Frontotemporoparietal asymmetry and lack of illness awareness in schizophrenia

Human Brain Mapping

Volumn 34, Issue 5, 2013, Pages 1035-1043

  Gerretsen, Philip ^a,b   Chakravarty, M Mallar ^a,c,d   Mamo, David ^a,b   Menon, Mahesh ^a,b   Pollock, Bruce G ^a,b   Rajji, Tarek K ^a,b   Graff Guerrero, Ariel ^a,b  

^a CENTRE FOR ADDICTION AND MENTAL HEALTH   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c ROTMAN RESEARCH INSTITUTE   (Canada)

^d HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

Anosognosia; Deformation based analysis; Illness awareness; Insight; Schizophrenia; VBM

Indexed keywords

ADULT; AGED; ANGULAR GYRUS; ANOSOGNOSIA; ARTICLE; AWARENESS; BRAIN ASYMMETRY; BRAIN SIZE; DISEASE SEVERITY; FEMALE; FRONTOTEMPOROPARIETAL ASYMMETRY; GRAY MATTER; HUMAN; INSULA; LEFT HEMISPHERE; MAJOR CLINICAL STUDY; MALE; PARIETAL LOBE; PREFRONTAL CORTEX; PRIORITY JOURNAL; RIGHT HEMISPHERE; SCHIZOPHRENIA; TEMPORAL LOBE; VOXEL BASED MORPHOMETRY; WHITE MATTER;

ADULT; AGED; AWARENESS; BRAIN MAPPING; FEMALE; FRONTAL LOBE; FUNCTIONAL LATERALITY; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; NERVE FIBERS, MYELINATED; PSYCHIATRIC STATUS RATING SCALES; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY; TEMPORAL LOBE; YOUNG ADULT;

EID: 84875899642     PISSN: 10659471     EISSN: 10970193     Source Type: Journal    
DOI: 10.1002/hbm.21490     Document Type: Article

References (58)

1. Amador XF, Flaum M, Andreasen NC, Strauss DH, Yale SA, Clark SC, Gorman JM ( 1994): Awareness of illness in schizophrenia and schizoaffective and mood disorders. Arch Gen Psychiatry 51: 826-36.
2. APM ( 2000): The Diagnostic and Statistical Manual of Mental Disorders: American Psychiatric Pub Group.
3. Ashburner J ( 2007): A fast diffeomorphic image registration algorithm. Neuroimage 38: 95-113.
4. Ashburner J, Friston KJ ( 2005): Unified segmentation. Neuroimage 26: 839-851.
5. Babinski J (1914): Contribution à l'étude des troubles mentaux dans l'hémiplégie organique cérébrale (anosognosie). Revue Neurologique 27:845-848.
6. Basch MF ( 1988): Understanding Psychotherapy: The Science Behind the Art. New York: Basic Books.
7. Bassitt DP, Neto MR, de Castro CC, Busatto GF ( 2007): Insight and regional brain volumes in schizophrenia. Eur Arch Psychiatry Clin Neurosci 257: 58-62.
8. Berge D, Carmona S, Rovira M, Bulbena A, Salgado P, Vilarroya O ( 2010): Gray matter volume deficits and correlation with insight and negative symptoms in first-psychotic-episode subjects. Acta Psychiatr Scand 123: 431-439.
9. Birchwood M, Smith J, Drury V, Healy J, Macmillan F, Slade M ( 1994): A self-report Insight Scale for psychosis: reliability, validity and sensitivity to change. Acta Psychiatr Scand 89: 62-67.
10. Buckley PF, Wirshing DA, Bhushan P, Pierre JM, Resnick SA, Wirshing WC ( 2007): Lack of insight in schizophrenia: impact on treatment adherence. CNS Drugs 21: 129-141.
11. Chakravarty MM, Sadikot AF, Germann J, Hellier P, Bertrand G, Collins DL ( 2009): Comparison of piece-wise linear, linear, and nonlinear atlas-to-patient warping techniques: analysis of the labeling of subcortical nuclei for functional neurosurgical applications. Hum Brain Mapp 30: 3574-3595.
12. Chung MK, Worsley KJ, Paus T, Cherif C, Collins DL, Giedd JN, Rapoport JL, Evans AC ( 2001): A unified statistical approach to deformation-based morphometry. Neuroimage 14: 595-606.
13. Collins DL, Neelin P, Peters TM, Evans AC ( 1994): Automatic 3D intersubject registration of MR volumetric data in standardized Talairach space. J Comput Assist Tomogr 18: 192-205.
14. Collins DL, Holmes CJ, Peters TM, Evans AC ( 1995): Automatic 3-D model-based neuroanatomical segmentation. Human Brain Mapping 3: 190-208.
15. Cooke MA, Fannon D, Kuipers E, Peters E, Williams SC, Kumari V ( 2008): Neurological basis of poor insight in psychosis: a voxel-based MRI study. Schizophr Res 103: 40-51.
16. Cuesta MJ, Peralta V, Zarzuela A ( 2000): Reappraising insight in psychosis. Multi-scale longitudinal study. Br J Psychiatry 177: 233-240.
17. David AS ( 1990): Insight and psychosis. Br J Psychiatry 156: 798-808.
18. Drake RJ, Dunn G, Tarrier N, Bentall RP, Haddock G, Lewis SW ( 2007): Insight as a predictor of the outcome of first-episode nonaffective psychosis in a prospective cohort study in England. J Clin Psychiatry 68: 81-86.
19. Flashman LA, McAllister TW, Johnson SC, Rick JH, Green RL, Saykin AJ ( 2001): Specific frontal lobe subregions correlated with unawareness of illness in schizophrenia: a preliminary study. J Neuropsychiatry Clin Neurosci 13: 255-257.
20. Friston KJ, Holmes A, Poline JB, Price CJ, Frith CD ( 1996): Detecting activations in PET and fMRI: levels of inference and power. Neuroimage 4( 3 Pt 1): 223-235.
21. Glick SD, Ross DA, Hough LB ( 1982): Lateral asymmetry of neurotransmitters in human brain. Brain Res 234: 53-63.
22. Grabner G, Janke AL, Budge MM, Smith D, Pruessner J, Collins DL ( 2006): Symmetric atlasing and model based segmentation: an application to the hippocampus in older adults. Med Image Comput Comput Assist Interv 9( Pt 2): 58-66.
23. Henley SM, Ridgway GR, Scahill RI, Kloppel S, Tabrizi SJ, Fox NC, Kassubek J ( 2010): Pitfalls in the use of voxel-based morphometry as a biomarker: examples from huntington disease. AJNR Am J Neuroradiol 31: 711-719.
24. Honea R, Crow TJ, Passingham D, Mackay CE ( 2005): Regional deficits in brain volume in schizophrenia: a meta-analysis of voxel-based morphometry studies. Am J Psychiatry 162: 2233-2345.
25. Hugdahl K ( 2000): Lateralization of cognitive processes in the brain. Acta Psychol (Amst) 105: 211-235.
26. Jablensky A, Sartorius N, Ernberg G, Anker M, Korten A, Cooper JE, Day R, Bertelsen A ( 1992): Schizophrenia: manifestations, incidence and course in different cultures. A World Health Organization ten-country study. Psychol Med Monogr Suppl 22: 1-97.
27. Kay SR, Fiszbein A, Opler LA ( 1987): The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull 13: 261-276.
28. Kemp R, David A ( 1996): Psychological predictors of insight and compliance in psychotic patients. Br J Psychiatry 169: 444-450.
29. Klein A, Andersson J, Ardekani BA, Ashburner J, Avants B, Chiang MC, Christensen GE, Collins DL, Gee J, Hellier P, Song JH, Jenkinson M, Lepage C, Rueckert D, Thompson P, Vercauteren T, Woods RP, Mann JJ, Parsey RV ( 2009): Evaluation of 14 nonlinear deformation algorithms applied to human brain MRI registration. Neuroimage 46: 786-802.
30. McEvoy JP, Apperson LJ, Appelbaum PS, Ortlip P, Brecosky J, Hammill K, Geller JL, Roth L ( 1989): Insight in schizophrenia. Its relationship to acute psychopathology. J Nerv Ment Dis 177: 43-47.
31. Mohamed S, Rosenheck R, McEvoy J, Swartz M, Stroup S, Lieberman JA ( 2009): Cross-sectional and longitudinal relationships between insight and attitudes toward medication and clinical outcomes in chronic schizophrenia. Schizophr Bull 35: 336-346.
32. Morgan KD, Dazzan P, Morgan C, Lappin J, Hutchinson G, Suckling J, Fearon P, Jones PB, Leff J, Murray RM, et al. ( 2010): Insight, grey matter and cognitive function in first-onset psychosis. Br J Psychiatry 197: 141-148.
33. Oertel-Knochel V, Linden DE: 0000 Cerebral Asymmetry in Schizophrenia. Neuroscientist 2011 Apr 25 [Epub ahead of print] PMID: 21518811.
34. Oke A, Keller R, Mefford I, Adams RN ( 1978): Lateralization of norepinephrine in human thalamus. Science 200: 1411-1413.
35. Olfson M, Marcus SC, Wilk J, West JC ( 2006): Awareness of illness and nonadherence to antipsychotic medications among persons with schizophrenia. Psychiatr Serv 57: 205-211.
36. Orfei MD, Robinson RG, Bria P, Caltagirone C, Spalletta G ( 2008): Unawareness of illness in neuropsychiatric disorders: phenomenological certainty versus etiopathogenic vagueness. Neuroscientist 14: 203-222.
37. Pallanti S, Quercioli L, Pazzagli A ( 1999): Effects of clozapine on awareness of illness and cognition in schizophrenia. Psychiatry Res 86: 239-249.
38. Parellada M, Boada L, Fraguas D, Reig S, Castro-Fornieles J, Moreno D, Gonzalez-Pinto A, Otero S, Rapado-Castro M, Graell M, et al. ( 2011): Trait and state attributes of insight in first episodes of early-onset schizophrenia and other psychoses: a 2-year longitudinal study. Schizophr Bull 37: 38-51.
39. Posner MI, Petersen SE ( 1990): The attention system of the human brain. Ann Rev Neurosci 13: 13-25.
40. Ramachandran VS ( 1995): Anosognosia in parietal lobe syndrome. Conscious Cogn 4: 22-51.
41. Ramachandran VS, McGeoch PD, Williams L ( 2007): Can vestibular caloric stimulation be used to treat Dejerine-Roussy Syndrome? Med Hypotheses 69: 486-488.
42. Robbins S, Evans AC, Collins DL, Whitesides S ( 2004): Tuning and comparing spatial normalization methods. Med Image Anal 8: 311-323.
43. Sanz M, Constable G, Lopez-Ibor I, Kemp R, David AS ( 1998): A comparative study of insight scales and their relationship to psychopathological and clinical variables. Psychol Med 28: 437-446.
44. Sapara A, Cooke M, Fannon D, Francis A, Buchanan RW, Anilkumar AP, Barkataki I, Aasen I, Kuipers E, Kumari V ( 2007): Prefrontal cortex and insight in schizophrenia: a volumetric MRI study. Schizophr Res 89: 22-34.
45. Shad MU, Muddasani S, Prasad K, Sweeney JA, Keshavan MS ( 2004) Insight and prefrontal cortex in first-episode schizophrenia. Neuroimage 22: 1315-1320.
46. Shad MU, Muddasani S, Keshavan MS ( 2006): Prefrontal subregions and dimensions of insight in first-episode schizophrenia-a pilot study. Psychiatry Res 146: 35-42.
47. Shad MU, Keshavan MS, Tamminga CA, Cullum CM, David A ( 2007): Neurobiological underpinnings of insight deficits in schizophrenia. Int Rev Psychiatry 19: 437-446.
48. Sheehan DV, Lecrubier Y, Sheehan KH, Amorim P, Janavs J, Weiller E, Hergueta T, Baker R, Dunbar GC ( 1998): The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry 59( Suppl 20): 22-33;quiz 34-57.
49. Sled JG, Zijdenbos AP, Evans AC ( 1998): A nonparametric method for automatic correction of intensity nonuniformity in MRI data. IEEE Trans Med Imaging 17: 87-97.
50. Spalletta G, Tomaiuolo F, Marino V, Bonaviri G, Trequattrini A, Caltagirone C ( 2003): Chronic schizophrenia as a brain misconnection syndrome: a white matter voxel-based morphometry study. Schizophr Res 64: 15-23.
51. Toga AW, Thompson PM ( 2003): Mapping brain asymmetry. Nat Rev Neurosci 4: 37-48.
52. Tsang O, Gholipour A, Kehtarnavaz N, Gopinath K, Briggs R, Panahi I ( 2008): Comparison of tissue segmentation algorithms in neuroimage analysis software tools. Conf Proc IEEE Eng Med Biol Soc 2008: 3924-3928.
53. Tucker DM, Williamson PA ( 1984): Asymmetric neural control systems in human self-regulation. Psychol Rev 91: 185-215.
54. Van Essen DC ( 2005): A Population-Average, Landmark- and Surface-based (PALS) atlas of human cerebral cortex. Neuroimage 28: 635-662.
55. Wagner HN, Jr., Burns HD, Dannals RF, Wong DF, Langstrom B, Duelfer T, Frost JJ, Ravert HT, Links JM, Rosenbloom SB, et al. ( 1983): Imaging dopamine receptors in the human brain by positron tomography. Science 221: 1264-1266.
56. White T, O'Leary D, Magnotta V, Arndt S, Flaum M, Andreasen NC ( 2001): Anatomic and functional variability: the effects of filter size in group fMRI data analysis. Neuroimage 13: 577-588.
57. Wilke M, Kassubek J, Ziyeh S, Schulze-Bonhage A, Huppertz HJ ( 2003): Automated detection of gray matter malformations using optimized voxel-based morphometry: a systematic approach. Neuroimage 20: 330-343.
58. Worsley KJ, Liao CH, Aston J, Petre V, Duncan GH, Morales F, Evans AC ( 2002): A general statistical analysis for fMRI data. Neuroimage 15: 1-15.