Lifestyle-related biomarkers and endometrial cancer survival: Elevated gamma-glutamyltransferase as an important risk factor

Cancer Epidemiology

Volumn 37, Issue 2, 2013, Pages 156-161

  Edlinger, Michael ^a   Concin, Nicole ^a   Concin, Hans ^b   Nagel, Gabriele ^b,c   Ulmer, Hanno ^a   Göbel, Georg ^a  

^a INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^b AGENCY FOR PREVENTIVE AND SOCIAL MEDICINE   (Austria)

^c UNIVERSITY OF ULM   (Germany)

Author keywords

Endometrial cancer; Gamma glutamyltransferase; Lifestyle; Risk factors; Survival

Indexed keywords

CHOLESTEROL; GAMMA GLUTAMYLTRANSFERASE; GLUCOSE; TRIACYLGLYCEROL; URIC ACID;

ADENOSQUAMOUS CARCINOMA; ADULT; AGE; AGED; ARTICLE; BODY MASS; CANCER MORTALITY; CANCER PATIENT; CANCER RISK; CANCER STAGING; CANCER SURVIVAL; CHOLESTEROL BLOOD LEVEL; COHORT ANALYSIS; DIASTOLIC BLOOD PRESSURE; DISEASE ASSOCIATION; ENDOMETRIUM CANCER; FEMALE; FEMALE GENITAL SYSTEM; FOLLOW UP; GAMMA GLUTAMYL TRANSFERASE BLOOD LEVEL; GLUCOSE BLOOD LEVEL; HISTOLOGY; HUMAN; HUMAN TISSUE; HYPERURICEMIA; LIFESTYLE; MAJOR CLINICAL STUDY; MEDICAL EXAMINATION; PRESSURE; PRIORITY JOURNAL; SQUAMOUS CELL CARCINOMA; SYSTOLIC BLOOD PRESSURE; TRIACYLGLYCEROL BLOOD LEVEL; URIC ACID BLOOD LEVEL;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, ADENOSQUAMOUS; CARCINOMA, SQUAMOUS CELL; ENDOMETRIAL NEOPLASMS; FEMALE; FOLLOW-UP STUDIES; GAMMA-GLUTAMYLTRANSFERASE; HUMANS; LIFE STYLE; LONGITUDINAL STUDIES; MIDDLE AGED; NEOPLASM STAGING; PROGNOSIS; RISK FACTORS; SURVIVAL RATE;

EID: 84875809850     PISSN: 18777821     EISSN: 1877783X     Source Type: Journal    
DOI: 10.1016/j.canep.2012.12.003     Document Type: Article

References (43)

1. Ferlay J., Shin H.R., Bray F., Forman D., Mathers C., Parkin DM GLOBOCAN 2008 v1.2, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 10 2010, International Agency for Research on Cancer, Lyon, [accessed 12.08.11]. http://globocan.iarc.fr/.
2. SEER Cancer Statistics Review, 1975-2008 2011, National Cancer Institute, Bethesda, based on November 2010 SEER data submission, posted to the SEER web site. http://seer.cancer.gov/csr/1975_2008/, N. Howlader, A.M. Noone, M. Krapcho, N. Neyman, R. Aminou, W. Waldron (Eds.).
3. Sorosky J.I. Endometrial cancer. Obstet Gynecol 2008, 111:436-447.
4. Lewin S.N. Revised FIGO staging system for endometrial cancer. Clin Obstet Gynecol 2011, 54:215-218.
5. Courneya K.S., Karvinen K.H., Campbell K.L., Pearcey R.G., Dundas G., Capstick V., et al. Associations among exercise, body weight, and quality of life in a population-based sample of endometrial cancer survivors. Gynecol Oncol 2005, 97:422-430.
6. Schmandt R.E., Iglesias D.A., Na Co N., Lu K.H. Understanding obesity and endometrial cancer risk: opportunities for prevention. Am J Obstet Gynecol 2011, 205:518-525.
7. Smith R.A., von Eschenbach A.C., Wender R., Levin B., Byers T., Rothenberger D., et al. American Cancer Society guidelines for the early detection of cancer: update of early detection guidelines for prostate, colorectal, and endometrial cancers. Also: update 2001-testing for early lung cancer detection. CA Cancer J Clin 2001, 51:38-75.
8. Ruhl C.E., Everhart J.E. Elevated serum alanine aminotransferase and gamma-glutamyltransferase and mortality in the United States population. Gastroenterology 2009, 136:477-485.
9. Pompella A., De Tata V., Paolicchi A., Zunino F. Expression of gamma-glutamyltransferase in cancer cells and its significance in drug resistance. Biochem Pharmacol 2006, 71:231-238.
10. Corti A., Duarte T.L., Giommarelli C., De Tata V., Paolicchi A., Jones G.D., et al. Membrane gamma-glutamyl transferase activity promotes iron-dependent oxidative DNA damage in melanoma cells. Mutat Res 2009, 669:112-121.
11. Corti A., Franzini M., Paolicchi A., Pompella A. Gamma-glutamyltransferase of cancer cells at the crossroads of tumor progression, drug resistance and drug targeting. Anticancer Res 2010, 30:1169-1181.
12. Hannuksela M.L., Liisanantti M.K., Nissinen A.E., Savolainen M.J. Biochemical markers of alcoholism. Clin Chem Lab Med 2007, 45:953-961.
13. World Cancer Research Fund/American Institute for Cancer Research Food, nutrition, physical activity, and the prevention of cancer: a global perspective 2007, AICR, Washington, DC.
14. World Health Organization Global health risks; mortality and burden of disease attributable to selected major risks 2009, World Health Organization, Geneva.
15. Stocks T., Rapp K., Bjørge T., Manjer J., Ulmer H., Selmer R., et al. Blood glucose and risk of incident and fatal cancer in the metabolic syndrome and cancer project (Me-Can): analysis of six prospective cohorts. PLoS Med 2009, 6(12):e1000201.
16. Stocks T., van Hemelrijck M., Manjer J., Bjørge T., Ulmer H., Hallmans G., et al. Blood pressure and risk of cancer incidence and mortality in the metabolic syndrome and cancer project. Hypertension 2012, 59:802-810.
17. Bjørge T., Stocks T., Lukanova A., Tretli S., Selmer R., Manjer J., et al. Metabolic syndrome and endometrial carcinoma. Am J Epidemiol 2010, 171:892-902.
18. Edlinger M., Nagel G., Hilbe W., Diem G., Concin H., Strasak A.M., et al. Associations of serum uric acid and gamma-glutamyltransferase with cancer in the Vorarlberg Health Monitoring and Promotion Programme (VHM&PP) - a short review. Mag Eur Med Oncol 2011, 4:50-54.
19. Seebacher V., Polterauer S., Grimm C., Rahhal J., Hofstetter G., Bauer E.M., et al. Prognostic significance of gamma-glutamyltransferase in patients with endometrial cancer: a multi-centre trial. Br J Cancer 2012, 106:1551-1555.
20. Ulmer H., Kelleher C., Diem G., Concin H. Long-term tracking of cardiovascular risk factors among men and women in a large population-based health system: the Vorarlberg Health Monitoring & Promotion Programme. Eur Heart J 2003, 24:1004-1013.
21. Rapp K., Schroeder J., Klenk J., Stoehr S., Ulmer H., Concin H., et al. Obesity and incidence of cancer: a large cohort study of over 145000 adults in Austria. Br J Cancer 2005, 93:1062-1067.
22. Rapp K., Schroeder J., Klenk J., Ulmer H., Concin H., Diem G., et al. Fasting blood glucose and cancer risk in a cohort of more than 140000 adults in Austria. Diabetologia 2006, 49:945-952.
23. Ulmer H., Borena W., Rapp K., Klenk J., Strasak A., Diem G., et al. Serum triglyceride concentration and cancer risk in a large cohort study in Austria. Br J Cancer 2009, 101:1202-1206.
24. Strasak A.M., Pfeiffer R.M., Brant L.J., Rapp K., Hilbe W., Oberaigner W., et al. Time-dependent association of total serum cholesterol and cancer incidence in a cohort of 172210 men and women: a prospective 19-year follow-up study. Ann Oncol 2009, 20:1113-1120.
25. World Health Organization, International Society of Hypertension Writing Group 2003 World Health Organization (WHO)/International Society of Hypertension (ISH) statement on management of hypertension. J Hypertens 2003, 21:1983-1992.
26. Janssen K.J., Donders A.R., Harrell F.E., Vergouwe Y., Chen Q., Grobbee D.E., et al. Missing covariate data in medical research: to impute is better than to ignore. J Clin Epidemiol 2010, 63:721-727.
27. Harrell F.E. Regression modeling strategies; with applications to linear models, logistic regression, and survival analysis 2001, Springer, New York.
28. Simic T., Dragicevic D., Savic-Radojevic A., Cimbaljevic S., Tulic C., Mimic-Oka J. Serum gamma glutamyl-transferase is a sensitive und unspecific marker of metastatic renal cell carcinoma. Int J Urol 2007, 14:289-293.
29. Polterauer S., Hofstetter G., Grimm C., Rahhal J., Mailath-Pokorny M., Kohl M., et al. Relevance of gamma-glutamyltransferase - a marker for apoptotic balance - in predicting tumor stage and prognosis in cervical cancer. Gynecol Oncol 2011, 122:590-594.
30. Perry I.J., Wannamethee S.G., Shaper A.G. Prospective study of serum gamma-glutamyltransferase and risk of NIDDM. Diabetes Care 1998, 21:732-737.
31. Conen D., Vollenweider P., Rousson V., Marques-Vidal P., Paccaud F., Waeber G., et al. Use of a Mendelian randomization approach to assess the causal relation of gamma-glutamyltransferase with blood pressure and serum insulin levels. Am J Epidemiol 2010, 172:1431-1441.
32. Fraser A., Harris R., Sattar N., Ebrahim S., Davey Smith G., Lawlor D.A. Alanine aminotransferase, gamma-glutamyltransferase, and incident diabetes: the British Women's Heart and Health Study and meta-analysis. Diabetes Care 2009, 32:741-750.
33. Ruttmann E., Brant L.J., Concin H., Diem G., Rapp K., Ulmer H., et al. Gamma-glutamyltransferase as a risk factor for cardiovascular disease mortality. An epidemiological investigation in a cohort of 163,944 Austrian adults. Circulation 2005, 112:2130-2137.
34. Lawlor D.A., Sattar N., Smith G.D., Ebrahim S. The associations of physical activity and adiposity with alanine aminotransferase and gamma-glutamyltransferase. Am J Epidemiol 2005, 161:1081-1088.
35. Breitling L.P., Arndt V., Drath C., Rothenbacher D., Brenner H. Smoking and γ-glutamyltransferase: opposite interactions with alcohol consumption and body mass index. PLoS One 2010, 5(9):e13116.
36. Lee D.H., Jacobs D.R. Association between serum concentrations of persistent organic pollutants and gamma glutamyltransferase: results from the National Health and Examination Survey 1999-2002. Clin Chem 2006, 52:1825-1827.
37. von Gruenigen V.E., Waggoner S.E., Frasure H.E., Kavanagh M.B., Janata J.W., Rose P.G., et al. Lifestyle challenges in endometrial cancer survivorship. Obstet Gynecol 2011, 117:93-100.
38. Grossman E., Messerli F.H., Boyko V., Goldbourt U. Is there an association between hypertension and cancer mortality?. Am J Med 2002, 112:479-486.
39. Weiderpass E. Lifestyle and cancer risk. J Prev Med Public Health 2010, 43:459-471.
40. Courneya K.S. Physical activity in cancer survivors: a field in motion. Psychooncology 2009, 18:337-342.
41. Irwin M.L. Physical activity interventions for cancer survivors. Br J Sports Med 2009, 43:32-38.
42. Fentiman I.S. Gamma-glutamyl transferase: risk and prognosis of cancer (editorial). Br J Cancer 2012, 106:1467-1468.
43. Mancia G. Angiotensin receptor antagonists and increased risk of cancer. Further evidence against. J Hypertens 2011, 29:653-654.