Genetic risk prediction in a small cohort of healthy adults in Atlanta

Genetics Research

Volumn 95, Issue 1, 2013, Pages 30-37

  Zhao, Jing ^a   Arafat, Dalia ^b   Brigham, Kenneth L ^b   Gibson, Greg ^a  

^a GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; TRIACYLGLYCEROL;

ADULT; AGED; ARTICLE; ASTHMA; BODY HEIGHT; BODY MASS; CHOLESTEROL BLOOD LEVEL; COHORT ANALYSIS; CORONARY ARTERY DISEASE; FEMALE; FRAMINGHAM RISK SCORE; GENETIC ASSOCIATION; GENETIC RISK; GENETIC TRAIT; GENETIC VARIABILITY; GENOTYPE; HUMAN; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; MULTIFACTORIAL INHERITANCE; NON INSULIN DEPENDENT DIABETES MELLITUS; NORMAL HUMAN; PHENOTYPE; PREDICTION; RISK ASSESSMENT; SINGLE NUCLEOTIDE POLYMORPHISM; TRIACYLGLYCEROL BLOOD LEVEL; UNITED STATES;

ADULT; AGED; ASTHMA; BODY HEIGHT; BODY MASS INDEX; CHOLESTEROL; CORONARY ARTERY DISEASE; DIABETES MELLITUS, TYPE 2; ETHNIC GROUPS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; GEORGIA; HUMANS; LONGITUDINAL STUDIES; MALE; MIDDLE AGED; MULTIFACTORIAL INHERITANCE; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; QUANTITATIVE TRAIT LOCI; RISK FACTORS; TRIGLYCERIDES;

EID: 84875753341     PISSN: 00166723     EISSN: 14695073     Source Type: Journal    
DOI: 10.1017/S0016672313000025     Document Type: Article

References (24)

1. Aschard, H., Chen, J., Cornelis, M. C., Chibnik, L. B., Karlson, E. W. & Kraft, P. (2012). Inclusion of gene-gene and gene-environment interactions unlikely to dramatically improve risk prediction for complex disease. American Journal of Human Genetics 90, 962-972.
2. Ashley, E. A., Butte, A. J., Wheeler, M. T., Chen, R., Klein, T. E., Dewey, F. E., Dudley, J. T., Ormond, K. E., Pavlovic, A., Morgan, A. A. et al. (2010). Clinical assessment incorporating a personal genome. Lancet 375, 1525-1535.
3. Bell, J. (2004). Predicting disease using genomics. Nature 429, 453-456.
4. Collins, F. S., Green, E. D., Guttmacher, A. E. & Guyer, M. S. (2003). A vision for the future of genomics research. Nature 422, 835-847.
5. D'Agostino, R. B. Sr, Vasan, R. S., Pencina, M. J., Wolf, P. A., Cobain, M., Massaro, J. M., Kannel, W. B. (2008). General cardiovascular risk profile for use in primary care: the Framingham Heart Study. Circulation 117, 743-753.
6. Fan, J., Upadhye, S. & Worster, A. (2006). Understanding receiver operating characteristic (ROC) curves. Canadian Journal of Emergency Medicine 8, 19-20.
7. Gudbjartsson, D. F., Walters, G. B., Thorleifsson, G., Stefansson, H., Halldorsson, B. V., Zusmanovich, P., Sulem, P., Thorlacius, S., Gylfason, A., Steinberg, S. et al. (2008). Many sequence variants affecting diversity of adult human height. Nature Genetics 40, 609-615.
8. Hill, W. G., Goddard, M. E. & Visscher, P. M. (2008). Data and theory point to mainly additive genetic variance for complex traits. PLoS Genetics 4, e1000008.
9. Howie, B., Marchini, J. & Stephens, M. (2011). Genotype imputation with thousands of genomes. G3: Genes, Genomics, Genetics 1, 457-470.
10. Johansen, C. T. & Hegele, R. A. (2012). The complex genetic basis of plasma triglycerides. Current Atherosclerosis Reports 14, 227-234.
11. Kang, J., Kugathasan, S., Georges, M., Zhao, H., Cho, J. H. & NIDDK IBD Genetics Consortium. (2011). Improved risk prediction for Crohn's disease with a multilocus approach. Human Molecular Genetics 20, 2435-2442.
12. Khoury, M. J., Jones, K. & Grosse, S. D. (2006). Quantifying the health benefits of genetic tests : the importance of a population perspective. Genetics in Medicine 8, 191-195.
13. Kraft, P. & Hunter, D. J. (2009). Genetic risk prediction-Are we there yet? New England Journal of Medicine 360, 1701-1703.
14. Lango Allen, H., Estrada, K., Lettre, G., Berndt, S. I., Weedon, M. N., Rivadeneira, F., Willer, C. J., Jackson, A. U., Vedantam, S., Raychaudhuri, S. et al. (2010). Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature 467, 832-838.
15. Makowsky, R., Pajewski, N. M., Klimentidis, Y. C., Vazquez, A. I., Duarte, C. W., Allison, D. B. & de los Campos, G. (2011). Beyond missing heritability : prediction of complex traits. PLoS Genetics. 7, e1002051.
16. Manolio, T. A., Collins, F. S., Cox, N. J., Goldstein, D. B., Hindorff, L. A., Hunter, D. J., McCarthy, M. I., Ramos, E. M., Cardon, L. R., Chakravarti, A. et al. (2009). Finding the missing heritability of complex diseases. Nature 461, 747-753.
17. Peden, J. F. & Farrall, M. (2011). Thirty-five common variants for coronary artery disease : the fruits of much collaborative labour. Human Molecular Genetics 20, 198-205.
18. Peterson, R. E., Maes, H. H., Holmans, P., Sanders, A. R., Levinson, D. F., Shi, J., Kendler, K. S., Gejman, P. V. & Webb, B. T. (2011). Genetic risk sum score comprised of common polygenic variation is associated with body mass index. Human Genetics 129, 221-230.
19. Speliotes, E. K., Willer, C. J., Berndt, S. I., Monda, K. L., Thorleifsson, G., Jackson, A. U., Allen, H. L., Lindgren, C. M., Luan, J., Magi, R. et al. (2011). Association analyses of 249 796 individuals reveal 18 new loci associated with body mass index. Nature Genetics 42, 937-948.
20. Stahl, E. A., Wegmann, D., Trynka, G., Gutierrez-Achury, J., Do, R., Voight, B. F., Kraft, P., Chen, R., Kallberg, H. J., Kurreeman, F. A., Diabetes Genetics Replication and Meta-analysis Consortium, Myocardial Infarction Genetics Consortium et al. (2012). Bayesian inference analyses of the polygenic architecture of rheumatoid arthritis. Nature Genetics 44, 483-489.
21. Teslovich, T., Musunuru, K., Smith, A. V., Edmondson, A. C., Stylianou, I. M., Koseki, M., Pirruccello, J. P., Ripatti, S., Chasman, D. I., Willer, C. J. et al. (2010). Biological, clinical and population relevance of 95 loci for blood lipids. Nature 466, 707-713.
22. Wilson, P. W., Meigs, J. B., Sullivan, L., Fox, C. S., Nathan, D. M. & D'Agostino, R. B. Sr (2007). Prediction of incident diabetes mellitus in middle-aged adults: the Framingham Offspring Study. Archives of Internal Medicine 167, 1068-1074.
23. Wray, N. R., Goddard, M. E. & Visscher, P. M. (2008). Prediction of individual genetic risk of complex disease. Current Opinion in Genetics and Development 18, 257-263.
24. Yang, J., Benyamin, B., McEvoy, B. P., Gordon, S., Henders, A. K., Nyholt, D. R., Madden, P. A., Heath, A. C., Martin, N. G., Montgomery, G. W., Goddard, M. A. & Visscher, P. M. (2010). Common SNPs explain a large proportion of the heritability for human height. Nature Genetics 42, 565-569.