Continuous flow synthesis

Drug Discovery Today: Technologies

Volumn 10, Issue 1, 2013, Pages

  Yoshida, Jun Ichi ^a   Nagaki, Aiichiro ^a   Yamada, Daisuke ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMSILAROTENE; CYCLOPENTENONE DERIVATIVE; NATURAL PRODUCT; PAUCIFLOROL F; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIVIRAL ACTIVITY; AUTOMATION; CELL STRAIN HL 60; CHEMICAL REACTION; CONTINUOUS FLOW REACTOR; DRUG CYTOTOXICITY; DRUG DEVELOPMENT; DRUG INDUSTRY; DRUG MANUFACTURE; DRUG RESEARCH; DRUG SYNTHESIS; HUMAN; LABORATORY; REVIEW;

CHEMISTRY, ORGANIC; CHEMISTRY, PHARMACEUTICAL; COMBINATORIAL CHEMISTRY TECHNIQUES; DRUG DISCOVERY;

EID: 84875709140     PISSN: None     EISSN: 17406749     Source Type: Journal    
DOI: 10.1016/j.ddtec.2012.10.013     Document Type: Review

References (43)

1. L. Kiwi-Minsker, and A. Renken Microstructured reactors for catalytic reactions Catal. Today 110 2005 2 14
2. C.G. Frost, and L. Mutton Heterogeneous catalytic synthesis using microreactor technology Green Chem. 12 2010 1687 1703
3. M. Baumann The flow synthesis of heterocycles for natural product and medicinal chemistry applications Mol. Divers. 15 2011 613 630
4. G. Whitesides The origins and the future of microfluidics Nature 442 2006 368 373
5. A.J. deMello Control and detection of chemical reactions in microfluidic systems Nature 442 2006 394 402
6. H. Song Reactions in droplets in microfluidic channels Angew. Chem. Int. Ed. 45 2006 7336 7356
7. S.V. Ley The changing face of organic synthesis Tetrahedron 66 2010 6270 6292
8. K. Geyer Developing continuous-flow microreactors as tools for synthetic chemists Synlett 15 2009 2382 2391
9. R.L. Hartman, and K.F. Jensen Microchemical systems for continuous-flow synthesis Lab Chip 9 2009 2495 2507
10. T. Fukuyama Adventures in inner space: microflow systems for practical organic Synlett 2 2008 151 163
11. B. Ahmed-Omer Advanced organic synthesis using microreactor technology Org. Biomol. Chem. 5 2007 733 740
12. P. Watts, and C. Wiles Recent advances in synthetic micro reaction technology Chem. Commun. 2007 443 467
13. P. Watts, and S.J. Haswell The application of micro reactors for organic synthesis Chem. Soc. Rev. 34 2005 235 246
14. J. Kobayashi Multiphase organic synthesis in microchannel reactors Chem. Asian J. 1 2006 22 35
15. A. Ziogas Electrochemical microstructured reactors: design and application in organic synthesis J. Appl. Electrochem. 39 2009 2297 2313
16. V. Hessel Novel process windows-gate to maximizing process intensification via flow Chem. Eng. Technol. 32 2009 1655 1681
17. T. Illg Flow chemistry using milli- and microstructured reactors-from conventional to novel process windows Bioorg. Med. Chem. 18 2010 3707 3719
18. J.C. Brandt Controlling hazardous chemicals in microreactors: synthesis with iodine azide Beilstein J. Org. Chem. 5 2009 30
19. N. Kockmann Enabling continuous-flow chemistry in microstructured devices for pharmaceutical and fine-chemical production Chem. Eur. J. 14 2008 7470 7477
20. D.M. Roberge Microreactor technology and continuous processes in the fine chemical and pharmaceutical industry: is the revolution underway? Org. Process Res. Dev. 12 2008 905 910
21. Y. Kikutani, and T. Kitamori Micro-flow reaction systems for combinatorial syntheses Macromol. Rapid Commun. 25 2004 158 168
22. S. Suga 'Cation Flow' method. A new approach to conventional and combinatorial organic syntheses using electrochemical microflow systems J. Am. Chem. Soc. 123 2001 7941 7942
23. S. Suga Cationic three-component coupling involving an optically active enamine derivative. From time integration to space integration of reactions Chem. Lett. 39 2010 404 405
24. J. Yoshida Space integration of reactions: an approach to increase capability of organic synthesis Synlett 9 2011 1189 1195
25. A.J. Bard Integrated Chemical Systems 1994 Wiley
26. D. Webb, and T.F. Jamison Continuous flow multi-step organic synthesis Chem. Sci. 1 2010 675 680
27. H.R. Sahoo Multistep continuous-flow microchemical synthesis involving multiple reactions and separations Angew. Chem. Int. Ed. 46 2007 5704 5708
28. H. Kagechika, and K. Shudo Synthetic retinoids: recent developments concerning structure and clinical utility J. Med. Chem. 48 2005 5875 5883
29. A. Nagaki Flash synthesis of TAC-101 and its analogues from 1,3,5-tribromobezene using integrated flow microreactor systems RSC Adv. 1 2011 758 760
30. N. Aoki, and K. Mae Microstructured devices for purification and separation processes. Extraction V. Hessel, A. Renken, J.C. Schouten, J. Yoshida, Micro Process Engineering vol 1 2009 Wiley-VCH 325 345
31. J. Yoshida Flash Chemistry: Fast Organic Synthesis in Microsystems 2008 Wiley-Blackwell
32. J. Yoshida Flash chemistry using electrochemical method and microsystems Chem. Commun. 2005 4509 4516
33. J. Yoshida Flash chemistry: fast chemical synthesis by using microreactors Chem. Eur. J. 14 2008 7450 7459
34. J. Yoshida Flash chemistry: flow microreactor synthesis based on high-resolution reaction time control Chem. Rec. 10 2010 332 341
35. A. Nagaki Aryllithium compounds bearing alkoxycarbonyl groups: generation and reactions using a microflow system Angew. Chem. Int. Ed. 47 2008 7833 7836
36. A. Nagaki Oxiranyl anion methodology using microflow system J. Am. Chem. Soc. 131 2009 1654 1655
37. A. Nagaki Nitro-substituted aryl lithium compounds in microreactor synthesis: switch between kinetic and thermodynamic control Angew. Chem. Int. Ed. 48 2009 8063 8065
38. A. Nagaki Generation and reaction of cyano-substituted aryllithium compounds using microreactors Org. Biomol. Chem. 8 2010 1212 1217
39. Y. Tomida Asymmetric carbolithiation of conjugated enynes: a flow microreactor enables the use of configurationally unstable intermediates before they epimerize J. Am. Chem. Soc. 133 2011 3744 3747
40. H. Kim Ketones survive in organolithium reactions in flash chemistry. A flow-microreactor approach to protecting-group-free synthesis using organolithium compounds Nat. Commun. 2 2011 264
41. R.L. Hartman Deciding whether to go with the flow: evaluating the merits of flow reactors for synthesis Angew. Chem. Int. Ed. 50 2011 7502 7518
42. C. Wiles, and P. Watts Continuous flow reactors: a perspective Green Chem. 14 2012 38 54
43. J. Yoshida Green and sustainable chemical synthesis using flow microreactors ChemSusChem 4 2011 331 340