rats and cultured neurons injured by glutamate or hy poxia. Planta Med 2007; 73: 636-643.
5. Heurteaux C, Gandin C, Borsotto M, Widmann C, Br au F, L hui l lier M, et a l : Neu ropro-tective and neuroproliferative activities of NeuroAid (MLC601, MLC901), a Chinese medicine, in vitro and in vivo. Neurophar-macolog y 2010; 58: 987-1001.
6. Quintard H, Borsot to M, Veyssiere J, Gandin C, Labbal F, Widmann C, et al: MLC901, a traditional Chinese medicine protects the brain against global ischemia. Neurophar-macolog y 2011; 61: 622-631.
7. Chen C, Venketasubramanian N, Gan RN, Lambert C, Picard D, Chan BP, et al: Danqi Piantang Jiaonang (DJ), a traditional Chinese medicine, in poststroke recovery. Stroke 2009; 40:859-863.
8. Venketasubramanian N, Chen CL, Gan RN, Chan BP, Chang HM, Tan SB, et al: A doubleblind, placebo-controlled, randomized, multicenter study to investigate CHInese Medicine Neuroaid Efficacy on Stroke recovery (CHIMES Study). Int J Stroke 2009; 4: 54-60.
9. Mahoney FI, Barthel DW: Functional evaluation: the Barthel Index. Md State Med J 1965; 14: 61-65.
10. Encephalopathy Emergency Scientific Research Coordination Team of the State Traditional Chinese Medicine Authority: The standards for evaluating the Diagnostic Therapeutic Effects of Apoplexy (DTER). Zhonghua Shen Jing Ke ZaZhi 1996; 29: 379.
11. Turner-Stokes L, Nyein K, Turner-Stokes T, Gatehouse C: The UK FIM+FAM: development and evaluation. Functional Assessment Measure. Clin Rehabil 1999; 13: 277-287.
12. Fugl-Meyer AR, Jaasko L, Leyman I, Olsson S, Steglind S: The post-stroke hemiplegic patient. 1. A method for evaluation of physical performance. Scand J Rehabil Med 1975; 7: 13-31.
13. Review Manager (RevMan) Computer Program, version 5.1. Copenhagen, the Nordic Cochrane Centre, the Cochrane Collaboration, 2011.
14. Harandi AA, Abolfazli R, Hatemian A, Ghra goz lee K, Gha f far-Pour M, Karimi M, et al: Safety and efficacy of MLC601 in Iranian patients after stroke: a double-blind, placebo-controlled clinical trial. Stroke Res Treat 2011; 2011:721613.
15. Kong KH, Wee SK, Ng CY, Chua K, Chan KF, Venketasubramanian N, et al: A double-blind, placebo-controlled, randomized phase II pilot study to investigate the potential efficacy of the traditional Chinese medicine Neuroaid (MLC 601) in enhancing recovery after stroke (TIERS). Cerebrovasc Dis 2009; 28: 514-521.
16. Shahripour BR, Shamsaei G, Pakdaman H, Majdinasab N, Nejad EM, Sajedi SA, et al: The effect of NeuroAiD (MLC601) on cerebral blood flow velocity in subjects' post brain infarct in the middle cerebral artery territory. Eur J Intern Med 2011; 22: 509-513.
17. Ghandehari K, Mood ZI, Ebrahimzadeh S, Picard D, Zhang Y: NeuroAid (M L C 6 01) versus piracetam in the recovery of post-infarct homonymous hemianopsia. Neural Regen Res 2011; 6:418-422.
18. CIOMS: Reporting Adverse Drug Reactions. Geneva, CIOMS, 2000. http://www.cioms. ch/publications/reporting-adverse-drug. pdf.
19. MedDRA MSSO NGC: Welcome to Med-DRA and the MSSO. 2010 (updated 22 Nov 2010; cited 23 Nov 2012). http://www.med-dramsso.com/index.asp.
20. FDA: What Is a Serious Adverse Event? 2012 (updated 23 June 2011; cited 29 Nov 2012). http://www.fda.gov/safety/medwatch/how-toreport/ucm053087.htm.
21. ICOH: Clinical safety data management: definitions and standards for expedited reporting E2A. Federal Register 1995; 60: 11284-11287.
22. Young SHY, Zhao Y, Koh A, Singh R, Chan BPL, CHnag HM, Venketasubramanian N, Chen C, CHIMES investigators: Safety prof ile of M LC6 01 (Neu roa id) in acute ischemic stroke patients: a Singaporean substudy on the Chinese medicine Neuroaid efficacy on stroke recovery study. Cerebrovasc Dis 2010; 30:1-6.