In vitro effect of anti-β2 glycoprotein I antibodies on P-selectin expression, a marker of platelet activation

Reumatismo

Volumn 64, Issue 1, 2012, Pages 35-39

  Bontadi, Agnese ^a   Ruffatti, A ^a   Giannini, S ^b   Falcinelli, E ^b   Tonello, M ^a   Hoxha, A ^a   Gresele, P ^b   Punzi, L ^a  

^a UNIVERSITY OF PADOVA   (Italy)

^b UNIVERSITY OF PERUGIA   (Italy)

Author keywords

Anti 2Glicoprotein I antibodies; Antiphospholipid syndrome; P selectin; Platelet activation

Indexed keywords

BETA2 GLYCOPROTEIN 1 ANTIBODY; BIOLOGICAL MARKER; PADGEM PROTEIN; THROMBIN RECEPTOR ACTIVATING PEPTIDE 6; AUTOANTIBODY; AUTOANTIGEN; BETA2 GLYCOPROTEIN 1; PEPTIDE FRAGMENT; THROMBIN RECEPTOR PEPTIDE (42-47);

AFFINITY CHROMATOGRAPHY; ANTIBODY BLOOD LEVEL; ANTIGEN BINDING; ARTICLE; BLOOD ANALYSIS; CAUSAL ATTRIBUTION; CLINICAL ARTICLE; CONTROLLED STUDY; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; HUMAN; IN VITRO STUDY; MOLECULAR PATHOLOGY; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; THROMBOCYTE ACTIVATION; THROMBOSIS; ACUTE DISEASE; ADULT; ANTIPHOSPHOLIPID SYNDROME; BIOSYNTHESIS; BLOOD; COMPARATIVE STUDY; COMPLICATION; FEMALE; GENETICS; IMMUNOLOGY; ISOLATION AND PURIFICATION; PREGNANCY; PREGNANCY COMPLICATION; PREGNANCY COMPLICATIONS, HEMATOLOGIC; THROMBOPHILIA;

ACUTE DISEASE; ADULT; ANTIPHOSPHOLIPID SYNDROME; AUTOANTIBODIES; AUTOANTIGENS; BETA 2-GLYCOPROTEIN I; CHROMATOGRAPHY, AFFINITY; FEMALE; FLOW CYTOMETRY; HUMANS; IN VITRO TECHNIQUES; P-SELECTIN; PEPTIDE FRAGMENTS; PLATELET ACTIVATION; PREGNANCY; PREGNANCY COMPLICATIONS; PREGNANCY COMPLICATIONS, HEMATOLOGIC; THROMBOPHILIA;

EID: 84875903874     PISSN: 00487449     EISSN: None     Source Type: Journal    
DOI: 10.4081/reumatismo.2012.35     Document Type: Article

References (22)

1. Levine JS, Branch DW, Rauch J. The antiphospholipid syndrome. N Engl J Med. 2002; 346: 752-63.
2. Miyakis S, Lockshin MD, Atsumi T, Branch DW, Brey RL, Cervera R, et al. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost. 2006; 4: 295-306.
3. McNeil HP, Simpson RJ, Chesterman CN, Krilis SA. Anti-phospholipid antibodies are directed against a complex antigen that includes a lipid-binding inhibitor of coagulation: beta 2-glycoprotein I (apolipoprotein H). Proc Natl Acad Sci USA. 1990; 87: 4120-4.
4. Nimpf J, Wurm H, Kostner GM. Interaction of beta 2-glycoprotein-I with human blood platelets: influence upon ADP-induced aggregation. Thromb Haemost. 1985; 54: 397-401.
5. Schousboe I. Beta-2 glycoprotein I: a plasma inhibitor of the coontact activation of the intrinsic blood coagulation pathway. Blood. 1985; 66: 1086-91.
6. Shi T, Giannakopoulos B, Yan X, et al. Anti-62-glycoprotein I antibodies in complex with t2-glycoprotein I can activate platelets in a dysregulated manner via glycoprotein Ib-IXV. Arthritis Rheum. 2006; 54: 2558-67.
7. Urbanus RT, Pennings MT, Derksen RHWM, et al. Platelet activation by dimeric β2-glycoprotein I requires signaling via both glycoprotein Ibα gand apoliprotein E receptor 2'. J Thromb Haemost. 2008; 6: 1405-12.
8. Meroni PL, Borghi MO, Raschi E, et al. Pathogenesis of antiphospholipid syndrome: understanding the antibodies. Nat Rev Rheumatol. 2011; 7: 330-9.
9. Forastiero R, Martinuzzo M, Carreras LO, Maclouf J. Anti-beta2 glycoprotein I antibodies and platelet activation in patients with antiphospholipid antibodies: association with increased excretion of platelet-derived thromboxane urinary metabolites. Thromb Haemost. 1998; 79: 42-5.
10. Jy W, Tiede M, Bidot CJ, Horstman LL, Jimenez JJ, Chirinos J, Ahn YS. Platelet activation rather than endothelial injury identifies risk of thrombosis in subjects positive for antiphospholipid antibodies. Thromb Res. 2007; 121: 319-25.
11. Lindemann S, Gawaz M. Platelets and atherosclerosis. In: Gresele P, Fuster V, Lopez J, Page CP, Vermylen J. Platelets in cardiovascular and hemorrhagic disorders: a clinical handbook. eds Cambridge University press, Cambridge, UK. 2007: 293-307.
12. Pitchford SC, Momi S, Giannini S, Casali L, Spina D, Page CP, Gresele P. Platelet P-selectin is required for pulmonary eosinophil and lymphocyte recruitment in a murine model of allergic inflammation. Blood. 2005; 105: 2074-81.
13. Falcinelli E, Guglielmini G, Torti M, Gresele P. Intraplatelet signaling mechanisms of the priming effect of matrix metalloproteinase-2 on platelet aggregation. J Thromb Haemost. 2005; 3: 2526-35.
14. Falcinelli E, Giannini S, Boschetti E, Gresele P. Platelets release active matrix metalloproteinase-2 in vivo in humans at a site of vascular injury: lack of inhibition by aspirin. Br J Haematology. 2007; 138: 221-230.
15. Henn V, Slupsky JR, Grafe M, Anagnostopoulos I, Forster R, Muller-Berghaus G, Kroczek RA. CD40L on activated platelets triggers an inflammatory reaction of endothelial cells. Nature. 1998; 391: 591-4.
16. Gawaz M, Langer H, May AE. Platelets in inflammation and atherogenesis. J Clin Invest. 2005; 115: 3378-84.
17. Pierangeli SS, Colden-Stanfield M, Liu X, et al. Antiphospholipid antibodies from antiphospholipid syndrome patients activate endothelial cells in vitro and in vivo. Circulation. 1999; 99: 1997-2002.
18. Simantov R, La Sala JM, Lo SK, et al. Activation of cultured vascular endothelial cells by antiphospholipid antibodies. J Clin Invest. 1995; 96: 2211-9.
19. Reber G, Tincani A, Sanmarco M, de Moerloose P, Boffa MC. Proposal for the measurement of anti-b2-Glycoprotein I antibodies. Standardization Group of the European Forum on Antiphospholipid Antibodies. J Thromb Haemost. 2004; 2: 1860-2.
20. Fischetti F, Durigutto P, Pellis V, Debeus A, Macor P, Bulla R, et al. Thrombus formation induced by antibodies to beta2-glycoprotein I is complement dependent and requires a priming factor. Blood. 2005; 106: 2340-6.
21. Amital H, Govoni M, Maya R, Meroni PL, Ori B, Shoenfeld Y, et al. Role of infectious agents in systemic rheumatic diseases. Clin Exp Rheumatol. 2008; 26 (Suppl.): S27-32.
22. Shoenfeld Y, Blank M, Cervera R, Font J, Raschi E, Meroni PL. Infectious origin of the antiphospholipid syndrome. Ann Rheum Dis. 2006; 65: 2-6.