Atypical Leydig Cell Hyperplasia in Adult Rats with Low T and High LH Induced by Prenatal Di(n-butyl) Phthalate Exposure

Toxicologic Pathology

Volumn 41, Issue 3, 2013, Pages 480-486

  Wakui, Shin ^a,b   Takahashi, Hiroyuki ^b   Mutou, Tomoko ^c   Shirai, Masaru ^a   Jutabha, Promsuk ^d   Anzai, Naohiko ^d   Wempe, Michael F ^e   Kansaku, Norio ^a   Hano, Hiroshi ^b   Inomata, Tomo ^a   Endou, Hitoshi ^f  

^a AZABU UNIVERSITY   (Japan)

^b JIKEI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c Drug Safety Testing Center   (Japan)

^d DOKKYO MEDICAL UNIVERSITY   (Japan)

^e UNIVERSITY OF COLORADO   (United States)

^f J Pharma Co   (Japan)

Author keywords

atypical Leydig cell; electron microscopy; hyperplasia; prenatal DBP exposure; rats; testis

Indexed keywords

CYCLINE; LUTEINIZING HORMONE; NUCLEOLIN; PHTHALIC ACID DIBUTYL ESTER; TESTOSTERONE; VIMENTIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL HYPERPLASIA; CELL NUCLEUS; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; FILOPODIUM; IMMUNOHISTOCHEMISTRY; LEYDIG CELL; MICROSCOPY; NONHUMAN; PRENATAL EXPOSURE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RIBOSOME; SEMINIFEROUS TUBULE; TIGHT JUNCTION;

RATTUS;

EID: 84875820377     PISSN: 01926233     EISSN: 15331601     Source Type: Journal    
DOI: 10.1177/0192623312457272     Document Type: Article

References (23)

1. Akingbemi B. T. Youker R. T. Sottas C. M. Ge R. Katz E. Klinefelter G. R. Zirkin B. R. Hardy P. (2001). Modulation of rat Leydig cell steroidgenic function by di(2-ethlhexyl) phthalate. Biol Reprod 65, 1252–59.
2. Alam M. S. Ohsako S. Matsuwaki T. Zhu X. B. Tsunekawa N. Kanai Y. Sone H. Tohyama C. Kuromaru M. (2010). Induction of spermatogenic cell apoptosis in prepubertal rat testes irrespective of testicular steroidogenesis: A possible estrogenic effect of di(n-butyl) phthalate. Reproduction 139, 427–37.
3. N.J., Barlow, S.L., Phillips, P.P.D., Foster, Male reproductive tract lesions at 6, 12, and 18 months of age following in utero exposure to di(n-butyl) phthalate, Toxicol Pathol, (2004), 34, 79-90
4. Connell C. J. Christensen A. K. (1975). The ultrastructure of the canine testicular interstitial tissue. Biol Reprod 12, 368.
5. Crabo B. (1963). Fine structure of the interstitial cells of the rabbit testes. Z Zelforsch 61, 587.
6. Ghadially F. N. (1975). Microbodies (peroxisomes, miroperoxisomes and catalosomes). In Ultrastructural Pathology of the Cell and Matrix, Vol. II., pp.767–826, Butterworths, London, UK.
7. Gray L. E. Jr. Furr J. (2006). Differential expression of the phthalate syndrome of reproductive tract malformations in male Sprague-Dawley and Wistar rat strains. In Program and Abstracts of U.S. Society for Study of Reproduction, July 29 and August 1, Omaha, NE. Abstract 2006-A41.
8. Harris C. A. Henttu P. Parker M. G. Sumpter J. P. (1997). The estrogenic activity of phthalate esters in vitro. Environ Health Perspect 105, 802–11.
9. M., Holm, E.E.D., Meyts, A.M., Adersson, N.E., Skakkebaek, Leydig cell micronodules are a common finding in testicular biopsies from men with impaired spermatogenesis and are associated with decreased testosterone/LH ratio, J Pathol, (2003), 199, 278-386
10. Hoppin J.A. Brock B.T. Davis B.T. Baierd D.D. (2002). Reproducibility of urinary phthalate metabolites in first morning urine samples. Environ Health Perspect 110, 515–518.
11. Hu G. X. Lian Q. Q. Ge R. S. Hardy D. O. Li X. K. (2009). Phthalate-induced testicular dysgenesis syndrome: Leydig cell influence. Trends Endocrinol Metab 20, 139–45.
12. Hubinger J. C. Jean C. Donald C. (2006). Analysis of consumer cosmetic products for phthalate esters. J Cosmet Sci 57, 127–37.
13. Jegou B. Sharpe R. M. (1993). Paracrine mechanisms in testicular control. In Molecular Biology of the Male Reproductive System, pp. 271–301, Academic Press, San Diego, CA.
14. Jones H. B. Garsid e D. A. Liu R. Roberts J. C. (1993). The influence of phthalate esters on Leydig cell structure and function in vitro and in vivo. Exp Mole Pathol 58, 179–93.
15. Kawakami T. Isama1 K. Matsuoka A. (2011). Analysis of phthalic acid diesters, monoester, and other plasticizers in polyvinyl chloride household products in Japan. J Environ Sci Health 46, 855–64.
16. Mahood I. K. Hallmark N. McKinnell C. Walker M. Fisher J. S. Sharpe R. M. (2005). Abnormal Leydig cell aggregation in the fetal testis of rats exposed to di(n-butyl) phthalate and its possible role in testicular dysgenesis. Endocrinology 146, 613–23.
17. R.F., McConnell, H.H., Westen, B.M., Ulland, M.C., Bosland, J.M., Ward, Proliferative lesions of the testis in rats with selected examples from mice, Standardized System of Nomenclature and Diagnostic Criteria, Society of Toxicologic Pathology, STP/ARP/AFIP, Washington, DC, (1992)
18. Mylchreest E. Sar M. Wallace D. G. Foster P. M. (2002). Fetal testosterone insufficiency and abnormal proliferation of Leydig cells and gonocytes in rats exposed to di(n-butyl) phthalate. Reprod Toxicol 16, 19–28.
19. OSHA. (2009). Occupational Safety and Health Guideline for Dibutyl Phthalate. http//www.osha.gov/SLTC/healthguidelines/dibutylphthalate/recognition/html.
20. Russell L. Burguet S. (1977). Ultrastructure of Leydig cells as revealed by secondary tissue treatment with ferrocyanide-osmium mixture. Tissue Cell 9, 751–66.
21. Seeley E. S. Nachury M. V. (2009). Constructing and deconstructing roles for the primary cilium in tissue architecture and cancer. Methods Cell Biol 94, 299–313.
22. Soderstrom K. O. (1987). Leydig cell hyperplasia. Arch Androl 17, 57–65.
23. Takayama H. (1981). Single cilia formation in cells of the testicular interstitium in fertile men. Int J Andol 4, 246–56.