Synthesis and biological evaluation of novel aliphatic amido-quaternary ammonium salts for anticancer chemotherapy: Part II

European Journal of Medicinal Chemistry

Volumn 63, Issue , 2013, Pages 621-628

  Yang, Jee Sun ^a   Song, Doona ^a   Ko, Won Jin ^a   Kim, Bunyea ^a   Kim, Bo Kyung ^c   Park, Song Kyu ^b   Won, Misun ^c   Lee, Kiho ^b   Lee, Kyeong ^d   Kim, Hwan Mook ^e   Han, Gyoonhee ^a  

^a Yonsei University   (South Korea)

^b Korea University   (South Korea)

^c Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^d Dongguk University   (South Korea)

^e Gachon University   (South Korea)

Author keywords

Aliphatic amido quaternary ammonium salts; GTPase RAt Sarcoma (Ras); NSC126188; Open ring form of aliphatic amido quaternary ammonium salts; Perifosine; RhoB

Indexed keywords

N [2 (DIETHYLAMINO)ETHYL] N METHYLPALMITAMIDE; N [2 (DIETHYLAMINO)ETHYL] N METHYLTETRADECANAMIDE; N [2 (DIMETHYLAMINO)ETHYL] N METHYLPALMITAMIDE; N [2 (DIMETHYLAMINO)ETHYL] N METHYLSTEARAMIDE; N [2 (DIMETHYLAMINO)ETHYL] N METHYLTETRADECANAMIDE; N [3 (DIMETHYLAMINO) 2,2 DIMETHYLPROPYL]PALMITAMIDE; N [3 (DIMETHYLAMINO) 2,2 DIMETHYLPROPYL]STEARAMIDE; N [3 (DIMETHYLAMINO) 2,2 DIMETHYLPROPYL]TETRADECANAMIDE; N [3 (DIMETHYLAMINO)PROPYL] N METHYLPALMITAMIDE; N [3 (DIMETHYLAMINO)PROPYL] N METHYLTETRADECANAMIDE; N [3 (DIMETHYLAMINO)PROPYL]PALMITAMIDE; N [3 (DIMETHYLAMINO)PROPYL]STEARAMIDE; N [3 (DIMETHYLAMINO)PROPYL]TETRADECANAMIDE; N BENZYL N,N DIMETHYL 3 (N METHYLPALMITAMIDO)PROPAN 1 AMINIUM BROMIDE; N BENZYL N,N DIMETHYL 3 (N METHYLTETRADECANAMIDO)PROPAN 1 AMINIUM BROMIDE; N ETHYL N,N DIMETHYL 2 [[(N METHYLPALMITAMIDO)ETHANAMINIUM IODIDE]ETHYL] DIMETHYL AMMONIUM IODIDE; N ETHYL N,N DIMETHYL 3 (N METHYLPALMITAMIDO)PROPAN 1 AMINIUM IODIDE; N,N DIETHYL N [2 (N METHYLPALMITAMIDO)ETHYL]PROP 2 EN 1 AMINIUM BROMIDE; N,N DIETHYL N [2 (N METHYLTETRADECANAMIDO)ETHYL]PROP 2 EN 1 AMINIUM BROMIDE; N,N DIMETHYL N [3 (N METHYLTETRADECANAMIDO)PROPYL]PROP 2 EN 1 AMINIUM BROMIDE; N,N,N TRIETHYL 2 (N METHYLTETRADECANAMIDO)ETHANAMINIUM IODIDE; N,N,N TRIMETHYL 2 (N METHYLPALMITAMIDO)ETHANAMINIUM IODIDE; N,N,N TRIMETHYL 2 (N METHYLSTEARAMIDO)ETHANAMINIUM IODIDE; N,N,N TRIMETHYL 2 (N METHYLTETRADECANAMIDO)ETHANAMINIUM IODIDE; N,N,N TRIMETHYL 3 (N METHYLTETRADECANAMIDO)PROPAN 1 AMINIUM IODIDE; N,N,N TRIMETHYL 3 TETRADECANAMIDOPROPAN 1 AMINIUM IODIDE; QUATERNARY AMMONIUM DERIVATIVE; RHO FACTOR; RHOB PROTEIN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER CHEMOTHERAPY; CONTROLLED STUDY; DRUG POTENCY; DRUG SYNTHESIS; FEMALE; HELA CELL; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; PROTEIN EXPRESSION; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; HELA CELLS; HUMANS; INHIBITORY CONCENTRATION 50; MODELS, CHEMICAL; MOLECULAR STRUCTURE; QUATERNARY AMMONIUM COMPOUNDS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84875932912     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.12.063     Document Type: Article

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