Class III PI3K Vps34: Essential roles in autophagy, endocytosis, and heart and liver function

Annals of the New York Academy of Sciences

Volumn 1280, Issue 1, 2013, Pages 48-51

  Jaber, Nadia ^a   Zong, Wei Xing ^a  

^a STONY BROOK UNIVERSITY   (United States)

Author keywords

Authophagy; Endocytosis; Homeostasis; PI3K; Vps34

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; 3 METHYLADENINE; AUTOPHAGY PROTEIN 5; CRE RECOMBINASE; EPIDERMAL GROWTH FACTOR RECEPTOR; MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATIDYLINOSITOL; PHOSPHATIDYLINOSITOL 3 KINASE; WORTMANNIN;

ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CELL SURVIVAL; DNA DAMAGE; ELECTRON MICROSCOPY; ENDOCYTOSIS; ENDOSOME; ENZYME ACTIVITY; FATTY LIVER; GENE DELETION; GENETIC SCREENING; HEART FUNCTION; HEPATOMEGALY; HOMEOSTASIS; HUMAN; IN VITRO STUDY; IN VIVO STUDY; INTRACELLULAR SIGNALING; KNOCKOUT GENE; LIVER FUNCTION; NONHUMAN; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN METABOLISM; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; YEAST;

EID: 84875656897     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/nyas.12026     Document Type: Article

References (10)

1. Kihara, A., T. Noda, N. Ishihara & Y. Ohsumi. 2001. Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase Y sorting in Saccharomyces cerevisiae. J. Cell Biol. 152: 519-530.
2. Rabinowitz, J.D. & E. White. 2010. Autophagy and metabolism. Science 330: 1344-1348.
3. Mizushima, N., B. Levine, A.M. Cuervo & D.J. Klionsky. 2008. Autophagy fights disease through cellular self-digestion. Nature 451: 1069-1075.
4. Huotari, J. & A. Helenius. 2011. Endosome maturation. EMBO J. 30: 3481-3500.
5. Volinia, S. et al. 1995. A human phosphatidylinositol 3-kinase complex related to the yeast Vps34p-Vps15p protein sorting system. EMBO J. 14: 3339-3348.
6. Blommaart, E.F., U. Krause, J.P. Schellens, H. Vreeling-Sindelarova & A.J. Meijer. 1997. The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes. Europ. J. Biochem. 243: 240-246.
7. Petiot, A., E. Ogier-Denis, E.F. Blommaart, A.J. Meijer & P. Codogno. 2000. Distinct classes of phosphatidylinositol 3'-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells. J. Biol.l Chem. 275: 992-998.
8. Backer, J.M. 2008. The regulation and function of Class III PI3Ks: novel roles for Vps34. Biochem. J. 410: 1-17.
9. Zhou, X. et al. 2010. Deletion of PIK3C3/Vps34 in sensory neurons causes rapid neurodegeneration by disrupting the endosomal but not the autophagic pathway. Proc. Natl. Acad. Sci. USA 107: 9424-9429.
10. Jaber, N. et al. 2012. Class III PI3K Vps34 plays an essential role in autophagy and in heart and liver function. Proc. Natl. Acad. Sci. USA 109: 2003-2008.