Is fibromyalgia an endocrine/endorphin deficit disorder? Is low dose naltrexone a new treatment option?

Psychosomatics

Volumn 53, Issue 6, 2012, Pages 591-594

  Ramanathan, Seethalakshmi ^a   Panksepp, Jaak ^b,c   Johnson, Brian ^a  

^a State University of New York Upstate Medical University: College of Medicine   (United States)

^b WASHINGTON STATE UNIVERSITY   (United States)

^c NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMITRIPTYLINE; MILNACIPRAN; NALTREXONE; NAPROXEN; VITAMIN D;

ADULT; ANXIETY; ARTICLE; BURN; CARPAL TUNNEL SYNDROME; CASE REPORT; COLD PRESSOR TEST; CONTROLLED STUDY; DETERIORATION; DIARRHEA; DRUG DOSE INCREASE; DRUG DOSE REDUCTION; DRUG WITHDRAWAL; DRY EYE; DUAL ENERGY X RAY ABSORPTIOMETRY; DYSURIA; ENDURANCE; EYE PAIN; FATIGUE; FIBROMYALGIA; FOOT PAIN; GASTROINTESTINAL SYMPTOM; HUMAN; HYPOPARATHYROIDISM; INSOMNIA; IRRITABILITY; LOW DRUG DOSE; MALE; MUSCLE RIGIDITY; MYALGIA; OCULAR PRURITUS; OSTEOPENIA; PAIN THRESHOLD; QUALITY OF LIFE; SEDATION; SIDE EFFECT; THIRST; UNSTEADINESS; VITAMIN D DEFICIENCY; XEROSTOMIA; YAWNING;

ADULT; ENDORPHINS; FEMALE; FIBROMYALGIA; HUMANS; MALE; NALTREXONE; NARCOTIC ANTAGONISTS; PAIN MEASUREMENT; PAIN THRESHOLD; QUALITY OF LIFE; TREATMENT OUTCOME;

EID: 84875804700     PISSN: 00333182     EISSN: 15457206     Source Type: Journal    
DOI: 10.1016/j.psym.2011.11.006     Document Type: Article

References (20)

1. Neumann L., Buskila D. Epidemiology of fibromyalgia. Current Pain and Headache Reports 2003, 7(5):362-368.
2. Wolfe F., Smythe H.A., Yunus M.B., Bennett R.M., Bombardier C., Goldenberg D.L., et al. The American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia. Report of the Multicenter Criteria Committee. Arthritis Rheum 1990, 33(2):160-172.
3. Smith H.S., Barkin R.L. Fibromyalgia syndrome: a discussion of the syndrome and pharmacotherapy. Am J Therapeut 2010, 17(4):418-439.
4. Arnold L.M., Hudson J.I., Kck P.E., Auchenbach M.B., Javaras K.N., Hess E.V. Comorbidity of fibromyalgia and psychiatric disorders. J Clin Psychiatry 2006, 67:1219-1225.
5. Solitar B.M. Fibromyalgia: knowns, unknowns, and current treatment. Bull NYU Hospital Joint Dis 2010, 68(3):157-161.
6. Simms R.W. Fibromyalgia is not a muscle disorder. Am J Med Sci 1998, 315(6):346-350.
7. Bradley L.A., Alberts K.R., Alarcon G.S., Alexander M.T., Mountz J.M., Weigent D.A., et al. Abnormal brain regional cerebral blood flow and cerebrospinal fluid levels of Substance P in patients and nonpatients with fibromyalgia. Arthritis Rheum 1996, 39:S212.
8. Ernberg M., Voog U., Alstergren P., Lundeberg T., Kopp S. Plasma and serum serotonin levels and their relationship to orofacial pain and anxiety in fibromyalgia. J Orofac Pain 2000, 14:37-46.
9. Neeck G. Pathogenic mechanisms of fibromyalgia. Ageing Res Rev 2002, 1:243-255.
10. Leslie J.C. Neuroendocrine abnormalities in fibromyalgia and related disorders. Am J Med Sci 1998, 315(6):359-366.
11. Stein D.J., van Honk J., Ipser J., Solms M., Panksepp J. Opioids: from physical pain to the pain of social isolation. CNS Spectrums 2007, 12:669-670. 672-4.
12. Vaeroy H., Helle R., Førre O., Kåss E., Terenius L. Cerebrospinal fluid levels of β-endorphin in patients with fibromyalgia (fibrositis syndrome). J Rheumatol 1998, 15(12):1804-1806.
13. 7. Pain 1991, 46(2):139-143.
14. Agarwal Y.P. Low dose naltrexone therapy in multiple sclerosis. Med Hypotheses 2005, 64(4):721-724.
15. Younger J.W., Zautra A.J., Cummins E.T. Effects of naltrexone on pain sensitivity and mood in fibromyalgia: no evidence for endogenous opioid. Pathophysiology. PLoS ONE 2009, 4(4):e5180.
16. Younger J., Mackey S. Fibromyalgia symptoms are reduced by low-dose naltrexone: a pilot study. Pain Med 2009, 10(4):663-672.
17. Borner C., Warnick B., Smida M., Hartig R., Lindquist J.A., Schraven B., et al. Mechanisms of opioid-mediated inhibition of human T cell receptor signaling. J Immunol 2009, 183:882-889.
18. Brown N., Panksepp J. Low-dose naltrexone for disease prevention and quality of life. Med Hypotheses 2009, 72:333-337.
19. Walsh N.E., Schoenfeld L., Ramamurthy S., Hoffman J. Normative model for cold pressor test. Am J Phys Med Rehab 1989, 68(1):6-11.
20. Berger A., Sadosky A., Dukes E.M., Edelsberg J., Zlateva G., Oster G. Patterns of healthcare utilization and cost in patients with newly diagnosed fibromyalgia. Am J Manag Care 2010, 16(5 Suppl):S126-S137.