DNA integrity is a critical molecular indicator for the assessment of male infertility

Molecular Medicine Reports

Volumn 7, Issue 5, 2013, Pages 1631-1635

  Omran, Huda Mossa ^a   Bakhiet, Moiz ^a   Dashti, Mariam Ghloom ^a  

^a ARABIAN GULF UNIVERSITY   (Bahrain)

Author keywords

Aneuploidy; Oxidative stress; Semen analysis; Sperm DNA

Indexed keywords

DNA;

ADULT; ANEUPLOIDY; ARTICLE; CHROMATIN CONDENSATION; COLORIMETRY; FLOW CYTOMETRY; HUMAN; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; MALE INFERTILITY; SEMEN ANALYSIS; SEMINAL PLASMA; SPERMATOZOON; SPERMATOZOON COUNT; SPERMATOZOON DENSITY;

ADULT; ANEUPLOIDY; BIOLOGICAL MARKERS; DNA; FLOW CYTOMETRY; HUMANS; INFERTILITY, MALE; MALE; MIDDLE AGED; REFERENCE VALUES; SEMEN; YOUNG ADULT;

EID: 84875971902     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2013.1390     Document Type: Article

References (28)

1. Sharma RS, Gaur KK, Pal PC, Manocha M, Tomar D, Khan AA, et al: Semen characteristics: Advancement in andrological assessment. Indian J Clin Biochem 20: 173-183, 2005.
2. Tremellen K: Oxidative stress and male infertility -a clinical perspective. Hum Reprod Update 14: 243-258, 2008.
3. Makker K, Agarwal A and Sharma R: Oxidative stress and male infertility. Indian J Med Res 129: 357-367, 2009.
4. Mahfouz R, Sharma R, Lackner J, Aziz N and Agarwal A: Evaluation of chemiluminescence and flow cytometry as tools in assessing production of hydrogen peroxide and superoxide anion in human spermatozoa. Fertil Steril 92: 819-827, 2009.
5. Eskenazi B, Kidd SA, Marks AR, Sloter E, Block G and Wyrobek AJ: Antioxidant intake is associated with semen quality in healthy men. Hum Reprod 20: 1006-1012, 2005.
6. Agarwal A, Sharma RK, Nallella KP, Thomas AJ Jr, Alvarez Jg and Sikka SC: Reactive oxygen species as an independent marker of male factor infertility. Fertil Steril 86: 878-885, 2006.
7. Pasqualotto FF, Sundaram A, Sharma RK, Borges E Jr, Pasqualotto EB and Agarwal A: Semen quality and oxidative stress scores in fertile and infertile patients with varicocele. Fertil Steril 89: 602-607, 2008.
8. Varghese AC, Bragais FM, Mukhopadahyay D, Kundu S, Pal M, Bhattacharyya AK and Agarwal A: Human sperm DNA integrity in normal and abnormal semen samples and its correlation with sperm characterstics. Andrologia 41: 207-215, 2009.
9. Carrell DT, Emery BR and Hammoud S: Altered protamine expression and diminished spermatogenesis: what is the link? Hum Reprod Update 13: 313-327, 2007.
10. Evenson DP and Wixon R: Clincal aspects of sperm DNA fragmentation detection and male infertility. Theriogenology 65: 979-991, 2006.
11. Bungum M, Humaidan P, Axmon A, Spano M, Bungum L, Erenpreiss J and Giwercman A: Sperm DNA integrity assessment in prediction of assisted reproduction technology outcome. Hum Reprod 22: 174-179, 2007.
12. Prisant N, Escalier D, Soufir JC, Morillon M, Schoevaert D, Misrahi M and Tachdjian G: Ultrastructural nuclear defects and increased chromosome aneuploidies in spermatozoa with elongated heads. Hum Reprod 22: 1052-1059, 2007.
13. Ehemann V, Sykora J, Vera-Delgado J, Lange A and Otto HF: Flow cytometric detection of spontaneous apoptosis in human breast cancer using the TUNEL-technique. Cancer Lett 194: 125-131, 2003.
14. Hacker-Klom UB, Göhde W, Nieschlag E and Behre HM: DNA flow cytometry of human semen. Hum Reprod 14: 2506-2512, 1999.
15. Said TM, Kattal N, Sharma RK, Sikka SC, Thomas AJ Jr, Mascha E and Agarwal A: Enhanced chemiluminescence assay vs colorimetric assay for measurement of the total antioxidant capacity of human seminal plasma. J Androl 24: 676-680, 2003.
16. Aziz N and Agarwal A: Evaluation of sperm damage: beyond the World Health Organization criteria. Fertil Steril 90: 484-485, 2008.
17. Aitken RJ, Baker MA and O'Bryan M: Shedding light on chemiluminescence: the application of chemiluminescence in diagnostic andrology. J Androl 25: 455-465, 2004.
18. Marcus-Braun N, Braun G, Potashnik G and Har-Vardi I: Effect of cryopreservation on quality and fertilization capacity of human sperm. Eur J Obstet Gynecol Reprod Biol 116: 63-66, 2004.
19. Agarwala A and Allamaneni SS: The effect of sperm DNA damage on assisted reproduction outcomes. A review. Minerva Ginecol 56: 235-245, 2004.
20. Zini A and Sigman M: Are tests of sperm DNA damage clinically useful? Pros and cons. J Androl 30: 219-229, 2009.
21. Elshal M, El-Sayed IH, Elsaied MA, El-Masry SA and Kumosani TA: Sperm head defects and disturbances in spermatozoal chromatin and DNA integrities in idiopathic infertile subjects: association with cigarette smoking. Clin Biochem 42: 589-594, 2009.
22. Trisini AT, Singh NP, Duty SM and Hauser R: Relationship between human semen parameters and deoxyribonucleic acid damage assessed by the neutral comet assay. Fertil Steril 82: 1623-1632, 2004.
23. Rubes J, Vozdova M, Robbins WA, Rezacova O, Perreault SD and Wyrobek AJ: Stable variants of sperm aneuploidy among healthy men show associations between germinal and somatic aneuploidy. Am J Hum Genet 70: 1507-1519, 2002.
24. Matzuk MM and Lamb DJ: Genetic dissection of mammalian fertility pathways. Nat Cell Biol 4 (Suppl): S41-S49, 2002.
25. Vegetti W, Van Assche E, Frias A, et al: Correlation between semen parameters and sperm aneuploidy rates investigated by fluorescence in-situ hybridization in infertile men. Hum Reprod 15: 351-365, 2000.
26. Calogero AE, De Palma A, Grazioso C, Barone N, Romeo R, Rapazzo G and D'Agata R: Aneuploidy rate in spermatozoa of selected men with abnormal semen parameters. Hum Reprod 16: 1172-1179, 2001.
27. Sharma RK, Pasqualotto AE, Nelson DR, Thomas AJ Jr and Agarwal A: Relationship between seminal white blood cell counts and oxidative stress in men treated at an infertility clinic. J Androl 22: 575-583, 2001.
28. Aitken S and Roman SD: Antioxidative system and oxidative stress in the testis. In: Molecular mechanisms in Spermatogenesis. Cheng CY (ed). Landes Bioscience, New York, 2008.