Discovery of (R)-2-amino-6-borono-2-(2-(piperidin-1-yl)ethyl)hexanoic acid and congeners as highly potent inhibitors of human arginases i and II for treatment of myocardial reperfusion injury

Journal of Medicinal Chemistry

Volumn 56, Issue 6, 2013, Pages 2568-2580

  Van Zandt, Michael C ^a   Whitehouse, Darren L ^a   Golebiowski, Adam ^a   Ji, Min Koo ^a   Zhang, Mingbao ^a   Beckett, R Paul ^a   Jagdmann, G Erik ^a   Ryder, Todd R ^a   Sheeler, Ryan ^a   Andreoli, Monica ^a   Conway, Bruce ^a   Mahboubi, Keyvan ^a   D'Angelo, Gerard ^a   Mitschler, Andre ^b   Cousido Siah, Alexandra ^b   Ruiz, Francesc X ^b   Howard, Eduardo I ^b,c   Podjarny, Alberto D ^b   Schroeter, Hagen ^d  

^a Institutes for Pharmaceutical Discovery   (United States)

^b UNIVERSITÉ DE STRASBOURG   (France)

^c UNIVERSIDAD NACIONAL DE LA PLATA   (Argentina)

^d MARS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 6 BORONO 2 (2 (PIPERIDIN 1 YL)ETHYL)HEXANOIC ACID; 2 AMINO 6 BORONO 2 (2 (PIPERIDIN 1 YL)ETHYL)HEXANOIC ACID CONGENER; ARGINASE; ARGINASE 1; ARGINASE 2; CARDIOVASCULAR AGENT; HYDROLASE INHIBITOR; RECOMBINANT ENZYME; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ASSAY; CHO CELL; CONTROLLED STUDY; CRYSTALLIZATION; DISEASE MODEL; DRUG BIOAVAILABILITY; DRUG DESIGN; DRUG EFFICACY; DRUG SYNTHESIS; ENZYME INHIBITION; HEART INFARCTION; HEART INFARCTION SIZE; HUMAN; IC 50; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; REPERFUSION INJURY; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

AMINO ACIDS; ANIMALS; ARGINASE; BORON COMPOUNDS; CAPROATES; CHO CELLS; CRICETINAE; CRICETULUS; DRUG DISCOVERY; ENZYME INHIBITORS; HUMANS; MALE; MODELS, MOLECULAR; MYOCARDIAL REPERFUSION INJURY; PROTEIN CONFORMATION; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84875750349     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm400014c     Document Type: Article

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