MAPK phosphatase-2 (MKP-2) is induced by hCG and plays a role in the regulation of CYP11A1 expression in MA-10 leydig cells

Endocrinology

Volumn 154, Issue 4, 2013, Pages 1488-1500

  Gómez, Natalia V ^a   Gorostizaga, Alejandra B ^a   García, María M Mori Sequeiros ^a   Brion, Laura ^b   Acquier, Andrea ^a   González Calvar, Silvia I ^a,c   Méndez, Carlos F ^a   Podestá, Ernesto J ^a   Paz, Cristina ^a  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c Facultad de Ciencias Naturales e Instituto M Lillo   (Argentina)

Author keywords

[No Author keywords available]

Indexed keywords

8 BROMO CYCLIC AMP; CHOLESTEROL MONOOXYGENASE (SIDE CHAIN CLEAVING); CHORIONIC GONADOTROPIN; CYCLIC AMP DEPENDENT PROTEIN KINASE; LUTEINIZING HORMONE RECEPTOR; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE PHOSPHATASE; MITOGEN ACTIVATED PROTEIN KINASE PHOSPHATASE 2; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CHIMERA; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; GENE EXPRESSION; GENETIC TRANSCRIPTION; HALF LIFE TIME; LEYDIG CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN EXPRESSION; PROTEIN MODIFICATION; PROTEIN PROCESSING; PROTEIN STABILITY; STEROIDOGENESIS; TRANSIENT EXPRESSION; UPREGULATION;

8-BROMO CYCLIC ADENOSINE MONOPHOSPHATE; ANIMALS; CELL LINE, TUMOR; CHOLESTEROL SIDE-CHAIN CLEAVAGE ENZYME; CHORIONIC GONADOTROPIN; LEYDIG CELLS; MALE; MICE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; PHOSPHORYLATION; PROTEIN TYROSINE PHOSPHATASES; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, LH; RNA, MESSENGER; UP-REGULATION;

EID: 84875853641     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2012-2032     Document Type: Article

References (36)

1. Dickinson RJ, Keyse SM. Diverse physiological functions for dualspecificity MAP kinase phosphatases. J Cell Sci. 2006;119:4607-4615.
2. Keyse SM. Dual-specificity MAP kinase phosphatases (MKPs) and cancer. Cancer Metastasis Rev. 2008;27:253-261.
3. Boutros T, Chevet E, Metrakos P. Mitogen-activated protein (MAP) kinase/MAP kinase phosphatase regulation: roles in cell growth, death, and cancer. Pharmacol Rev. 2008;60:261-310.
4. Cagnol S, Chambard JC. ERK and cell death: mechanisms of ERKinduced cell death-apoptosis, autophagy and senescence. FEBS J. 2010;277:2-21.
5. Ashwell JD. The many paths to p38 mitogen-activated protein kinase activation in the immune system. Nat Rev Immunol. 2006;6: 532-540.
6. Raman M, Chen W, Cobb MH. Differential regulation and properties of MAPKs. Oncogene. 2007;26:3100-3112.
7. Hömme M, Schmitt CP, Mehls O, Schaefer F. Mechanism of mitogen-activated protein kinase inhibition by parathyroid hormone in osteoblast-like cells. J Am Soc Nephrol. 2004;15:2844-2850.
8. Fuller SJ, Davies EL, Gillespie-Brown J, Sun H, Tonks NK. Mitogenactivated protein kinase phosphatase 1 inhibits the stimulation of gene expression by hypertrophic agonists in cardiac myocytes. Biochem J. 1997;323(Pt 2):313-319.
9. Le T, Schimmer BP. The regulation of MAPKs in Y1 mouse adrenocortical tumor cells. Endocrinology. 2001;142:4282-4287.
10. Hirakawa T, Ascoli M. The lutropin/choriogonadotropin receptorinduced phosphorylation of the extracellular signal-regulated kinases in Leydig cells is mediated by a protein kinase A-dependent activation of ras. Mol Endocrinol. 2003;17:2189-2200.
11. Bey P, Gorostizaga AB, Maloberti PM, et al. Adrenocorticotropin induces mitogen-activated protein kinase phosphatase 1 in Y1 mouse adrenocortical tumor cells. Endocrinology. 2003;144:1399-1406.
12. Sewer MB, Waterman MR. CAMP-dependent protein kinase enhancesCYP17transcription viaMKP-1activation inH295Rhuman adrenocortical cells. J Biol Chem. 2003;278:8106-8111.
13. Casal AJ, Ryser S, Capponi AM, Wang-Buholzer CF. Angiotensin II-induced mitogen-activated protein kinase phosphatase-1 expression in bovine adrenal glomerulosa cells: implications in mineralocorticoid biosynthesis. Endocrinology. 2007;148:5573-5581.
14. Brion L, Maloberti PM, Gomez NV, et al. MAPK phosphatase-1 (MKP-1) expression is up-regulated by hCG/cAMP and modulates steroidogenesis in MA-10 Leydig cells. Endocrinology. 2011;152: 2665-2677.
15. Podesta EJ, Dufau ML, Catt KJ. Adenosine 3′,5′-monophosphate- dependent protein kinase of Leydig cells: in vitro activation and relationship to gonadotropin action upon cyclic AMP and steroidogenesis. FEBS Lett. 1976;70:212-216.
16. Clark BJ, Wells J, King SR, Stocco DM. The purification, cloning, and expression of a novel luteinizing hormone-induced mitochondrial protein in MA-10 mouse Leydig tumor cells. Characterization of the steroidogenic acute regulatory protein (StAR). J Biol Chem. 1994;269:28314-28322.
17. Stocco DM, Clark BJ. Role of the steroidogenic acute regulatory protein (StAR) in steroidogenesis. Biochem Pharmacol. 1996;51: 197-205.
18. Arakane F, King SR, Du Y, et al. Phosphorylation of steroidogenic acute regulatory protein (StAR) modulates its steroidogenic activity. J Biol Chem. 1997;272:32656-32662.
19. Poderoso C, Converso DP, Maloberti P, et al. A mitochondrial kinase complex is essential to mediate an ERK1/2-dependent phosphorylation of a key regulatory protein in steroid biosynthesis. PLoS One. 2008;3:e1443.
20. Payne AH, Youngblood GL. Regulation of expression of steroidogenic enzymes in Leydig cells. Biol Reprod. 1995;52:217-225.
21. Lavoie HA, King SR. Transcriptional regulation of steroidogenic genes: STARD1, CYP11A1 andHSD3B. Exp BiolMed(Maywood). 2009;234:880-907.
22. Gyles SL, Burns CJ, Whitehouse BJ, et al.ERKsregulate cyclicAMPinduced steroid synthesis through transcription of the steroidogenic acute regulatory (StAR) gene. J Biol Chem. 2001;276:34888-34895.
23. Yamashita S, Tai P, Charron J, Ko C, Ascoli M. The Leydig cell MEK/ERK pathway is critical for maintaining a functional population of adult Leydig cells and for fertility. Mol Endocrinol. 2011; 25:1211-1222.
24. Castillo AF, Maciel FC, Castilla R, et al. cAMP increases mitochondrial cholesterol transport through the induction of arachidonic acid release inside this organelle in Leydig cells. FEBS J. 2006;273:5011-5021.
25. Ascoli M. Characterization of several clonal lines of cultured Leydig tumor cells: gonadotropin receptors and steroidogenic responses. Endocrinology. 1981;108:88-95.
26. Castilla R, Gadaleta M, Castillo AF, et al. New enzymes involved in the mechanism of action of epidermal growth factor in a clonal strain of Leydig tumor cells. Endocrinology. 2008;149:3743-3752.
27. Pfaffl MW. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res. 2001;29:e45.
28. Maloberti P, Castilla R, Castillo F, et al. Silencing the expression of mitochondrial acyl-CoA thioesterase I and acyl-CoA synthetase 4 inhibits hormone-induced steroidogenesis. FEBS J. 2005;272: 1804-1814.
29. Martinelle N, Holst M, Soder O, Svechnikov K. Extracellular signalregulated kinases are involved in the acute activation of steroidogenesis in immature rat Leydig cells by human chorionic gonadotropin. Endocrinology. 2004;145:4629-4634.
30. Zhang T, Roberson MS. Role of MAP kinase phosphatases in GnRH-dependent activation of MAP kinases. J Mol Endocrinol. 2006;36:41-50.
31. Zhang T, Mulvaney JM, Roberson MS. Activation of mitogen-activated protein kinase phosphatase 2 by gonadotropin-releasing hormone. Mol Cell Endocrinol. 2001;172:79-89.
32. Peng DJ, Zhou JY, Wu GS. Post-translational regulation of mitogenactivated protein kinase phosphatase-2 (MKP-2) by ERK. Cell Cycle. 2010;9:4650-4655.
33. Sloss CM, Cadalbert L, Finn SG, Fuller SJ, Plevin R. Disruption of two putative nuclear localization sequences is required for cytosolic localization of mitogen-activated protein kinase phosphatase-2. Cell Signal. 2005;17:709-716.
34. Guo IC, Huang CY, Wang CK, Chung BC. Activating protein-1 cooperates with steroidogenic factor-1 to regulate 3′,5′-cyclic adenosine 5′-monophosphate-dependent human CYP11A1 transcription in vitro and in vivo. Endocrinology. 2007;148:1804-1812.
35. Winnay JN, Hammer GD. Adrenocorticotropic hormone-mediated signaling cascades coordinate a cyclic pattern of steroidogenic factor 1-dependent transcriptional activation. Mol Endocrinol. 2006;20: 147-166.
36. Lan HC, Li HJ, Lin G, Lai PY, Chung BC. Cyclic AMP stimulates SF-1-dependent CYP11A1 expression through homeodomain-interacting protein kinase 3-mediated Jun N-terminal kinase and c-Jun phosphorylation. Mol Cell Biol. 2007;27:2027-2036.