Randomised Phase II Trial (NCT00637975) Evaluating Activity and Toxicity of Two Different Escalating Strategies for Pregabalin and Oxycodone Combination Therapy for Neuropathic Pain in Cancer Patients

PLoS ONE

Volumn 8, Issue 4, 2013, Pages

  Garassino, Marina Chiara ^a   Piva, Sheila ^b   la Verde, Nicla ^b   Spagnoletti, Ilaria ^b   Iorno, Vittorio ^c   Carbone, Claudia ^b   Febbraro, Antonio ^b   Bianchi, Anna ^b   Bramati, Annalisa ^b   Moretti, Anna ^b   Ganzinelli, Monica ^d   Marabese, Mirko ^d   Gentili, Marta ^b   Torri, Valter ^d   Farina, Gabriella ^b  

^a NATIONAL CANCER INSTITUTE   (Italy)

^b AO Fatebenefratelli and Oftalmico ^*  (Italy)

^c Policlinico Maggiore   (Italy)

^d MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

OXYCODONE; PREGABALIN;

ADULT; AGED; ARTICLE; CANCER PATIENT; COMBINATION CHEMOTHERAPY; CONFUSION; CONSTIPATION; CONTROLLED STUDY; DROWSINESS; DRUG DOSE ESCALATION; DRUG DOSE INCREASE; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; DRUG WITHDRAWAL; EDMONTON SYMPTOM ASSESSMENT SYSTEM; FEMALE; FOLLOW UP; HUMAN; ITALY; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; NAUSEA; NEUROPATHIC PAIN; NUMERICAL RATING SCALE; OPIOID RECEPTOR KAPPA 1 GENE; OPIOID RECEPTOR MU 1 GENE; PAIN ASSESSMENT; PHASE 2 CLINICAL TRIAL; PROSPECTIVE STUDY; PRURITUS; RANDOMIZED CONTROLLED TRIAL; RATING SCALE; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; AGED; AGED, 80 AND OVER; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG THERAPY, COMBINATION; FEMALE; GAMMA-AMINOBUTYRIC ACID; HUMANS; MALE; MIDDLE AGED; NEOPLASMS; NEURALGIA; OXYCODONE; POLYMORPHISM, SINGLE NUCLEOTIDE; TREATMENT OUTCOME;

EID: 84875955479     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0059981     Document Type: Article

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