Worrisome trend of new multiple mechanisms of linezolid resistance in staphylococcal clones diffused in Italy

Journal of Clinical Microbiology

Volumn 51, Issue 4, 2013, Pages 1256-1259

  Campanile, Floriana ^a   Mongelli, Gino ^a   Bongiorno, Dafne ^a   Adembri, Chiara ^b   Ballardini, Milva ^c   Falcone, Marco ^d   Menichetti, Francesco ^e   Repetto, Antonella ^f   Sabia, Carla ^g   Sartor, Assunta ^h   Scarparo, Claudio ^h   Tascini, Carlo ^e   Venditti, Mario ^d   Zoppi, Federica ^b   Stefania, Stefania ^a  

^a UNIVERSITY OF CATANIA   (Italy)

^b CAREGGI UNIVERSITY HOSPITAL   (Italy)

^c SAN FILIPPO NERI HOSPITAL   (Italy)

^d SAPIENZA UNIVERSITY OF ROME   (Italy)

^e UNIVERSITY OF PISA   (Italy)

^f SANTA MARIA DELLA MISERICORDIA HOSPITAL   (Italy)

^g UNIVERSITY HOSPITAL OF UDINE   (Italy)

^h UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; COTRIMOXAZOLE; DALFOPRISTIN; DALFOPRISTIN PLUS QUINUPRISTIN; DAPTOMYCIN; LEVOFLOXACIN; LINCOSAMIDE DERIVATIVE; LINEZOLID; OXAZOLIDINONE DERIVATIVE; PHENICOL DERIVATIVE; PLEUROMUTILIN; POLYPEPTIDE ANTIBIOTIC AGENT; RNA 23S; TEICOPLANIN; UNCLASSIFIED DRUG; VANCOMYCIN;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL GENE; BLOODSTREAM INFECTION; CFR GENE; CONTROLLED STUDY; GENE INSERTION; GENE MUTATION; ITALY; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR CLONING; MULTIDRUG RESISTANCE; MULTILOCUS SEQUENCE TYPING; NONHUMAN; PRIORITY JOURNAL; PROSPECTIVE STUDY; PULSED FIELD GEL ELECTROPHORESIS; SEQUENCE ALIGNMENT; STAPHYLOCOCCUS; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS CAPITIS; STAPHYLOCOCCUS EPIDERMIDIS; STAPHYLOCOCCUS HOMINIS; TREND STUDY;

ACETAMIDES; ANTI-BACTERIAL AGENTS; DRUG RESISTANCE, BACTERIAL; GENES, BACTERIAL; HUMANS; ITALY; MUTATION; OXAZOLIDINONES; PREVALENCE; PROSPECTIVE STUDIES; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS;

EID: 84875836031     PISSN: 00951137     EISSN: 1098660X     Source Type: Journal    
DOI: 10.1128/JCM.00098-13     Document Type: Article

References (20)

1. Gonzales RD, Schreckenberger PC, Graham MB, Kelkar S, DenBesten K, Quinn JP. 2001. Infections due to vancomycin-resistant Enterococcus faecium resistant to linezolid. Lancet 357:1179.
2. Tsiodras S, Gold HS, Sakoulas G, Eliopoulos GM, Wennersten C, Venkataraman L, Moellering RC, Ferraro MJ. 2001. Linezolid resistance in clinical isolate of Staphylococcus aureus. Lancet 38:207-208.
3. Stefani S, Bongiorno D, Mongelli G, Campanile F. 2010. Linezolid resistance in staphylococci. Pharmaceuticals 3:1988-2006.
4. Long KS, Vester B. 2012. Resistance to linezolid caused by modifications at its binding site on the ribosome. Antimicrob. Agents Chemother. 56: 603-661.
5. Schwarz S, Werckenthin C, Kehrenberg C. 2000. Identification of a plasmid-borne chloramphenicol-florfenicol resistance gene in Staphylococcus sciuri. Antimicrob. Agents Chemother. 44:2530-2533.
6. Seral C, Sáenz Y, Algarate S, Duran E, Luque P, Torres C, Castillo FJ. 2011. Nosocomial outbreak of methicillin-and linezolid-resistant Staphylococcus epidermidis associated with catheter-related infections in intensive care unit patients. Int. J. Med. Microbiol. 301:354-358.
7. Wong A, Reddy SP, Smyth DS, Aguero-Rosenfeld ME, Sakoulas G, Robinson DA. 2010. Polyphyletic emergence of linezolid-resistant staphylococci in the United States. Antimicrob. Agents Chemother. 54:742-748.
8. Mendes RE, Deshpande LM, Costello A, Farrell DJ. 2012. Molecular epidemiology of Staphylococcus epidermidis clinical isolates from U.S. hospitals. Antimicrob. Agents Chemother. 56:4656-4661.
9. Bongiorno D, Campanile F, Mongelli G, Baldi MT, Provenzani R, Reali S, Lo Russo C, Santagati M, Stefani S. 2010. DNA methylase modifications and other linezolid resistance mutations in coagulase-negative staphylococci in Italy. J. Antimicrob. Chemother. 65:2336-2340.
10. Clinical and Laboratory Standard Institutes (CLSI). 2012. Performance standards for antimicrobial susceptibility testing; approved standard M100-S20. CLSI, Wayne, PA.
11. European Committee on Antimicrobial Susceptibility Testing (EUCAST). 2012. Clinical breakpoints. http://www.eucast.org/clinical-breakpoints/.
12. Locke JB, Hilgers M, Shaw KJ. 2009. Mutations in ribosomal protein L3 are associated with oxazolidinone resistance in staphylococci of clinical origin. Antimicrob. Agents Chemother. 53:5275-5278.
13. Pringle M, Poehlsgaard J, Vester B, Long KS. 2004. Mutations in ribosomal protein L3 and 23S ribosomal RNA at the peptidyl transferase centre are associated with reduced susceptibility to tiamulin in Brachyspira spp. isolates. Mol. Microbiol. 54:1295-1306.
14. Holzel CS, Harms KS, Schwaiger K, Bauer J. 2010. Resistance to linezolid in a porcine Clostridium perfrigens strain carrying a mutation in the rplD gene encoding the ribosomal protein L4. Antimicrob. Agents Chemother. 54:1351-1353.
15. Miragaia M, Thomas JC, Couto I, Enright MC, de Lencastre H. 2007. Inferring a population structure for Staphylococcus epidermidis from multilocus sequence typing data. J. Bacteriol. 189:2540-2552.
16. Widerstrom M, Monsen T, Karlsson C, Edebro H, Johansson A, Wistrom J. 2009. Clonality among multidrug-resistant hospital-associated Staphylococcus epidermidis in northern Europe. Scand. J. Infect. Dis. 41: 642-649.
17. Widerstrom M, McCullough CA, Coombs GW, Monsen T, Christiansen KJ. 2012. A multidrug-resistant Staphylococcus epidermidis clone (ST2) is an ongoing cause of hospital-acquired infection in a Western Australian hospital. J. Clin. Microbiol. 50:2147-2151.
18. Iorio NL, Caboclo RF, Azevedo MB, Barcellos AG, Neves FP, Domingues RM, dos Santos KR. 2012. Characteristics related to antimicrobial resistance and biofilm formation of widespread methicillinresistant Staphylococcus epidermidis ST2 and ST23 lineages in Rio de Janeiro hospitals, Brazil. Diagn. Microbiol. Infect. Dis. 72:32-40.
19. Li M, Wang X, Gao Q, Lu Y. 2009. Molecular characterization of Staphylococcus epidermidis strains isolated from a teaching hospital in Shanghai, China. J. Med. Microbiol. 58(Pt 4):456-461.
20. Ibrahem S, Salmenlinna S, Lyytikainen O, Vaara M, Vuopio-Varkila J. 2008. Molecular characterization of methicillin-resistant Staphylococcus epidermidis strains from bacteraemic patients. Clin. Microbiol. Infect. 14: 1020-1027.