Expert-based drug lists to measure anticholinergic burden: Similar names, different results

Psychogeriatrics

Volumn 13, Issue 1, 2013, Pages 17-24

  Lertxundi, Unax ^a   Domingo Echaburu, Saioa ^b   Hernandez, Rafael ^a   Peral, Javier ^c   Medrano, Juan ^a  

^a Red de Salud Mental de Araba   (Spain)

^b Hospital Alto Deba   (Spain)

^c HOSPITAL DE GALDAKAO   (Spain)

Author keywords

Cholinergics antagonists adverse effects; Drug utilization; Observer variation

Indexed keywords

ALPRAZOLAM; AMANTADINE; AMITRIPTYLINE; AMPICILLIN; ATROPINE; AZATHIOPRINE; BENZATROPINE; BROMOCRIPTINE; BROMPHENIRAMINE; CAPTOPRIL; CARBAMAZEPINE; CARBINOXAMINE; CEFALOTIN; CEFAMANDOLE; CHLORDIAZEPOXIDE; CHLORPHENIRAMINE; CHLORPROMAZINE; CHLORTALIDONE; CHOLINERGIC RECEPTOR BLOCKING AGENT; CIMETIDINE; CLEMASTINE; CLINDAMYCIN; CLOMIPRAMINE; CLONAZEPAM; CLORAZEPATE; CLOZAPINE; CODEINE; CYCLOBENZAPRINE; CYPROHEPTADINE; UNINDEXED DRUG;

AGED; ANTICHOLINERGIC COGNITIVE BURDEN SCALE; ANTICHOLINERGIC DRUG SCALE; ANTICHOLINERGIC RISK SCALE; ANTICHOLINERGIC SYNDROME; ARTICLE; CLINICAL ASSESSMENT; HOSPITALIZATION; HUMAN; LENGTH OF STAY; MAJOR CLINICAL STUDY; MENTAL HOSPITAL; PRIORITY JOURNAL; SCORING SYSTEM;

AGED; AGED, 80 AND OVER; CHOLINERGIC ANTAGONISTS; COGNITION; COGNITION DISORDERS; COST OF ILLNESS; DRUG UTILIZATION; FEMALE; HUMANS; MALE; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY;

EID: 84875651990     PISSN: 13463500     EISSN: 14798301     Source Type: Journal    
DOI: 10.1111/j.1479-8301.2012.00418.x     Document Type: Article

References (20)

1. Campbell N, Boustani M, Limbil T etal. The cognitive impact of anticholinergics: a clinical review. Clin Interv Aging 2009; 4: 225-233.
2. Mulsant B, Pollock B, Kirshner M, Shen C, Ganguly M. Serum anticholinergic activity in a community-based sample of older adults. Arch Gen Psychiatry 2003; 60: 198-203.
3. Plaschke K, Kopitz J, Mattern J, Martin E, Teschendorf P. Increased cortisol levels and anticholinergic activity in cognitively unimpaired patients. J Neuropsychiatry Clin Neurosci 2010; 22: 433-441.
4. Flacker JM, Wei JY. Endogenous anticholinergic substances may exist during acute illness in elderly medical patients. J Gerontol A Biol Sci Med Sci 2001; 56: 353-355.
5. Hori K, Konishi K, Watanabe K etal. Influence of anticholinergic activity in serum on clinical symptoms of Alzheimer's disease. Neuropsychobiology 2011; 63: 147-153.
6. Rudd KM, Raehl CL, Bond CA, Abbruscato TJ, Stenhouse AC. Methods for assessing drug-related anticholinergic activity. Pharmacotherapy 2005; 25: 1592-1601.
7. Carnahan RM, Lund BC, Perry PJ, Pollock BG, Culp KR. The anticholinergic drug scale as a measure of drug-related anticholinergic burden. Associations with serum anticholinergic activity. J Clin Pharmacol 2006; 46: 1481-1486.
8. Rudolph J, Salow MJ, Angelini MC, McGlinchey RE. The anticholinergic risk scale and anticholinergic adverse effects in older persons. Arch Intern Med 2008; 165: 508-513.
9. Kumpula EK, Bell JS, Soini H, Pitkälä H. Anticholinergic drug use and mortality among residents of long-term care facilities: a prospective cohort study. J Clin Pharmacol 2011; 51: 256-263.
10. Lowry E, Woodman RJ, Soiza RL, Mangoni A. Associations between the Anticholinergic risk scale score and physical function: potential implications for adverse outcomes in older hospitalized patients. J Am Med Dir Assoc 2011; 12: 565-572.
11. Boustani MA, Campbell NL, Munger S, Maidment I, Fox GC. Impact of anticholinergics on the aging brain: a review and practical application. Aging Health 2008; 4: 311-320.
12. Fox C, Richardson K, Maidment ID etal. Anticholinergic medication use and cognitive impairment in the older population: the medical research council cognitive function and ageing study. J Am Geriatr Soc 2011; 59: 1477-1483.
13. Kolanowski A, Fick DM, Campbell J, Litaker M, Boustani M. A preliminary study of anticholinergic burden and relationship to a quality of life indicator, engagement in activities, in nursing home residents with dementia. J Am Med Dir Assoc 2009; 10: 252-257.
14. Fox C, Livingston G, Maidment ID etal. The impact of anticholinergic burden in Alzheimer's Dementia-the Laser-AD study. Age Ageing 2011; 40: 730-735.
15. Cohen J. A coefficient of agreement for nominal scales. Educ Psychol Meas 1960; 20: 37-46.
16. Bland MJ, Altman DG. Statistical methods for assessing agreement between two methods of clinical measurement. Lancet 1986; 1: 307-310.
17. Practice guideline for the treatment of patients with schizophrenia Second Edition. 2010. Work group on schizophrenia. [Cited 26 Oct 2011.] Available from URL: http://psychiatryonline.org/content.aspx?bookid=28§ionid=1665359#46733
18. Chew ML, Mulsant BH, Pollock BG etal. Anticholinergic activity of 107 medications commonly used by older adults. J Am Geriatr Soc 2008; 56: 1333-1341.
19. Hilmer SN, Mager DE, Simonsick EM etal. A drug burden index to define the functional burden of medications in older people. Arch Intern Med 2007; 23 (167): 781-787.
20. Ministerio de Sanidad y Consumo. Nomenclator digitalis. November 2011. [Cited 7 Nov 2011.] Available from URL: http://www.msc.es/profesionales/farmacia/nomenclatorDI.htm