A prospective randomized trial of perioperative seizure prophylaxis in patients with intraparenchymal brain tumors: Clinical article

Journal of Neurosurgery

Volumn 118, Issue 4, 2013, Pages 873-883

  Wu, Adam S ^a   Trinh, Victoria T ^a   Suki, Dima ^a   Graham, Susan ^a   Forman, Arthur ^a   Weinberg, Jeffrey S ^a   McCutcheon, Ian E ^a   Prabhu, Sujit S ^a   Heimberger, Amy B ^a   Sawaya, Raymond ^a   Wang, Xuemei ^a   Qiao, Wei ^a   Hess, Kenneth R ^a   Lang, Frederick F ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

Brain metastasis; Epilepsy; Glioma; Phenytoin; Seizure prophylaxis; Tumor resection

Indexed keywords

PHENYTOIN;

ADULT; AGED; APHASIA; ARTICLE; ATAXIA; BRAIN MAPPING; BRAIN METASTASIS; CONFUSION; CONSCIOUSNESS LEVEL; CONTROLLED STUDY; CRANIOTOMY; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG SAFETY; DRY SKIN; FEMALE; GASTROINTESTINAL SYMPTOM; GLIOMA; HEMIPARESIS; HUMAN; LIVER FUNCTION TEST; LOADING DRUG DOSE; MAJOR CLINICAL STUDY; MALE; NAUSEA; NEUROLOGIC DISEASE; OUTCOME ASSESSMENT; PHOTOPHOBIA; POSTOPERATIVE COMPLICATION; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; RASH; SEIZURE; SIDE EFFECT; THROMBOCYTOPENIA; VOMITING;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANTICONVULSANTS; BAYES THEOREM; BRAIN NEOPLASMS; CRANIOTOMY; FEMALE; GLIOMA; HUMANS; INCIDENCE; KAPLAN-MEIER ESTIMATE; MALE; MIDDLE AGED; PERIOPERATIVE CARE; PHENYTOIN; PROSPECTIVE STUDIES; SEIZURES; SUPRATENTORIAL NEOPLASMS; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84875842751     PISSN: 00223085     EISSN: 19330693     Source Type: Journal    
DOI: 10.3171/2012.12.JNS111970     Document Type: Article

References (23)

1. Agbi CB, Bernstein M: Seizure prophylaxis for brain tumour patients. Brief review and guide for family physicians. Can Fam Physician 39:1153-1156, 1159-1160, 1163-1164, 1993
2. Berry DA: Bayesian clinical trials. Nat Rev Drug Discov 5: 27-36, 2006
3. Bollini P, Riva R, Albani F, Ida N, Cacciari L, Bollini C, et al: Decreased phenytoin level during antineoplastic therapy: a case report. Epilepsia 24:75-78, 1983
4. Cabral R, King TT, Scott DF: Incidence of postoperative epilepsy after a transtentorial approach to acoustic nerve tumours. J Neurol Neurosurg Psychiatry 39:663-665, 1976
5. Cabral RJ, King TT, Scott DF: Epilepsy after two different neurosurgical approaches to the treatment of ruptured intracranial aneurysm. J Neurol Neurosurg Psychiatry 39:1052-1056, 1976
6. Chaichana KL, Parker SL, Olivi A, Quiñones-Hinojosa A: Long-term seizure outcomes in adult patients undergoing primary resection of malignant brain astrocytomas. Clinical article. J Neurosurg 111:282-292, 2009
7. Cohen N, Strauss G, Lew R, Silver D, Recht L: Should prophylactic anticonvulsants be administered to patients with newlydiagnosed cerebral metastases? A retrospective analysis. J Clin Oncol 6:1621-1624, 1988
8. Cook J: Predictive probability interim analysis. Feb. 26, 2006 (https://biostatistics.mdanderson.org/SoftwareDownload/ProductSupportFiles/ PredictiveProbabilit/PredictiveInterimAnalysis.pdf) [Accessed December 17, 2012]
9. Englot DJ, Berger MS, Barbaro NM, Chang EF: Predictors of seizure freedom after resection of supratentorial low-grade gliomas. A review. J Neurosurg 115:240-244, 2011
10. Forsyth PA, Weaver S, Fulton D, Brasher PM, Sutherland G, Stewart D, et al: Prophylactic anticonvulsants in patients with brain tumour. Can J Neurol Sci 30:106-112, 2003
11. Franceschetti S, Binelli S, Casazza M, Lodrini S, Panzica F, Pluchino F, et al: Influence of surgery and antiepileptic drugs on seizures symptomatic of cerebral tumours. Acta Neurochir (Wien) 103:47-51, 1990
12. Glantz MJ, Cole BF, Friedberg MH, Lathi E, Choy H, Furie K, et al: A randomized, blinded, placebo-controlled trial of divalproex sodium prophylaxis in adults with newly diagnosed brain tumors. Neurology 46:985-991, 1996
13. Lee ST, Lui TN, Chang CN, Cheng WC, Wang DJ, Heimburger RF, et al: Prophylactic anticonvulsants for prevention of immediate and early postcraniotomy seizures. Surg Neurol 31: 361-364, 1989
14. Leppik IE: Compliance during treatment of epilepsy. Epilepsia 29 (Suppl 2):S79-S84, 1988
15. Lim DA, Tarapore P, Chang E, Burt M, Chakalian L, Barbaro N, et al: Safety and feasibility of switching from phenytoin to levetiracetam monotherapy for glioma-related seizure control following craniotomy: a randomized phase II pilot study. J Neurooncol 93:349-354, 2009
16. North JB, Penhall RK, Hanieh A, Frewin DB, Taylor WB: Phenytoin and postoperative epilepsy. A double-blind study. J Neurosurg 58:672-677, 1983
17. North JB, Penhall RK, Hanieh A, Hann CS, Challen RG, Frewin DB: Postoperative epilepsy: a double-blind trial of phenytoin after craniotomy. Lancet 315:384-386, 1980
18. Sartorius CJ, Berger MS: Rapid termination of intraoperative stimulation-evoked seizures with application of cold Ringer's lactate to the cortex. Technical note. J Neurosurg 88:349-351, 1998
19. Sartorius CJ, Wright G: Intraoperative brain mapping in a community setting-technical considerations. Surg Neurol 47: 380-388, 1997
20. Sirven JI, Wingerchuk DM, Drazkowski JF, Lyons MK, Zimmerman RS: Seizure prophylaxis in patients with brain tumors: a meta-analysis. Mayo Clin Proc 79:1489-1494, 2004
21. Szelényi A, Joksimovic B, Seifert V: Intraoperative risk of seizures associated with transient direct cortical stimulation in patients with symptomatic epilepsy. J Clin Neurophysiol 24: 39-43, 2007
22. Temkin NR, Dikmen SS, Wilensky AJ, Keihm J, Chabal S, Winn HR: A randomized, double-blind study of phenytoin for the prevention of post-traumatic seizures. N Engl J Med 323: 497-502, 1990
23. Wathen JK: Predictive probability user's guide, version 1.4. April 19, 2007 (https://biostatistics.mdanderson.org/SoftwareDownload/ProductSupportFiles/ PredictiveProbabilit/PredictiveProbabilitiesUsersGuide.pdf) [Accessed December 17, 2012]