Improvement of the Bovine Corneal Opacity and Permeability (BCOP) assay as an in vitro alternative to the Draize rabbit eye irritation test

Toxicology in Vitro

Volumn 27, Issue 4, 2013, Pages 1298-1311

  Verstraelen, Sandra ^a   Jacobs, An ^a   De Wever, Bart ^a,b   Vanparys, Philippe ^b,c  

^a FLEMISH INSTITUTE FOR TECHNOLOGICAL RESEARCH VITO   (Belgium)

^b ALTEXA Development (Business Development Services in ALTernatives to EXperiments on Animals)   (Monaco)

^c ALTOXICON BVBA   (Belgium)

Author keywords

BCOP; Eye irritation; Laser light based opacitometer

Indexed keywords

1 NITROPROPANE; 1,2,4 TRIMETHYLBENZENE; 2,6 DICHLOROBENZOYL CHLORIDE; 4 METHYL 2 PENTANONE; AMMONIUM NITRATE; ANTHRACENE; BENZALKONIUM CHLORIDE; BUTYL ACETATE; DIMETHYL SULFOXIDE; DODECYL SULFATE SODIUM; EDETIC ACID; ETHYL 2 METHYLACETOACETATE; FLUORESCEIN SODIUM; GAMMA BUTYROLACTONE; GLYCEROL; HEXANE; IMIDAZOLE; INDUSTRIAL CHEMICAL; IRRITANT AGENT; METHYL CYANOACETATE; PARAFLUORANILINE; PETROLEUM ETHER; POTASSIUM CYANATE; PROPYL PARABEN; PYRIDINE; SHAMPOO; TARTARIC ACID DERIVATIVE; TETRAAMINOPYRIMIDINE SULFATE; TRICHLOROACETIC ACID; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ACCURACY; ARTICLE; BOVINE CORNEAL OPACITY AND PERMEABILITY ASSAY; CAMERA; CONTROLLED STUDY; CORNEA OPACITY; CORNEA PERMEABILITY; DISEASE SEVERITY; DRAIZE RABBIT EYE IRRITATION TEST; DRUG POTENCY; EYE IRRITATION; IN VITRO IRRITANCY SCORE; IN VITRO STUDY; IN VIVO STUDY; LABORATORY DEVICE; LABORATORY TEST; NONHUMAN; OPACITOMETER; PREDICTION; SCORING SYSTEM; SPECKLE NOISE REDUCER;

ANIMAL TESTING ALTERNATIVES; ANIMALS; BIOLOGICAL ASSAY; CATTLE; CORNEA; CORNEAL OPACITY; EQUIPMENT DESIGN; IRRITANTS; LASERS; PERMEABILITY; RABBITS;

BOVINAE; ORYCTOLAGUS CUNICULUS;

EID: 84875787745     PISSN: 08872333     EISSN: 18793177     Source Type: Journal    
DOI: 10.1016/j.tiv.2013.02.018     Document Type: Article

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