Prophylactic theophylline for the prevention of severe renal dysfunction in term and post-term neonates with perinatal asphyxia: A systematic review and meta-Analysis of randomized controlled trials

Journal of Perinatology

Volumn 33, Issue 4, 2013, Pages 271-277

  Al Wassia, H ^a   Alshaikh, B ^b   Sauve, R ^c  

^a UNIVERSITY OF CALGARY   (Canada)

^b UNIVERSITY OF CALGARY   (Canada)

^c KING ABDUL AZIZ UNIVERSITY HOSPITAL   (Saudi Arabia)

Author keywords

adenosine antagonists; perinatal asphyxia; renal failure; term infants

Indexed keywords

BETA 2 MICROGLOBULIN; CREATININE; PLACEBO; THEOPHYLLINE;

CLINICAL EVALUATION; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DISEASE SEVERITY; DRUG EFFICACY; GLOMERULUS FILTRATION RATE; HUMAN; INFANT; KIDNEY DYSFUNCTION; KIDNEY FUNCTION; MAJOR CLINICAL STUDY; META ANALYSIS; PERINATAL ASPHYXIA; PREMATURITY; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; RISK REDUCTION; SYSTEMATIC REVIEW; TREATMENT RESPONSE; URINARY EXCRETION;

ASPHYXIA NEONATORUM; GLOMERULAR FILTRATION RATE; HUMANS; INFANT, NEWBORN; INFANT, POSTMATURE; INTENSIVE CARE, NEONATAL; OUTCOME ASSESSMENT (HEALTH CARE); RANDOMIZED CONTROLLED TRIALS AS TOPIC; RENAL INSUFFICIENCY; SEVERITY OF ILLNESS INDEX; THEOPHYLLINE; TREATMENT OUTCOME; VASODILATOR AGENTS;

EID: 84875757678     PISSN: 07438346     EISSN: 14765543     Source Type: Journal    
DOI: 10.1038/jp.2012.97     Document Type: Review

References (39)

1. Lawn JE, Cousens SN, Wilczynska K. Estimating the causes of four million neonatal death in the year 2000: statistical annex. In: The World Health Report 2005. WHO: Geneva, 2005.
2. Perlman JM, Tack ED, Martin T, Shackelford G, Amon E. Acute systemic organ injury in term infants after asphyxia. Am J Dis Child 1989; 143(5): 617-620.
3. Aggarwal A, Kumar P, Chowdhary G, Majumdar S, Narang A. Evaluation of renal functions in asphyxiated newborns. J Trop Pediatr 2005; 51(5): 295-299.
4. Gupta BD, Sharma P, Bagla J, Parakh M, Soni JP. Renal failure in asphyxiated neonates. Indian Pediatr 2005; 42(9): 928-934.
5. Karlowicz MG, Adelman RD. Nonoliguric and oliguric acute renal failure in asphyxiated term neonates. Pediatr Nephrol 1995; 9(6): 718-722.
6. Kaur S, Jain S, Saha A, Chawla D, Parmar VR, Basu S et al. Evaluation of glomerular and tubular renal function in neonates with birth asphyxia. Ann Trop Paediatr 2011; 31(2): 129-134.
7. Nouri S, Mahdhaoui N, Beizig S, Zakhama R, Salem N, Ben Dhafer S et al. Acute renal failure in full term neonates with perinatal asphyxia. Prospective study of 87 cases. Archives de pediatrie: organe officiel de la Societe francaise de pediatrie 2008; 15(3): 229-235.
8. Perlman JM, Tack ED. Renal injury in the asphyxiated newborn infant: relationship to neurologic outcome. J Pediatr 1988; 113(5): 875-879.
9. Brocklebank JT. Renal failure in the newly born. Arch Dis Child 1988; 63(8): 991-994.
10. Singh M. 1999. Care of Newborn. 5th edn. Sagar Publication: New Delhi, 1999, pp 113-114.
11. Perlman JM. Systemic abnormalities in term infants following perinatal asphyxia: relevance to long-term neurologic outcome. Clin Perinatol 1989; 16(2): 475-484.
12. Gaudio KM, Ardito TA, Reilly HF, Kashgarian M, Siegel NJ. Accelerated cellular recovery after an ischemic renal injury. Am J Pathol 1983; 112(3): 338-346.
13. Hammerman MR, Miller SB. Therapeutic use of growth factors in renal failure. J Am Soc Nephrol 1994; 5(1): 1-11.
14. Lee T-F, Liu J-Q, Li Y-Q, Nasim K, Chaba T, Bigam DL et al. Improved renal recovery with postresuscitation N-Acetylcysteine treatment in asphyxiated newborn pigs. Shock 2011; 35(4): 428-433.
15. Sutter PM, Thulin G, Stromski M, Ardito T, Gaudio KM, Kashgarian M et al. Beneficial effect of thyroxin in the treatment of ischemic acute renal failure. Pediat Nephrol 1988; 2(1): 1-7.
16. Gouyon JB, Guignard JP. Functional renal insufficiency: role of adenosine. Biol Neonate 1988; 53(4): 237-242.
17. Osswald H, Schmitz HJ, Kemper R. Tissue content of adenosine, inosine and hypoxanthine in the rat kidney after ischemia and postischemic recirculation. Pflugers Arch Eur J Physiol 1977; 371(1-2): 45-49.
18. Gouyon JB, Guignard JP. Theophylline prevents the hypoxemia-induced renal hemodynamic changes in rabbits. Kidney Int 1988; 33(6): 1078-1083.
19. Osswald H. Renal effects of adenosine and their inhibition by theophylline in dogs. Naunyn-Schmiedebergs Arch Pharmacoly 1975; 288(1): 79-86.
20. Prevot A, Mosig D, Rijtema M, Guignard J-P. Renal effects of adenosine A1-receptor blockade with 8-cyclopentyl-1,3-dipropylxanthine in hypoxemic newborn rabbits. Pediat Res 2003; 54(3): 400-405.
21. Bell M, Jackson E, Mi Z, McCombs J, Carcillo J. Low-dose theophylline increases urine output in diuretic-dependent critically ill children. Intensive Care Med 1998; 24(10): 1099-1105.
22. Bidani AK, Churchill PC, Packer W. Theophylline-induced protection in myoglobinuric acute renal failure: further characterization. Can J Physiol Pharmacol 1987; 65(1): 42-45.
23. Ng GYT, Baker EH, Farrer KFM. Aminophylline as an adjunct diuretic for neonates- A case series. Pediat Nephrol 2005; 20(2): 220-222.
24. Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gotzsche PC, Ioannidis JPA et al. The PRISMA statement for reporting systematic reviews and meta-Analyses of studies that evaluate health care interventions: explanation and elaboration. J Clin Epidemiol 2009; 62(10): e1-34.
25. Higgins JPT, Green S (eds). Cochrane Handbook for Systematic Review of Interventions. Version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011; Available from www.cochrane-handbook.org.
26. Egger M, Smith GD, Altman DG. Systematic Reviews in Health Care: Meta-Analysis in Context, 2nd edn. BMJ Publishing: London, England, 2001, pp 87-108.
27. Jadad AR, Moore RA, Carroll D, Jenkinson C, Reynolds DJ, Gavaghan DJ et al. Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials 1996; 17(1): 1-12.
28. Bakr AF. Prophylactic theophylline to prevent renal dysfunction in newborns exposed to perinatal asphyxia-A study in a developing country. Pediat Nephrol 2005; 20(9): 1249-1252.
29. Bhat MA, Shah ZA, Makhdoomi MS, Mufti MH. Theophylline for renal function in term neonates with perinatal asphyxia: a randomized, placebo-controlled trial. J Pediatr 2006; 149(2): 180-184.
30. Eslami Z, Shajari A, Kheirandish M, Heidary A. Theophylline for prevention of kidney dysfunction in neonates with severe asphyxia. Iran J Kidney Dis 2009; 3(4): 222-226.
31. Jenik AG, Ceriani Cernadas JM, Gorenstein A, Ramirez JA, Vain N, Armadans M et al. A randomized, double-blind, placebo-controlled trial of the effects of prophylactic theophylline on renal function in term neonates with perinatal asphyxia. Pediatrics 2000; 105(4): E45.
32. Huet F, Semama D, Grimaldi M, Guignard JP, Gouyon JB. Effects of theophylline on renal insufficiency in neonates with respiratory distress syndrome. Intensive Care Med 1995; 21(6): 511-514.
33. Cattarelli D, Spandrio M, Gasparoni A, Bottino R, Offer C, Chirico G. A randomised, double blind, placebo controlled trial of the effect of theophylline in prevention of vasomotor nephropathy in very preterm neonates with respiratory distress syndrome. Arch Dis Child Fetal Neonatal Ed 2006; 91(2): F80-F84.
34. Lowry JA, Jarrett RV, Wasserman G, Pettett G, Kauffman RE. Theophylline toxicokinetics in premature newborns. Arch Pediatr Adolesc Med 2001; 155(8): 934-939.
35. Pesce AJ, Rashkin M, Kotagal U. Standards of laboratory practice: theophylline and caffeine monitoring. National Academy of Clinical Biochemistry. Clin Chem 1998; 44(5): 1124-1128.
36. Aranda JV, Chemtob S, Laudignon N, Sasyniuk BI. Pharmacologic effects of theophylline in the newborn. J Allergy Clin Immunol 1986; 78(4 Pt 2): 773-780.
37. Gounaris A, Kokori P, Varchalama L, Konstandinidi K, Skouroliakou M, Alexiou N et al. Theophylline and gastric emptying in very low birthweight neonates: a randomised controlled trial. Arch Dis Child Fetal Neonatal Ed 2004; 89(4): F297-F299.
38. Stapleton FB, Jones DP, Green RS. Acute renal failure in neonates: incidence, etiology and outcome. Pediatr Nephrol 1987; 1(3): 314-320.
39. Azzopardi D, Strohm B, Edwards AD, Halliday H, Juszczak E, Levene M et al. Treatment of asphyxiated newborns with moderate hypothermia in routine clinical practice: how cooling is managed in the UK outside a clinical trial. Arch Dis Child Fetal Neonatal Ed 2009; 94(4): F260-F264.