Fragment-Based Design of Novel Quinazolinon Derivatives as Human Acrosin Inhibitors

Chemical Biology and Drug Design

Volumn 81, Issue 4, 2013, Pages 437-441

  Ning, Weiwei ^a   Zhu, Ju ^a   Zheng, Canhui ^a   Liu, Xuefei ^a   Song, Yunlong ^a   Zhou, Youjun ^a   Zhang, Xiaomeng ^a   Zhang, Ling ^a   Sheng, Chunquan ^a   Lv, Jiaguo ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Binding mode; Human acrosin; Lead structure; Male contraceptives; Quinazolinon inhibitor

Indexed keywords

4 AMINOBENZAMIDINE; 4 GUANIDINOBENZOATE; ACROSIN; CONTRACEPTIVE AGENT; ISOXAZOLECARBALDEHYDE; N ALPHA TOSYL LYSYL CHLOROMETHYLKETONE; QUINAZOLINONE DERIVATIVE; SERINE PROTEINASE INHIBITOR; SURAMIN; UNCLASSIFIED DRUG;

ARTICLE; BIOASSAY; DRUG DESIGN; DRUG SYNTHESIS; FRAGMENTATION REACTION; HYDROGEN BOND; HYDROPHOBICITY; IC 50; IN VITRO STUDY; MOLECULAR DOCKING; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

ACROSIN; BINDING SITES; CATALYTIC DOMAIN; DRUG DESIGN; HUMANS; HYDROGEN BONDING; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MOLECULAR DOCKING SIMULATION; QUINAZOLINONES; SERINE PROTEINASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84875670729     PISSN: 17470277     EISSN: 17470285     Source Type: Journal    
DOI: 10.1111/cbdd.12106     Document Type: Article

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