In situ osmometry: Validation and effect of sample collection technique

Optometry and Vision Science

Volumn 90, Issue 4, 2013, Pages 359-365

  Gokhale, Moneisha ^a   Stahl, Ulrike ^a   Jalbert, Isabelle ^a  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

dry eyes; in situ osmometer; tear osmolarity; vapor pressure osmometer

Indexed keywords

A-COEFFICIENT; DRY EYE; IN-SITU MEASUREMENT; OSMOLARITY; SAMPLE COLLECTION; SAN DIEGO , CA; TEAR FILMS; VAPOR PRESSURE OSMOMETERS;

BINARY MIXTURES; INSTRUMENTS; MEASUREMENTS; VAPORS;

OSMOSIS;

ADULT; ARTICLE; CHEMISTRY; COMPARATIVE STUDY; DRY EYE; EQUIPMENT DESIGN; FEMALE; HUMAN; LABORATORY DIAGNOSIS; LACRIMAL FLUID; MALE; METABOLISM; METHODOLOGY; MIDDLE AGED; OSMOLARITY; OSMOMETRY; PATHOPHYSIOLOGY; REFERENCE VALUE; REPRODUCIBILITY; VALIDATION STUDY; VAPOR PRESSURE;

ADULT; DRY EYE SYNDROMES; EQUIPMENT DESIGN; FEMALE; HUMANS; MALE; MIDDLE AGED; OSMOLAR CONCENTRATION; OSMOMETRY; REFERENCE VALUES; REPRODUCIBILITY OF RESULTS; SPECIMEN HANDLING; TEARS; VAPOR PRESSURE; YOUNG ADULT;

EID: 84875872081     PISSN: 10405488     EISSN: 15389235     Source Type: Journal    
DOI: 10.1097/OPX.0b013e31828aaf10     Document Type: Article

References (32)

1. Luo L, Li DQ, Corrales RM, Pflugfelder SC. Hyperosmolar saline is a proinflammatory stress on the mouse ocular surface. Eye Contact Lens 2005;31:186-93. (Pubitemid 43197004)
2. Narayanan S, Corrales RM, Farley W, McDermott AM, Pflugfelder SC. Interleukin-1 receptor-1-deficient mice show attenuated production of ocular surface inflammatory cytokines in experimental dry eye. Cornea 2008;27:811-7.
3. Yoon KC, Jeong IY, Park YG, Yang SY. Interleukin-6 and tumor necrosis factorYalpha levels in tears of patients with dry eye syndrome. Cornea 2007;26:431-7.
4. Gilbard JP, Farris RL. Tear osmolarity and ocular surface disease in keratoconjunctivitis sicca. Arch Ophthalmol 1979;97:1642-6. (Pubitemid 9231540)
5. Korb DR, Herman JP, Blackie CA, Scaffidi RC, Greiner JV, Exford JM, Finnemore VM. Prevalence of lid wiper epitheliopathy in subjects with dry eye signs and symptoms. Cornea 2010;29: 377-83.
6. Definition and Classification Subcommittee of the International Dry Eye WorkShop. The definition and classification of dry eye disease: report of the Definition and Classification Subcommittee of the International Dry Eye WorkShop (2007). Ocul Surf 2007;5:75-92.
7. Benelli U, Nardi M, Posarelli C, Albert TG. Tear osmolarity measurement using the TearLab Osmolarity System in the assessment of dry eye treatment effectiveness.Cont Lens Anterior Eye 2010;33:61-7.
8. Larmo PS, Jarvinen RL, SetalaNL, Yang B, Viitanen MH, Engblom JR, Tahvonen RL, Kallio HP. Oral sea buckthorn oil attenuates tear film osmolarity and symptoms in individuals with dry eye. J Nutr 2010; 140:1462-8.
9. Messmer EM, Bulgen M, Kampik A. Hyperosmolarity of the tear film in dry eye syndrome. Dev Ophthalmol 2010;45:129-38.
10. Ogasawara K, Mitsubayashi K, Tsuru T, Karube I. Electrical conductivity of tear fluid in healthy persons and keratoconjunctivitis sicca patients measured by a flexible conductimetric sensor. Graefes Arch Clin Exp Ophthalmol 1996;234:542-6. (Pubitemid 26305899)
11. Versura P, Profazio V, Campos EC. Performance of tear osmolarity compared to previous diagnostic tests for dry eye diseases.Curr Eye Res 2010;35:553-64.
12. Lemp MA, Bron AJ, Baudouin C, Benitez Del Castillo JM, Geffen D, Tauber J, Foulks GN, Pepose JS, Sullivan BD. Tear osmolarity in the diagnosis and management of dry eye disease. Am J Ophthalmol 2011;151:792-8.
13. Sullivan BD, Whitmer D, Nichols KK, Tomlinson A, Foulks GN, Geerling G, Pepose JS, Kosheleff V, Porreco A, Lemp MA. An objective approach to dry eye disease severity. Invest Ophthalmol Vis Sci 2010;51:6125-30.
14. Suzuki M, Massingale ML, Ye F, Godbold J, Elfassy T, Vallabhajosyula M, Asbell PA. Tear osmolarity as a biomarker for dry eye disease severity. Invest Ophthalmol Vis Sci 2010; 51:4557-61.
15. Szalai E, Berta A, Szekanecz Z, Szucs G, Modis L, Jr. Evaluation of tear osmolarity in non-Sjogren and Sjogren syndrome dry eye patients with the TearLab system. Cornea 2012;31:867-71.
16. TomlinsonA,Khanal S,Ramaesh K, Diaper C,McFadyen A.Tear film osmolarity: determination of a referent for dry eye diagnosis. Invest Ophthalmol Vis Sci 2006;47:4309-15. (Pubitemid 46579353)
17. Gilbard JP, Gray KL, Rossi SR. A proposed mechanism for increased tear-film osmolarity in contact lens wearers. Am J Ophthalmol 1986; 102:505-7. (Pubitemid 17183714)
18. Sweeney TE, Beuchat CA. Limitations of methods of osmometry: measuring the osmolality of biological fluids. Am J Physiol 1993; 264:R469-80. (Pubitemid 23109894)
19. Stahl U, Jones L, Willcox M, Stapleton F. Tear osmolality measurementsVeffect of instrumentation and of freezing. Invest Ophthalmol Vis Sci 2009;50:E-abstract 2611.
20. Nelson JD, Wright JC. Tear film osmolality determination: an evaluation of potential errors in measurement.Curr Eye Res 1986;5:677-81. (Pubitemid 17195450)
21. Gram H. Observations on the regulation of osmotic pressure (conductivity, chlorides, freezing point, and proteins of serum). JBiolChem 1923;56:593-624.
22. Keech A, Senchyna M, Sullivan BD, Lemp MA, Jones LW, Brubaker MJ. Impact of time between collection on human tear film fluid osmolarity. Invest Ophthalmol Vis Sci 2010;51:E-abstract 4174.
23. Khanal S, Millar TJ. Barriers to clinical uptake of tear osmolarity measurements. Br J Ophthalmol 2012;96:341-4.
24. Tomlinson A, McCann LC, Pearce EI. Comparison of human tear film osmolarity measured by electrical impedance and freezing point depression techniques. Cornea 2010;29:1036-41.
25. Ocusense Inc. Tearlab Osmolarity System: Section IV 510(k) Summary. Intended Use and Indications for Use: May 14, 2009. Available at: http://www.accessdata.fda.gov/cdrh-docs/pdf8/K083184. pdf. Accessed January 29, 2013.
26. Murube J. Tear osmolarity. Ocul Surf 2006;4:62-73. (Pubitemid 351902296)
27. Bland JM, Altman DG. Statistical methods for assessing agreement between two methods of clinicalmeasurement. Lancet 1986;1:307-10. (Pubitemid 16134762)
28. Faul F, Erdfelder E, Lang AG, Buchner A. G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods 2007;39:175-91.
29. Eperjesi F, AujlaM,BartlettH.Reproducibility and repeatability of the OcuSense TearLab osmometer. Graefes Arch Clin Exp Ophthalmol 2012;250:1201-5.
30. Gilbard JP, Farris RL, Santamaria J, 2nd. Osmolarity of tear microvolumes in keratoconjunctivitis sicca. Arch Ophthalmol 1978;96:677-81. (Pubitemid 8301697)
31. Fouke JM,Wolin AD, SaundersKG,NeumanMR,McFadden ER, Jr. Sensor for measuring surface fluid conductivity in vivo. IEEE Trans Biomed Eng 1988;35:877-81.
32. Oncel BA, Pinarci E, Akova YA. Diurnal variation of the tear osmolarity in normal subjects measured by a new microchip system. Eur J Ophthalmol 2012;22(Suppl. 7):S1-S4.