VDR hypermethylation and HIV-induced T cell loss

Journal of Leukocyte Biology

Volumn 93, Issue 4, 2013, Pages 623-631

  Chandel, Nirupama ^a   Husain, Mohammad ^a   Goel, Hersh ^a   Salhan, Divya ^a   Lan, Xiqian ^a   Malhotra, Ashwani ^a   McGowan, Joseph ^a   Singhal, Pravin C ^a  

^a HOFSTRA UNIVERSITY   (United States)

Author keywords

DNA methyltransferase; Double strand break; Reactive oxygen species; Renin angiotensin system

Indexed keywords

AZACITIDINE; CATALASE; DNA METHYLTRANSFERASE 3B; LOSARTAN; REACTIVE OXYGEN METABOLITE; SEOCALCITOL; TEMPOL; VITAMIN D RECEPTOR;

APOPTOSIS; ARTICLE; CELL LOSS; CONTROLLED STUDY; CPG ISLAND; DNA REPAIR; DNA STRAND BREAKAGE; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; METHYLATION; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE;

ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS; ANTIMETABOLITES, ANTINEOPLASTIC; APOPTOSIS; AZACITIDINE; CALCITRIOL; CATALASE; CELLS, CULTURED; CPG ISLANDS; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DNA METHYLATION; DNA REPAIR; ENZYME INHIBITORS; EPIGENESIS, GENETIC; GENE EXPRESSION REGULATION, NEOPLASTIC; HIV-1; HUMANS; LOSARTAN; LYMPHOCYTE COUNT; RAS PROTEINS; REACTIVE OXYGEN SPECIES; RECEPTORS, CALCITRIOL; T-LYMPHOCYTES;

EID: 84875677701     PISSN: 07415400     EISSN: 19383673     Source Type: Journal    
DOI: 10.1189/jlb.0812383     Document Type: Article

References (36)

1. Lang, W., Perkins, H., Anderson, R. E., Royce, R., Jewell, N., Winkelstein Jr., W. (1989) Patterns of T lymphocyte changes with human immunodeficiency virus infection: from seroconversion to the development of AIDS. J. Acquir. Immune Defic. Syndr. 2, 63-69.
2. Baker, J. V., Peng, G., Rapkin, J., Krason, D., Reilly, C., Cavert, W. P., Abrams, D. I., MacArthur, R. D., Henry, K., Neaton, J. D. (2008) Terry Beirn Community Programs for Clinical Research on AIDS (CPCRA). Poor initial CD4+ recovery with antiretroviral therapy prolongs immune depletion and increases risk for AIDS and non-AIDS diseases. J. Acquir. Immune Defic. Syndr. 48, 541-546.
3. Lewin, S. R., Rouzioux, C. (2011) HIV cure and eradication: how will we get from the laboratory to effective clinical trials? AIDS 25, 885-897.
4. Buhl, R., Holroyd, K. J., Mastrangeli, A., Cantin, A. M., Jaffe, H. A., Wells, F. B., Saltini, C. (1989) Systemic glutathione deficiency in symptom-free HIV-seropositive individuals. Lancet 2, 1294-1198.
5. Droege, W. (1993) Cysteine and glutathione deficiency in AIDS patients: a rationale for the treatment with N-acetyl-cysteine. Pharmacology 46, 61-65.
6. Dworkin, B. M. (1994) Selenium deficiency in HIV infection and the acquired deficiency syndrome (AIDS). Chem. Biol. Interact. 91, 181-186.
7. Eck, H. P., Stahl-Henning, C., Hunsmann, G., Droege, W. (1991) Metabolic disorder as early consequence of simian immunodeficiency virus infection in rhesus macaques. Lancet 338, 346-347.
8. Giorgi, G., Michell, L., Fiaschi, A. I., Dal Pra, P., Bozzo, M. (1990) Glutathione deficiency in human HIV infection. Pharmacol. Res. 22 (Suppl. 2), 231.
9. Favier, A., Sappey, C., Leclerc, P., Faure, P. Micoud, M. (1994) Antioxidant status and lipid peroxidation in patients infected with HIV. Chem. Biol. Interact. 91, 165-180.
10. Sonnerberg, A., Carlin, G., Akerlund, B., Jastrand, C. (1988) Increased production of malondialdehyde in patients with HIV infection. Scand. J. Infect. Dis. 20, 287-290.
11. Nabel, G. E., Baltimore, D. (1987) An inducible transcription factor activates expression of human immunodeficiency virus in T-cells. Nature 326, 711-713.
12. Fidelus, R. K. (1990) The generation of oxygen radicals: a positive signal for lymphocyte activation. Cell Immunol. 113, 175-182.
13. Stephensen, C. B., Marquis, G. S., Douglas, S. D., Wilson, C. M. (2005) Immune activation and oxidative damage in HIV-positive and HIV-negative adolescents. J. Acquir. Immune Defic. Syndr. 38, 180-190.
14. Wolf, G. (2005) Role of reactive oxygen species in angiotensin II-mediated renal growth, differentiation, and apoptosis. Antioxid. Redox Signal. 7, 1337-1345.
15. Kim, C. H., Vaziri, N. D. (2005) Hypertension promotes integrin expression and reactive oxygen species generation by circulating leukocytes. Kidney Int. 67, 1462-1470.
16. Senchenkova, E. Y., Russell, J., Kurmaeva, E., Ostanin, D., Granger, D. N. (2011) Role of T lymphocytes in angiotensin II-mediated microvascular thrombosis. Hypertension 58, 959-965.
17. Li, Y. C., Kong, J., Wei, M., Chen, Z. F., Liu, S. Q., Cao, L. P. (2002) 1, 25-Dihydroxyvitamin D (3) is a negative endocrine regulator of the renin-angiotensin system. J. Clin. Invest. 110, 229-238.
18. Li, Y. C., Qiao, G., Uskokovic, M., Xiang, W., Zheng, W., Kong, J. Vitamin, D. (2004) A negative endocrine regulator of the renin-angiotensin system and blood pressure. J. Steroid Biochem. Mol. Biol. 89-90, 387-392.
19. Von Essen, M. R., Kongsbak, M., Schjerling, P., Olgaard, K., Odum, N., Geisler, C. (2010) Vitamin D controls T cell antigen receptor signaling and activation of human T cells. Nat. Immunol. 11, 344-349.
20. Irvin, B. J., Williams, B. L., Nilson, A. E., Maynor, H. O., Abraham, R. T. (2000) Pleiotropic contributions of phospholipase C-β1 (PLC-β1) to Tcell antigen receptor-mediated signaling: reconstitution studies of a PLC-β1-deficient Jurkat T-cell line. Mol. Cell Biol. 20, 9149-9161.
21. Christakos, S., Dhawan, P., Benn, B., Porta, A., Hediger, M., Oh, G. T., Jeung, E. B., Zhong, Y., Ajibade, D., Dhawan, K., Joshi, S. (2007) Vitamin D: molecular mechanism of action. Ann. N. Y. Acad. Sci. 1116, 340-348.
22. Arrowsmith, C. H., Bountra, C., Fish, P. V., Lee, K., Schapira, M. (2012) Epigenetic protein families: a new frontier for drug discovery. Nat. Rev. Drug Discov. 11, 384-400.
23. Salhan, D., Husain, M., Subrati, A., Goyal, R., Singh, T., Rai, P., Malhotra, A., Singhal, P. C. (2012) HIV-induced tubular cell injury: role of ROS-induced down regulated VDR. Am. J. Physiol. Renal Physiol. 303, F503-F514.
24. Zhang, Y., Jeltsch, A. (2010) The application of next generation sequencing in DNA methylation analysis. Genes 1, 85-101.
25. Marik, R., Fackler, M., Gabrielson, E., Zeiger, M. A., Sukumar, S., Stearns, V., Umbricht, C. B. (2010) DNA methylation-related vitamin D receptor insensitivity in breast cancer. Cancer Biol. Ther. 10, 44-53.
26. Su, J., Yan, H., Wei, Y., Liu, H., Liu, H., Wang, F., Lv, J., Wu, Q., Zhang, Y. (2013) CpG γMPs: identification of CpG methylation patterns of genomic regions from high-throughput bisulfite sequencing data. Nucleic Acids Res. 41, 1-15.
27. Youngblood, B., Reich, N. O. (2008) The early expressed HIV-1 genes regulate DNMT1 expression. Epigenetics 3, 149-156.
28. Perry, S. W., Norman, J. P., Litzburg, A., Zhang, D., Dewhurst, S., Gelbard, H. A. (2005) HIV-1 transactivator of transcription protein induces mitochondrial hyperpolarization and synaptic stress leading to apoptosis. J. Immunol. 174, 4333-4344.
29. Demple, B., Harrison, L. (1994) Repair of oxidative damage to DNA: enzymology and biology. Annu. Rev. Biochem. 63, 915-948.
30. Duthie, S. J., Ma, A., Ross, M. A., Collins, A. R. (1996) Antioxidant supplementation decreases oxidative DNA damage in human lymphocytes. Cancer Res. 56, 1291-1295.
31. Cummins, N. W., Badley, A. D. (2010) Mechanisms of HIV-associated lymphocyte apoptosis: 2010. Cell Death Dis. 1, e99.
32. Minami, R., Yamamoto, M., Takahama, S., Miyamura, T., Watanabe, H., Suematsu, E. (2006) RCAS1 induced by HIV-Tat is involved in the apoptosis of HIV-1 infected and uninfected CD4+ T cells. Cell Immunol. 243, 41-47.
33. Mitra, D., Steiner, M., Lynch, D. H., Staiano-Coico, L., Laurence, J. (1996) HIV-1 upregulates Fas ligand expression in CD4+ T cells in vitro and in vivo: association with Fas-mediated apoptosis and modulation by aurintricarboxylic acid. Immunology 87, 581-585.
34. Ndolo, T., Dhillon, N. K., Nguyen, H., Guadalupe, M., Mudryj, M., Dandekar, S. (2002) Simian immunodeficiency virus Nef protein delays the progression of CD4+ T cells through G1/S phase of the cell cycle. J. Virol. 76, 3587-3595.
35. Oyaizu, N., McCloskey, T. W., Than, S., Hu, R., Pahwa, S. (1995) Mechanism of apoptosis in peripheral blood mononuclear cells of HIV-infected patients. Adv. Exp. Med. Biol. 374, 101-114.
36. Yamshchikov, A. V., Desai, N. S., Blumberg, H. M., Ziegler, T. R., Tangpricha, V. (2009) Vitamin D for treatment and prevention of infectious diseases: a systematic review of randomized controlled trials. Endocr. Pract. 15, 438-449.