Cystic fibrosis-related diabetes in adults: Inpatient management of 121 patients during 410 admissions

Journal of Diabetes Science and Technology

Volumn 6, Issue 5, 2012, Pages 1038-1044

  Rasouli, Neda ^a,b   Seggelke, Stacey ^a   Gibbs, Joanna ^a   Hawkins, Matthew ^a   Casciano, Matthew L ^c   Cohlmia, Elizabeth ^a   Taylor Cousar, Jennifer ^a,d   Wang, Cecilia ^a,b   Pereira, Rocio ^a   Hsia, Elisa ^a   Draznin, Boris ^a  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^b Veterans Affairs Eastern Colorado Healthcare System   (United States)

^c UNIVERSITY OF COLORADO HOSPITAL   (United States)

^d DEPARTMENT OF MEDICINE   (United States)

Author keywords

Cystic fibrosis; Diabetes; Glycemic control; Inpatient management

Indexed keywords

GLUCOSE; ISOPHANE INSULIN; LONG ACTING INSULIN; METHYLPREDNISOLONE; PREDNISONE; SHORT ACTING INSULIN; STEROID; ANTIDIABETIC AGENT; INSULIN;

ADOLESCENT; ADULT; ADULT DISEASE; AGED; BLOOD GLUCOSE MONITORING; CONFERENCE PAPER; CONTINUOUS INFUSION; CYSTIC FIBROSIS; CYSTIC FIBROSIS RELATED DIABETES; CYSTIC FIBROSIS RELATED DIABETES MELLITUS; DIABETES MELLITUS; DIABETIC PATIENT; DISEASE ASSOCIATION; ENTERIC FEEDING; FEMALE; GLUCOSE BLOOD LEVEL; HOSPITAL ADMISSION; HOSPITAL MANAGEMENT; HOSPITAL PATIENT; HUMAN; HYPERGLYCEMIA; INSULIN INFUSION; INSULIN PUMP; INSULIN RESISTANCE; INSULIN SENSITIVITY; INSULIN TREATMENT; LOW DRUG DOSE; MAJOR CLINICAL STUDY; MALE; MONOTHERAPY; PATIENT CARE; RETROSPECTIVE STUDY; STEROID THERAPY; ARTICLE; DRUG EFFECT; EVALUATION; METABOLISM; MIDDLE AGED; NON INSULIN DEPENDENT DIABETES MELLITUS; STATISTICS; UTILIZATION REVIEW;

ADULT; BLOOD GLUCOSE; CYSTIC FIBROSIS; DIABETES MELLITUS, TYPE 2; ENTERAL NUTRITION; FEMALE; HUMANS; HYPOGLYCEMIC AGENTS; INPATIENTS; INSULIN; INSULIN INFUSION SYSTEMS; MALE; MIDDLE AGED; PATIENT ADMISSION; RETROSPECTIVE STUDIES; YOUNG ADULT;

EID: 84875812143     PISSN: None     EISSN: 19322968     Source Type: Journal    
DOI: 10.1177/193229681200600507     Document Type: Conference Paper

References (36)

1. Correlation between genotype and phenotype in patients with cystic fibrosis. The Cystic Fibrosis Genotype-Phenotype Consortium. N Engl J Med. 1993;329(18):1308-13.
2. Welsh MJ, Tsui LC, Boat TF, Beaudet AL. Cystic fibrosis. In: Scriver CR, Beaudet AL, Sly WS, Valle D, editors. The Metabolic and Molecular Bases of Inherited Disease. 7th edition. Texas: McGraw-Hill; 1995. p. 3799-876.
3. Moran A, Becker D, Casella SJ, Gottlieb PA, Kirkman MS, Marshall BC, Slovis B; CFRD Consensus Conference Committee. Epidemiology, pathophysiology, and prognostic implications of cystic fibrosis-related diabetes. Diabetes Care. 2010;33(12):2677-83.
4. Stecenko AA, Moran A. Update on cystic fibrosis-related diabetes. Curr Opin Pulm Med. 2010;16(6):611-5.
5. Noronha RM, Calliari LE, Damaceno N, Muramatu LH, Monte O. Update on diagnosis and monitoring of cystic fibrosis-related diabetes mellitus (CFRD). Arq Bras Endocrinol Metabol. 2011;55(8):613-21.
6. Moran A, Dunitz J, Nathan B, Saeed A, Holme B, Thomas W. Cystic fibrosis-related diabetes: current trends in prevalence, incidence, and mortality. Diabetes Care. 2009;32(9):1626-31. Epub 2009 Jun 19.
7. Marshall BC, Butler SM, Stoddard M, Moran AM, Liou TG, Morgan WJ. Epidemiology of cystic fibrosis-related diabetes. J Pediatr. 2005;146(5):681-7. (Pubitemid 40616255)
8. Laguna TA, Nathan BM, Moran A. Managing diabetes in cystic fibrosis. Diabetes Obes Metab. 2010;12(10):858-64. doi: 10.1111/j.1463-1326.2010.01250.x.
9. Lippe BM, Sperling MA, Dooley RR. Pancreatic alpha and beta cell functions in cystic fibrosis. J Pediatr. 1977;90(5):751-5. (Pubitemid 8082243)
10. Moran A, Diem P, Klein DJ, Levitt MD, Robertson RP. Pancreatic endocrine function in cystic fibrosis. J Pediatr. 1991;118(5):715-23.
11. Arrigo T, Cucinotta D, Conti Nibali S, Di Cesare E, Di Benedetto A, Magazzù G, De Luca F. Longitudinal evaluation of glucose tolerance and insulin secretion in non-diabetic children and adolescents with cystic fibrosis: results of a two-year follow-up. Acta Paediatr. 1993;82(3):249-53. (Pubitemid 23107541)
12. Lombardo F, De Luca F, Rosano M, Sferlazzas C, Lucanto C, Arrigo T, Messina MF, Crisafulli G, Wasniewska M, Valenzise M, Cucinotta D. Natural history of glucose tolerance, beta-cell function and peripheral insulin sensitivity in cystic fibrosis patients with fasting euglycemia. Eur J Endocrinol. 2003;149(1):53-9. (Pubitemid 36874204)
13. Bismuth E, Laborde K, Taupin P, Velho G, Ribault V, Jennane F, Grasset E, Sermet I, de Blic J, Lenoir G, Robert JJ. Glucose tolerance and insulin secretion, morbidity, and death in patients with cystic fibrosis. J Pediatr. 2008;152(4):540-5, 545.e1. Epub 2007 Nov 26.
14. Hardin DS, LeBlanc A, Lukenbough S, Seilheimer DK. Insulin resistance is associated with decreased clinical status in cystic fibrosis. J Pediatr. 1997;130(6):948-56. (Pubitemid 27495124)
15. Hardin DS, Leblanc A, Marshall G, Seilheimer DK. Mechanisms of insulin resistance in cystic fibrosis. Am J Physiol Endocrinol Metab. 2001;281(5):E1022-8.
16. Nathan B, Moran A. Treatment recommendations for cystic fibrosis-related diabetes: too little, too late? Thorax. 2011;66(7):555-6. Epub 2011 May 4.
17. Moran A, Brunzell C, Cohen RC, Katz M, Marshall BC, Onady G, Robinson KA, Sabadosa KA, Stecenko A, Slovis B; CFRD Guidelines Committee. Clinical care guidelines for cystic fibrosis-related diabetes: a position statement of the American Diabetes Association and a clinical practice guideline of the Cystic Fibrosis Foundation, endorsed by the Pediatric Endocrine Society. Diabetes Care. 2010;33(12):2697-708.
18. O'Riordan SM, Robinson PD, Donaghue KC, Moran A; ISPAD Clinical Practice Consensus. Management of cystic fibrosis-related diabetes. Pediatr Diabetes. 2008;9(4 Pt 1):338-44.
19. Frohnert BI, Ode KL, Moran A, Nathan BM, Laguna T, Holme B, Thomas W. Impaired fasting glucose in cystic fibrosis. Diabetes Care. 2010;33(12):2660-4.
20. Milla CE, Warwick WJ, Moran A. Trends in pulmonary function in patients with cystic fibrosis correlate with the degree of glucose intolerance at baseline. Am J Respir Crit Care Med. 2000;162(3 Pt 1):891-5.
21. Ntimbane T, Krishnamoorthy P, Huot C, Legault L, Jacob SV, Brunet S, Levy E, Guéraud F, Lands LC, Comte B. Oxidative stress and cystic fibrosis-related diabetes: a pilot study in children. J Cyst Fibros. 2008;7(5):373-84. Epub 2008 Apr 16.
22. Milla CE, Billings J, Moran A. Diabetes is associated with dramatically decreased survival in female but not in male subjects with cystic fibrosis. Diabetes Care. 2005;28(9):2141-4. (Pubitemid 41242458)
23. Koch C, Rainisio M, Madessani U, Harms HK, Hodson ME, Mastella G, McKenzie SG, Navarro J, Strandvik B; Investigators of the European Epidemiology Registry of Cystic Fibrosis. Presence of cystic fibrosis-related diabetes mellitus is tightly linked to poor lung function in patients with cystic fibrosis: data from the European Epidemiology Registry of Cystic Fibrosis. Pediatr Pulmonol. 2001;32(5):343-50. (Pubitemid 33015650)
24. Adler AI, Shine B, Haworth C, Leelarathna L, Bilton D. Hyperglycemia and death in cystic fibrosis-related diabetes. Diabetes Care. 2011;34(7):1577-8. Epub 2011 May 18.
25. Chamnan P, Shine BS, Haworth CS, Bilton D, Adler AI. Diabetes as a determinant of mortality in cystic fibrosis. Diabetes Care. 2010;33(2):311-6. Epub 2009 Nov 16.
26. Van den Berg JM, Kouwenberg JM, Heijerman HG. Demographics of glucose metabolism in cystic fibrosis. J Cystic Fibrosis. 2009;8(4):276-9. Epub 2009 May 24.
27. Seggelke SA, Gibbs J, Draznin B. Pilot study of using neutral protamine Hagedorn insulin to counteract the effect of methylprednisolone in hospitalized patients with diabetes. J Hosp Med. 2011;6(3):175-6. doi: 10.1002/jhm.874.
28. Rafii M, Chapman K, Stewart C, Kelly E, Hanna A, Wilson DC, Tullis E, Pencharz PB. Changes in response to insulin and the effects of varying glucose tolerance on whole-body protein metabolism in patients with cystic fibrosis. Am J Clin Nutr. 2005;81(2):421-6. (Pubitemid 43073344)
29. Ramsey BW, Farrell PM, Pencharz P. Nutritional assessment and management in cystic fibrosis: a consensus report. The Consensus Committee. Am J Clin Nutr. 1992;55(1):108-16.
30. Hsia E, Seggelke SA, Gibbs J, Rasouli N, Draznin B. Comparison of 70/30 biphasic insulin with glargine/lispro regimen in noncritically ill diabetic patients on continuous enteral nutrition therapy. Nutr Clin Pract. 2011;26(6):714-7.
31. Bevier WC, Zisser HC, Jovanovic L, Finan DA, Palerm CC, Seborg DE, Doyle FJ 3rd. Use of continuous glucose monitoring to estimate insulin requirement in patients with type 1 diabetes mellitus during a short course of prednisone. J Diabetes Sci Technol. 2008;2(4):578-83.
32. Rolon MA, Benali K, Munck A, Navarro J, Clement A, Tubiana-Rufi N, Czernichow P, Polak M. Cystic fibrosis-related diabetes mellitus: clinical impact of prediabetes and effects of insulin therapy. Acta Paediatr. 2001;90(8):860-7. (Pubitemid 32762829)
33. Brennan AL, Gyi KM, Wood DM, Johnson J, Holliman R, aines DL, Phillips BJ, Geddes DM, Hodson ME, Baker EH. Airway glucose concentrations and effect on growth of respiratory pathogens in cystic fibrosis. 2007;6(2):101-9. Epub 2006 Jul 17.
34. Finkelstein SM, Wielinski CL, Elliott GR, Warwick WJ, Barbosa J, Wu SC, Klein DJ. Diabetes mellitus associated with cystic fibrosis. J Pediatr. 1988;112(3):373-7. (Pubitemid 18079818)
35. Moran A, Hardin D, Rodman D, Allen, HF, Beall RJ, Borowitz D, Brunzell C, Campbell PW 3rd, Chesrown SE, Duchow C, Fink RJ, Fitzsimmons SC, Hamilton N, Hirsch I, Howenstine MS, Klein DJ, Madhun Z, Pencharz PB, Quittner AL, Robbins MK, Shindler T, Schissel K, Schwarzenberg SJ, Stallings VA, Zipf WB, Tullis DE. Diagnosis, screening and management of cystic fibrosis related diabetes mellitus: a consensus conference report. Diab Res Clin Pract. 1999;45(1):61-73. (Pubitemid 29356125)
36. Nathan BM, Laguna T, Moran A. Recent trends in cystic fibrosis-related diabetes. Curr Opin Endocrinol Diabetes Obes. 2010;17(4):335-41.