Association between a functional polymorphism in Toll-like receptor 3 and chronic hepatitis C in liver transplant recipients

Transplant Infectious Disease

Volumn 15, Issue 2, 2013, Pages 111-119

  Lee, S O ^a,b   Brown, R A ^a   Razonable, R R ^a  

^a MAYO CLINIC   (United States)

^b University of Ulsan College of Medicine   (South Korea)

Author keywords

Chronic hepatitis C; Cirrhosis; Graft failure; HCV; Liver transplantation; Mortality; Polymorphism; Toll like receptor 3

Indexed keywords

TOLL LIKE RECEPTOR 3;

ADULT; AGE; ARTICLE; CONTROLLED STUDY; FEMALE; GENETIC ASSOCIATION; GRAFT FAILURE; HEPATITIS C; HUMAN; LIVER TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; MORTALITY; ORGAN DONOR; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; TREATMENT OUTCOME;

ADULT; AGED; FEMALE; GRAFT REJECTION; HEPACIVIRUS; HEPATITIS C, CHRONIC; HUMANS; LIVER TRANSPLANTATION; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS; TOLL-LIKE RECEPTOR 3; TRANSPLANTATION, HOMOLOGOUS; TREATMENT OUTCOME;

EID: 84875943357     PISSN: 13982273     EISSN: 13993062     Source Type: Journal    
DOI: 10.1111/tid.12033     Document Type: Article

References (15)

1. Alexopoulou L, Holt AC, Medzhitov R, Flavell RA. Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature 2001; 413 (6857): 732-738.
2. Villacres MC, Literat O, DeGiacomo M, Du W, Frederick T, Kovacs A. Defective response to Toll-like receptor 3 and 4 ligands by activated monocytes in chronic hepatitis C virus infection. J Viral Hepat 2008; 15 (2): 137-144.
3. Ranjith-Kumar CT, Miller W, Sun J, et al. Effects of single nucleotide polymorphisms on Toll-like receptor 3 activity and expression in cultured cells. J Biol Chem 2007; 282 (24): 17696-17705.
4. Lauer GM, Walker BD. Hepatitis C virus infection. N Engl J Med 2001; 345 (1): 41-52.
5. Eid AJ, Brown RA, Paya CV, Razonable RR. Association between toll-like receptor polymorphisms and the outcome of liver transplantation for chronic hepatitis C virus. Transplantation 2007; 84 (4): 511-516.
6. Brown RA, Razonable RR. A real-time PCR assay for the simultaneous detection of functional N284I and L412F polymorphisms in the human Toll-like receptor 3 gene. J Mol Diagn 2010; 12 (4): 493-497.
7. Razonable RR, Burak KW, van Cruijsen H, et al. The pathogenesis of hepatitis C virus is influenced by cytomegalovirus. Clin Infect Dis 2002; 35 (8): 974-981.
8. Cristofaro P, Opal SM. Role of Toll-like receptors in infection and immunity: clinical implications. Drugs 2006; 66 (1): 15-29.
9. Wang B, Trippler M, Pei R, et al. Toll-like receptor activated human and murine hepatic stellate cells are potent regulators of hepatitis C virus replication. J Hepatol 2009; 51 (6): 1037-1045.
10. Qi R, Hoose S, Schreiter J, et al. Secretion of the human Toll-like receptor 3 ectodomain is affected by single nucleotide polymorphisms and regulated by Unc93b1. J Biol Chem 2010; 285 (47): 36635-36644.
11. Gorbea C, Makar KA, Pauschinger M, et al. A role for Toll-like receptor 3 variants in host susceptibility to enteroviral myocarditis and dilated cardiomyopathy. J Biol Chem 2010; 285 (30): 23208-23223.
12. Askar E, Bregadze R, Mertens J, et al. TLR3 gene polymorphisms and liver disease manifestations in chronic hepatitis C. J Med Virol 2009; 81 (7): 1204-1211.
13. Berenguer M, Ferrell L, Watson J, et al. HCV-related fibrosis progression following liver transplantation: increase in recent years. J Hepatol 2000; 32 (4): 673-684.
14. Burak KW, Kremers WK, Batts KP, et al. Impact of cytomegalovirus infection, year of transplantation, and donor age on outcomes after liver transplantation for hepatitis C. Liver Transpl 2002; 8 (4): 362-369.
15. Kim DY, Moon J, Island ER, et al. Liver transplantation using elderly donors: a risk factor analysis. Clin Transplant 2011; 25 (2): 270-276.