Perineural invasion and preoperative serum CA19-9 as predictors of survival in biliary tract cancer

Anticancer Research

Volumn 33, Issue 2, 2013, Pages 583-594

  Kawamata, Hiroshi ^a   Yamashita, Keishi ^a   Nakamura, Kazunori ^a   Katagiri, Hiroyuki ^a   Ishii, Kenichiro ^a   Takahashi, Yoshihito ^a   Furuta, Kazunori ^a   Kumamoto, Yusuke ^a   Watanabe, Masahiko ^a,b  

^a KITASATO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b KITASATO UNIVERSITY   (Japan)

Author keywords

Biliary tract cancer; CA19 9; CEA; Perineural invasion

Indexed keywords

CA 19-9 ANTIGEN; CARCINOEMBRYONIC ANTIGEN; CISPLATIN; DOXIFLURIDINE; FLUOROURACIL; GEMCITABINE; GIMERACIL PLUS OTERACIL POTASSIUM PLUS TEGAFUR; MINOCYCLINE; MITOMYCIN; UFT;

ACCURACY; ADULT; AGED; ARTICLE; BILE DUCT CANCER; BILIARY TRACT CANCER; BILIARY TRACT DRAINAGE; CANCER ADJUVANT THERAPY; CANCER INVASION; CANCER PROGNOSIS; CANCER RADIOTHERAPY; CANCER STAGING; CANCER SURGERY; CANCER SURVIVAL; FEMALE; HISTOPATHOLOGY; HUMAN; LONG TERM SURVIVAL; MAJOR CLINICAL STUDY; MALE; PREOPERATIVE PERIOD; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SHORT TERM SURVIVAL; SURVIVAL PREDICTION;

ADULT; AGED; AGED, 80 AND OVER; BILIARY TRACT NEOPLASMS; CA-19-9 ANTIGEN; FEMALE; HUMANS; KAPLAN-MEIER ESTIMATE; MALE; MIDDLE AGED; NEOPLASM INVASIVENESS; NEOPLASM STAGING; PREOPERATIVE PERIOD; PROGNOSIS; TUMOR MARKERS, BIOLOGICAL;

EID: 84875888380     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (58)

1. Braconi C and Patel T: Cholangiocarcinoma: New insights into disease pathogenesis and biology. Infect Dis Clin North Am 24: 871-884, 2010.
2. Nagorney DM, Donohue JH, Farnell MB, Schleck CD and Ilstrup DM: Outcomes after curative resections of cholangiocarcinoma. Arch Surg 128: 871-877, 1993.
3. Nakeeb A, Tran KQ, Black MJ, Erickson BA, Ritch PS, Quebbeman EJ, Wilson SD, Demeure MJ, Rilling WS, Dua KS and Pitt HA: Improved survival in resected biliary malignancies. Surgery 132: 555-563, 2002.
4. Nathan H, Pawlik TM, Wolfgang CL, Choti MA, Cameron JL and Schulick RD: Trends in survival after surgery for cholangiocarcinoma: A 30-year population-based SEER database analysis. J Gastrointest Surg 11: 1488-1496, 2007.
5. Tocchi A, Mazzoni G, Liotta G, Lepre L, Cassini D and Miccini M: Late development of bile duct cancer in patients who had biliary-enteric drainage for benign disease: a follow-up study of more than 1,000 patients. Ann Surg 234: 210-214, 2001.
6. Burak K, Angulo P, Pasha TM, Egan K, Petz J and Lindor KD: Incidence and risk factors for cholangiocarcinoma in primary sclerosing cholangitis. Am J Gastroenterol 99: 523-526, 2004.
7. Qiao QL, Zhang TP, Guo JC, Zhan HX, Zhao JX, Liu YC, Wan YL, Leng XS and Zhao YP: Prognostic factors after pancreatoduodenectomy for distal bile duct cancer. Am Surg 77: 1445-1448, 2011.
8. Hong SM, Kim MJ, Pi DY, Jo D, Cho HJ, Yu E and Ro JY: Analysis of extrahepatic bile duct carcinomas according to the New American Joint Committee on Cancer staging system focused on tumor classification problems in 222 patients. Cancer 104: 802-810, 2005.
9. Todoroki T, Kawamoto T, Koike N, Fukao K, Shoda J and Takahashi H: Treatment strategy for patients with middle and lower third bile duct cancer. Br J Surg 88: 364-370, 2001.
10. Vauthey JN, Pawlik TM, Abdalla EK, Arens JF, Nemr RA, Wei SH, Kennamer DL, Ellis LM and Curley SA: Is extended hepatectomy for hepatobiliary malignancy justified? Ann Surg 239: 722-730, 2004.
11. Jang JY, Kim SW, Park DJ, Ahn YJ, Yoon YS, Choi MG, Suh KS, Lee KU and Park YH: Actual long-term outcome of extrahepatic bile duct cancer after surgical resection Ann Surg 241: 77-84, 2005.
12. Kim TH, Han SS, Park SJ, Lee WJ, Woo SM, Moon SH, Yoo T, Kim SS, Kim SH, Hong EK, Kim DY and Park JW: Role of adjuvant chemoradiotherapy for resected extrahepatic biliary tract cancer. Int J Radiat Oncol Biol Phys 81: e853-859, 2011.
13. Vern-Gross TZ, Shivnani AT, Chen K, Lee CM, Tward JD, MacDonald OK, Crane CH, Talamonti MS, Munoz LL and Small W Jr.: Survival outcomes in resected extrahepatic cholangio-carcinoma: Effect of adjuvant radiotherapy in a surveillance, epidemiology, and end results analysis. Int J Radiat Oncol Biol Phys 81: 189-198, 2011.
14. Murakami Y, Uemura K, Sudo T, Hayashidani Y, Hashimoto Y, Nakamura H, Nakashima A and Sueda T: Adjuvant gemcitabine plus S-1 chemotherapy improves survival after aggressive surgical resection for advanced biliary carcinoma. Ann Surg 250: 950-956, 2009.
15. Bhuiya MR, Nimura Y, Kamiya J, Kondo S, Nagino M and Hayakawa N: Clinicopathologic factors influencing survival of patients with bile duct carcinoma: multivariate statistical analysis. World J Surg 17: 653-657, 1993.
16. Fong Y, Blumgart LH, Lin E, Fortner JG and Brennan MF: Outcome of treatment for distal bile duct cancer. Br J Surg 83: 1712-1715, 1996.
17. Yoshida T, Matsumoto T, Sasaki A, Morii Y, Aramaki M and Kitano S: Prognostic factors after pancreatoduodenectomy with extended lymphadenectomy for distal bile duct cancer. Arch Surg 137: 69-73, 2002.
18. Bahra M, Jacob D, Langrehr JM, Neumann UP and Neuhaus P: Carcinoma of the distal and middle bile duct: Surgical results, prognostic factors, and long-term follow-up. J Hepatobiliary Pancreat Surg 15: 501-507, 2008.
19. Murakami Y, Uemura K, Sudo T, Hashimoto Y, Nakashima A, Kondo N, Sakabe R, Ohge H and Sueda T: Prognostic factors after surgical resection for intrahepatic, hilar, and distal cholangiocarcinoma. Ann Surg Oncol 18: 651-658, 2011.
20. Hatzaras I, Schmidt C, Muscarella P, Melvin WS, Ellison EC and Bloomston M: Elevated CA 19-9 portends poor prognosis in patients undergoing resection of biliary malignancies. The Official Journal of the International Hepato Pancreato Biliary Association 12: 134-138, 2010.
21. Allema JH, Reinders ME, van Gulik TM, Koelemay MJ, Van Leeuwen DJ, de Wit LT, Gouma DJ and Obertop H: Prognostic factors for survival after pancreaticoduodenectomy for patients with carcinoma of the pancreatic head region. Cancer 75: 2069-2076, 1995.
22. Woo SM, Ryu JK, Lee SH, Yoo JW, Park JK, Kim YT, Jang JY, Kim SW, Kang GH and Yoon YB: Recurrence and prognostic factors of ampullary carcinoma after radical resection: Comparison with distal extrahepatic cholangiocarcinoma. Ann Surg Oncol 14: 3195-3201, 2007.
23. Japanese Society of Billiary Surgery (JSBS): the General Rules for Surgical and Pathological Studies on Cancer of the Billiary Tract The 5th Edition: 2003
24. Sakamoto Y, Kosuge T, Shimada K, Sano T, Ojima H, Yamamoto J, Yamasaki S, Takayama T, Makuuchi M: Prognostic factors of surgical resection in middle and distal bile duct cancer: an analysis of 55 patients concerning the significance of ductal and radial margins. Surgery 137: 396-402, 2005.
25. Ebata T, Nagino M, Nishio H, Igami T, Yokoyama Y and Nimura Y: Pancreatic and duodenal invasion in distal bile duct cancer: Paradox in the tumor classification of the American Joint Committee on Cancer. World J Surg 31: 2008-2015, 2007.
26. Kim K, Chie EK, Jang JY, Kim SW, Oh DY, Im SA, Kim TY, Bang YJ and Ha SW: Is duodenal invasion a relevant prognosticator in patients undergoing adjuvant chemoradiotherapy for distal common bile duct cancer? Int J Radiat Oncol Biol Phys 77: 1186-1190, 2010.
27. He P, Shi JS, Chen WK, Wang ZR, Ren H and Li H: Multivariate statistical analysis of clinicopathologic factors influencing survival of patients with bile duct carcinoma. World J Gastroenterol 8: 943-946, 2002.
28. Hong SM, Kim MJ, Cho H, Pi DY, Jo D, Yu E and Ro JY: Superficial vs. deep pancreatic parenchymal invasion in the extrahepatic bile duct carcinomas: A significant prognostic factor. Mod Pathol 18: 969-975, 2005.
29. Murakami Y, Uemura K, Hayashidani Y, Sudo T, Hashimoto Y, Ohge H and Sueda T: Prognostic significance of lymph node metastasis and surgical margin status for distal cholangiocarcinoma. J Surg Oncol 95: 207-212, 2007.
30. Tanaka A, Watanabe T, Okuno K and Yasutomi M: Perineural invasion as a predictor of recurrence of gastric cancer. Cancer 73: 550-555, 1994.
31. Nakai T, Koh K, Kawabe T, Son E, Yoshikawa H and Yasutomi M: Importance of microperineural invasion as a prognostic factor in ampullary carcinoma. Br J Surgery 84: 1399-1401, 1997.
32. Yamaguchi R, Nagino M, Oda K, Kamiya J, Uesaka K and Nimura Y: Perineural invasion has a negative impact on survival of patients with gallbladder carcinoma. Br J Surg 89: 1130-1136, 2002.
33. Shimizu Y, Kimura F, Shimizu H, Yoshidome H, Ohtsuka M and Miyazaki M: The morbidity, mortality, and prognostic factors for ampullary carcinoma and distal cholangiocarcinoma. Hepatogastroenterology 55: 699-703, 2008.
34. Shirai K, Ebata T, Oda K, Nishio H, Nagasaka T, Nimura Y and Nagino M: Perineural invasion is a prognostic factor in intrahepatic cholangiocarcinoma. World J Surg 32: 2395-2402, 2008.
35. Sakamoto Y, Shimada K, Nara S, Esaki M, Ojima H, Sano T, Yamamoto J and Kosuge T: Surgical management of infrahilar/suprapancreatic cholangiocarcinoma: an analysis of the surgical procedures, surgical margins, and survivals of 77 patients. J Gastrointest Surg 14: 335-343, 2010.
36. Yamaguchi K, Chijiiwa K, Saiki S, Shimizu S, Takashima M and Tanaka M: Carcinoma of the extrahepatic bile duct: mode of spread and its prognostic implications. Hepatogastroenterology 44: 1256-1261, 1997.
37. Sudo T, Murakami Y, Uemura K, Hayashidani Y, Hashimoto Y, Ohge H, Shimamoto F and Sueda T: Prognostic impact of perineural invasion following pancreatoduodenectomy with lymphadenectomy for ampullary carcinoma. Dig Dis Sci 53: 2281-2286, 2008.
38. Smith RA, Ghaneh P, Sutton R, Raraty M, Campbell F and Neoptolemos JP: Prognosis of resected ampullary adenocarcinoma by preoperative serum CA19-9 levels and platelet-lymphocyte ratio. J Gastrointest Surg 12: 1422-1428, 2008.
39. Yamashita K, Sakuramoto S, Kikuchi S, Katada N, Kobayashi N and Watanabe M: Surgical resection of stage IV gastric cancer and prognosis. Anticancer Res 27: 4381-4386, 2007.
40. Katoh H, Yamashita K, Kokuba Y, Satoh T, Ozawa H, Hatate K, Ihara A, Nakamura T, Onosato W and Watanabe M: Surgical resection of stage IV colorectal cancer and prognosis. World J Surg 32: 1130-1137, 2008.
41. Waraya M, Yamashita K, Katagiri H, Ishii K, Takahashi Y, Furuta K and Watanabe M: Preoperative serum CA19-9 and dissected peripancreatic tissue margin as determiners of longterm survival in pancreatic cancer. Ann Surg Oncol 16: 1231-1240, 2009.
42. Magnani JL: The discovery, biology, and drug development of sialyl Lea and sialyl Lex. Cancer Res 65: 4963-4968, 2005.
43. Yokoigawa N, Takeuchi N, Toda M, Inoue M, Kaibori M, Yanagida H, Tanaka H, Ogura T, Takada H, Okumura T, Kwon AH, Kamiyama Y and Nakada H: Enhanced production of interleukin 6 in peripheral blood monocytes stimulated with mucins secreted into the bloodstream. Clin Cancer Res 11: 6127-6132, 2005.
44. Yokoigawa N, Takeuchi N, Toda M, Inoue M, Kaibori M, Yanagida H, Inaba T, Tanaka H, Ogura T, Takada H, Okumura T, Kwon AH, Kamiyama Y and Nakada H: Overproduction of PGE2 in peripheral blood monocytes of gastrointestinal cancer patients with mucins in their bloodstream. Cancer Lett 245: 149-155, 2007.
45. Takao S, Uchikura K, Yonezawa S, Shinchi H and Aikou T: Mucin core protein expression in extrahepatic bile duct carcinoma is associated with metastases to the liver and poor prognosis. Cancer 86: 1966-1975, 1999.
46. Boonla C, Wongkham S, Sheehan JK, Wongkham C, Bhudhisawasdi V, Tepsiri N and Pairojkul C: Prognostic value of serum MUC5AC mucin in patients with cholangiocarcinoma. Cancer 98: 1438-1443, 2003.
47. Juntavee A, Sripa B, Pugkhem A, Khuntikeo N and Wongkham S: Expression of sialyl Lewis(a) relates to poor prognosis in cholangiocarcinoma. World J Gastroenterol 11: 249-254, 2005.
48. Kannagi R, Izawa M, Koike T, Miyazaki K and Kimura N: Carbohydrate-mediated cell adhesion in cancer metastasis and angiogenesis. Cancer Sci 95: 377-384, 2004.
49. Honn KV, Tang DG and Crissman JD: Platelets and cancer metastasis: a causal relationship? Cancer Metastasis Rev 11: 325-351, 1992.
50. Kayahara M, Nagakawa T, Ohta T, Kitagawa H, Tajima H and Miwa K: Role of nodal involvement and the periductal softtissue margin in middle and distal bile duct cancer. Ann Surg Oncol 229: 76-83, 1999.
51. Kim S, Kim SW, Bang YJ, Heo DS and Ha SW: Role of postoperative radiotherapy in the management of extrahepatic bile duct cancer. Int J Radiat Oncol Biol Phys 54: 414-419, 2002.
52. DeOliveira ML, Cunningham SC, Cameron JL, Kamangar F, Winter JM, Lillemoe KD, Choti MA, Yeo CJ and Schulick RD: Cholangiocarcinoma: Thirty-one-year experience with 564 patients at a single institution. Ann Surg 245: 755-762, 2007.
53. Nomura T, Tsuchiya Y, Nashimoto A, Yabusaki H, Takii Y, Nakagawa S, Sato N, Kanbayashi C and Tanaka O: Prognostic factors for radical resection of middle and distal bile duct cancer. Hepatogastroenterology 56: 294-298, 2009.
54. Fernández-Ruiz M, Guerra-Vales JM and Colina-Ruizdelgado F: Comorbidity negatively influences prognosis in patients with extrahepatic cholangiocarcinoma. World J Gastroenterol 15: 5279-5286, 2009.
55. Yusoff AR, Razak MM, Yoong BK, Vijeyasingam R and Siti ZM: Survival analysis of cholangiocarcinoma: A 10-year experience in Malaysia. World J Gastroenterol 18: 458-465, 2012.
56. Sasaki R, Takeda Y, Funato O, Nitta H, Kawamura H, Uesugi N, Sugai T, Wakabayashi G and Ohkohchi N: Significance of ductal margin status in patients undergoing surgical resection for extrahepatic cholangiocarcinoma. World J Surg 31: 1788-1796, 2007.
57. Nakanishi Y, Kondo S, Zen Y, Yonemori A, Kubota K, Kawakami H, Tanaka E, Hirano S, Itoh T and Nakanuma Y: Impact of residual in situ carcinoma on postoperative survival in 125 patients with extrahepatic bile duct carcinoma. J Hepatobiliary Pancreat Sci 17: 166-173, 2010.
58. Higuchi R, Ota T, Araida T, Kobayashi M, Furukawa T and Yamamoto M: Prognostic relevance of ductal margins in operative resection of bile duct cancer. Surgery 148: 7-14, 2010.