Excess female siblings and male fetal loss in families with systemic lupus erythematosus

Journal of Rheumatology

Volumn 40, Issue 4, 2013, Pages 430-434

  Aggarwal, Rachna ^a,c   Sestak, Andrea L ^b   Chakravarty, Eliza F ^a,c   Harley, John B ^e   Scofield, R Hal ^a,c,d  

^a UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER   (United States)

^c OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

^d VETERANS AFFAIRS MEDICAL CENTER   (United States)

^e UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

Fetal loss; Pregnancy; Sex ratio; Systemic lupus erythematosus

Indexed keywords

ARTICLE; BIRTH RATE; CONTROLLED STUDY; FAMILY HISTORY; FAMILY RELATION; FEMALE; FETUS; FETUS WASTAGE; GENETIC SCREENING; HUMAN; INFANT; MAJOR CLINICAL STUDY; MALE; MOTHER; PREGNANCY; PRIORITY JOURNAL; REPRODUCTIVE HISTORY; SEX RATIO; SIBLING; SPONTANEOUS ABORTION; STILLBIRTH; SYSTEMIC LUPUS ERYTHEMATOSUS;

ADULT; FEMALE; FETAL DEATH; HUMANS; LUPUS ERYTHEMATOSUS, SYSTEMIC; MALE; PREGNANCY; REGISTRIES; SEX FACTORS; SIBLINGS;

EID: 84875866946     PISSN: 0315162X     EISSN: 14992752     Source Type: Journal    
DOI: 10.3899/jrheum.120643     Document Type: Article

References (43)

1. Crow MK. Developments in the clinical understanding of lupus. Arthritis Res Ther 2009;11:245.
2. Kurien BT, Scofield RH. Autoantibody determination in the diagnosis of systemic lupus erythematosus. Scand J Immunol 2006;64:227-35.
3. Flesher DL, Sun X, Behrens TW, Graham RR, Criswell LA. Recent advances in the genetics of systemic lupus erythematosus. Exp Rev Clin Immunol 2010;6:461-79.
4. Danchenko N, Satia JA, Anthony MS. Epidemiology of systemic lupus erythematosus: A comparison of worldwide disease burden. Lupus 2006;15:308-18.
5. Lu LJ, Wallace DJ, Ishimori ML, Scofield RH, Weisman MH. Review: Male systemic lupus erythematosus: a review of sex disparities in this disease. Lupus 2010;19:119-29.
6. Devlin AB, Costenbader K, Ramsey-Goldman R. Systemic lupus erythematosus. In: Ramsey-Goldman R, Manzi S. Women and health. London: Academic Press; 2000:704.
7. Soares PM, Borba EF, Bonfa E, Hallak J, Corrêa AL, Silva CA. Gonad evaluation in male systemic lupus erythematosus. Arthritis Rheum 2007;56:2352-61.
8. Mackworth-Young CG, Parke AL, Morley KD, Fotherby K, Hughes GR. Sex hormones in male patients with systemic lupus erythematosus: A comparison with other disease groups. Eur J Rheumatol Inflam 1983;6:228-32.
9. Scofield RH, Bruner GR, Namjou B, Kimberly RP, Ramsey-Goldman R, Petri M, et al. Klinefelter's syndrome (47,XXY) in male systemic lupus erythematosus patients: Support for the notion of a gene-dose effect from the X chromosome. Arthritis Rheum 2008;58:2511-7.
10. Cooney CM, Bruner GR, Aberle T, Namjou-Khales B, Myers LK, Feo L, et al. 46,X,del(X)(q13) Turner's syndrome women with systemic lupus erythematosus in a pedigree multiplex for SLE. Genes Immunol 2009;10:478-81.
11. Moorthy LN, Peterson MG, Onel KB, Lehman TJ. Do children with lupus have fewer male siblings? Lupus 2008;17:128-31.
12. Moser KL, Neas BR, Salmon JE, Yu H, Gray-McGuire C, Asundi N, et al. Genome scan of human systemic lupus erythematosus: Evidence for linkage on chromosome 1q in African-American pedigrees. Proc Natl Acad Sci USA 1998;95:14869-74.
13. Rasmussen A, Sevier S, Kelly J, Glenn S, Aberle T, Cooney CM, et al. The Lupus Family Registry and Repository. Rheumatol 2011;50:47-59.
14. Tan EM, Cohen AS, Fries JF, Masi AT, McShane DJ, Rothfield NF, et al. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1982;25:1271-7.
15. Hochberg MC. Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1997;40:1725.
16. Human sex ratios: Adaptations and mechanism, problems and prospects. In: Hardy ICW. Sex ratios: Concept and research methods. Cambridge, UK: Cambridge University Press; 2002:288.
17. Oleinick A. Family studies in lupus erythematosus. 1. Prenatal factors. Arthritis Rheum 1969;12:10-6.
18. Cooper GS, Stroehla BC. The epidemiology of autoimmune diseases. Autoimmun Rev 2003;2:119-25.
19. McMurray RW, May W. Sex hormones and systemic lupus erythematosus: Review and meta-analysis. Arthritis Rheum 2003;48:2100-10.
20. Sekigawa I, Fujishiro M, Yamaguchi A, Kawasaki M, Inui A, Nozawa K, et al. A new hypothesis of the possible mechanisms of gender differences in systemic lupus erythematosus. Clin Exp Rheumatol 2010;28:419-23.
21. El-Mansoury M, Bryman I, Berntorp K, Hanson C, Wilhelmsen L, Landin-Wilhelmsen K. Hypothyroidism is common in Turner syndrome: Results of a five-year follow-up. J Clin Endocrinol Metab 2005;90:2131-5.
22. Mortensen KH, Cleemann L, Hjerrild BE, Nexo E, Locht H, Jeppesen EM, et al. Increased prevalence of autoimmunity in Turner syndrome - influence of age. Clin Exp Immunol 2009;156:205-10.
23. Carrel L, Willard HF. X-inactivation profile reveals extensive variability in X-linked gene expression in females. Nature 2005;434:400-4.
24. Ehrenreich M, Tarlow MM, Godlewska-Janusz E, Schwartz RA. Incontinentia pigmenti (Bloch-Sulzberger syndrome): A systemic disorder. Cutis 2007;79:355-62.
25. The International Incontinentia Pigmenti Consortium. Genomic rearrangement in NEMO impairs NF-kappa-B activation and is a cause of incontinentia pigmenti. Nature 2000;405:466-72.
26. Courtois G, Israel A. IKK regulation and human genetics. Curr Top Microbiol Immunol 2011;349:73-95.
27. Wallace DJ. A reason for the rarity of male lupus. Lupus 1998;7:60.
28. James WH. The variations of human sex ratio at birth during and after wars, and their potential explanations. J Theoretical Biol 2009;257:116-23.
29. Miklos DB, Kim HT, Zorn E, Hochberg EP, Guo L, Mattes-Ritz A, et al. Antibody response to DBY minor histocompatibility antigen is induced after allogeneic stem cell transplantation and in healthy female donors. Blood 2004;103:353-9.
30. Wadia PP, Sahaf B, Miklos DB. Recombinant antigen microarrays for serum/plasma antibody detection. Meth Molec Biol 2011;723:81-104.
31. Nielsen HS, Wu F, Aghai Z, Steffensen R, van Halteren AG, Spierings E, et al. H-Y antibody titers are increased in unexplained secondary recurrent miscarriage patients and associated with low male:female ratio in subsequent live births. Human Reproduc 2010;25:2745-52.
32. Wang L, Zhou D, Lee J, Niu H, Faust TW, Frattini S, et al. Female mouse fetal loss mediated by maternal autoantibodies. J Exp Med 2012;209:1083-9.
33. Kumar MA, Jain A, Dechant VE, Saito T, Rafeal T, Aizawa H, et al. Anti-N-methyl-D-aspartate receptor encephalitis during pregnancy. Arch Neurol 2010;67:884-7.
34. Li QZ, Karp DR, Quan J, Branch VK, Zhou J, Lian Y, et al. Risk factors for ANA positivity in healthy persons. Arthritis Res Ther 2011;13:R38.
35. Marin GG, Cardiel MH, Cornejo H, Viveros ME. Prevalence of antinuclear antibodies in 3 groups of healthy individuals: blood donors, hospital personnel, and relatives of patients with autoimmune diseases. J Clin Rheumatol 2009;15:325-9.
36. Aggarwal R, Namjou B, Li S, D'Souza A, Tsao BP, Bruner BF, et al. Male-only systemic lupus. J Rheumatol 2010;37:1480-7.
37. Ticconi C, Rotondi F, Veglia M, Pietropolli A, Bernardini S, Ria F, et al. Antinuclear autoantibodies in women with recurrent pregnancy loss. Am J Reproduc Immunol 2010;64:384-92.
38. Abbassi-Ghanavati M. Thyroid autoantibodies and pregnancy outcomes. Clin Obstet Gynecol 2011;54:499-505.
39. Negro R, Schwartz A, Gismondi R, Tinelli A, Mangieri T, Stagnaro-Green A. Thyroid antibody positivity in the first trimester of pregnancy is associated with negative pregnancy outcomes. J Clin Endocrinol Metab 2011;96:E920-4.
40. Thangaratinam S, Tan A, Knox E, Kilby MD, Franklyn J, Coomarasamy A. Association between thyroid autoantibodies and miscarriage and preterm birth: Meta-analysis of evidence. BMJ 2011;342:d2616.
41. Salmon JE, Giraldi G, Locjshin MD. The antiphospholipid syndrome as a disorder initiated by inflammation: Implications for the therapy of pregnant patients. Nat Clin Pract Rheumatol 2007;3:140-7.
42. Smyth A, Oliveira GHM, Lahu BD, Bailey KR, Norby SM, Garvoic VD. A systematic review and meta-analysis of pregnancy outcomes in patients with systemic lupus erythematosus and lupus nephritis. Clin J Am Soc Nephrol 2010;5:2060-8.
43. Elblom-Kullberg S, Kautianien H, Alha P, Helve T, Leirisalo-Repo M, Julkunen H. Reproductive health in women with systemic lupus erythematosus compared to population controls. Scand J Rheumatol 2009;38:375-80.