Mesenchymal stromal cell supported umbilical cord blood ex vivo expansion enhances regulatory T cells and reduces graft versus host disease

Cytotherapy

Volumn 15, Issue 5, 2013, Pages 610-619

  Fan, Xiubo ^a   Gay, Florence Pik Hoon ^b   Ong, Shin Yeu ^a   Ang, Justina May Lynn ^b   Chu, Pat Pak Yan ^a   Bari, Sudipto ^a   Lim, Tony Kiat Hon ^a   Hwang, William Ying Khee ^a  

^a SINGAPORE GENERAL HOSPITAL   (Singapore)

^b DUKE NUS MEDICAL SCHOOL   (Singapore)

Author keywords

ex vivo expansion; graft versus host disease; mesenchymal stromal cell; regulatory T cells; umbilical cord blood

Indexed keywords

FLT3 LIGAND; SOMATOMEDIN BINDING PROTEIN 2; THROMBOPOIETIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL EXPANSION; CELL MEDIATED CYTOTOXICITY; CELL VACUOLE; CORD BLOOD STEM CELL TRANSPLANTATION; CRYPT CELL; CYTOKINE RELEASE; ENGRAFTMENT; EX VIVO STUDY; FEEDER CELL; FLOW CYTOMETRY; GRAFT VERSUS HOST REACTION; HEMATOPOIESIS; HISTOLOGY; HLA TYPING; HUMAN; HUMAN CELL; IN VIVO STUDY; INTESTINE CELL; MESENCHYMAL STROMA CELL; MIXED LYMPHOCYTE REACTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; SURVIVAL; UMBILICAL CORD BLOOD;

ANIMALS; BONE MARROW CELLS; CELLS, CULTURED; COCULTURE TECHNIQUES; FETAL BLOOD; GRAFT VS HOST DISEASE; HEMATOPOIESIS; HUMANS; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMAL CELLS; MICE; T-LYMPHOCYTES, REGULATORY; TRANSPLANTATION, HETEROLOGOUS;

EID: 84875702865     PISSN: 14653249     EISSN: 14772566     Source Type: Journal    
DOI: 10.1016/j.jcyt.2012.12.007     Document Type: Article

References (27)

1. T.A.S. Amos, and M.Y. Gordon Sources of human hematopoietic stem-cells for transplantation - a review Cell Transplant 4 1995 547 569
2. J.N. Barker, and J.E. Wagner Umbilical cord blood transplantation: current practice and future innovations Crit Rev Oncol Hematol 48 2003 35 43
3. A. Sideri, N. Neokleous, G.P. Brunet de la, B. Guerton, M.C. Le Bousse Kerdiles, and G. Uzan An overview of the progress on double umbilical cord blood transplantation Haematologica 96 2011 1213 1220
4. L.K. Eldjerou, S. Chaudhury, L.A. Baisre-de, M. He, M.E. Arcila, and G. Heller An in vivo model of double-unit cord blood transplantation that correlates with clinical engraftment Blood 116 2010 3999 4006
5. M. De Lima, J. McMannis, A. Gee, K. Komanduri, D. Couriel, and B.S. Andersson Transplantation of ex vivo expanded cord blood cells using the copper chelator tetraethylenepentamine: a phase I/II clinical trial Bone Marrow Transplant 41 2008 771 778
6. G. Goldstein, A. Toren, and A. Nagler Human umbilical cord blood biology, transplantation and plasticity Curr Med Chem 13 2006 1249 1259
7. S.N. Robinson, P.J. Simmons, H. Yang, A.M. Alousi, L.J. Marcos de, and E.J. Shpall Mesenchymal stem cells in ex vivo cord blood expansion Best Pract Res Clin Haematol 24 2011 83 92
8. Q. Bashir, S.N. Robinson, M.J. de Lima, S. Parmar, and E. Shpall Umbilical cord blood transplantation Clin Adv Hematol Oncol 8 2010 786 801
9. S.N. Robinson, J. Ng, T. Niu, H. Yang, J.D. McMannis, and S. Karandish Superior ex vivo cord blood expansion following co-culture with bone marrow-derived mesenchymal stem cells Bone Marrow Transplant 37 2006 359 366
10. C. Delaney, S. Heimfeld, C. Brashem-Stein, H. Voorhies, R.L. Manger, and I.D. Bernstein Notch-mediated expansion of human cord blood progenitor cells capable of rapid myeloid reconstitution Nat Med 16 2010 232 236
11. M. De Lima, J.D. Mcmannis, C. Hosing, P. Kebriaei, S. Robinson, and S. Kelly Rapid engraftment of neutrophils and platelets with mesenchymal stem cell based cord blood (CB) expansion (EXP). Poster presented at: 51st ASH Annual Meeting and Exposition Blood 2009 114(3394a)
12. A. Sideri, N. Neokleous, P.B. De La Grange, B. Guerton, M.C. Le Bousse Kerdilles, and G. Uzan An overview of the progress on double umbilical cord blood transplantation Haematologica 96 2011 1213 1220
13. N. Neokleous, A. Sideri, and C. Peste-Tsilimidos Double cord blood transplantation: co-operation or competition? Hematol Rep 3 2011 e6
14. K. Ballen, A.M. Mendizabal, C. Cutler, I. Politikos, K. Jamieson, and E.J. Shpall Phase II trial of parathyroid hormone after double umbilical cord blood transplantation Biol Blood Marrow Transplant 18 2012 1851 1858
15. J.A. Somers, A. Brand, H.Y. van, A. Mulder, M. Oudshoorn, and K. Sintnicolaas Double umbilical cord blood transplantation: a study of early engraftment kinetics in leukocyte subsets using HLA-specific monoclonal antibodies Biol Blood Marrow Transplant 19 2013 266 273
16. C.Y. Fong, K. Gauthaman, S. Cheyyatraivendran, H.D. Lin, A. Biswas, and A. Bongso Human umbilical cord Wharton's jelly stem cells and its conditioned medium support hematopoietic stem cell expansion ex vivo J Cell Biochem 113 2012 658 668
17. A. Matsumoto, S. Takeishi, T. Kanie, E. Susaki, I. Onoyama, and Y. Tateishi p57 is required for quiescence and maintenance of adult hematopoietic stem cells Cell Stem Cell 9 2011 262 271
18. C.C. Zhang, M. Kaba, S. Iizuka, H. Huynh, and H.F. Lodish Angiopoietin-like 5 and IGFBP2 stimulate ex vivo expansion of human cord blood hematopoietic stem cells as assayed by NOD/SCID transplantation Blood 111 2008 3415 3423
19. H.J. Deeg, R. Storb, E.D. Thomas, N. Flournoy, M.S. Kennedy, and M. Banaji Cyclosporine as prophylaxis for graft-versus-host disease: a randomized study in patients undergoing marrow transplantation for acute nonlymphoblastic leukemia Blood 65 1985 1325 1334
20. L. Hao, L. Gao, X.H. Chen, Z.M. Zou, X. Zhang, and P.Y. Kong Human umbilical cord blood-derived stromal cells prevent graft-versus-host disease in mice following haplo-identical stem cell transplantation Cytotherapy 13 2011 83 91
21. J.A. Grass, T. Wafa, A. Reames, D. Wages, L. Corash, and J.L. Ferrara Prevention of transfusion-associated graft-versus-host disease by photochemical treatment Blood 93 1999 3140 3147
22. G.R. Hill, J.M. Crawford, K.R. Cooke, Y.S. Brinson, L. Pan, and J.L. Ferrara Total body irradiation and acute graft-versus-host disease: the role of gastrointestinal damage and inflammatory cytokines Blood 90 1997 3204 3213
23. L.M. Ong, X. Fan, P.P. Chu, F.P. Gay, S. Bari, and J.M. Ang Cotransplantation of ex vivo expanded and unexpanded cord blood units in immunodeficient mice using insulin growth factor binding protein-2-augmented mesenchymal cell cocultures Biol Blood Marrow Transplant 18 2012 674 682
24. R. Abdi, P. Fiorina, C.N. Adra, M. Atkinson, and M.H. Sayegh Immunomodulation by mesenchymal stem cells: a potential therapeutic strategy for type 1 diabetes Diabetes 57 2008 1759 1767
25. S.K. Sze, D.P. de Kleijn, R.C. Lai, T.E. Khia Way, H. Zhao, and K.S. Yeo Elucidating the secretion proteome of human embryonic stem cell-derived mesenchymal stem cells Mol Cell Proteomics 6 2007 1680 1689
26. P.L. Bollyky, B.A. Falk, S.A. Long, A. Preisinger, K.R. Braun, and R.P. Wu CD44 costimulation promotes FoxP3+ regulatory T cell persistence and function via production of IL-2, IL-10, and TGF-beta J Immunol 183 2009 2232 2241
27. A. Scholzen, D. Mittag, S.J. Rogerson, B.M. Cooke, and M. Plebanski Plasmodium falciparum-mediated induction of human CD25Foxp3 CD4 T cells is independent of direct TCR stimulation and requires IL-2, IL-10 and TGFbeta PLoS Pathog 5 2009 e1000543