Pregnancy Prediction in Single Embryo Transfer Cycles after ICSI Using QPCR: Validation in Oocytes from the Same Cohort

PLoS ONE

Volumn 8, Issue 4, 2013, Pages

  Wathlet, Sandra ^a   Adriaenssens, Tom ^a   Segers, Ingrid ^a   Verheyen, Greta ^b   van Landuyt, Lisbet ^b   Coucke, Wim ^c   Devroey, Paul ^b   Smitz, Johan ^a  

^a UNIVERSITY HOSPITAL BRUSSELS   (Belgium)

^b CENTRE FOR REPRODUCTIVE MEDICINE   (Belgium)

^c SCIENTIFIC INSTITUTE OF PUBLIC HEALTH   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

EPHRIN B2; GLUCOSE TRANSPORTER 1; GLUTATHIONE PEROXIDASE 3; GLUTATHIONE TRANSFERASE A3; GLUTATHIONE TRANSFERASE A4; PROGESTERONE RECEPTOR; THROMBOSPONDIN 1; TRANSFORMING GROWTH FACTOR BETA1;

ADULT; ARTICLE; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE ID GENE; CLINICAL ARTICLE; CONTROLLED STUDY; CUMULUS CELL; EMBRYO TRANSFER; EPHRIN B2 GENE; FEMALE; GENE EXPRESSION; GENETIC ANALYSIS; GLUTATHIONE PEROXIDASE 3 GENE; GLUTATHIONE S TRANSFERASE ALPHA 3 GENE; GLUTATHIONE S TRANSFERASE ALPHA 4 GENE; HUMAN; HUMAN CELL; INOSITOL 1,4,5 TRISPHOSPHATE RECEPTOR TYPE 1 GENE; INTRACYTOPLASMIC SPERM INJECTION; MARKER GENE; MATHEMATICAL MODEL; OOCYTE; PREDICTION; PREDICTIVE VALUE; PREGNANCY; PROGESTERONE RECEPTOR GENE; QUANTITATIVE REAL TIME POLYMERASE CHAIN REACTION; REAL TIME POLYMERASE CHAIN REACTION; RECEIVER OPERATING CHARACTERISTIC; SOLUTE CARRIER FAMILY 2 MEMBER 1 GENE; STANNIOCALCIN 1 GENE; THROMBOSPONDIN 1 GENE; TRANSFORMING GROWTH FACTOR BETA 1 GENE;

ADULT; AREA UNDER CURVE; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 1; CUMULUS CELLS; EPHRIN-B2; FEMALE; GENE EXPRESSION PROFILING; GLUTATHIONE REDUCTASE; GLUTATHIONE TRANSFERASE; HUMANS; MODELS, BIOLOGICAL; MULTIVARIATE ANALYSIS; OOCYTES; PREGNANCY; PREGNANCY RATE; REAL-TIME POLYMERASE CHAIN REACTION; RETROSPECTIVE STUDIES; ROC CURVE; SPERM INJECTIONS, INTRACYTOPLASMIC; TRANSCRIPTOME;

EID: 84875728301     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0054226     Document Type: Article

References (37)

1. Huang Z, Wells D, (2010) The human oocyte and cumulus cells relationship: new insights from the cumulus cell transcriptome. Mol Hum Reprod 16: 715-725.
2. McKenzie LJ, Pangas SA, Carson SA, Kovanci E, Cisneros P, et al. (2004) Human cumulus granulosa cell gene expression: a predictor of fertilization and embryo selection in women undergoing IVF. Hum Reprod 19: 2869-2874.
3. Hasegawa J, Yanaihara A, Iwasaki S, Otsuka Y, Negishi M, et al. (2005) Reduction of progesterone receptor expression in human cumulus cells at the time of oocyte collection during IVF is associated with good embryo quality. Hum Reprod 20: 2194-2200.
4. Cillo F, Brevini TA, Antonini S, Paffoni A, Ragni G, et al. (2007) Association between human oocyte developmental competence and expression levels of some cumulus genes. Reproduction 134: 645-650.
5. Zhang X, Jafari N, Barnes RB, Confino E, Milad M, et al. (2005) Studies of gene expression in human cumulus cells indicate pentraxin 3 as a possible marker for oocyte quality. Fertil Steril 83 (Suppl 1): 1169-1179.
6. Feuerstein P, Cadoret V, Dalbies-Tran R, Guerif F, Bidault R, et al. (2007) Gene expression in human cumulus cells: one approach to oocyte competence. Hum Reprod 22: 3069-3077.
7. van Montfoort AP, Geraedts JP, Dumoulin JC, Stassen AP, Evers JL, et al. (2008) Differential gene expression in cumulus cells as a prognostic indicator of embryo viability: a microarray analysis. Mol Hum Reprod 14: 157-168.
8. Anderson RA, Sciorio R, Kinnell H, Bayne RA, Thong KJ, et al. (2009) Cumulus gene expression as a predictor of human oocyte fertilisation, embryo development and competence to establish a pregnancy. Reproduction 138: 629-637.
9. Fragouli E, Wells D, Iager AE, Kayisli UA, Patrizio P (2012) Alteration of gene expression in human cumulus cells as a potential indicator of oocyte aneuploidy. Hum Reprod.
10. Ouandaogo ZG, Haouzi D, Assou S, Dechaud H, Kadoch IJ, et al. (2011) Human cumulus cells molecular signature in relation to oocyte nuclear maturity stage. PLoS One 6: e27179.
11. Assidi M, Montag M, Van der Ven K, Sirard MA, (2011) Biomarkers of human oocyte developmental competence expressed in cumulus cells before ICSI: a preliminary study. J Assist Reprod Genet 28: 173-188.
12. Assou S, Haouzi D, Mahmoud K, Aouacheria A, Guillemin Y, et al. (2008) A non-invasive test for assessing embryo potential by gene expression profiles of human cumulus cells: a proof of concept study. Mol Hum Reprod 14: 711-719.
13. Gebhardt KM, Feil DK, Dunning KR, Lane M, Russell DL (2011) Human cumulus cell gene expression as a biomarker of pregnancy outcome after single embryo transfer. Fertil Steril 96: 47-52 e42.
14. Wathlet S, Adriaenssens T, Segers I, Verheyen G, Van de Velde H, et al. (2011) Cumulus cell gene expression predicts better cleavage-stage embryo or blastocyst development and pregnancy for ICSI patients. Hum Reprod 26: 1035-1051.
15. Wathlet S, Adriaenssens T, Segers I, Verheyen G, Janssens R, et al. (2012) New candidate genes to predict pregnancy outcome in single embryo transfer cycles when using cumulus cell gene expression. Fertil Steril.
16. Adriaenssens T, Mazoyer C, Segers I, Wathlet S, Smitz J, (2009) Differences in collagen expression in cumulus cells after exposure to highly purified menotropin or recombinant follicle-stimulating hormone in a mouse follicle culture model. Biol Reprod 80: 1015-1025.
17. Adriaenssens T, Wathlet S, Segers I, Verheyen G, De Vos A, et al. (2010) Cumulus cell gene expression is associated with oocyte developmental quality and influenced by patient and treatment characteristics. Hum Reprod 25: 1259-1270.
18. Grondahl ML, Borup R, Lee YB, Myrhoj V, Meinertz H, et al. (2009) Differences in gene expression of granulosa cells from women undergoing controlled ovarian hyperstimulation with either recombinant follicle-stimulating hormone or highly purified human menopausal gonadotropin. Fertil Steril 91: 1820-1830.
19. Egawa M, Yoshioka S, Higuchi T, Sato Y, Tatsumi K, et al. (2003) Ephrin B1 is expressed on human luteinizing granulosa cells in corpora lutea of the early luteal phase: the possible involvement of the B class Eph-ephrin system during corpus luteum formation. J Clin Endocrinol Metab 88: 4384-4392.
20. Verploegen S, Lammers JW, Koenderman L, Coffer PJ, (2000) Identification and characterization of CKLiK, a novel granulocyte Ca(++)/calmodulin-dependent kinase. Blood 96: 3215-3223.
21. Luo CW, Kawamura K, Klein C, Hsueh AJ, (2004) Paracrine regulation of ovarian granulosa cell differentiation by stanniocalcin (STC) 1: mediation through specific STC1 receptors. Mol Endocrinol 18: 2085-2096.
22. Luo CW, Pisarska MD, Hsueh AJ, (2005) Identification of a stanniocalcin paralog, stanniocalcin-2, in fish and the paracrine actions of stanniocalcin-2 in the mammalian ovary. Endocrinology 146: 469-476.
23. Pastore A, Federici G, Bertini E, Piemonte F, (2003) Analysis of glutathione: implication in redox and detoxification. Clin Chim Acta 333: 19-39.
24. Raffalli-Mathieu F, Orre C, Stridsberg M, Hansson Edalat M, Mannervik B, (2008) Targeting human glutathione transferase A3-3 attenuates progesterone production in human steroidogenic cells. Biochem J 414: 103-109.
25. Govinden R, Bhoola KD, (2003) Genealogy, expression, and cellular function of transforming growth factor-beta. Pharmacol Ther 98: 257-265.
26. Liu X, Andoh K, Abe Y, Kobayashi J, Yamada K, et al. (1999) A comparative study on transforming growth factor-beta and activin A for preantral follicles from adult, immature, and diethylstilbestrol-primed immature mice. Endocrinology 140: 2480-2485.
27. Makrigiannakis A, Coukos G, Christofidou-Solomidou M, Montas S, Coutifaris C, (2000) Progesterone is an autocrine/paracrine regulator of human granulosa cell survival in vitro. Ann N Y Acad Sci 900: 16-25.
28. Hamel M, Dufort I, Robert C, Leveille MC, Leader A, et al. (2010) Identification of follicular marker genes as pregnancy predictors for human IVF: new evidence for the involvement of luteinization process. Mol Hum Reprod 16: 548-556.
29. Berridge MJ, (2009) Inositol trisphosphate and calcium signalling mechanisms. Biochim Biophys Acta 1793: 933-940.
30. Olson AL, Pessin JE, (1996) Structure, function, and regulation of the mammalian facilitative glucose transporter gene family. Annu Rev Nutr 16: 235-256.
31. Adams JC, (1997) Thrombospondin-1. Int J Biochem Cell Biol 29: 861-865.
32. Hayashi H, Sakai K, Baba H, Sakai T, (2012) Thrombospondin-1 is a novel negative regulator of liver regeneration after partial hepatectomy through transforming growth factor-beta1 activation in mice. Hepatology 55: 1562-1573.
33. Van Landuyt L, De Vos A, Joris H, Verheyen G, Devroey P, et al. (2005) Blastocyst formation in in vitro fertilization versus intracytoplasmic sperm injection cycles: influence of the fertilization procedure. Fertil Steril 83: 1397-1403.
34. Van Landuyt L, Verpoest W, Verheyen G, De Vos A, Van de Velde H, et al. (2011) Closed blastocyst vitrification of biopsied embryos: evaluation of 100 consecutive warming cycles. Hum Reprod 26: 316-322.
35. Buttke TM, Sandstrom PA, (1994) Oxidative stress as a mediator of apoptosis. Immunol Today 15: 7-10.
36. Tatemoto H, Sakurai N, Muto N, (2000) Protection of porcine oocytes against apoptotic cell death caused by oxidative stress during In vitro maturation: role of cumulus cells. Biol Reprod 63: 805-810.
37. Lee MS, Liu CH, Lee TH, Wu HM, Huang CC, et al. (2010) Association of creatin kinase B and peroxiredoxin 2 expression with age and embryo quality in cumulus cells. J Assist Reprod Genet 27: 629-639.