Alterations in the tear proteome of dry eye patients-A matter of the clinical phenotype

Investigative Ophthalmology and Visual Science

Volumn 54, Issue 3, 2013, Pages 2385-2392

  Boehm, Nils ^a   Funke, Sebastian ^a   Wiegand, Michaela ^a   Wehrwein, Nelli ^a   Pfeiffer, Norbert ^a   Grus, Franz H ^a  

^a UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BETA 2 MICROGLOBULIN; BIOLOGICAL MARKER; CALGRANULIN; MAMMAGLOBIN B; PROLINE RICH PROTEIN; PROTEOLIPID PROTEIN; PROTEOME; TEAR PROTEIN;

ARTICLE; CONTROLLED STUDY; DRY EYE; FEMALE; HUMAN; INFORMATION PROCESSING; MAJOR CLINICAL STUDY; MALE; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; NASOPHARYNX CARCINOMA; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ANALYSIS; RETINA TEAR; SCORING SYSTEM; SENSITIVITY AND SPECIFICITY; SURFACE ENHANCED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY;

ADULT; AGED; BIOLOGICAL MARKERS; DRY EYE SYNDROMES; EYE PROTEINS; FEMALE; HUMANS; MALE; MIDDLE AGED; PHENOTYPE; PROTEOME; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TEARS;

EID: 84875666688     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.11-8751     Document Type: Article

References (39)

1. DEWS. Research in dry eye: report of the Research Subcommittee of the International Dry Eye WorkShop (2007). Ocul Surf. 2007;5:179-193.
2. Lemp MA. Report of the National Eye Institute/Industry workshop on Clinical Trials in Dry Eyes. CLAO J. 1995;21: 221-232.
3. Schein OD, Munoz B, Tielsch JM, Bandeen-Roche K, West K. Prevalence of dry eye among the elderly. Am J Ophthalmol. 1997;124:723-728.
4. Jie Y, Xu L, Wu YY, Jonas JB. Prevalence of dry eye among adult Chinese in the Beijing Eye Study. Eye (Lond). 2009;23:688-693.
5. Guo B, Lu P, Chen X, Zhang R, Chen W. Prevalence of dry eye disease in Mongolians at high altitude in China: the Henan eye study. Ophthalmic Epidemiol. 2010;17:234-241.
6. Lee AJ, Lee J, Saw SM, et al. Prevalence and risk factors associated with dry eye symptoms: a population based study in Indonesia. Br J Ophthalmol. 2002;86:1347-1351.
7. Khanal S, Tomlinson A, Diaper CJ. Tear physiology of aqueous deficiency and evaporative dry eye. Optom Vis Sci. 2009;86: 1235-1240.
8. Sullivan BD, Whitmer D, Nichols KK, et al. An objective approach to dry eye disease severity. Invest Ophthalmol Vis Sci. 2010;51:6125-6130.
9. Versura P, Profazio V, Campos EC. Performance of tear osmolarity compared to previous diagnostic tests for dry eye diseases. Curr Eye Res. 2010;35:553-564.
10. Suzuki M, Massingale ML, Ye F, et al. Tear osmolarity as a biomarker for dry eye disease severity. Invest Ophthalmol Vis Sci. 2010;51:4557-4561.
11. Lam H, Bleiden L, de Paiva CS, et al. Tear cytokine profiles in dysfunctional tear syndrome. Am J Ophthalmol. 2009;147: 198-205, e1.
12. Massingale ML, Li X, Vallabhajosyula M, et al. Analysis of inflammatory cytokines in the tears of dry eye patients. Cornea. 2009;28:1023-1027.
13. Boehm N, Riechardt AI, Wiegand M, Pfeiffer N, Grus FH. Proinflammatory cytokine profiling of tears from dry-eye patients by means of antibody-microarrays. Invest Ophthalmol Vis Sci. 2011;52:7725-7730.
14. Lei Z, Beuerman RW, Chew AP, et al. Quantitative analysis of Nlinked glycoproteins in tear fluid of climatic droplet keratopathy by glycopeptide capture and iTRAQ. J Proteome Res. 2009;8:1192-2003.
15. Tomosugi N, Kitagawa K, Takahashi N, Sugai I, Ishikawa S. Diagnostic potential of tear proteomic patterns in Sjogren's syndrome. J Proteome Res. 2005;4:820-825.
16. Tsai PS, Evans JE, Green KM, et al. Proteomic analysis of human meibomian gland secretions. Br J Ophthalmol. 2006; 90:372-377.
17. Zhou L, Beuerman RW, Ang LP, et al. Elevation of human alphadefensins and S100 calcium-binding proteins A8 and A9 in tear fluid of patients with pterygium. Invest Ophthalmol Vis Sci. 2009;50:2077-2086.
18. Li K, Liu X, Chen Z, Huang Q, Wu K. Quantification of tear proteins and sPLA2-IIa alteration in patients with allergic conjunctivitis. Mol Vis. 2010;16:2084-2091.
19. Herber S, Grus FH, Sabuncuo P, Augustin AJ. Two-dimensional analysis of tear protein patterns of diabetic patients. Electrophoresis. 2001;22:1838-1844.
20. Zhou L, Beuerman RW, Chan CM, et al. Identification of tear fluid biomarkers in dry eye syndrome using iTRAQ quantitative proteomics. J Proteome Res. 2009;8:4889-4905.
21. Ohashi Y, Ishida R, Kojima T, et al. Abnormal protein profiles in tears with dry eye syndrome. Am J Ophthalmol. 2003;136: 291-299.
22. Danjo Y, Lee M, Horimoto T, Hamano K. Ocular surface damage and tear lactoferrin in dry eye syndrome. Acta Ophthalmol (Copenh). 1994;72:433-437.
23. Grus FH, Podust VN, Bruns K, et al. SELDI-TOF-MS ProteinChip array profiling of tears from patients with dry eye. Invest Ophthalmol Vis Sci. 2005;46:863-876.
24. Green-Church KB, Nichols KK, Kleinholz NM, Zhang L, Nichols JJ. Investigation of the human tear film proteome using multiple proteomic approaches. Mol Vis. 2008;14:456-470.
25. Saijyothi AV, Angayarkanni N, Syama C, et al. Two dimensional electrophoretic analysis of human tears: collection method in dry eye syndrome. Electrophoresis. 2010;31:3420-3427.
26. Hoh H, Schirra F, Kienecker C, Ruprecht KW. Lid-parallel conjunctival folds are a sure diagnostic sign of dry eye [in German]. Ophthalmologe. 1995;92:802-808.
27. Foulks GN, Bron AJ. Meibomian gland dysfunction: a clinical scheme for description, diagnosis, classification, and grading. Ocul Surf. 2003;1:107-126.
28. DEWS. The definition and classification of dry eye disease: report of the Definition and Classification Subcommittee of the International Dry Eye WorkShop (2007). Ocul Surf. 2007; 5:75-92.
29. Tong L, Zhou L, Beuerman RW, Zhao SZ, Li XR. Association of tear proteins with Meibomian gland disease and dry eye symptoms. Br J Ophthalmol. 2010;95:848-852.
30. Grus FH, Augustin AJ. Analysis of tear protein patterns by a neural network as a diagnostical tool for the detection of dry eyes. Electrophoresis. 1999;20:875-880.
31. Grus FH, Zimmermann CW. Identification and classification of autoantibody repertoires (Western blots) with a pattern recognition algorithm by an artificial neural network. Electrophoresis. 1997;18:1120-1125.
32. Kramann C, Boehm N, Lorenz K, et al. Effect of contact lenses on the protein composition in tear film: a ProteinChip study. Graefes Arch Clin Exp Ophthalmol. 2011;249:233-243.
33. Versura P, Nanni P, Bavelloni A, et al. Tear proteomics in evaporative dry eye disease. Eye (Lond). 2010;24:1396-1402.
34. Dickinson DP, Thiesse M. A major human lacrimal gland mRNA encodes a new proline-rich protein family member. Invest Ophthalmol Vis Sci. 1995;36:2020-2031.
35. Fung KY, Morris C, Sathe S, Sack R, Duncan MW. Characterization of the in vivo forms of lacrimal-specific proline-rich proteins in human tear fluid. Proteomics. 2004;4:3953-3959.
36. Nichols JJ, Green-Church KB. Mass spectrometry-based proteomic analyses in contact lens-related dry eye. Cornea. 2009;28:1109-1117.
37. Lehrer RI, Xu G, Abduragimov A, et al. Lipophilin, a novel heterodimeric protein of human tears. FEBS Lett. 1998;432: 163-167.
38. Kerkhoff C, Klempt C, Sorg M. Novel insights into structure and function of MRP8 (S100A8) and MRP14 (S100A9). Biochim Biophys Acta. 1998;1448:200-211.
39. Roth J, Vogl T, Sorg C, Sunderkotter C. Phagocyte-specific S100 proteins: a novel group of proinflammatory molecules. Trends Immunol. 2003;24:155-158.