Acute kidney injury in the critically ill: Is iodinated contrast medium really harmful?

Critical Care Medicine

Volumn 41, Issue 4, 2013, Pages 1017-1026

  Ehrmann, Stephan ^a   Badin, Julie ^a   Savath, Laurent ^b   Pajot, Olivier ^c   Garot, Denis ^a   Pham, Tài ^d   Capdevila, Xavier ^b   Perrotin, Dominique ^a   Lakhal, Karim ^b  

^a UNIVERSITY HOSPITAL OF TOURS   (France)

^b LAPEYRONIE HOSPITAL   (France)

^c CENTRE HOSPITALIER VICTOR DUPOUY   (France)

^d HENRI MONDOR HOSPITAL   (France)

Author keywords

adverse effects; contrast medium; intensive care units; kidney disease epidemiology; kidney diseases chemically induced; tomography X ray computed

Indexed keywords

IODINATED CONTRAST MEDIUM;

ACUTE KIDNEY FAILURE; ADULT; AGED; ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; CRITICALLY ILL PATIENT; FEMALE; HUMAN; INCIDENCE; MAJOR CLINICAL STUDY; MALE; MORTALITY; OBSERVATIONAL STUDY; PRIORITY JOURNAL; PROSPECTIVE STUDY; SEQUENTIAL ORGAN FAILURE ASSESSMENT SCORE;

ACUTE KIDNEY INJURY; ADULT; AGED; COHORT STUDIES; CONTRAST MEDIA; CRITICAL ILLNESS; FEMALE; FRANCE; HUMANS; INTENSIVE CARE; INTENSIVE CARE UNITS; IODINE COMPOUNDS; MALE; MIDDLE AGED; ODDS RATIO; PROSPECTIVE STUDIES; RISK FACTORS;

EID: 84875776315     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e318275871a     Document Type: Article

References (32)

1. McCullough PA: Acute kidney injury with iodinated contrast. Crit Care Med 2008; 36(4 Suppl):S204-S211
2. Persson PB, Hansell P, Liss P: Pathophysiology of contrast mediuminduced nephropathy. Kidney Int 2005; 68:14-22
3. Brøchner AC, Toft P: Pathophysiology of the systemic inflammatory response after major accidental trauma. Scand J Trauma Resusc Emerg Med 2009; 17:43
4. Gustot T: Multiple organ failure in sepsis: Prognosis and role of systemic inflammatory response. Curr Opin Crit Care 2011; 17:153-159
5. Tsukamoto T, Chanthaphavong RS, Pape HC: Current theories on the pathophysiology of multiple organ failure after trauma. Injury 2010; 41:21-26
6. Tyml K: Critical role for oxidative stress, platelets, and coagulation in capillary blood flow impairment in sepsis. Microcirculation 2011; 18: 152-162
7. Bentley ML, Corwin HL, Dasta J: Drug-induced acute kidney injury in the critically ill adult: Recognition and prevention strategies. Crit Care Med 2010; 38(6 Suppl):S169-S174
8. Katzberg RW, Newhouse JH: Intravenous contrast medium-induced nephrotoxicity: Is the medical risk really as great as we have come to believe? Radiology 2010; 256:21-28
9. Rao QA, Newhouse JH: Risk of nephropathy after intravenous administration of contrast material: A critical literature analysis. Radiology 2006; 239:392-397
10. Lakhal K, Ehrmann S, Chaari A, et al: Acute Kidney Injury Network definition of contrast-induced nephropathy in the critically ill: Incidence and outcome. J Crit Care 2011; 26:593-599
11. Hoste EA, Doom S, De Waele J, et al: Epidemiology of contrast-associated acute kidney injury in ICU patients: A retrospective cohort analysis. Intensive Care Med 2011; 37:1921-1931
12. Ng CS, Shaw AD, Bell CS, et al: Effect of IV contrast medium on renal function in oncologic patients undergoing CT in ICU. AJR Am J Roentgenol 2010; 195:414-422
13. Rashid AH, Brieva JL, Stokes B: Incidence of contrast-induced nephropathyin intensive care patients undergoing computerised tomography and prevalence of risk factors. Anaesth Intensive Care 2009; 37:968-975
14. Haveman JW, Gansevoort RT, Bongaerts AH, et al: Low incidence of nephropathy in surgical ICU patients receiving intravenous contrast: A retrospective analysis. Intensive Care Med 2006; 32:1199-1205
15. Polena S, Yang S, Alam R, et al: Nephropathy in critically Ill patients without preexisting renal disease. Proc West Pharmacol Soc 2005; 48:134-135
16. Huber W, Jeschke B, Page M, et al: Reduced incidence of radiocontrastinduced nephropathy in ICU patients under theophylline prophylaxis: A prospective comparison to series of patients at similar risk. Intensive Care Med 2001; 27:1200-1209
17. Huber W, Eckel F, Hennig M, et al: Prophylaxis of contrast material-induced nephropathy in patients in intensive care: Acetylcysteine, theophylline, or both? A randomized study. Radiology 2006; 239:793-804
18. Valette X, Parienti JJ, Plaud B, et al: Incidence, morbidity, and mortality of contrast-induced acute kidney injury in a surgical intensive care unit: A prospective cohort study. J Crit Care 2012; 27:322.e1-322.e5
19. Burns KE, Priestap F, Martin C: N-acetylcysteine in critically ill patients undergoing contrast-enhanced computed tomography: A randomized trial. Clin Nephrol 2010; 74:323-326
20. Mehta RL, Kellum JA, Shah SV, et al: Acute Kidney Injury Network: Report of an initiative to improve outcomes in acute kidney injury. Crit Care 2007; 11:R31
21. Austin PC: Some methods of propensity-score matching had superior performance to others: Results of an empirical investigation and Monte Carlo simulations. Biom J 2009; 51:171-184
22. Hosmer DW, Lemeshow S: Applied Logistic Regression. Second Edition. New York, Wiley-Interscience Publication, 2000
23. Vincent JL, de Mendonça A, Cantraine F, et al: Use of the SOFA score to assess the incidence of organ dysfunction/failure in intensive care units: Results of a multicenter, prospective study. Working group on "sepsisrelated problems" of the European Society of Intensive Care Medicine. Crit Care Med 1998; 26:1793-1800
24. Newhouse JH, Kho D, Rao QA, et al: Frequency of serum creatinine changes in the absence of iodinated contrast material: Implications for studies of contrast nephrotoxicity. AJR Am J Roentgenol 2008; 191:376-382
25. Cramer BC, Parfrey PS, Hutchinson TA, et al: Renal function following infusion of radiologic contrast material. A prospective controlled study. Arch Intern Med 1985; 145:87-89
26. Heller CA, Knapp J, Halliday J, et al: Failure to demonstrate contrast nephrotoxicity. Med J Aust 1991; 155:329-332
27. Langner S, Stumpe S, Kirsch M, et al: No increased risk for contrastinduced nephropathy after multiple CT perfusion studies of the brain with a nonionic, dimeric, iso-osmolal contrast medium. AJNR Am J Neuroradiol 2008; 29:1525-1529
28. Oleinik A, Romero JM, Schwab K, et al: CT angiography for intracerebral hemorrhage does not increase risk of acute nephropathy. Stroke 2009; 40:2393-2397
29. Kim DY, Kobayashi L, Costantini TW, et al: Is contrast exposure safe among the highest risk trauma patients? J Trauma Acute Care Surg 2012; 72:61-66
30. Quintavalle C, Brenca M, De Micco F, et al: In vivo and in vitro assessment of pathways involved in contrast media-induced renal cells apoptosis. Cell Death Dis 2011; 2:e155
31. Pannu N, Wiebe N, Tonelli M: Prophylaxis strategies for contrast-induced nephropathy. JAMA 2006; 295:2765-2779
32. Brochard L, Abroug F, Brenner M, et al: An Official ATS/ERS/ESICM/SCCM/ SRLF Statement: Prevention and management of acute renal failure in the ICU patient: An international consensus conference in intensive care medicine. Am J Respir Crit Care Med 2010; 181:1128-1155