A novel metformin derivative, HL010183, inhibits proliferation and invasion of triple-negative breast cancer cells

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 8, 2013, Pages 2305-2313

  Koh, Minsoo ^a   Lee, Jong Cheol ^b   Min, Changhee ^c   Moon, Aree ^a  

^a Duksung Women's University   (South Korea)

^b Korea Research Institute of Chemical Technology   (South Korea)

^c HanAll Biopharma Co Ltd   (South Korea)

Author keywords

Anti cancer agent; Invasion; Metformin; Triple negative breast cancer; Xenograft model

Indexed keywords

ANTINEOPLASTIC AGENT; HL 010183; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MAMMALIAN TARGET OF RAPAMYCIN; METFORMIN; METFORMIN DERIVATIVE; METFORMIN GABAPENTIN; METFORMIN GAMMA AMINOBUTYRIC ACID; METFORMIN PREGABALIN; N2,N2 DIMETHYL N4 (2 PROPYLPHENYL) 1,3,5 TRIAZINE 2,4,6 TRIAMINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER INHIBITION; CANCER INVASION; CARCINOMA CELL; CELL PROLIFERATION; CONTROLLED STUDY; DRUG POTENCY; DRUG SYNTHESIS; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; TRIPLE NEGATIVE BREAST CANCER;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; METFORMIN; MICE; MICE, INBRED BALB C; MICE, NUDE; NEOPLASM INVASIVENESS; TRIPLE NEGATIVE BREAST NEOPLASMS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84875727908     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.02.015     Document Type: Article

References (29)

1. M. Jalving, J.A. Gietema, J.D. Lefrandt, S. de Jong, A.K. Reyners, R.O. Gans, and E.G. de Vries Eur. J. Cancer 46 2010 2369
2. J.D. Lalau, and J.M. Race Drugs 58 1999 55
3. J.L. Wright, and J.L. Stanford Cancer Causes Control 20 2009 1617
4. S. Jiralerspong, S.L. Palla, S.H. Giordano, F. Meric-Bernstam, C. Liedtke, C.M. Barnett, L. Hsu, M.C. Hung, G.N. Hortobagyi, and A.M. Gonzalez-Angulo J. Clin. Oncol. 27 2009 3297
5. D. Li, S.C. Yeung, M.M. Hassan, M. Konopleva, and J.L. Abbruzzese Gastroenterology 137 2009 482
6. C.J. Currie, C.D. Poole, and E.A. Gale Diabetologia 52 2009 1766
7. I. Ben Sahra, K. Laurent, A. Loubat, S. Giorgetti-Peraldi, P. Colosetti, P. Auberger, J.F. Tanti, Y. Le Marchand-Brustel, and F. Bost Oncogene 27 2008 35761
8. B. Liu, Z. Fan, S.M. Edgerton, X.S. Deng, I.N. Alimova, S.E. Lind, and A.D. Thor Cell Cycle 8 2009 2031
9. K. Kisfalvi, G. Eibl, J. Sinnett-Smith, and E. Rozengurt Cancer Res. 69 2009 6539
10. M. Buzzai, R.G. Jones, R.K. Amaravadi, J.J. Lum, R.J. DeBerardinis, F. Zhao, B. Viollet, and C.B. Thompson Cancer Res. 67 2007 6745
11. R. Rattan, R.P. Graham, J.L. Maguire, S. Giri, and V. Shridhar Neoplasia 13 2011 483
12. A. Jemal, E. Ward, and M.J. Thun Breast Cancer Res. 9 2007 R28
13. C. Sotiriou, S.Y. Neo, L.M. McShane, E.L. Korn, P.M. Long, A. Jazaeri, P. Martiat, S.B. Fox, A.L. Harris, and E.T. Liu Proc. Natl. Acad. Sci. U.S.A. 100 2003 10393
14. A. Jemal, R. Siegel, J. Xu, and E. Ward CA Cancer J. Clin. 60 2010 277
15. A. Moon, M.S. Kim, T.G. Kim, S.H. Kim, H.E. Kim, Y.Q. Chen, and H.R. Kim Int. J. Cancer 85 2000 176
16. H. Song, S.H. Ki, S.G. Kim, and A. Moon Cancer Res. 66 2006 10487
17. B.K. Tan, R. Adya, J. Chen, H. Lehnert, L.J. Sant Cassia, and H.S. Randeva J. Clin. Endocrinol. Metab. 96 2011 808
18. Y.P. Hwang, and H.G. Jeong Br. J. Pharmacol. 160 2010 1195
19. A. Vazquez-Martin, C. Oliveras-Ferraros, S. del Barco, B. Martin-Castillo, and J.A. Menendez Ann. Oncol. 20 2009 592
20. M.A. Lea, J. Chacko, S. Bolikal, J.Y. Hong, R. Chung, A. Ortega, and C. Desbordes Anticancer Res. 31 2011 421
21. M.V. Appleyard, K.E. Murray, P.J. Coates, S. Wullschleger, S.E. Bray, N.M. Kernohan, S. Fleming, D.R. Alessi, and A.M. Thompson Br. J. Cancer 106 2012 1117
22. J.S. Bryans, and D.J. Wustrow Med. Res. Rev. 19 1999 149
23. S.Z. Young, and A. Bordey Physiology (Bethesda) 24 2009 171
24. R.M. Neve, K. Chin, J. Fridlyand, J. Yeh, F.L. Baehner, T. Fevr, L. Clark, N. Bayani, J.P. Coppe, F. Tong, T. Speed, P.T. Spellman, S. DeVries, A. Lapuk, N.J. Wang, W.L. Kuo, J.L. Stilwell, D. Pinkel, D.G. Albertson, F.M. Waldman, F. McCormick, R.B. Dickson, M.D. Johnson, M. Lippman, S. Ethier, A. Gazdar, and J.W. Gray Cancer Cell 10 2006 515
25. J. Joseph, B. Niggemann, K.S. Zaenker, and F. Entschladen Cancer Res. 62 2002 6467
26. H.M. Schuller, H.A. Al-Wadei, and M. Majidi Cancer 112 2008 767
27. J.H. Lin, and A.Y. Lu Pharmacol. Rev. 49 1997 403
28. M.S. Kim, E.J. Lee, H.R. Choi Kim, and A. Moon Cancer Res. 63 2003 5454
29. I.C. Shin, S.H. Kim, H. Song, H.R. Choi Kim, and A. Moon J. Biol. Chem. 280 2005 14675