Homeostasis model assessment of insulin resistance for evaluating insulin sensitivity in patients with type 2 diabetes on insulin therapy

Endocrine Journal

Volumn 60, Issue 3, 2013, Pages 283-290

  Okita, Kohei ^a   Iwahashi, Hiromi ^a   Kozawa, Junji ^a   Okauchi, Yukiyoshi ^a   Funahashi, Tohru ^a   Imagawa, Akihisa ^a   Shimomura, Iichiro ^a  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Glucose clamp test; Homeostasis model assessment of insulin resistance (HOMA IR); Insulin therapy

Indexed keywords

ADIPONECTIN; C REACTIVE PROTEIN; GLIBENCLAMIDE; GLUCOSE; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; ISOPHANE INSULIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; NOVORIN R; PIG INSULIN; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BEDTIME DOSAGE; BODY FAT DISTRIBUTION; BODY MASS; CLINICAL ASSESSMENT TOOL; CLINICAL EVALUATION; DIABETES CONTROL; DIASTOLIC BLOOD PRESSURE; ENDOCRINE FUNCTION TEST; FEMALE; GLUCAGON STIMULATION TEST; GLUCOSE BLOOD LEVEL; GLYCEMIC CONTROL; HOMEOSTASIS MODEL ASSESSMENT OF INSULIN RESISTANCE; HUMAN; INSTRUMENT VALIDATION; INSULIN RESISTANCE; INSULIN SENSITIVITY; INSULIN TREATMENT; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PROTEIN BLOOD LEVEL; WAIST CIRCUMFERENCE;

ADIPONECTIN; AGE FACTORS; AGED; BLOOD PRESSURE; BODY MASS INDEX; C-REACTIVE PROTEIN; DIABETES MELLITUS, TYPE 2; FEMALE; GLUCAGON; GLUCOSE CLAMP TECHNIQUE; HOMEOSTASIS; HUMANS; INSULIN; INSULIN RESISTANCE; INTRA-ABDOMINAL FAT; MALE; MIDDLE AGED; MODELS, BIOLOGICAL; REPRODUCIBILITY OF RESULTS; TRIGLYCERIDES; WAIST CIRCUMFERENCE;

EID: 84875911756     PISSN: 09188959     EISSN: 13484540     Source Type: Journal    
DOI: 10.1507/endocrj.EJ12-0320     Document Type: Article

References (30)

1. DeFronzo RA, Bonadonna RC, Ferrannini E (1992) Pathogenesis of NIDDM. A balanced overview. Diabetes Care 15:318-368.
2. Ferrannini E (1998) Insulin resistance versus insulin deficiency in non-insulin-dependent diabetes mellitus: problems and prospects. Endocr Rev 19:477-490.
3. DeFronzo RA, Tobin JD, Andres R (1979) Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol 237:E214-223.
4. Monzollio LU, Hamdy O (2003) Evaluation of insulin sensitivity in clinical practice and in research settings. Nutr Rev 61:397-412.
5. Borai A, Livingstone C, Gordon A, Fems A (2007) The biochemical assessment of insulin resistance. Ann Clin Biochem 44:324-342.
6. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Turner RC, et al. (1985) Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28:412-419.
7. Turner RC, Holman RR, Matthews D, Hockaday TD, Peto J (1979) Insulin deficiency and insulin resistance interaction in diabetes: estimation of their relative contribution by feedback analysis from basal plasma insulin and glucose concentrations. Metabolism 28:1086-1096.
8. Bonora E, Targher G, Alberiche M, Bonadonna RC, Saggiani F, et al. (2000) Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity: studies in subjects with various degrees of glucose tolerance and insulin sensitivity. Diabetes Care 23:57-63.
9. Mari A, Pacini G, Murphy E, Ludvik B, Nolan JJ (2001) A model-based method for assessing insulin sensitivity from the oral glucose tolerance test. Diabetes Care 24:539-548.
10. Kang ES, Yun YS, Park SW, Kim HJ, Ahn CW, Song YD, et al. (2005) Limitation of the validity of the homeostasis model assessment as an index of insulin resistance in Korea. Metabolism 54:206-211.
11. Del Prato S (2009) Role of glucotoxicity and lipotoxicity in the pathophysiology of Type 2 diabetes mellitus and emerging treatment strategies. Diabet Med 26:1185-1192.
12. Cavaghan MK (2000) Interactions between insulin resistance and insulin secretion in the development of glucose intolerance. J Clin Invest 106:329-333.
13. Poitout V, Robertson RP (2002) Minireview: Secondary beta-cell failure in type 2 diabetes-a convergence of glucotoxicity and lipotoxicity. Endocrinology 143:339-342.
14. Emoto M, Nishizawa Y, Maekawa K, Hiura Y, Morii H, et al. (1999) Homeostasis model assessment as a clinical index of insulin resistance in type 2 diabetic patients treated with sulfonylureas. Diabetes Care 22:818-822.
15. Ryo M, Maeda K, Funahashi T, Matsuzawa Y, Shimomura I, et al. (2005) A new simple method for the measurement of visceral fat accumulation by bioelectrical impedance. Diabetes Care 28:451-453.
16. Bonora E, Moghetti P, Zancanaro C, Cigolini M, Querena M, et al. (1989) Estimates of in vivo insulin action in man: comparison of insulin tolerance tests with euglycemic and hyperglycemic glucose clamp studies. J Clin Endocr Metab 68: 374-378.
17. Arita Y, Kihara S, Ouchi N, Takahashi M, Maeda K, et al. (1999) Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem Biophys Res Commun 257:79-83.
18. DeFronzo RA, Ferrannini E, Simonson DC (1989) Fasting hyperglycemia in non-insulin-dependent diabetes mellitus: contributions of excessive hepatic glucose production and impaired tissue glucose uptake. Metabolism 38:387-395.
19. Yamashita S (1996) Insulin resistance and body fat distribution. Diabetes Care 19:287-291.
20. DeFronzo RA, Ferrannini E (1991) Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. Diabetes Care 14:173-194.
21. Altinova AE, Toruner F, Bukan N, Yasar DG, Akturk M, et al. (2007) Decreased plasma adiponectin is associated with insulin resistance and HDL cholesterol in overweight subjects. Endocr J 54:221-226.
22. Ryo M, Nakamura T, Kihara S, Kumada M, Shibazaki S, et al. (2004) Adiponectin as a biomarker of the metabolic syndrome. Circ J 68:975-981.
23. Ziemke F, Mantzoros CS (2010) Adiponectin in insulin resistance: lessons from translational research. Am J Clin Nutr 91:258S-261S.
24. Akinmokun A, Selby PL, Ramaiya K, Alberti KG (1992) The short insulin tolerance test for determination of insulin sensitivity: a comparison with the euglycaemic clamp. Diabet Med 9:432-437.
25. Hirst S, Phillips DI, Vines SK, Clark PM, Hales CN (1993) Reproducibility of the short insulin tolerance test. Diabet Med 10:839-842.
26. Coordt MC, Ruhe RC, McDonald RB (1995) Aging and insulin secretion. Proc Soc Exp Biol Med 209:213-222.
27. Meneilly GS, Ryan AS, Minaker KL, Elahi D (1998) The effect of age and glycemic level on the response of the beta-cell to glucose-dependent insulinotropic polypeptide and peripheral tissue sensitivity to endogenously released insulin. J Clin Endocrinol Metab 83:2925-2932.
28. Santulli G, Lombardi A, Sorriento D, Anastasio A, Del Giudice C, et al. (2012) Age-related impairment in insulin release: the essential role of β(2) -adrenergic receptor. Diabetes 61:692-701.
29. Mari A, Ahrén B, Pacini G (2005) Assessment of insulin secretion in relation to insulin resistance. Curr Opin Clin Nutr Metab Care 8:529-533.
30. Fukushima M, Suzuki H, Seino Y (2004) Insulin secretion capacity in the development from normal glucose tolerance to type 2 diabetes. Diabetes Res Clin Pract 66 Suppl 1:S37-S43.