Population dynamics of normal and leukaemia stem cells in the haematopoietic stem cell niche show distinct regimes where leukaemia will be controlled

Journal of the Royal Society Interface

Volumn 10, Issue 81, 2013, Pages

  MacLean, Adam L ^a   Lo Celso, Cristina ^a   Stumpf, Michael P H ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Approximate Bayesian computation; Haematopoiesis; Population biology; Robustness; Stem cells

Indexed keywords

BAYESIAN NETWORKS; BLOOD; BONE; ECOLOGY; FLOWCHARTING; MATHEMATICAL MODELS; ROBUSTNESS (CONTROL SYSTEMS);

APPROXIMATE BAYESIAN; ECOLOGICAL NICHE; HAEMATOPOIESIS; HAEMATOPOIETIC STEM CELLS; ONCOGENIC POTENTIAL; PARAMETER SPACES; THERAPEUTIC APPLICATION; THERAPEUTIC TARGETS;

STEM CELLS;

ARTICLE; BAYES THEOREM; DYNAMICS; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; HUMAN; LEUKEMIA; LEUKEMIA STEM CELL; MATHEMATICAL MODEL; NONHUMAN; PROGENY; STEM CELL; STEM CELL NICHE; BIOLOGICAL MODEL; BONE MARROW CELL; CANCER STEM CELL; CYTOLOGY; PATHOPHYSIOLOGY; TUMOR MICROENVIRONMENT;

BAYES THEOREM; BONE MARROW CELLS; CELLULAR MICROENVIRONMENT; HEMATOPOIETIC STEM CELLS; HUMANS; LEUKEMIA; MODELS, BIOLOGICAL; NEOPLASTIC STEM CELLS;

MLCS; MLOWN;

EID: 84875708161     PISSN: 17425689     EISSN: 17425662     Source Type: Journal    
DOI: 10.1098/rsif.2012.0968     Document Type: Article

References (53)

1. Lanza R (ed). 2009 Essentials of stem cell biology. Waltham, MA: Academic Press.
2. Martinez-Agosto JA, Mikkola HKA, Hartenstein V, Banerjee U. 2007 The hematopoietic stem cell and its niche: a comparative view. Genes Dev. 21, 3044-3060. (doi:10.1101/gad.1602607)
3. Wolkenhauer O, Shibata DK, Mesarović MD. 2011 A stem cell niche dominance theorem. BMC Syst. Biol. 5, 4. (doi:10.1186/1752-0509-5-4)
4. Wang LD, Wagers AJ. 2011 Dynamic niches in the origination and differentiation of haematopoietic stem cells. Nat. Rev. Mol. Cell Biol. 12, 643-655. (doi:10.1038/nrm3184)
5. Wilson A, Trumpp A. 2006 Bone-marrow haematopoietic-stem-cell niches. Nat. Rev. Immunol. 6, 93-106. (doi:10.1038/nri1779)
6. Forsberg EC, Smith-Berdan S. 2009 Parsing the niche code: the molecular mechanisms governing hematopoietic stem cell adhesion and differentiation. Haematologica 94, 1477-1481. (doi:10.3324/haematol.2009.013730)
7. Renstrom J, Kroger M, Peschel C, Oostendorp RAJ. 2010 How the niche regulates hematopoietic stem cells. Chem. Biol. Interact. 184, 7-15. (doi:10.1016/j.cbi.2009.11.012)
8. Trumpp A, Essers M, Wilson A. 2010 Awakening dormant haematopoietic stem cells. Nat. Rev. Immunol. 10, 201-209. (doi:10.1038/nri2726)
9. Zhang J et al. 2003 Identification of the haematopoietic stem cell niche and control of the niche size. Nature 425, 836-841. (doi:10.1038/nature02041)
10. Calvi LM et al. 2003 Osteoblastic cells regulate the haematopoietic stem cell niche. Nature 425, 841-846. (doi:10.1038/nature02040)
11. Ehninger A, Trumpp A. 2011 The bone marrow stem cell niche grows up: mesenchymal stem cells and macrophages move in. J. Exp. Med. 208, 421-428. (doi:10.1084/jem.20110132)
12. Franks LM, Teich N (eds). 1997 Introduction to the cellular and molecular biology of cancer, 3rd edn. Oxford, UK: Oxford University Press.
13. Wang JCY, Dick JE. 2005 Cancer stem cells: lessons from leukemia. Trends Cell Biol. 15, 494-501. (doi:10.1016/j.tcb.2005.07.004)
14. Lapidot T et al. 1994 A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature 367, 645-648. (doi:10.1038/ 367645a0)
15. Shipitsin M, Polyak K. 2008 The cancer stem cell hypothesis: in search of definitions, markers, and relevance. Lab. Investig. 88, 459-463. (doi:10. 1038/labinvest.2008.14)
16. Lane SW et al. 2011 Differential niche and Wnt requirements during acute myeloid leukemia progression. Blood 118, 2849-2856. (doi:10.1182/blood-2011-03- 345165)
17. Henry CJ, Marusyk A, Zaberezhnyy V, Adane B, DeGregori J. 2010 Declining lymphoid progenitor fitness promotes aging-associated leukemogenesis. Proc. Natl Acad. Sci. 107, 21 713-21 718. (doi:10. 1073/pnas.1005486107)
18. Marusyk A, Casás-Selves M, Henry CJ, Zaberezhnyy V, Klawitter J, Christians U, DeGregori J. 2009 Irradiation alters selection for oncogenic mutations in hematopoietic progenitors. Cancer Res. 69, 7262-7269. (doi:10.1158/0008-5472.CAN-09-0604)
19. Daukste L, Basse B, Baguley BC, Wall DJN. 2009 Using a stem cell and progeny model to illustrate the relationship between cell cycle times of in vivo human tumour cell tissue populations, in vitro primary cultures and the cell lines derived from them. J. Theor. Biol. 260, 563-571. (doi:10.1016/j. jtbi.2009.06.019)
20. Johnston MD, Maini PK, Jonathan Chapman S, Edwards CM, Bodmer WF. 2010 On the proportion of cancer stem cells in a tumour. J. Theor. Biol. 266, 708-711. (doi:10.1016/j.jtbi.2010.07.031)
21. Solé RV, Rodríguez-Caso C, Deisboeck TS, Saldaña J. 2008 Cancer stem cells as the engine of unstable tumor progression. J. Theor. Biol. 253, 629-637. (doi:10.1016/j.jtbi.2008.03.034)
22. Enderling H, Anderson ARA, Chaplain MAJ, Beheshti A, Hlatky L, Hahnfeldt P. 2009 Paradoxical dependencies of tumor dormancy and progression on basic cell kinetics. Cancer Res. 69, 8814-8821. (doi:10.1158/0008-5472.CAN-09-2115)
23. Sieburg HB, Rezner BD, Muller-Sieburg CE. 2011 Predicting clonal self-renewal and extinction of hematopoietic stem cells. Proc. Natl. Acad. Sci. USA 108, 4370-4375. (doi:10.1073/pnas.1011414108)
24. Duff C, Smith-Miles K, Lopes L, Tian T. 2011 Mathematical modelling of stem cell differentiation: the PU.1-GATA-1 interaction. J. Math. Biol. (doi:10.1007/s00285-011-0419-3)
25. Aïnseba B, Benosman C. 2011 Global dynamics of hematopoietic stem cells and differentiated cells in a chronic myeloid leukemia model. J. Math. Biol. 62, 975-997. (doi:10.1007/s00285-010-0360-x)
26. Hofbauer J, Sigmund K. 1998 Evolutionary games and population dynamics. Cambridge, UK: Cambridge University Press.
27. May RM. 1973 Stability and complexity in model ecosystems. Princeton, NJ: Princeton University Press.
28. Dalerba P, Cho RW, Clarke MF. 2007 Cancer stem cells: models and concepts. Annu. Rev. Med. 58, 267-284. (doi:10.1146/annurev.med.58.062105. 204854)
29. Roy A et al. 2012 Perturbation of fetal liver hematopoietic stem and progenitor cell development by trisomy 21. Proc. Natl Acad. Sci. USA 109, 17 579-17 584. (doi:10.1073/pnas. 1211405109)
30. Chaidos A et al. 2012 Clinical drug resistance linked to inter-convertible phenotypic and functional states of tumor-propagating cells in multiple myeloma. Blood (doi:10.1182/blood-2012-06-436220)
31. Wang X, Rosol M, Ge S, Peterson D, McNamara G, Pollack H, Kohn DB, Nelson MD, Crooks GM. 2003 Dynamic tracking of human hematopoietic stem cell engraftment using in vivo bioluminescence imaging. Blood 102, 3478-3482. (doi:10.1182/blood-2003-05-1432)
32. Celso CL, Wu JW, Lin CP. 2009 In vivo imaging of hematopoietic stem cells and their microenvironment. J. Biophoton. 2, 619-631. (doi:10.1002/jbio. 200910072)
33. Paik EJ, Zon LI. 2010 Hematopoietic development in the zebrafish. Int. J. Dev. Biol. 54, 1127-1137. (doi:10.1387/ijdb.093042ep)
34. Boisset J-C, van Cappellen W, Andrieu-Soler C, Galjart N, Dzierzak E, Robin C. 2010 In vivo imaging of haematopoietic cells emerging from the mouse aortic endothelium. Nature 464, 116-120. (doi:10. 1038/nature08764)
35. Quintana E, Shackleton M, Sabel MS, Fullen DR, Johnson TM, Morrison SJ. 2008 Efficient tumour formation by single human melanoma cells. Nature 456, 593-598. (doi:10.1038/nature07567)
36. Johnston MD, Maini PK, Chapman SJ, Edwards CM, Bodmer WF. 2010 On the proportion of cancer stem cells in a tumour. J. Theor. Biol. 266, 708-711. (doi:10.1016/j.jtbi.2010.07.031)
37. Mangel M, Bonsall MB. 2008 Phenotypic evolutionary models in stem cell biology: replacement, quiescence, and variability. PLoS ONE 3, e1591.
38. Sompayrac L. 2008 How the immune system works, 3rd edn. Oxford, UK: Blackwell Publishing.
39. Krivtsov AV et al. 2006 Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9. Nature 442, 818-822. (doi:10.1038/nature04980)
40. Roughgarden J, May RM, Levin SA (eds). 1989 Perspectives in ecological theory. Princeton, NJ: Princeton University Press.
41. Aguila HL, Rowe DW. 2005 Skeletal development, bone remodeling, and hematopoiesis. Immunol. Rev. 208, 7-18. (doi:10.1111/j.0105-2896.2005. 00333.x)
42. Jost J. 2005 Dynamical systems: examples of complex behaviour. Berlin, Germany: Springer.
43. Santner TJ, Williams BJ, Notz WI. 2003 The design and analysis of computer experiments. Berlin, Germany: Springer.
44. Toni T, Welch D, Strelkowa N, Ipsen A, Stumpf MPH. 2009 Approximate Bayesian computation scheme for parameter inference and model selection in dynamical systems. J. R. Soc. Interface 6, 187-202. (doi:10.1098/rsif.2008.0172)
45. Beaumont MA, Zhang W, Balding DJ. 2002 Approximate Bayesian computation in population genetics. Genetics 162, 2025-2035.
46. Marjoram P, Molitor J, Plagnol V, Tavare S. 2003 Markov chain Monte Carlo without likelihoods. Proc. Natl Acad. Sci. USA 100, 15 324-15 328. (doi:10. 1073/pnas.0306899100)
47. Toni T, Stumpf MPH. 2010 Simulation-based model selection for dynamical systems in systems and population biology. Bioinformatics 26, 7. (doi:10. 1093/bioinformatics/btp619)
48. Liepe J, Barnes C, Cule E, Erguler K, Kirk P, Toni T, Stumpf MPH. 2010 ABC-SysBio - approximate Bayesian computation in Python with GPU support. Bioinformatics 26, 1797-1799. (doi:10.1093/bioinformatics/btq278)
49. Barnes C, Silk D, Sheng X, Stumpf M. 2011 Bayesian design of synthetic biological systems. Proc. Natl Acad. Sci. USA 108, 15 190-15 195. (doi:10.1073/pnas.1017972108)
50. Secrier M, Toni T, Stumpf MPH. 2009 The ABC of reverse engineering biological signalling systems. Mol. BioSyst. 5, 12. (doi:10.1039/b908951a)
51. Erguler K, Stumpf MPH. 2011 Practical limits for reverse engineering of dynamical systems: a statistical analysis of sensitivity and parameter inferability in systems biology models. Mol. BioSyst. 7, 1593. (doi:10.1039/c0mb00107d)
52. Gutenkunst RN, Waterfall JJ, Casey FP, Brown KS, Myers CR, Sethna JP. 2007 Universally sloppy parameter sensitivities in systems biology models. PLoS Comput. Biol. 3, 1871-1878. (doi:10.1371/journal.pcbi.0030189)
53. Kitano H. 2007 Towards a theory of biological robustness. Mol. Syst. Biol. 3, 137.