Is HCV core antigen a reliable marker of viral load? An evaluation of HCV core antigen automated immunoassay

Annals of Gastroenterology

Volumn 26, Issue 2, 2013, Pages 146-149

  Hadziyannis, Emilia ^a   Minopetrou, Martha ^a   Georgiou, Anastasia ^a   Spanou, Fotini ^a   Koskinas, John ^a  

^a UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

Author keywords

Core antigen; HCV RNA; Hepatitis C

Indexed keywords

HEPATITIS B CORE ANTIGEN; VIRUS RNA;

ANTIGEN DETECTION; ARTICLE; BRANCHED DNA SIGNAL AMPLIFICATION ASSAY; CHEMILUMINESCENCE IMMUNOASSAY; DIAGNOSTIC TEST ACCURACY STUDY; HEPATITIS C; HUMAN; INTERMETHOD COMPARISON; MAJOR CLINICAL STUDY; SENSITIVITY AND SPECIFICITY; VIRAL CLEARANCE; VIRUS LOAD;

EID: 84875971562     PISSN: 11087471     EISSN: 17927463     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Chevaliez S. Virological tools to diagnose and monitor hepatitis C virus infection. Clin Microbiol Infect 2011;17:116-121.
2. Bouvier Alias M, Patel K, Dahari H, et al. Clinical utility of total HCV core antigen quantification: a new indirect marker of HCV replication. Hepatology 2002;36:211-218.
3. Morota K, Fujinami R, Kinukawa H, et al. A new sensitive and automated chemiluminescent microparticle immunoassay for quantitative determination of hepatitis C virus core antigen. J Virol Methods 2009;157:8-14.
4. Lee SC, Antony A, Lee N, et al. Improved version 2.0 qualitative and quantitative AMPLICOR reverse transcription-PCR tests for hepatitis C virus RNA: calibration to international units, enhanced genotype reactivity, and performance characteristics. J Clin Microbiol 2000;38:4171-4179.
5. Alter HJ, Sanchez-Pescador R, Urdea MS, et al. Evaluation of branched DNA signal amplification for the detection of hepatitis C virus RNA. J Viral Hepat 1995;2:121-132.
6. Beld M, Sentjens R, Rebers S, et al. Performance of the New Bayer VERSANT HCV RNA 3.0 assay for quantitation of hepatitis C virus RNA in plasma and serum: conversion to international units and comparison with the Roche COBAS Amplicor HCV Monitor, Version 2.0, assay. J Clin Microbiol 2002;40:788-793.
7. Elbeik T, Surtihadi J, Destree M, et al. Multicenter evaluation of the performance characteristics of the bayer VERSANT HCV RNA 3.0 assay (bDNA). J Clin Microbiol 2004;42:563-569.
8. Park Y, Lee JH, Kim BS, Kim do Y, Han KH, Kim HS. New automated hepatitis C virus (HCV) core antigen assay as an alternative to real-time PCR for HCV RNA quantification. J Clin Microbiol 2010;48:2253-2256.
9. Fabrizi F, Lunghi G, Aucella F, et al. Novel assay using total hepatitis C virus (HCV) core antigen quantification for diagnosis of HCV infection in dialysis patients. J Clin Microbiol 2005;43:414-420.
10. Komatsu F, Takasaki K. Determination of serum hepatitis C virus (HCV) core protein using a novel approach for quantitative evaluation of HCV viraemia in anti-HCV-positive patients. Liver 1999;19:375-380.
11. Maynard M, Pradat P, Berthillon P, et al. Clinical relevance of total HCV core antigen testing for hepatitis C monitoring and for predicting patients' response to therapy. J Viral Hepat 2003;10:318-313.
12. Pradat P, Maynard M, Buti M, et al. The predictive value of core antigen testing for the management of hepatitis C patients receiving pegylated interferon/ribavirin treatment. J Med Virol 2004;73:392-396.
13. Veillon P, Payan C, Picchio G, Maniez-Montreuil M, Guntz P, Lunel F. Comparative evaluation of the total hepatitis C virus core antigen, branched-DNA, and amplicor monitor assays in determining viremia for patients with chronic hepatitis C during interferon plus ribavirin combination therapy. J Clin Microbiol 2003;41:3212-3220.
14. Alzahrani AJ. Simultaneous detection of hepatitis C virus core antigen and antibodies in Saudi drug users using a novel assay. J Med Virol 2008;80:603-606.
15. Laperche S, Le Marrec N, Girault A, et al. Simultaneous detection of hepatitis C virus (HCV) core antigen and anti-HCV antibodies improves the early detection of HCV infection. J Clin Microbiol 2005;43:3877-3883.
16. Vermeersch P, Van Ranst M, Lagrou K. Evaluation of the use of a combined HCV antigen/antibody assay in routine laboratory practice. Acta Clin Belg 2010;65:245-247.
17. Yang JF, Lin YY, Hsieh MH, et al. Performance characteristics of a combined hepatitis C virus core antigen and anti-hepatitis C virus antibody test in different patient groups. Kaohsiung J Med Sci 2011;27:258-263.
18. Ross RS, Viazov S, Salloum S, Hilgard P, Gerken G, Roggendorf M. Analytical performance characteristics and clinical utility of a novel assay for total hepatitis C virus core antigen quantification. J Clin Microbiol 2010;48:1161-1168.
19. Medici MC, Furlini G, Rodella A, et al. Hepatitis C virus core antigen: Analytical performances, correlation with viremia and potential applications of a quantitative, automated immunoassay. J Clin Virol 2011;51:264-269.
20. Hadziyannis E, Fried MW, Nolte FS. Evaluation of two methods for quantitation of hepatitis C virus RNA. Mol Diagn 1997;2:39-46.
21. Schuttler CG, Thomas C, Discher T, et al. Variable ratio of hepatitis C virus RNA to viral core antigen in patient sera. J Clin Microbiol 2005;42:1977-1981.
22. European Association for the Study of the Liver. EASL Clinical Practice Guidelines: management of hepatitis C virus infection. J Hepatol 2011;55: 245-264.