Creation of highly congested quaternary centers via Cu-catalyzed conjugate addition of alkenyl alanates to β-substituted cyclic enones

Organic Letters

Volumn 15, Issue 7, 2013, Pages 1594-1597

  Müller, Daniel ^a   Alexakis, Alexandre ^a  

^a UNIVERSITY OF GENEVA   (Switzerland)

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EID: 84875955360     PISSN: 15237060     EISSN: 15237052     Source Type: Journal    
DOI: 10.1021/ol400378v     Document Type: Article

References (29)

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27. From our previous work we know that β-alkenylaluminums react faster than α-alkenyaluminums. Hence, under non-catalyzed conditions one would expect 9-13% of β-alkenyl addition product which is not the case. Observations concerning isomerization of alkenyl nucleophiles were also made for Rh-catalyzed 1,4-additions: Corey, E. J.; Lalic, G. Tetrahedron Lett. 2008, 49, 4894-4896
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