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Volumn 20, Issue 2, 2013, Pages

Lenalidomide in multiple myeloma-a practice guideline

Author keywords

IMiD; Lenalidomide; Multiple myeloma; Practice guideline

Indexed keywords

ACETYLSALICYLIC ACID; BORTEZOMIB; CYCLOPHOSPHAMIDE; DEXAMETHASONE; ENOXAPARIN; LENALIDOMIDE; MELPHALAN; PLACEBO; PREDNISONE; THALIDOMIDE;

EID: 84875904689     PISSN: None     EISSN: 17187729     Source Type: Journal    
DOI: 10.3747/co.20.1252     Document Type: Article
Times cited : (15)

References (67)
  • 1
    • 36349010285 scopus 로고    scopus 로고
    • Lenalidomide plus dexamethasone for relapsed multiple myeloma in North America
    • on behalf of the Multiple Myeloma (009) Study Investigators
    • Weber DM, Chen C, Niesvizky R, et al. on behalf of the Multiple Myeloma (009) Study Investigators. Lenalidomide plus dexamethasone for relapsed multiple myeloma in North America. N Engl J Med 2007;357:2133-42.
    • (2007) N Engl J Med , vol.357 , pp. 2133-2142
    • Weber, D.M.1    Chen, C.2    Niesvizky, R.3
  • 2
    • 36349023319 scopus 로고    scopus 로고
    • Lenalidomide plus dexamethasone for relapsed or refractory multiple myeloma
    • on behalf of the Multiple Myeloma (010) Study Investigators
    • Dimopoulos M, Spencer A, Attal M, et al. on behalf of the Multiple Myeloma (010) Study Investigators. Lenalidomide plus dexamethasone for relapsed or refractory multiple myeloma. N Engl J Med 2007;357:2123-32.
    • (2007) N Engl J Med , vol.357 , pp. 2123-2132
    • Dimopoulos, M.1    Spencer, A.2    Attal, M.3
  • 3
    • 0028896975 scopus 로고
    • The practice guidelines development cycle: A conceptual tool for practice guidelines development and implementation
    • Browman GP, Levine MN, Mohide EA, et al. The practice guidelines development cycle: a conceptual tool for practice guidelines development and implementation. J Clin Oncol 1995;13:502-12.
    • (1995) J Clin Oncol , vol.13 , pp. 502-512
    • Browman, G.P.1    Levine, M.N.2    Mohide, E.A.3
  • 4
    • 36849070772 scopus 로고    scopus 로고
    • American Society of Clinical Oncology guideline: Recommendations for venous thromboembolism prophylaxis and treatment in patients with cancer
    • on behalf of the American Society of Clinical Oncology
    • Lyman GH, Khorana AA, Falanga A, et al. on behalf of the American Society of Clinical Oncology. American Society of Clinical Oncology guideline: recommendations for venous thromboembolism prophylaxis and treatment in patients with cancer. J Clin Oncol 2007;25:5490-505.
    • (2007) J Clin Oncol , vol.25 , pp. 5490-5505
    • Lyman, G.H.1    Khorana, A.A.2    Falanga, A.3
  • 5
    • 84875900578 scopus 로고    scopus 로고
    • National Institute for Health and Clinical Excellence (nice). Lenalidomide for the treatment of multiple myeloma in people who have received at least one prior therapy. London, UK: nice, Available online at, cited December 15, 2011
    • National Institute for Health and Clinical Excellence (nice). Lenalidomide for the treatment of multiple myeloma in people who have received at least one prior therapy. London, UK: nice; 2009. [Available online at: http://www.nice.org.uk/nicemedia/pdf/TA171Guidance.pdf; cited December 15, 2011]
    • (2009)
  • 6
    • 79952692583 scopus 로고    scopus 로고
    • Lenalidomide in multiple myeloma: An evidence-based review of its role in therapy
    • Richardson P, Mitsiades C, Laubach J, et al. Lenalidomide in multiple myeloma: an evidence-based review of its role in therapy. Core Evid 2010;4:215-45.
    • (2010) Core Evid , vol.4 , pp. 215-245
    • Richardson, P.1    Mitsiades, C.2    Laubach, J.3
  • 7
    • 84875885041 scopus 로고    scopus 로고
    • Thalidomide (thal), le-nalidomide (len), and dexamethasone (dex)-associated venousthromboembolism (vte) and reported vte rates pre-and post-fda approval: Optimal prophylaxis strategies are still unclear [abstract]
    • Boen M, McKoy J, West D, et al. Thalidomide (thal), le-nalidomide (len), and dexamethasone (dex)-associated venousthromboembolism (vte) and reported vte rates pre-and post-fda approval: optimal prophylaxis strategies are still unclear [abstract]. Blood 2008;112:A2403.
    • (2008) Blood , vol.112
    • Boen, M.1    McKoy, J.2    West, D.3
  • 8
    • 79953319183 scopus 로고    scopus 로고
    • Rates of venous thromboembolism in multiple myeloma patients undergoing immunomodulatory therapy with thalidomide or lenalidomide: A systematic review and meta-analysis
    • Carrier M, Le Gal G, Tay J, Wu C, Lee AY. Rates of venous thromboembolism in multiple myeloma patients undergoing immunomodulatory therapy with thalidomide or lenalidomide: a systematic review and meta-analysis. J Thromb Haemost 2011;9:653-63.
    • (2011) J Thromb Haemost , vol.9 , pp. 653-663
    • Carrier, M.1    Le Gal, G.2    Tay, J.3    Wu, C.4    Lee, A.Y.5
  • 9
    • 78649686431 scopus 로고    scopus 로고
    • Lenalidomide and high-dose dexamethasone compared with dexamethasone as initial therapy for multiple myeloma: A randomized Southwest Oncology Group trial (S0232)
    • Zonder JA, Crowley J, Hussein MA, et al. Lenalidomide and high-dose dexamethasone compared with dexamethasone as initial therapy for multiple myeloma: a randomized Southwest Oncology Group trial (S0232). Blood 2010;116:5838-41.
    • (2010) Blood , vol.116 , pp. 5838-5841
    • Zonder, J.A.1    Crowley, J.2    Hussein, M.A.3
  • 10
    • 73249146496 scopus 로고    scopus 로고
    • Lenalidomide plus high-dose dexamethasone versus lenalidomide plus low-dose dexamethasone as initial therapy for newly diagnosed multiple myeloma: An open-label randomised controlled trial
    • Rajkumar SV, Jacobus S, Callander NS, et al. Lenalidomide plus high-dose dexamethasone versus lenalidomide plus low-dose dexamethasone as initial therapy for newly diagnosed multiple myeloma: an open-label randomised controlled trial. Lancet Oncol 2010;11:29-37.
    • (2010) Lancet Oncol , vol.11 , pp. 29-37
    • Rajkumar, S.V.1    Jacobus, S.2    Callander, N.S.3
  • 11
    • 33750607347 scopus 로고    scopus 로고
    • A random-ized phase 2 study of lenalidomide therapy for patients with relapsed or relapsed and refractory multiple myeloma
    • Richardson PG, Blood E, Mitsiades CS, et al. A random-ized phase 2 study of lenalidomide therapy for patients with relapsed or relapsed and refractory multiple myeloma. Blood 2006;108:3458-64.
    • (2006) Blood , vol.108 , pp. 3458-3464
    • Richardson, P.G.1    Blood, E.2    Mitsiades, C.S.3
  • 12
    • 84875893971 scopus 로고    scopus 로고
    • Elotu-zumab with lenalidomide and low-dose dexamethasone in patients with relapsed multiple myeloma: A randomized phase ii study [abstract 8014]
    • Avail-able online at, cited January 10, 2013]
    • Richardson PGG, Moreau P, Jakubowiak AJ, et al. Elotu-zumab with lenalidomide and low-dose dexamethasone in patients with relapsed multiple myeloma: a randomized phase ii study [abstract 8014]. J Clin Oncol 2011;29:. [Avail-able online at: http://www.asco.org/ASCOv2/Meetings/Abstracts&vmview=abst_detail_view&confID=102&?abstractID=80348; cited January 10, 2013]
    • (2011) J Clin Oncol , vol.29
    • Richardson, P.G.G.1    Moreau, P.2    Jakubowiak, A.J.3
  • 13
    • 84860893333 scopus 로고    scopus 로고
    • Final results from the multi-center, randomized, phase 2 evolution study of combi-nations of bortezomib (v), dexamethasone (d), cyclophospha-mide (c), and lenalidomide (r) in previously untreated multiple myeloma (mm)
    • Kumar A, Flinn I, Richardson P, et al. Final results from the multi-center, randomized, phase 2 evolution study of combi-nations of bortezomib (v), dexamethasone (d), cyclophospha-mide (c), and lenalidomide (r) in previously untreated multiple myeloma (mm). Haematologica 2011;96(suppl 1):S100.
    • (2011) Haematologica , vol.96 , Issue.SUPPL. 1
    • Kumar, A.1    Flinn, I.2    Richardson, P.3
  • 14
    • 80053246543 scopus 로고    scopus 로고
    • Maintenance treat-ment with lenalidomide after transplantation for myeloma: Analysis of secondary malignancies within the IFM 2005-02 trial [abstract]
    • Attal M, Olivier P, Lauwers VC, et al. Maintenance treat-ment with lenalidomide after transplantation for myeloma: analysis of secondary malignancies within the IFM 2005-02 trial [abstract]. Haematologica 2011;96(suppl 1):S23.
    • (2011) Haematologica , vol.96 , Issue.SUPPL. 1
    • Attal, M.1    Olivier, P.2    Lauwers, V.C.3
  • 15
    • 85118598130 scopus 로고    scopus 로고
    • 2) and autologous transplantation in newly diagnosed myeloma patients: A phase iii trial [abstract O272]
    • 2) and autologous transplantation in newly diagnosed myeloma patients: a phase iii trial [abstract O272]. Bone Marrow Transplant 2011;46(suppl 1):S38.
    • (2011) Bone Marrow Transplant , vol.46 , Issue.SUPPL. 1
    • Palumbo, A.1    Cavallo, F.2    Nagler, A.3
  • 16
    • 13944253830 scopus 로고    scopus 로고
    • Revlimid 25 mg (REV 25) × 20 versus 50 mg (REV 50) × 10 q 28 days with bridging of 5 mg × 10 versus 10 mg × 5 as post-transplant salvage therapy for multiple myeloma [abstract 1642]
    • Zangari M, Barlogie B, Jacobson J, et al. Revlimid 25 mg (REV 25) × 20 versus 50 mg (REV 50) × 10 q 28 days with bridging of 5 mg × 10 versus 10 mg × 5 as post-transplant salvage therapy for multiple myeloma [abstract 1642]. Blood 2003;102:1642.
    • (2003) Blood , vol.102 , pp. 1642
    • Zangari, M.1    Barlogie, B.2    Jacobson, J.3
  • 17
    • 73949154067 scopus 로고    scopus 로고
    • Survival effect of venous thromboembolism in patients with multiple myeloma treated with lenalidomide and high-dose dexamethasone
    • Zangari M, Tricot G, Polavaram L, et al. Survival effect of venous thromboembolism in patients with multiple myeloma treated with lenalidomide and high-dose dexamethasone. J Clin Oncol 2010;28:132-5.
    • (2010) J Clin Oncol , vol.28 , pp. 132-135
    • Zangari, M.1    Tricot, G.2    Polavaram, L.3
  • 18
    • 77953862198 scopus 로고    scopus 로고
    • The efficacy and safety of lenalidomide plus dexamethasone in relapsed and/or refractory multiple myeloma patients with impaired renal function
    • Dimopoulos M, Alegre A, Stadtmauer EA, et al. The efficacy and safety of lenalidomide plus dexamethasone in relapsed and/or refractory multiple myeloma patients with impaired renal function. Cancer 2010;116:3807-14.
    • (2010) Cancer , vol.116 , pp. 3807-3814
    • Dimopoulos, M.1    Alegre, A.2    Stadtmauer, E.A.3
  • 19
    • 77957774888 scopus 로고    scopus 로고
    • Better quality of response to lenalidomide plus dexamethasone is associated with improved clinical outcomes in patients with relapsed or refractory multiple myeloma
    • Harousseau JL, Dimopoulos MA, Wang M, et al. Better quality of response to lenalidomide plus dexamethasone is associated with improved clinical outcomes in patients with relapsed or refractory multiple myeloma. Haematologica 2010;95:1738-44.
    • (2010) Haematologica , vol.95 , pp. 1738-1744
    • Harousseau, J.L.1    Dimopoulos, M.A.2    Wang, M.3
  • 20
    • 84875905008 scopus 로고    scopus 로고
    • Peripheral neuropa-thy in multiple myeloma patients treated with lenalidomide [abstract 5024]
    • Castaneda C, Weiss L, Minton NA, et al. Peripheral neuropa-thy in multiple myeloma patients treated with lenalidomide [abstract 5024]. Blood 2010;116:5024.
    • (2010) Blood , vol.116 , pp. 5024
    • Castaneda, C.1    Weiss, L.2    Minton, N.A.3
  • 21
    • 84875893143 scopus 로고    scopus 로고
    • Lenalidomide (len) therapy in combination with dexametha-sone (dex) is associated with a low incidence of viral infections [abstract 1950]
    • Baz R, Lonial S, Hussein M, Swern AS, Dimopoulos MA. Lenalidomide (len) therapy in combination with dexametha-sone (dex) is associated with a low incidence of viral infections [abstract 1950]. Blood 2010;116:1950.
    • (2010) Blood , vol.116 , pp. 1950
    • Baz, R.1    Lonial, S.2    Hussein, M.3    Swern, A.S.4    Dimopoulos, M.A.5
  • 22
    • 84555171511 scopus 로고    scopus 로고
    • Lenalidomide-based therapy leads to improvement of humoral immune system in relapsed or re-fractory multiple myeloma patients who respond to therapy [abstract 0395]
    • Baz R, Dimopoulos M, Richardson P, Yu Z, Hussein M, Chanan-Khan A. Lenalidomide-based therapy leads to improvement of humoral immune system in relapsed or re-fractory multiple myeloma patients who respond to therapy [abstract 0395]. Haematologica 2009;94(suppl 2):159.
    • (2009) Haematologica , vol.94 , Issue.SUPPL. 2 , pp. 159
    • Baz, R.1    Dimopoulos, M.2    Richardson, P.3    Yu, Z.4    Hussein, M.5    Chanan-Khan, A.6
  • 23
    • 79955803480 scopus 로고    scopus 로고
    • Neutropenia is a predictable and early event in affected pa-tients with relapsed/refractory multiple myeloma treated with lenalidomide in combination with dexamethasone [abstract 2978]
    • Lonial S, Baz R, Swern AS, Weber D, Dimopoulos MA. Neutropenia is a predictable and early event in affected pa-tients with relapsed/refractory multiple myeloma treated with lenalidomide in combination with dexamethasone [abstract 2978]. Blood 2009;114:2878.
    • Blood , vol.2009 , pp. 114
    • Lonial, S.1    Baz, R.2    Swern, A.S.3    Weber, D.4    Dimopoulos, M.A.5
  • 24
    • 79955824056 scopus 로고    scopus 로고
    • Lenalidomide plus dexamethasone has similar tolerability and efficacy in treatment of relapsed/refractory multiple myeloma patients with or without history of neuropathy [abstract 3873]
    • Delforge M, Facon T, Bravo ML, Dimopoulos MA. Lenalidomide plus dexamethasone has similar tolerability and efficacy in treatment of relapsed/refractory multiple myeloma patients with or without history of neuropathy [abstract 3873]. Blood 2009;114:A3873.
    • (2009) Blood , vol.114
    • Delforge, M.1    Facon, T.2    Bravo, M.L.3    Dimopoulos, M.A.4
  • 25
    • 85118598664 scopus 로고    scopus 로고
    • Full dose of lenalidomide for 12 months followed by a lower mainte-nance dose improves progression-free survival in patients with relapsed/refractory multiple myeloma [abstract 2874]
    • Dimopoulos MA, Hussein M, Swern AS, Weber D. Full dose of lenalidomide for 12 months followed by a lower mainte-nance dose improves progression-free survival in patients with relapsed/refractory multiple myeloma [abstract 2874]. Blood 2009;114:2874.
    • Blood , vol.2009 , pp. 114
    • Dimopoulos, M.A.1    Hussein, M.2    Swern, A.S.3    Weber, D.4
  • 26
    • 33846330418 scopus 로고    scopus 로고
    • Lenalidomide (Revlimid) combination with dexamethasone (Dex) is more effective than Dex alone in patients with re-lapsed or refractory multiple myeloma and independent of number of previous treatments [abstract 0494]
    • Dimopoulos MA, Anagnostopoulos A, Prince M, et al. Lenalidomide (Revlimid) combination with dexamethasone (Dex) is more effective than Dex alone in patients with re-lapsed or refractory multiple myeloma and independent of number of previous treatments [abstract 0494]. Haematologica 2006;91(suppl 1):181.
    • (2006) Haematologica , vol.91 , Issue.SUPPL. 1 , pp. 181
    • Dimopoulos, M.A.1    Anagnostopoulos, A.2    Prince, M.3
  • 27
    • 70450230539 scopus 로고    scopus 로고
    • Long-term follow-up on overall survival from the MM-009 and MM-010 phase iii trials of lenalidomide plus dexamethasone in patients with relapsed or refractory multiple myeloma
    • Dimopoulos MA, Chen C, Spencer A, et al. Long-term follow-up on overall survival from the MM-009 and MM-010 phase iii trials of lenalidomide plus dexamethasone in patients with relapsed or refractory multiple myeloma. Leukemia 2009;23:2147-52.
    • (2009) Leukemia , vol.23 , pp. 2147-2152
    • Dimopoulos, M.A.1    Chen, C.2    Spencer, A.3
  • 28
    • 58149384555 scopus 로고    scopus 로고
    • Lenalidomide plus dexamethasone is more effective than dexamethasone alone in patients with relapsed or refractory multiple myeloma regard-less of prior thalidomide exposure
    • Wang M, Dimopoulos MA, Chen C, et al. Lenalidomide plus dexamethasone is more effective than dexamethasone alone in patients with relapsed or refractory multiple myeloma regard-less of prior thalidomide exposure. Blood 2008;112:4445-51.
    • (2008) Blood , vol.112 , pp. 4445-4451
    • Wang, M.1    Dimopoulos, M.A.2    Chen, C.3
  • 29
    • 55049088450 scopus 로고    scopus 로고
    • Lenalidomide in combination with dexamethasone for the treatment of multiple myeloma after one prior therapy
    • Hazarika M, Rock E, Williams G, et al. Lenalidomide in combination with dexamethasone for the treatment of multiple myeloma after one prior therapy. Oncologist 2008;13:1120-7.
    • (2008) Oncologist , vol.13 , pp. 1120-1127
    • Hazarika, M.1    Rock, E.2    Williams, G.3
  • 30
    • 79953716823 scopus 로고    scopus 로고
    • Ef-fects of lenalidomide and dexamethasone treatment duration on survival in patients with relapsed or refractory multiple myeloma treated with lenalidomide and dexamethasone
    • San Miguel JF, Dimopoulos MA, Stadtmauer EA, et al. Ef-fects of lenalidomide and dexamethasone treatment duration on survival in patients with relapsed or refractory multiple myeloma treated with lenalidomide and dexamethasone. Clin Lymphoma Myeloma Leuk 2011;11:38-43.
    • (2011) Clin Lymphoma Myeloma Leuk , vol.11 , pp. 38-43
    • San Miguel, J.F.1    Dimopoulos, M.A.2    Stadtmauer, E.A.3
  • 31
    • 79959421179 scopus 로고    scopus 로고
    • High incidence of diarrhea in patients on long term therapy with lenalidomide and dexamethasone for multiple myeloma [abstract 8586]
    • Available online at, cited Janu-ary 12, 2013
    • Simpson L, Rajkumar SV, Dispenzieri A, et al. High incidence of diarrhea in patients on long term therapy with lenalidomide and dexamethasone for multiple myeloma [abstract 8586]. J Clin Oncol 2008;26(suppl 15):. [Available online at: http://www.asco.org/ASCOv2/Meetings/Abstracts&vmview=abst_detail_view&confID=55&abstractID=35993; cited Janu-ary 12, 2013]
    • (2008) J Clin Oncol , vol.26 , Issue.SUPPL. 15
    • Simpson, L.1    Rajkumar, S.V.2    Dispenzieri, A.3
  • 32
    • 66849126458 scopus 로고    scopus 로고
    • Lenalidomide/dexamethasone improves response and prolongs time toprogression, even in patients with IgA multiple myeloma: A sub-analysis of the MM-009/010 studies [abstract 284b]
    • Foa R, Weber D, Dimopoulos M, et al. Lenalidomide/dexamethasone improves response and prolongs time toprogression, even in patients with IgA multiple myeloma: a sub-analysis of the MM-009/010 studies [abstract 284b]. Blood 2007;110:284b.
    • (2007) Blood , vol.110
    • Foa, R.1    Weber, D.2    Dimopoulos, M.3
  • 33
    • 41649097366 scopus 로고    scopus 로고
    • Dexametha-sone dose adjustments seem to result in better efficacy and improved tolerability in patients with relapsed/refractory multiple myeloma who are treated with lenalidomide/dexamethasone (MM009/010 sub-analysis) [abstract]
    • San Miguel JF, Dimopoulos M, Weber D, et al. Dexametha-sone dose adjustments seem to result in better efficacy and improved tolerability in patients with relapsed/refractory multiple myeloma who are treated with lenalidomide/dexamethasone (MM009/010 sub-analysis) [abstract]. Blood 2007;110:2712.
    • Blood , vol.2007 , pp. 110
    • San Miguel, J.F.1    Dimopoulos, M.2    Weber, D.3
  • 34
    • 42649141003 scopus 로고    scopus 로고
    • Effect of len/dex in mm in different age groups [abstract]
    • Lonial S, Knight R, Dimopolous M, et al. Effect of len/dex in mm in different age groups [abstract]. Hematologica 2007;92(suppl 2);171.
    • (2007) Hematologica , vol.92 , Issue.SUPPL. 2 , pp. 171
    • Lonial, S.1    Knight, R.2    Dimopolous, M.3
  • 35
    • 35048873735 scopus 로고    scopus 로고
    • Lenalido-mide (l) in combination with dexamethasone (d) improves survival and time to progression in elderly patients (pts) with relapsed or refractory (rel/ref) multiple myeloma (mm) [abstract 3553]
    • Chanan-Khan A, Weber D, Dimopolous M, et al. Lenalido-mide (l) in combination with dexamethasone (d) improves survival and time to progression in elderly patients (pts) with relapsed or refractory (rel/ref) multiple myeloma (mm) [abstract 3553]. Blood 2006;108:1014.
    • (2006) Blood , vol.108 , pp. 1014
    • Chanan-Khan, A.1    Weber, D.2    Dimopolous, M.3
  • 36
    • 42649116903 scopus 로고    scopus 로고
    • Lenalidomide (l) in combination with dexamethasone (d) significantly improves time to progression (ttp) in non-stem cell transplant patients (pts) with relapsed or refractory (rel/ref) multiple myeloma (mm): Analysis from MM-009 and MM-010 randomized phase iii clinical trials
    • Chanan-Khan AA, Yu Z, Weber D, et al. Lenalidomide (l) in combination with dexamethasone (d) significantly improves time to progression (ttp) in non-stem cell transplant patients (pts) with relapsed or refractory (rel/ref) multiple myeloma (mm): analysis from MM-009 and MM-010 randomized phase iii clinical trials. Blood 2006;108:1015.
    • (2006) Blood , vol.108 , pp. 1015
    • Chanan-Khan, A.A.1    Yu, Z.2    Weber, D.3
  • 37
    • 85118598455 scopus 로고    scopus 로고
    • Ecog performance status affects efficacy, but not safety, of lenalidomide/dexamethasone in relapsed/refractory multiple myeloma (MM009/010 sub-analysis) [abstract 2721]
    • Chanan-Khan AA, Dimopoulos M, Weber D, et al. ecog performance status affects efficacy, but not safety, of lenalidomide/dexamethasone in relapsed/refractory multiple myeloma (MM009/010 sub-analysis) [abstract 2721]. Blood 2007;110:2721.
    • Blood , vol.2007 , pp. 110
    • Chanan-Khan, A.A.1    Dimopoulos, M.2    Weber, D.3
  • 38
    • 33748094595 scopus 로고    scopus 로고
    • Increased risk of thrombosis with lenalidomide in combination with dexa-methasone and erythropoietin [abstract 7506]
    • Available online at, cited January 12, 2013
    • Niesvizky R, Spencer A, Wang M, et al. Increased risk of thrombosis with lenalidomide in combination with dexa-methasone and erythropoietin [abstract 7506]. J Clin Oncol 2006;24(suppl 18):. [Available online at: http://www.asco.org/ASCOv2/Meetings/Abstracts&vmview=abst_detail_view&confID=40&abstractID=34300; cited January 12, 2013]
    • (2006) J Clin Oncol , vol.24 , Issue.SUPPL. 18
    • Niesvizky, R.1    Spencer, A.2    Wang, M.3
  • 39
    • 65349097489 scopus 로고    scopus 로고
    • Lenalido-mide in combination with dexamethasone at first relapse in comparison with its use as later salvage therapy in relapsed or refractory multiple myeloma
    • Stadtmauer EA, Weber DM, Niesvizky R, et al. Lenalido-mide in combination with dexamethasone at first relapse in comparison with its use as later salvage therapy in relapsed or refractory multiple myeloma. Eur J Haematol 2009;82:426-32.
    • (2009) Eur J Haematol , vol.82 , pp. 426-432
    • Stadtmauer, E.A.1    Weber, D.M.2    Niesvizky, R.3
  • 40
    • 80755171592 scopus 로고    scopus 로고
    • Risk of second primary malingnacies (spm) in relapsed/refractory multiple myeloma (rrmm) patients (pts) treated with lenalidomide and dexamethasone (len+dex): Analysis of MM-009/010 spm incidence rate (ir)
    • Richardson P, Orlowski RZ, San Miguel J, et al. Risk of second primary malingnacies (spm) in relapsed/refractory multiple myeloma (rrmm) patients (pts) treated with lenalidomide and dexamethasone (len+dex): analysis of MM-009/010 spm incidence rate (ir). Haematologica 2011;96(suppl 1):S25.
    • (2011) Haematologica , vol.96 , Issue.SUPPL. 1
    • Richardson, P.1    Orlowski, R.Z.2    San Miguel, J.3
  • 41
    • 84875880556 scopus 로고    scopus 로고
    • Lenalidomide and dexametha-sone (len plus dex) treatment in relapsed/refractory multiple myeloma (rrmm) patients (pts) and risk of second primary malignancies (spm): Analysis of MM-009/010 [abstract 8009]
    • Available online at, cited January 12, 2013
    • Dimopoulos MA, Orlowski RZ, Niesvizky R, Lonial S, Brandenburg NA, Weber DM. Lenalidomide and dexametha-sone (len plus dex) treatment in relapsed/refractory multiple myeloma (rrmm) patients (pts) and risk of second primary malignancies (spm): analysis of MM-009/010 [abstract 8009]. J Clin Oncol 2011;2:. [Available online at: http://www.asco.org/ASCOv2/Meetings/Abstracts&vmview=abst_detail_view&confID=102&abstractID=84539; cited January 12, 2013]
    • (2011) J Clin Oncol , vol.2
    • Dimopoulos, M.A.1    Orlowski, R.Z.2    Niesvizky, R.3    Lonial, S.4    Brandenburg, N.A.5    Weber, D.M.6
  • 42
    • 80054028441 scopus 로고    scopus 로고
    • Impact of lenalidomide dose on progression-free survival in patients with relapsed or refractory multiple myeloma
    • Dimopoulos MA, Hussein M, Swern AS, Weber D. Impact of lenalidomide dose on progression-free survival in patients with relapsed or refractory multiple myeloma. Leukemia 2011;25:1620-6.
    • (2011) Leukemia , vol.25 , pp. 1620-1626
    • Dimopoulos, M.A.1    Hussein, M.2    Swern, A.S.3    Weber, D.4
  • 43
    • 85118598199 scopus 로고    scopus 로고
    • Long-term outcomes and safety of continuous lenalidomide plus dexametha-sone (len+dex) treatment in patients (pts) with relapsed or refrac-tory multiple myeloma (rrmm) [abstract]
    • Dimopoulos MA, Hussein M, Swern AS, Weber DM. Long-term outcomes and safety of continuous lenalidomide plus dexametha-sone (len+dex) treatment in patients (pts) with relapsed or refrac-tory multiple myeloma (rrmm) [abstract]. Blood 2011;118:2929.
    • Blood , vol.2011 , pp. 118
    • Dimopoulos, M.A.1    Hussein, M.2    Swern, A.S.3    Weber, D.M.4
  • 44
    • 54949106553 scopus 로고    scopus 로고
    • A randomized Southwest Oncology Group study comparing dexamethasone (d) to lenalidomide plus dexamethasone (ld) as treatment of newly-diagnosed multiple myeloma (ndmm): Impact of cytogenetic abnormalities on efficacy of ld, and updated overall study results [abstract 8521]
    • Available online at, cited January 12, 2013
    • Zonder JA, Crowley JJ, Bolejack V, et al. A randomized Southwest Oncology Group study comparing dexamethasone (d) to lenalidomide plus dexamethasone (ld) as treatment of newly-diagnosed multiple myeloma (ndmm): impact of cytogenetic abnormalities on efficacy of ld, and updated overall study results [abstract 8521]. J Clin Oncol 2008;26:. [Available online at: http://www.asco.org/ASCOv2/Meetings/Abstracts&vmview=abst_detail_view&confID=55&abstractID=36278; cited January 12, 2013]
    • (2008) J Clin Oncol , vol.26
    • Zonder, J.A.1    Crowley, J.J.2    Bolejack, V.3
  • 45
    • 84873073127 scopus 로고    scopus 로고
    • Extended results of Southwest Oncology Group protocol S0232: Durable responses achieved with lenalidomide (l) plus high-dose dexamethasone (d) as first-line therapy for multiple myeloma
    • Zonder JA, Crowley J, Hussein M, et al. Extended results of Southwest Oncology Group protocol S0232: durable responses achieved with lenalidomide (l) plus high-dose dexamethasone (d) as first-line therapy for multiple myeloma. Haematologica 2011;96(suppl 1):S79.
    • (2011) Haematologica , vol.96 , Issue.SUPPL. 1
    • Zonder, J.A.1    Crowley, J.2    Hussein, M.3
  • 46
    • 84855948884 scopus 로고    scopus 로고
    • Outcome with lenalidomide plus dexamethasone followed by early autolo-gous stem cell transplantation in the ecog E4A03 randomized clinical trial [abstract]
    • Siegel DS, Jacobus S, Rajkumar SV, et al. Outcome with lenalidomide plus dexamethasone followed by early autolo-gous stem cell transplantation in the ecog E4A03 randomized clinical trial [abstract]. Blood 2010;116:38.
    • (2010) Blood , vol.116 , pp. 38
    • Siegel, D.S.1    Jacobus, S.2    Rajkumar, S.V.3
  • 47
    • 78650349052 scopus 로고    scopus 로고
    • Outcome of elderly patients 70 years and older with newly diagnosed myeloma in the ecog randomized trial of lenalidomide/high-dose dexa-methasone (rd) versus lenalidomide/low-dose dexamethasone (Rd) [abstract 370]
    • Jacobus S, Callander N, Siegel D, et al. Outcome of elderly patients 70 years and older with newly diagnosed myeloma in the ecog randomized trial of lenalidomide/high-dose dexa-methasone (rd) versus lenalidomide/low-dose dexamethasone (Rd) [abstract 370]. Haematologica 2010;95(suppl 2):149.
    • (2010) Haematologica , vol.95 , Issue.SUPPL. 2 , pp. 149
    • Jacobus, S.1    Callander, N.2    Siegel, D.3
  • 48
    • 80053965637 scopus 로고    scopus 로고
    • Impact of high-risk clas-sification by fish: An Eastern Cooperative Oncology Group (ecog) study E4A03
    • Jacobus SJ, Kumar S, Uno H, et al. Impact of high-risk clas-sification by fish: an Eastern Cooperative Oncology Group (ecog) study E4A03. Br J Haematol 2011;155:340-8.
    • (2011) Br J Haematol , vol.155 , pp. 340-348
    • Jacobus, S.J.1    Kumar, S.2    Uno, H.3
  • 49
    • 79957462827 scopus 로고    scopus 로고
    • Lenalidomide plus low-dose dexamethasone (ld): Superior one and two year survival regardless of age compared to lenalidomide plus high-dose dexamethasone (ld) [abstract 308]
    • Vesole DH, Jacobus S, Rajkumar SV, et al. Lenalidomide plus low-dose dexamethasone (ld): superior one and two year survival regardless of age compared to lenalidomide plus high-dose dexamethasone (ld) [abstract 308]. Blood 2010;116:308.
    • (2010) Blood , vol.116 , pp. 308
    • Vesole, D.H.1    Jacobus, S.2    Rajkumar, S.V.3
  • 50
    • 84875896766 scopus 로고    scopus 로고
    • Renal function measures improve on lenalidomide and dexamethasone and compete with patient characteristics to predict lenalidomide dose density and hematologic toxicity: An E4A03 analysis [abstract]
    • Harvey RD, Jacobus SJ, Rajkumar SV, Greipp PR, Lonial S. Renal function measures improve on lenalidomide and dexamethasone and compete with patient characteristics to predict lenalidomide dose density and hematologic toxicity: an E4A03 analysis [abstract]. Blood 2011;118:1882.
    • (2011) Blood , vol.118 , pp. 1882
    • Harvey, R.D.1    Jacobus, S.J.2    Rajkumar, S.V.3    Greipp, P.R.4    Lonial, S.5
  • 51
    • 84055161444 scopus 로고    scopus 로고
    • Aspirin or enoxaparin thromboprophylaxis for newly-diagnosed multiple myeloma patients treated with lenalidomide
    • Larocca A, Cavallo F, Bringhen S, et al. Aspirin or enoxaparin thromboprophylaxis for newly-diagnosed multiple myeloma patients treated with lenalidomide. Blood 2012;119:933-9.
    • (2012) Blood , vol.119 , pp. 933-939
    • Larocca, A.1    Cavallo, F.2    Bringhen, S.3
  • 52
    • 84875904398 scopus 로고    scopus 로고
    • A phase 3 study comparing melphalan-prednisone-lenalidomide (mpr) with high-dose melphalan and autologous transplantation (MEL200) in newly diagnosed patients with multiple myeloma (mm) [abstract]
    • Palumbo A, Cavallo F, Di Raimondo F, et al. A phase 3 study comparing melphalan-prednisone-lenalidomide (mpr) with high-dose melphalan and autologous transplantation (MEL200) in newly diagnosed patients with multiple myeloma (mm) [abstract]. Eur J Cancer 2011;47(suppl AS639):S639.
    • (2011) Eur J Cancer , vol.47 , Issue.SUPPL. AS639
    • Palumbo, A.1    Cavallo, F.2    Di Raimondo, F.3
  • 53
    • 84858791955 scopus 로고    scopus 로고
    • Melphalan/prednisone/lenalidomide (mpr) versus high-dose melphalan and autolo-gous transplantation (MEL200) in newly diagnosed multiple myeloma (mm) patients < 65 years: Results of a randomized phase iii study [abstract]
    • Palumbo A, Cavallo F, Hardan I, et al. Melphalan/prednisone/lenalidomide (mpr) versus high-dose melphalan and autolo-gous transplantation (MEL200) in newly diagnosed multiple myeloma (mm) patients < 65 years: results of a randomized phase iii study [abstract]. Blood 2011;118:3069.
    • (2011) Blood , vol.118 , pp. 3069
    • Palumbo, A.1    Cavallo, F.2    Hardan, I.3
  • 54
    • 79952205460 scopus 로고    scopus 로고
    • Lenalidomide (Revlimid) maintenance therapy for multiple myeloma after transplantation: The ifm 2005-02 trial, final analysis
    • Attal M. Lenalidomide (Revlimid) maintenance therapy for multiple myeloma after transplantation: the ifm 2005-02 trial, final analysis. Pharmacol Ther 2011;36:102.
    • (2011) Pharmacol Ther , vol.36 , pp. 102
    • Attal, M.1
  • 55
    • 79952836604 scopus 로고    scopus 로고
    • Maintenance treat-ment with lenalidomide after transplantation for myeloma: Final analysis of the ifm 2005-02 [abstract]
    • Attal M, Lauwers-Cances V, Marit G, et al. Maintenance treat-ment with lenalidomide after transplantation for myeloma: final analysis of the ifm 2005-02 [abstract]. Blood 2010;116:310.
    • (2010) Blood , vol.116 , pp. 310
    • Attal, M.1    Lauwers-Cances, V.2    Marit, G.3
  • 56
    • 77249145537 scopus 로고    scopus 로고
    • Novel three-and four-drug combinations of bortezomib, dexamethasone, cyclophospha-mide, and lenalidomide, for newly diagnosed multiple my-eloma: Encouraging results from the multi-center, randomized, phase 2 evolution study [abstract 127]
    • Kumar S, Flinn IW, Hari PN, et al. Novel three-and four-drug combinations of bortezomib, dexamethasone, cyclophospha-mide, and lenalidomide, for newly diagnosed multiple my-eloma: encouraging results from the multi-center, randomized, phase 2 evolution study [abstract 127]. Blood 2009;114:127.
    • (2009) Blood , vol.114 , pp. 127
    • Kumar, S.1    Flinn, I.W.2    Hari, P.N.3
  • 57
    • 84859769293 scopus 로고    scopus 로고
    • A phase 2 study of elotuzumab in combination with lenalidomide and low-dose dexamethasone in patients with relapsed/refractory multiple myeloma [abstract]
    • Lonial S, Jakubowiak AJ, Jagannath S, et al. A phase 2 study of elotuzumab in combination with lenalidomide and low-dose dexamethasone in patients with relapsed/refractory multiple myeloma [abstract]. Blood 2011;118:303.
    • (2011) Blood , vol.118 , pp. 303
    • Lonial, S.1    Jakubowiak, A.J.2    Jagannath, S.3
  • 59
    • 84863586261 scopus 로고    scopus 로고
    • Smoldering multiple myeloma (smm) at high-risk of progression to symptomatic disease: A phase iii, randomized, multicenter trial based on lenalidomide-dexamethasone (len-dex) as induction therapy followed by maintenance therapy with len alone vs no treatment. [abstract 991]
    • Mateos MV, Lopez-Corral L, Hernandez M, et al. Smoldering multiple myeloma (smm) at high-risk of progression to symptomatic disease: a phase iii, randomized, multicenter trial based on lenalidomide-dexamethasone (len-dex) as induction therapy followed by maintenance therapy with len alone vs no treatment. [abstract 991]. Blood 2011;118:991.
    • (2011) Blood , vol.118 , pp. 991
    • Mateos, M.V.1    Lopez-Corral, L.2    Hernandez, M.3
  • 60
    • 79960725350 scopus 로고    scopus 로고
    • Phase iii intergroup study of lenalidomide versus placebo maintenance therapy following single autologous stem cell transplant (asct) for multiple myeloma (mm): Calgb ecog bmt-cnt 100104
    • McCarthy PL, Owzar K, Anderson K, et al. Phase iii intergroup study of lenalidomide versus placebo maintenance therapy following single autologous stem cell transplant (asct) for multiple myeloma (mm): calgb ecog bmt-cnt 100104. Hae-matologica 2011;96(suppl 1):S23.
    • (2011) Hae-matologica , vol.96 , Issue.SUPPL. 1
    • McCarthy, P.L.1    Owzar, K.2    Anderson, K.3
  • 61
    • 84875898366 scopus 로고    scopus 로고
    • Incidence of second primary malignancy (spm) in melphalan-prednisone-lenalidomide combination followed by lenalidomide mainte-nance (mpr-r) in newly diagnosed multiple myeloma patients (pts) age 65 or older [abstract 8007]
    • Available online at, cited January 31, 2013
    • Palumbo AP, Delforge M, Catalano J, et al. Incidence of second primary malignancy (spm) in melphalan-prednisone-lenalidomide combination followed by lenalidomide mainte-nance (mpr-r) in newly diagnosed multiple myeloma patients (pts) age 65 or older [abstract 8007]. J Clin Oncol 2011;29:. [Available online at: http://www.asco.org/ASCOv2/Meetings/Abstracts&vmview=abst_detail_view&confID=102&abstractID=82234; cited January 31, 2013]
    • (2011) J Clin Oncol , vol.29
    • Palumbo, A.P.1    Delforge, M.2    Catalano, J.3
  • 62
    • 84860744403 scopus 로고    scopus 로고
    • Continuous lenalidomide treatment for newly diagnosed multiple myeloma
    • Palumbo A, Hajek R, Delforge M, et al. Continuous lenalidomide treatment for newly diagnosed multiple myeloma. N Engl J Med 2012;366:1759-69.
    • (2012) N Engl J Med , vol.366 , pp. 1759-1769
    • Palumbo, A.1    Hajek, R.2    Delforge, M.3
  • 63
    • 84860709392 scopus 로고    scopus 로고
    • Lenalidomide maintenance after stem-cell transplantation for multiple my-eloma
    • Attal M, Lauwers-Cances V, Marit G, et al. Lenalidomide maintenance after stem-cell transplantation for multiple my-eloma. N Engl J Med 2012;366:1782-91.
    • (2012) N Engl J Med , vol.366 , pp. 1782-1791
    • Attal, M.1    Lauwers-Cances, V.2    Marit, G.3
  • 64
    • 84860741191 scopus 로고    scopus 로고
    • Lenalidomide after stem-cell transplantation for multiple myeloma
    • McCarthy PL, Owzar K, Hofmeister CC, et al. Lenalidomide after stem-cell transplantation for multiple myeloma. N Engl J Med 2012;366:1770-81.
    • (2012) N Engl J Med , vol.366 , pp. 1770-1781
    • McCarthy, P.L.1    Owzar, K.2    Hofmeister, C.C.3
  • 65
    • 42649109758 scopus 로고    scopus 로고
    • Guideline summary: use of epoetin and darbepoetin in patients with cancer-2007 American Society of Clinical Oncology/American Society of Hematology clinical practice guideline update
    • Guideline summary: use of epoetin and darbepoetin in patients with cancer-2007 American Society of Clinical Oncology/American Society of Hematology clinical practice guideline update. J Oncol Pract 2008;4:48-52.
    • (2008) J Oncol Pract , vol.4 , pp. 48-52
  • 67
    • 33646494190 scopus 로고    scopus 로고
    • Lenalidomide and venous thrombosis in multiple myeloma
    • Knight R, DeLap RJ, Zeldis JB. Lenalidomide and venous thrombosis in multiple myeloma. N Engl J Med 2006;354:2079-80.
    • (2006) N Engl J Med , vol.354 , pp. 2079-2080
    • Knight, R.1    DeLap, R.J.2    Zeldis, J.B.3


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