Patients with Nonalcoholic Fatty Liver Disease (NAFLD) have Higher Oxidative Stress in Comparison to Chronic Viral Hepatitis

Journal of Clinical and Experimental Hepatology

Volumn 3, Issue 1, 2013, Pages 12-18

  Kumar, Amit ^a   Sharma, Arun ^a   Duseja, Ajay ^a   Das, Ashim ^a   Dhiman, Radha K ^a   Chawla, Yogesh K ^a   Kohli, Krishan K ^a   Bhansali, Anil ^a  

^a POSTGRADUATE INSTITUTE OF MEDICAL EDUCATION AND RESEARCH   (India)

Author keywords

ALT; AMA; ANA; ANOVA; Anti LKM; ASMA; AST; BMI; CD; CHB; CHC; CI; CVH; Cytokines; EDTA; ELISA; GPx; GR; GSH; HBV; HCC; HCV; HDL; Hepatitis B virus; Hepatitis C virus; HOMA IR; HV; ICMR; IL 1 ; KF rings; LDL; MDA; MS; NAFLD; NASH; NBT; Nonalcoholic steatohepatitis (NASH); Oxidative stress; PBS; RBC; SOD; TG; TGF ; TNF ; ULN; WBC; WHR

Indexed keywords

ALKADIENE; CATALASE; CYTOKINE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; INSULIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; MALONALDEHYDE; SUPEROXIDE DISMUTASE; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE ASSOCIATION; DISEASE MARKER; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HEPATITIS B; HEPATITIS C; HEPATITIS VIRUS; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; INSULIN RESISTANCE; LIPID PEROXIDATION; LIVER BIOPSY; MALE; METABOLIC SYNDROME X; MOLECULAR PATHOLOGY; NONALCOHOLIC FATTY LIVER; OUTCOME ASSESSMENT; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN DETERMINATION;

EID: 84875810154     PISSN: 09736883     EISSN: 22133453     Source Type: Journal    
DOI: 10.1016/j.jceh.2012.10.009     Document Type: Article

References (39)

1. Falck-Ytter Y., Younossi Z.M., Marchesini G., et al. Clinical features and natural history of nonalcoholic steatosis syndromes. Semin Liver Dis 2001, 21:17-26.
2. Ludwig J., Viggiano T., McGill D., et al. Nonalcoholic steatohepatitis. Mayo Clinic experience with a hitherto unnamed disease. Mayo Clin Proc 1980, 55:434-438.
3. Duseja A., Das A., Dhiman R.K., et al. Indian patients with nonalcoholic fatty liver disease presenting with raised transaminases are different at presentation. World J Gastroenterol 2007, 13:649-650.
4. Duseja A., Chawla Y. Nonalcoholic fatty liver disease in India - How much? How soon?. Trop Gastroenterol 2005, 26:1-3.
5. Duseja A., Sharma B., Kumar A., et al. Nonalcoholic fatty liver in a developing country is responsible for significant liver disease. Hepatology 2010, 52:2248-2249.
6. de Almeida B.B., Mathias M.G., Portari G.V., et al. Chronic acetonemia alters liver oxidative balance and lipid content in rats. A model of NASH?. Exp Clin Endocrinol Diabetes 2010, 118:61-63.
7. Machado M.V., Ravasco P., Jesus L., et al. Blood oxidative stress markers in non-alcoholic steatohepatitis and how it correlates with diet. Scand J Gastroenterol 2008, 43:95-102.
8. Madan K., Bhardwaj P., Thareja S., et al. Oxidant stress and antioxidant status among patients with nonalcoholic fatty liver disease (NAFLD). J Clin Gastroenterol 2006, 40:930-935.
9. Narasimhan S., Gokulakrishnan K., Sampathkumar R., et al. Oxidative stress is independently associated with non-alcoholic fatty liver disease (NAFLD) in subjects with and without type 2 diabetes. Clin Biochem 2010, 43:815-821.
10. Angulo P. Nonalcoholic fatty liver disease. N Eng J Med 2002, 346:1221-1231.
11. Sanyal A.J. AGA technical review on nonalcoholic fatty liver disease. Gastroenterology 2002, 123:1705-1725. American Gastroenterological Association.
12. Neuschwander-Tetri B.A., Caldwell S.H. Nonalcoholic Steatohepatitis: summary of an AASLD single topic conference. Hepatology 2003, 37:1202-1219.
13. The Asia-Pacific Perspective; Redefining Obesity and its Treatment 2000, Steering Committee of the Western Pacific Region of the World Health Organization, International Association for the Study of Obesity. International Study Task Force, Health Communications, Australia, 8-56.
14. Saverymuttu S.H., Joseph A.E.A., Maxwell J.D. Ultrasound scanning in the detection of hepatic fibrosis and steatosis. Br Med J (Clin Res Ed) 1986, 292:13-15.
15. Definition, Diagnosis and Classification of Diabetes Mellitus and its Complications. Part 1: Diagnosis and Classification of Diabetes Mellitus 1999, World Health Organisation, World Health Organisation, Geneva, 31-33.
16. Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA 2001, 285:2486-2497. Expert Panel on Detection, Evaluation and Treatment of High Cholesterol in Adults.
17. Duseja A., Das A., Das R., et al. The clinicopathological profile of Indian patients with nonalcoholic fatty liver disease (NAFLD) is different from that in the. West Dig Dis Sci 2007, 52:2368-2374.
18. Duseja A., Thumburu K.K., Das A., et al. Insulin tolerance test is comparable to homeostasis model assessment for insulin resistance in patients with nonalcoholic fatty liver disease. Indian J Gastroenterol 2007, 26:170-173.
19. Chitturi S., Abeygunasekera S., Farrell G.C., et al. NASH and insulin resistance: insulin hypersecretion and specific association with the insulin resistance syndrome. Hepatology 2002, 35:373-379.
20. Matteoni C.A., Younossi Z.M., Gramlich T., et al. Non-alcoholic fatty liver disease: a spectrum of clinical and pathological severity. Gastroenterology 1999, 116:1413-1419.
21. Brunt E.M., Janney C.G., Di Bisceglie A.M., et al. Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions. Am J Gastroenterol 1999, 94:2467-2474.
22. Buege J.A., Aust S.D. Microsomal lipid peroxidation. Methods Enzymol 1978, 52:302-310.
23. Beutler E., Duron O., Kelly B.M. Improved method for the determination of blood glutathione. J Lab Clin Med 1963, 61:882-888.
24. Williams C.H., Arscott J.D. Glutathione reductase. Methods Enzymol 1971, 177:503-539.
25. Flohe L., Gunzler W.A. Assay of glutathione peroxidase. Methods Enzymol 1984, 105:114-121.
26. Catalse Luck H. Methods Enzymatic Analysis 1971, p885-p888. Verlag Chemie, Basel. H.U. Bergmeyer (Ed.).
27. Nishikimi M., Appaji Rao N., Yagi K. The occurrence of superoxide anion in the reaction of reduced phenazine methosulfate and molecular oxygen. Biochem Biophys Res Commun 1972, 46:849-854.
28. de Alwis N.M., Day C.P. Non-alcoholic fatty liver disease: the mist gradually clears. J Hepatol 2008, 48:S104-S112.
29. Day C.P., James O.F. Steatohepatitis: a tale of two " hits" ?. Gastroenterology 1998, 114:842-845.
30. Sanyal A.J., Campbell-Sargent C., Mirshahi F., et al. Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities. Gastroenterology 2001, 120:1183-1192.
31. Yesilova Z., Yaman H., Oktenli C., et al. Systemic markers of lipid peroxidation and antioxidants in patients with nonalcoholic Fatty liver disease. Am J Gastroenterol 2005, 100:850-855.
32. Das K.S., Balakrishnan V., Mukherjee S., et al. Evaluation of blood oxidative stress-related parameters in alcoholic liver disease and non-alcoholic fatty liver disease. Scand J Clin Lab Invest 2008, 68:323-334.
33. Videla L.A., Iturriaga H., Pino M.E., et al. Content of hepatic reduced glutathione in chronic alcoholic patients: influence of the length of abstinence and liver necrosis. Clin Sci (Lond) 1984, 66:283-290.
34. Leclercq I.A., Farrell G.C., Field J., et al. CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine nonalcoholic steatohepatitis. J Clin Invest 2000, 105:1067-1075.
35. Soltys K., Dikdan G., Koneru B. Oxidative stress in fatty livers of obese Zucker rats: rapid amelioration and improved tolerance to warm ischemia with tocopherol. Hepatology 2001, 34:13-18.
36. Vendemiale G., Grattagliano I., Caraceni P., et al. Mitochondrial oxidative injury and energy metabolism alteration in rat fatty liver: effect of the nutritional status. Hepatology 2001, 33:808-815.
37. Kono Y., Fridovich I. Superoxide radical inhibits catalase. J Biol Chem 1982, 257:5751-5754.
38. Kubota S., Sato N., Matsumura T., et al. Chemiluminescence and superoxide dismutase in the plasma in patients with alcoholic and non-alcoholic liver injuries. Alcohol 1985, 2:469-472.
39. Kikugawa K., Kosugi H., Asakura T. Effects of MDA, a product of lipid peroxidation on the function and stability of haemoglobin. Arch Biochem Biophys 1984, 229:237.