Using mouse models of autism spectrum disorders to study the neurotoxicology of gene-environment interactions

Neurotoxicology and Teratology

Volumn 36, Issue , 2013, Pages 17-35

  Schwartzer, Jared J ^a   Koenig, Claire M ^a   Berman, Robert F ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Autism; Environmental pollutants; Genetics; Mouse model

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR BETA3; 4,4' ISOPROPYLIDENEDIPHENOL; FIPRONIL; HEAVY METAL; LEAD; MERCURY; NEUREXIN; NEUROLIGIN; ORGANOHALOGEN DERIVATIVE; ORGANOPHOSPHATE PESTICIDE; PESTICIDE; PHTHALIC ACID; PLASTICIZER; POLYBROMINATED DIPHENYL ETHER; POLYCHLORINATED BIPHENYL; PYRETHROID; SYNAPSE RECEPTOR;

4 AMINOBUTYRIC ACID A RECEPTOR BETA3 GENE; AUTISM; AUTOSOMAL DOMINANT DISORDER; COPY NUMBER VARIATION; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL FACTOR; FRAGILE X SYNDROME; GENE; GENE MUTATION; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE ENVIRONMENT INTERACTION; HUMAN; MOLECULAR PATHOLOGY; MOUSE; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; RETT SYNDROME; REVIEW; SYNAPSE; TIMOTHY SYNDROME; UBIQUITIN PROTEIN LIGASE E3 GENE;

ANIMALS; CHILD; CHILD DEVELOPMENT DISORDERS, PERVASIVE; DISEASE MODELS, ANIMAL; GENE-ENVIRONMENT INTERACTION; GENETIC PREDISPOSITION TO DISEASE; HUMANS; RISK FACTORS;

EID: 84875650738     PISSN: 08920362     EISSN: 18729738     Source Type: Journal    
DOI: 10.1016/j.ntt.2012.08.007     Document Type: Review

References (323)

1. Abrahams B.S., Geschwind D.H. Advances in autism genetics: on the threshold of a new neurobiology. Nat Rev Genet 2008, 9(5):341-355.
2. Adams J., Vorhees C.V., et al. Developmental neurotoxicity of anticonvulsants: human and animal evidence on phenytoin. Neurotoxicol Teratol 1990, 12(3):203-214.
3. Ahlbom J., Fredriksson A., et al. Neonatal exposure to a type-I pyrethroid (bioallethrin) induces dose-response changes in brain muscarinic receptors and behaviour in neonatal and adult mice. Brain Res 1994, 645(1-2):318-324.
4. Alkondon M., Costa A.C., et al. Selective blockade of NMDA-activated channel currents may be implicated in learning deficits caused by lead. FEBS Lett 1990, 261(1):124-130.
5. Allen J.R., Barsotti D.A. The effects of transplacental and mammary movement of PCBs on infant rhesus monkeys. Toxicology 1976, 6(3):331-340.
6. Alm H., Scholz B., et al. Proteomic evaluation of neonatal exposure to 2,2,4,4,5-pentabromodiphenyl ether. Environ Health Perspect 2006, 114(2):254-259.
7. Alonso-Magdalena P., Laribi O., et al. Low doses of bisphenol A and diethylstilbestrol impair Ca2+ signals in pancreatic alpha-cells through a nonclassical membrane estrogen receptor within intact islets of Langerhans. Environ Health Perspect 2005, 113(8):969-977.
8. American Psychological Association Diagnostic and statistical manual of mental disorders 2006, Revised, Washington, DC. 4th ed.
9. Amodeo D.A., Jones J.H., et al. Differences in BTBR T+ tf/J and C57BL/6J mice on probabilistic reversal learning and stereotyped behaviors. Behav Brain Res 2012, 227(1):64-72.
10. Andra S.S., Makris K.C. Thyroid disrupting chemicals in plastic additives and thyroid health. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 2012, 30(2):107-151.
11. Ashwood P., Krakowiak P., et al. Elevated plasma cytokines in autism spectrum disorders provide evidence of immune dysfunction and are associated with impaired behavioral outcome. Brain Behav Immun 2011, 25(1):40-45.
12. Atchison W.D., Hare M.F. Mechanisms of methylmercury-induced neurotoxicity. FASEB J 1994, 8(9):622-629.
13. Atchison W.D., Narahashi T. Methylmercury-induced depression of neuromuscular transmission in the rat. Neurotoxicology 1982, 3(3):37-50.
14. Atchison W.D., Joshi U., et al. Irreversible suppression of calcium entry into nerve terminals by methylmercury. J Pharmacol Exp Ther 1986, 238(2):618-624.
15. Auyeung B., Taylor K., et al. Foetal testosterone and autistic traits in 18 to 24-month-old children. Mol Autism 2010, 1(1):11.
16. Baccarelli A., Bollati V. Epigenetics and environmental chemicals. Curr Opin Pediatr 2009, 21(2):243-251.
17. Bader P.L., Faizi M., et al. Mouse model of Timothy syndrome recapitulates triad of autistic traits. Proc Natl Acad Sci U S A 2011, 108(37):15432-15437.
18. Baker K.B., Wray S.P., et al. Male and female Fmr1 knockout mice on C57 albino background exhibit spatial learning and memory impairments. Genes Brain Behav 2010, 9(6):562-574.
19. Bakker C.E., V.C., et al. Fmr1 knockout mice: a model to study fragile X mental retardation. The Dutch-Belgian Fragile X Consortium. Cell 1994, 78(1):23-33.
20. Barlow N.J., McIntyre B.S., et al. Male reproductive tract lesions at 6, 12, and 18months of age following in utero exposure to di(n-butyl) phthalate. Toxicol Pathol 2004, 32(1):79-90.
21. Bear M.F., Huber K.M., et al. The mGluR theory of fragile X mental retardation. Trends Neurosci 2004, 27(7):370-377.
22. Bellinger D.C. Very low lead exposures and children's neurodevelopment. Curr Opin Pediatr 2008, 20(2):172-177.
23. Belmonte M.K., Bourgeron T. Fragile X syndrome and autism at the intersection of genetic and neural networks. Nat Neurosci 2006, 9(10):1221-1225.
24. Belyaeva E.A., Dymkowska D., et al. Mitochondria as an important target in heavy metal toxicity in rat hepatoma AS-30D cells. Toxicol Appl Pharmacol 2008, 231(1):34-42.
25. Bemis J.C., Seegal R.F. PCB-induced inhibition of the vesicular monoamine transporter predicts reductions in synaptosomal dopamine content. Toxicol Sci 2004, 80(2):288-295.
26. Beri S., Tonna N., et al. DNA methylation regulates tissue-specific expression of Shank3. J Neurochem 2007, 101(5):1380-1391.
27. Besis A., Samara C. Polybrominated diphenyl ethers (PBDEs) in the indoor and outdoor environments - a review on occurrence and human exposure. Environ Pollut 2012, 169:217-229.
28. Bienvenu T., Chelly J. Molecular genetics of Rett syndrome: when DNA methylation goes unrecognized. Nat Rev Genet 2006, 7(6):415-426.
29. Bilousova T.V., Dansie L., et al. Minocycline promotes dendritic spine maturation and improves behavioural performance in the fragile X mouse model. J Med Genet 2009, 46(2):94-102.
30. Birnbaum L.S., Staskal D.F. Brominated flame retardants: cause for concern?. Environ Health Perspect 2004, 112(1):9-17.
31. Bizzari S., OppenBerg B., et al. Plasticizers 2000, Chemical economics handbook, Palo Alto, CA, SRI International.
32. Blatt G.J. GABAergic cerebellar system in autism: a neuropathological and developmental perspective. Int Rev Neurobiol 2005, 71:167-178.
33. Boas M., Feldt-Rasmussen U., et al. Thyroid effects of endocrine disrupting chemicals. Mol Cell Endocrinol 2012, 355(2):240-248.
34. Bontekoe C.J., Bakker C.E., et al. Instability of a (CGG)98 repeat in the Fmr1 promoter. Hum Mol Genet 2001, 10(16):1693-1699.
35. Boulton C.L., Southam E., et al. Nitric oxide-dependent long-term potentiation is blocked by a specific inhibitor of soluble guanylyl cyclase. Neuroscience 1995, 69(3):699-703.
36. Bozdagi O., Sakurai T., et al. Haploinsufficiency of the autism-associated Shank3 gene leads to deficits in synaptic function, social interaction, and social communication. Mol Autism 2010, 1(1):15.
37. Braga M.F., Pereira E.F., et al. Nanomolar concentrations of lead inhibit glutamatergic and GABAergic transmission in hippocampal neurons. Brain Res 1999, 826(1):22-34.
38. Bromer J.G., Zhou Y., et al. Bisphenol-A exposure in utero leads to epigenetic alterations in the developmental programming of uterine estrogen response. FASEB J 2010, 24(7):2273-2280.
39. Budimirovic D.B., Kaufmann W.E. What can we learn about autism from studying fragile X syndrome?. Dev Neurosci 2011, 33(5):379-394.
40. Burke K., Cheng Y., et al. Methylmercury elicits rapid inhibition of cell proliferation in the developing brain and decreases cell cycle regulator, cyclin E. Neurotoxicology 2006, 27(6):970-981.
41. Buxbaum J.D., Silverman J.M., et al. Association between a GABRB3 polymorphism and autism. Mol Psychiatry 2002, 7(3):311-316.
42. Caglayan A.O. Genetic causes of syndromic and non-syndromic autism. Dev Med Child Neurol 2010, 52(2):130-138.
43. Calafat A.M., Ye X., et al. Exposure of the U.S. population to bisphenol A and 4-tertiary-octylphenol: 2003-2004. Environ Health Perspect 2008, 116(1):39-44.
44. Calfa G., Percy A.K., et al. Experimental models of Rett syndrome based on Mecp2 dysfunction. Exp Biol Med (Maywood) 2011, 236(1):3-19.
45. Careaga M., Van de Water J., et al. Immune dysfunction in autism: a pathway to treatment. Neurotherapeutics 2010, 7(3):283-292.
46. Casida J.E., Quistad G.B. Organophosphate toxicology: safety aspects of nonacetylcholinesterase secondary targets. Chem Res Toxicol 2004, 17(8):983-998.
47. Chadman K.K. Fluoxetine but not risperidone increases sociability in the BTBR mouse model of autism. Pharmacol Biochem Behav 2011, 97(3):586-594.
48. Chauhan K.R., Kodavanti P.R., et al. Assessing the role of ortho-substitution on polychlorinated biphenyl binding to transthyretin, a thyroxine transport protein. Toxicol Appl Pharmacol 2000, 162(1):10-21.
49. Chen Y.J., Hsu C.C. Effects of prenatal exposure to PCBs on the neurological function of children: a neuropsychological and neurophysiological study. Dev Med Child Neurol 1994, 36(4):312-320.
50. Chen H.H., Ma T., et al. Developmental lead exposure and two-way active avoidance training alter the distribution of protein kinase C activity in the rat hippocampus. Neurochem Res 1997, 22(9):1119-1125.
51. Chen R.Z., Akbarian S., et al. Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice. Nat Genet 2001, 27(3):327-331.
52. Chevrier J., Harley K.G., et al. Polybrominated diphenyl ether (PBDE) flame retardants and thyroid hormone during pregnancy. Environ Health Perspect 2010, 118(10):1444-1449.
53. Ching T.T., Maunakea A.K., et al. Epigenome analyses using BAC microarrays identify evolutionary conservation of tissue-specific methylation of SHANK3. Nat Genet 2005, 37(6):645-651.
54. Churchill G.A., Airey D.C., et al. The Collaborative Cross, a community resource for the genetic analysis of complex traits. Nat Genet 2004, 36(11):1133-1137.
55. Clarkson T.W., Vyas J.B., et al. Mechanisms of mercury disposition in the body. Am J Ind Med 2007, 50(10):757-764.
56. Coburn C.G., Curras-Collazo M.C., et al. In vitro effects of environmentally relevant polybrominated diphenyl ether (PBDE) congeners on calcium buffering mechanisms in rat brain. Neurochem Res 2008, 33(2):355-364.
57. Cohen S., Gabel H.W., et al. Genome-wide activity-dependent MeCP2 phosphorylation regulates nervous system development and function. Neuron 2011, 72(1):72-85.
58. Collins W.T., Capen C.C. Ultrastructural and functional alterations of the rat thyroid gland produced by polychlorinated biphenyls compared with iodide excess and deficiency, and thyrotropin and thyroxine administration. Virchows Arch B Cell Pathol Incl Mol Pathol 1980, 33(3):213-231.
59. Collins W.T., Capen C.C. Biliary excretion of 125I-thyroxine and fine structural alterations in the thyroid glands of Gunn rats fed polychlorinated biphenyls (PCB). Lab Invest 1980, 43(2):158-164.
60. Company R., Serafim A., et al. Effect of cadmium, copper and mercury on antioxidant enzyme activities and lipid peroxidation in the gills of the hydrothermal vent mussel Bathymodiolus azoricus. Mar Environ Res 2004, 58(2-5):377-381.
61. Cook E.H., Scherer S.W. Copy-number variations associated with neuropsychiatric conditions. Nature 2008, 455(7215):919-923.
62. Cook E.H., Lindgren V., et al. Autism or atypical autism in maternally but not paternally derived proximal 15q duplication. Am J Hum Genet 1997, 60(4):928-934.
63. Correia C.T., Coutinho A.M., et al. Increased BDNF levels and NTRK2 gene association suggest a disruption of BDNF/TrkB signaling in autism. Genes Brain Behav 2010, 9(7):841-848.
64. Costa L.G. Current issues in organophosphate toxicology. Clin Chim Acta 2006, 366(1-2):1-13.
65. Costa L.G., Giordano G. Developmental neurotoxicity of polybrominated diphenyl ether (PBDE) flame retardants. Neurotoxicology 2007, 28(6):1047-1067.
66. Crawley J.N. Mouse behavioral assays relevant to the symptoms of autism. Brain Pathol 2007, 17(4):448-459.
67. Crofton K.M., Kodavanti P.R., et al. PCBs, thyroid hormones, and ototoxicity in rats: cross-fostering experiments demonstrate the impact of postnatal lactation exposure. Toxicol Sci 2000, 57(1):131-140.
68. Curtin L.R., Mohadjer L.K., et al. The National Health and Nutrition Examination Survey: sample design, 1999-2006. Vital Health Stat 2012, 2(155):1-39.
69. Dam K., Seidler F.J., et al. Chlorpyrifos exposure during a critical neonatal period elicits gender-selective deficits in the development of coordination skills and locomotor activity. Brain Res Dev Brain Res 2000, 121(2):179-187.
70. David R.M. Proposed mode of action for in utero effects of some phthalate esters on the developing male reproductive tract. Toxicol Pathol 2006, 34(3):209-219.
71. Delahunty C., Falconer S., et al. Levels of neonatal thyroid hormone in preterm infants and neurodevelopmental outcome at 5 1/2years: millennium cohort study. J Clin Endocrinol Metab 2010, 95(11):4898-4908.
72. DeLorey T.M., Handforth A., et al. Mice lacking the beta3 subunit of the GABAA receptor have the epilepsy phenotype and many of the behavioral characteristics of Angelman syndrome. J Neurosci 1998, 18(20):8505-8514.
73. DeLorey T.M., Sahbaie P., et al. Gabrb3 gene deficient mice exhibit impaired social and exploratory behaviors, deficits in non-selective attention and hypoplasia of cerebellar vermal lobules: a potential model of autism spectrum disorder. Behav Brain Res 2008, 187(2):207-220.
74. Dhossche D., Applegate H., et al. Elevated plasma gamma-aminobutyric acid (GABA) levels in autistic youngsters: stimulus for a GABA hypothesis of autism. Med Sci Monit 2002, 8(8):PR1-6.
75. Dietrich K.N. Human fetal lead exposure: intrauterine growth, maturation, and postnatal neurobehavioral development. Fundam Appl Toxicol 1991, 16(1):17-19.
76. Dingemans M.M., Ramakers G.M., et al. Neonatal exposure to brominated flame retardant BDE-47 reduces long-term potentiation and postsynaptic protein levels in mouse hippocampus. Environ Health Perspect 2007, 115(6):865-870.
77. Dingemans M.M., van Den Berg M., et al. Neurotoxicity of brominated flame retardants: (in)direct effects of parent and hydroxylated polybrominated diphenyl ethers on the (developing) nervous system. Environ Health Perspect 2011, 119(7):900-907.
78. Dolinoy D.C., Huang D., et al. Maternal nutrient supplementation counteracts bisphenol A-induced DNA hypomethylation in early development. Proc Natl Acad Sci U S A 2007, 104(32):13056-13061.
79. Eisenegger C., Haushofer J., et al. The role of testosterone in social interaction. Trends Cogn Sci 2011, 15(6):263-271.
80. Engel S.M., Berkowitz G.S., et al. Prenatal organophosphate metabolite and organochlorine levels and performance on the Brazelton Neonatal Behavioral Assessment Scale in a multiethnic pregnancy cohort. Am J Epidemiol 2007, 165(12):1397-1404.
81. Erway L.C., Shiau Y.W., et al. Genetics of age-related hearing loss in mice. III. Susceptibility of inbred and F1 hybrid strains to noise-induced hearing loss. Hear Res 1996, 93(1-2):181-187.
82. Eskenazi B., Marks A.R., et al. Organophosphate pesticide exposure and neurodevelopment in young Mexican-American children. Environ Health Perspect 2007, 115(5):792-798.
83. Etherton M.R., Blaiss C.A., et al. Mouse neurexin-1alpha deletion causes correlated electrophysiological and behavioral changes consistent with cognitive impairments. Proc Natl Acad Sci U S A 2009, 106(42):17998-18003.
84. Fabjan E., Hulzebos E., et al. A category approach for reproductive effects of phthalates. Crit Rev Toxicol 2006, 36(9):695-726.
85. Fan C.Y., Besas J., et al. Changes in mitogen-activated protein kinase in cerebellar granule neurons by polybrominated diphenyl ethers and polychlorinated biphenyls. Toxicol Appl Pharmacol 2010, 245(1):1-8.
86. Fatemi S.H., Halt A.R., et al. Glutamic acid decarboxylase 65 and 67kDa proteins are reduced in autistic parietal and cerebellar cortices. Biol Psychiatry 2002, 52(8):805-810.
87. Feng J., Schroer R., et al. High frequency of neurexin 1beta signal peptide structural variants in patients with autism. Neurosci Lett 2006, 409(1):10-13.
88. Foley A.G., Gannon S., et al. Class I histone deacetylase inhibition ameliorates social cognition and cell adhesion molecule plasticity deficits in a rodent model of autism spectrum disorder. Neuropharmacology 2012, 63(4):750-760.
89. Franco J.L., Braga H.C., et al. Mercurial-induced hydrogen peroxide generation in mouse brain mitochondria: protective effects of quercetin. Chem Res Toxicol 2007, 20(12):1919-1926.
90. Gauthier J., Spiegelman D., et al. Novel de novo SHANK3 mutation in autistic patients. Am J Med Genet B Neuropsychiatr Genet 2009, 150B(3):421-424.
91. Gavazzo P., Zanardi I., et al. Molecular determinants of Pb2+ interaction with NMDA receptor channels. Neurochem Int 2008, 52(1-2):329-337.
92. Ge R.S., Chen G.R., et al. Biphasic effects of postnatal exposure to diethylhexylphthalate on the timing of puberty in male rats. J Androl 2007, 28(4):513-520.
93. Geppert M., Khvotchev M., et al. Neurexin I alpha is a major alpha-latrotoxin receptor that cooperates in alpha-latrotoxin action. J Biol Chem 1998, 273(3):1705-1710.
94. Gimenez E., Montoliu L. A simple polymerase chain reaction assay for genotyping the retinal degeneration mutation (Pdeb(rd1)) in FVB/N-derived transgenic mice. Lab Anim 2001, 35(2):153-156.
95. Giordano G., Kavanagh T.J., et al. Neurotoxicity of a polybrominated diphenyl ether mixture (DE-71) in mouse neurons and astrocytes is modulated by intracellular glutathione levels. Toxicol Appl Pharmacol 2008, 232(2):161-168.
96. Glessner J.T., Wang K., et al. Autism genome-wide copy number variation reveals ubiquitin and neuronal genes. Nature 2009, 459(7246):569-573.
97. Gogolla N., Leblanc J.J., et al. Common circuit defect of excitatory-inhibitory balance in mouse models of autism. J Neurodev Disord 2009, 1(2):172-181.
98. Goines P.E., Croen L.A., et al. Increased midgestational IFN-gamma, IL-4 and IL-5 in women bearing a child with autism: a case-control study. Mol Autism 2011, 2:13.
99. Gould J.C., Leonard L.S., et al. Bisphenol A interacts with the estrogen receptor alpha in a distinct manner from estradiol. Mol Cell Endocrinol 1998, 142(1-2):203-214.
100. Gould G.G., Hensler J.G., et al. Density and function of central serotonin (5-HT) transporters, 5-HT1A and 5-HT2A receptors, and effects of their targeting on BTBR T+tf/J mouse social behavior. J Neurochem 2011, 116(2):291-303.
101. Grandjean P., Landrigan P.J. Developmental neurotoxicity of industrial chemicals. Lancet 2006, 368(9553):2167-2178.
102. Grandjean P., Weihe P., et al. Cognitive performance of children prenatally exposed to "safe" levels of methylmercury. Environ Res 1998, 77(2):165-172.
103. Greer P.L., Hanayama R., et al. The Angelman syndrome protein Ube3A regulates synapse development by ubiquitinating arc. Cell 2010, 140(5):704-716.
104. Gregg C., Zhang J., et al. High-resolution analysis of parent-of-origin allelic expression in the mouse brain. Science 2010, 329(5992):643-648.
105. Guy J., Hendrich B., et al. A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome. Nat Genet 2001, 27(3):322-326.
106. Hagberg B., Aicardi J., et al. A progressive syndrome of autism, dementia, ataxia, and loss of purposeful hand use in girls: Rett's syndrome: report of 35 cases. Ann Neurol 1983, 14(4):471-479.
107. Hagerman R. The physical and behavioral phenotype. Fragile X syndrome: diagnosis, treatment, and research 2002, 3:3-109. The Johns Hopkins University Press, Baltimore. R. Hagerman, P. Hagerman (Eds.).
108. Hagerman R., Lauterborn J., et al. Fragile X syndrome and targeted treatment trials. Results Probl Cell Differ 2012, 54:297-335.
109. Hallmayer J., Cleveland S., et al. Genetic heritability and shared environmental factors among twin pairs with autism. Arch Gen Psychiatry 2011, 68(11):1095-1102.
110. Harley K.G., Marks A.R., et al. PBDE concentrations in women's serum and fecundability. Environ Health Perspect 2010, 118(5):699-704.
111. Hatton D.D., Sideris J., et al. Autistic behavior in children with fragile X syndrome: prevalence, stability, and the impact of FMRP. Am J Med Genet A 2006, 140A(17):1804-1813.
112. Hauser R., Williams P., et al. Evidence of interaction between polychlorinated biphenyls and phthalates in relation to human sperm motility. Environ Health Perspect 2005, 113(4):425-430.
113. Heilmann C., Grandjean P., et al. Reduced antibody responses to vaccinations in children exposed to polychlorinated biphenyls. PLoS Med 2006, 3(8):e311.
114. Heimeier R.A., Shi Y.B. Amphibian metamorphosis as a model for studying endocrine disruption on vertebrate development: effect of bisphenol A on thyroid hormone action. Gen Comp Endocrinol 2010, 168(2):181-189.
115. Heo Y., Zhang Y., et al. Aberrant immune responses in a mouse with behavioral disorders. PLoS One 2011, 6(7):e20912.
116. Hertz-Picciotto I., Croen L.A., et al. The CHARGE study: an epidemiologic investigation of genetic and environmental factors contributing to autism. Environ Health Perspect 2006, 114(7):1119-1125.
117. Hertz-Picciotto I., Bergman A., et al. Polybrominated diphenyl ethers in relation to autism and developmental delay: a case-control study. Environ Health 2011, 10(1):1.
118. Hessl D., Dyer-Friedman J., et al. The influence of environmental and genetic factors on behavior problems and autistic symptoms in boys and girls with fragile X syndrome. Pediatrics 2001, 108(5):E88.
119. Heulens I., D'Hulst C., et al. Pharmacological treatment of fragile X syndrome with GABAergic drugs in a knockout mouse model. Behav Brain Res 2012, 229(1):244-249.
120. Holmes L.B., Harvey E.A., et al. The teratogenicity of anticonvulsant drugs. N Engl J Med 2001, 344(15):1132-1138.
121. Homanics G.E., DeLorey T.M., et al. Mice devoid of gamma-aminobutyrate type A receptor beta3 subunit have epilepsy, cleft palate, and hypersensitive behavior. Proc Natl Acad Sci U S A 1997, 94(8):4143-4148.
122. Huber K.M., Gallagher S.M., et al. Altered synaptic plasticity in a mouse model of fragile X mental retardation. Proc Natl Acad Sci U S A 2002, 99(11):7746-7750.
123. Hugo E.R., Brandebourg T.D., et al. Bisphenol A at environmentally relevant doses inhibits adiponectin release from human adipose tissue explants and adipocytes. Environ Health Perspect 2008, 116(12):1642-1647.
124. Hunsaker M.R., Arque G., et al. Mouse models of the fragile x premutation and the fragile X associated tremor/ataxia syndrome. Results Probl Cell Differ 2012, 54:255-269.
125. Hunter J.E., Rohr J.K., et al. Co-occurring diagnoses among FMR1 premutation allele carriers. Clin Genet 2010, 77(4):374-381.
126. Icenogle L.M., Christopher N.C., et al. Behavioral alterations in adolescent and adult rats caused by a brief subtoxic exposure to chlorpyrifos during neurulation. Neurotoxicol Teratol 2004, 26(1):95-101.
127. Ikeda T., Zhao X., et al. Fipronil modulation of gamma-aminobutyric acid(A) receptors in rat dorsal root ganglion neurons. J Pharmacol Exp Ther 2001, 296(3):914-921.
128. Ikeda T., Nagata K., et al. Fipronil modulation of GABAA receptor single-channel currents. Pest Manag Sci 2004, 60(5):487-492.
129. Jaakkola J.J., Knight T.L. The role of exposure to phthalates from polyvinyl chloride products in the development of asthma and allergies: a systematic review and meta-analysis. Environ Health Perspect 2008, 116(7):845-853.
130. Jacobson J.L., Jacobson S.W. Intellectual impairment in children exposed to polychlorinated biphenyls in utero. N Engl J Med 1996, 335(11):783-789.
131. Jamain S., Quach H., et al. Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism. Nat Genet 2003, 34(1):27-29.
132. Jamain S., Radyushkin K., et al. Reduced social interaction and ultrasonic communication in a mouse model of monogenic heritable autism. Proc Natl Acad Sci U S A 2008, 105(5):1710-1715.
133. Jaubert P.J., Golub M.S., et al. Complex, multimodal behavioral profile of the Homer1 knockout mouse. Genes Brain Behav 2007, 6(2):141-154.
134. Jiang Y., Tsai T.F., et al. Imprinting in Angelman and Prader-Willi syndromes. Curr Opin Genet Dev 1998, 8(3):334-342.
135. Jiang Y.H., Pan Y., et al. Altered ultrasonic vocalization and impaired learning and memory in Angelman syndrome mouse model with a large maternal deletion from Ube3a to Gabrb3. PLoS One 2010, 5(8):e12278.
136. Jorissen J. Literature review. Outcomes associated with postnatal exposure to polychlorinated biphenyls (PCBs) via breast milk. Advances in neonatal care: official journal of the National Association of Neonatal Nurses 2007, 7(5):230-237.
137. Juang M.S., Yonemura K. Increased spontaneous transmitter release from presynaptic nerve terminal by methylmercuric chloride. Nature 1975, 256(5514):211-213.
138. Juarez de Ku L.M., Sharma-Stokkermans M., et al. Thyroxine normalizes polychlorinated biphenyl (PCB) dose-related depression of choline acetyltransferase (ChAT) activity in hippocampus and basal forebrain of 15-day-old rats. Toxicology 1994, 94(1-3):19-30.
139. Kang S.C., Lee B.M. DNA methylation of estrogen receptor alpha gene by phthalates. J Toxicol Environ Health A 2005, 68(23-24):1995-2003.
140. Kavlock R., Barr D., et al. NTP-CERHR expert panel update on the reproductive and developmental toxicity of di(2-ethylhexyl) phthalate. Reprod Toxicol 2006, 22(3):291-399.
141. Kazantzis G., Al-Mufti A.W., et al. Epidemiology of organomercury poisoning in Iraq. II. Relationship of mercury levels in blood and hair to exposure and to clinical findings. Bull World Health Organ 1976, 53:37-48. Suppl.:.
142. Kelemenova S., Ostatnikova D. Neuroendocrine pathways altered in autism. Special role of reelin. Neuro Endocrinol Lett 2009, 30(4):429-436.
143. Keller J.M., McClellan-Green P.D., et al. Effects of organochlorine contaminants on loggerhead sea turtle immunity: comparison of a correlative field study and in vitro exposure experiments. Environ Health Perspect 2006, 114(1):70-76.
144. Kim K.H., Pessah I.N. Perinatal exposure to environmental polychlorinated biphenyls sensitizes hippocampus to excitotoxicity ex vivo. Neurotoxicology 2011, 32(6):981-985.
145. Kim H.G., Kishikawa S., et al. Disruption of neurexin 1 associated with autism spectrum disorder. Am J Hum Genet 2008, 82(1):199-207.
146. Kim K.H., Inan S.Y., et al. Excitatory and inhibitory synaptic transmission is differentially influenced by two ortho-substituted polychlorinated biphenyls in the hippocampal slice preparation. Toxicol Appl Pharmacol 2009, 237(2):168-177.
147. Kim S., Pickup S., et al. Association between sociability and diffusion tensor imaging in BALB/cJ mice. NMR Biomed 2012, 25(1):104-112.
148. Kodavanti P.R., Derr-Yellin E.C. Differential effects of polybrominated diphenyl ethers and polychlorinated biphenyls on [3H]arachidonic acid release in rat cerebellar granule neurons. Toxicol Sci 2002, 68(2):451-457.
149. Kodavanti P.R., Tilson H.A. Neurochemical effects of environmental chemicals: in vitro and in vivo correlations on second messenger pathways. Ann N Y Acad Sci 2000, 919:97-105.
150. Kodavanti P.R., Ward T.R. Differential effects of commercial polybrominated diphenyl ether and polychlorinated biphenyl mixtures on intracellular signaling in rat brain in vitro. Toxicol Sci 2005, 85(2):952-962.
151. Kodavanti P.R., Kannan N., et al. Differential effects of two lots of aroclor 1254: congener-specific analysis and neurochemical end points. Environ Health Perspect 2001, 109(11):1153-1161.
152. Kodavanti P.R., Ward T.R., et al. Polybrominated diphenyl ether (PBDE) effects in rat neuronal cultures: 14C-PBDE accumulation, biological effects, and structure-activity relationships. Toxicol Sci 2005, 88(1):181-192.
153. Kojima H., Takeuchi S., et al. Nuclear hormone receptor activity of polybrominated diphenyl ethers and their hydroxylated and methoxylated metabolites in transactivation assays using Chinese hamster ovary cells. Environ Health Perspect 2009, 117(8):1210-1218.
154. Kumar K.K., Aboud A.A., et al. The potential of induced pluripotent stem cells as a translational model for neurotoxicological risk. Neurotoxicology 2012, 33(3):518-529.
155. La Gamma E.F., Paneth N. Clinical importance of hypothyroxinemia in the preterm infant and a discussion of treatment concerns. Curr Opin Pediatr 2012, 24(2):172-180.
156. Lakatosova S., Ostatnikova D. Reelin and its complex involvement in brain development and function. Int J Biochem Cell Biol 2012, 44(9):1501-1504.
157. Lasley S.M., Gilbert M.E. Rat hippocampal glutamate and GABA release exhibit biphasic effects as a function of chronic lead exposure level. Toxicol Sci 2002, 66(1):139-147.
158. Lassiter T.L., MacKillop E.A., et al. Is fipronil safer than chlorpyrifos? Comparative developmental neurotoxicity modeled in PC12 cells. Brain Res Bull 2009, 78(6):313-322.
159. Latini G. Monitoring phthalate exposure in humans. Clin Chim Acta 2005, 361(1-2):20-29.
160. Latini G., De Felice C., et al. In utero exposure to di-(2-ethylhexyl)phthalate and duration of human pregnancy. Environ Health Perspect 2003, 111(14):1783-1785.
161. Latini G., Del Vecchio A., et al. In utero exposure to phthalates and fetal development. Curr Med Chem 2006, 13(21):2527-2534.
162. Lauder J.M., Schambra U.B. Morphogenetic roles of acetylcholine. Environ Health Perspect 1999, 107(Suppl. 1):65-69.
163. Laviola G., Adriani W., et al. Paradoxical effects of prenatal acetylcholinesterase blockade on neuro-behavioral development and drug-induced stereotypies in reeler mutant mice. Psychopharmacology (Berl) 2006, 187(3):331-344.
164. Leranth C., Hajszan T., et al. Bisphenol A prevents the synaptogenic response to estradiol in hippocampus and prefrontal cortex of ovariectomized nonhuman primates. Proc Natl Acad Sci U S A 2008, 105(37):14187-14191.
165. Levin M., Morsey B., et al. Specific non-coplanar PCB-mediated modulation of bottlenose dolphin and beluga whale phagocytosis upon in vitro exposure. J Toxicol Environ Health A 2004, 67(19):1517-1535.
166. Llansola M., Erceg S., et al. Prenatal exposure to polybrominated diphenylether 99 enhances the function of the glutamate-nitric oxide-cGMP pathway in brain in vivo and in cultured neurons. Eur J Neurosci 2007, 25(2):373-379.
167. Loikkanen J., Chvalova K., et al. Pb2+-induced toxicity is associated with p53-independent apoptosis and enhanced by glutamate in GT1-7 neurons. Toxicol Lett 2003, 144(2):235-246.
168. Longnecker M.P., Wolff M.S., et al. Comparison of polychlorinated biphenyl levels across studies of human neurodevelopment. Environ Health Perspect 2003, 111(1):65-70.
169. Loomis D., Browning S.R., et al. Cancer mortality among electric utility workers exposed to polychlorinated biphenyls. Occup Environ Med 1997, 54(10):720-728.
170. Lottrup G., Andersson A.M., et al. Possible impact of phthalates on infant reproductive health. Int J Androl 2006, 29(1):172-180. discussion 181-175.
171. Lovekamp T.N., Davis B.J. Mono-(2-ethylhexyl) phthalate suppresses aromatase transcript levels and estradiol production in cultured rat granulosa cells. Toxicol Appl Pharmacol 2001, 172(3):217-224.
172. Lovekamp-Swan T., Davis B.J. Mechanisms of phthalate ester toxicity in the female reproductive system. Environ Health Perspect 2003, 111(2):139-145.
173. Lupski J.R., Stankiewicz P. Genomic disorders: molecular mechanisms for rearrangements and conveyed phenotypes. PLoS Genet 2005, 1(6):e49.
174. Main K.M., Kiviranta H., et al. Flame retardants in placenta and breast milk and cryptorchidism in newborn boys. Environ Health Perspect 2007, 115(10):1519-1526.
175. Margolis S.S., Salogiannis J., et al. EphB-mediated degradation of the RhoA GEF Ephexin5 relieves a developmental brake on excitatory synapse formation. Cell 2010, 143(3):442-455.
176. Mariussen E., Fonnum F. Neurochemical targets and behavioral effects of organohalogen compounds: an update. Crit Rev Toxicol 2006, 36(3):253-289.
177. Martin C.L., Ledbetter D.H. Autism and cytogenetic abnormalities: solving autism one chromosome at a time. Curr Psychiatry Rep 2007, 9(2):141-147.
178. Maski K.P., Jeste S.S., et al. Common neurological co-morbidities in autism spectrum disorders. Curr Opin Pediatr 2011, 23(6):609-615.
179. Matsuya Y., Ihara D., et al. Synthesis and biological evaluation of pyrethroid insecticide-derivatives as a chemical inducer for Bdnf mRNA expression in neurons. Bioorg Med Chem 2012, 20(8):2564-2571.
180. McCanlies E.C., Fekedulegn D. Parental occupational exposures and autism spectrum disorder. J Autism Dev Disord 2012 Mar 8, [Epub ahead of print].
181. McFarlane H.G., Kusek G.K., et al. Autism-like behavioral phenotypes in BTBR T+tf/J mice. Genes Brain Behav 2008, 7(2):152-163.
182. Meeker J.D., Calafat A.M., et al. Di(2-ethylhexyl) phthalate metabolites may alter thyroid hormone levels in men. Environ Health Perspect 2007, 115(7):1029-1034.
183. Meerts I.A., van Zanden J.J., et al. Potent competitive interactions of some brominated flame retardants and related compounds with human transthyretin in vitro. Toxicol Sci 2000, 56(1):95-104.
184. Meerts I.A., Letcher R.J., et al. In vitro estrogenicity of polybrominated diphenyl ethers, hydroxylated PDBEs, and polybrominated bisphenol A compounds. Environ Health Perspect 2001, 109(4):399-407.
185. Meisler M.H., Kearney J., et al. Identification of epilepsy genes in human and mouse. Annu Rev Genet 2001, 35:567-588.
186. Messer R.L., Lockwood P.E., et al. Mercury (II) alters mitochondrial activity of monocytes at sublethal doses via oxidative stress mechanisms. J Biomed Mater Res B Appl Biomater 2005, 75(2):257-263.
187. Milligan S.R., Khan O., et al. Competitive binding of xenobiotic oestrogens to rat alpha-fetoprotein and to sex steroid binding proteins in human and rainbow trout (Oncorhynchus mykiss) plasma. Gen Comp Endocrinol 1998, 112(1):89-95.
188. Mitchell K.A., Elferink C.J. Timing is everything: consequences of transient and sustained AhR activity. Biochem Pharmacol 2009, 77(6):947-956.
189. Molloy C.A., Morrow A.L., et al. Elevated cytokine levels in children with autism spectrum disorder. J Neuroimmunol 2006, 172(1-2):198-205.
190. Moriyama K., Tagami T., et al. Thyroid hormone action is disrupted by bisphenol A as an antagonist. J Clin Endocrinol Metab 2002, 87(11):5185-5190.
191. Morse D.C., Groen D., et al. Interference of polychlorinated biphenyls in hepatic and brain thyroid hormone metabolism in fetal and neonatal rats. Toxicol Appl Pharmacol 1993, 122(1):27-33.
192. Morse D.C., Seegal R.F., et al. Long-term alterations in regional brain serotonin metabolism following maternal polychlorinated biphenyl exposure in the rat. Neurotoxicology 1996, 17(3-4):631-638.
193. Moss J., Howlin P. Autism spectrum disorders in genetic syndromes: implications for diagnosis, intervention and understanding the wider autism spectrum disorder population. J Intellect Disabil Res 2009, 53(10):852-873.
194. Moy S.S., Nadler J.J., et al. Mouse behavioral tasks relevant to autism: phenotypes of 10 inbred strains. Behav Brain Res 2007, 176(1):4-20.
195. Nadler J.J., Moy S.S., et al. Automated apparatus for quantitation of social approach behaviors in mice. Genes Brain Behav 2004, 3(5):303-314.
196. Naeher L.P., Tulve N.S., et al. Organophosphorus and pyrethroid insecticide urinary metabolite concentrations in young children living in a southeastern United States city. Sci Total Environ 2010, 408(5):1145-1153.
197. Nakanishi Y., Shigematsu N., et al. Respiratory involvement and immune status in yusho patients. Environ Health Perspect 1985, 59:31-36.
198. Nakatani J., Tamada K., et al. Abnormal behavior in a chromosome-engineered mouse model for human 15q11-13 duplication seen in autism. Cell 2009, 137(7):1235-1246.
199. Nicholls R.D., Knepper J.L. Genome organization, function, and imprinting in Prader-Willi and Angelman syndromes. Annu Rev Genomics Hum Genet 2001, 2:153-175.
200. Niemi W.D., Audi J., et al. PCBs reduce long-term potentiation in the CA1 region of rat hippocampus. Exp Neurol 1998, 151(1):26-34.
201. Oberle I., Rousseau F., et al. Instability of a 550-base pair DNA segment and abnormal methylation in fragile X syndrome. Science 1991, 252(5010):1097-1102.
202. Ostrea E.M., Morales V., et al. Prevalence of fetal exposure to environmental toxins as determined by meconium analysis. Neurotoxicology 2002, 23(3):329-339.
203. Ostrea E.M., Bielawski D.M., et al. Combined analysis of prenatal (maternal hair and blood) and neonatal (infant hair, cord blood and meconium) matrices to detect fetal exposure to environmental pesticides. Environ Res 2009, 109(1):116-122.
204. Parks L.G., Ostby J.S., et al. The plasticizer diethylhexyl phthalate induces malformations by decreasing fetal testosterone synthesis during sexual differentiation in the male rat. Toxicol Sci 2000, 58(2):339-349.
205. Pasca S.P., Portmann T., et al. Using iPSC-derived neurons to uncover cellular phenotypes associated with Timothy syndrome. Nat Med 2011, 17(12):1657-1662.
206. Patisaul H.B., Fortino A.E., et al. Neonatal genistein or bisphenol-A exposure alters sexual differentiation of the AVPV. Neurotoxicol Teratol 2006, 28(1):111-118.
207. Paul R., Pessah I.N., et al. Early onset of neurological symptoms in fragile X premutation carriers exposed to neurotoxins. Neurotoxicology 2010, 31(4):399-402.
208. Peca J., Feliciano C., et al. Shank3 mutant mice display autistic-like behaviours and striatal dysfunction. Nature 2011, 472(7344):437-442.
209. Pelka G.J., Watson C.M., et al. Mecp2 deficiency is associated with learning and cognitive deficits and altered gene activity in the hippocampal region of mice. Brain 2006, 129(Pt 4):887-898.
210. Peng S., Hajela R.K., et al. Characteristics of block by Pb2+ of function of human neuronal L-, N-, and R-type Ca2+ channels transiently expressed in human embryonic kidney 293 cells. Mol Pharmacol 2002, 62(6):1418-1430.
211. Percy A.K. Rett syndrome: exploring the autism link. Arch Neurol 2011, 68(8):985-989.
212. Pessah I.N., Hansen L.G., et al. Structure-activity relationship for noncoplanar polychlorinated biphenyl congeners toward the ryanodine receptor-Ca2+ channel complex type 1 (RyR1). Chem Res Toxicol 2006, 19(1):92-101.
213. Pessah I.N., Cherednichenko G., et al. Minding the calcium store: ryanodine receptor activation as a convergent mechanism of PCB toxicity. Pharmacol Ther 2010, 125(2):260-285.
214. Phelan M.C. Deletion 22q13.3 syndrome. Orphanet J Rare Dis 2008, 3:14.
215. Pieretti M., Zhang F.P., et al. Absence of expression of the FMR-1 gene in fragile X syndrome. Cell 1991, 66(4):817-822.
216. Pinelli M., Scala G., et al. Simulating gene-gene and gene-environment interactions in complex diseases: Gene-Environment iNteraction Simulator 2. BMC Bioinformatics 2012, 13(1):132.
217. Pobbe R.L., Pearson B.L., et al. Expression of social behaviors of C57BL/6J versus BTBR inbred mouse strains in the visible burrow system. Behav Brain Res 2010, 214(2):443-449.
218. Poimenova A., Markaki E., et al. Corticosterone-regulated actions in the rat brain are affected by perinatal exposure to low dose of bisphenol A. Neuroscience 2010, 167(3):741-749.
219. Porciuncula L.O., Rocha J.B., et al. Methylmercury inhibits glutamate uptake by synaptic vesicles from rat brain. Neuroreport 2003, 14(4):577-580.
220. Prasanth G.K., Divya L.M., et al. Bisphenol-A can bind to human glucocorticoid receptor as an agonist: an in silico study. J Appl Toxicol 2010, 30(8):769-774.
221. Qiao D., Seidler F.J., et al. Fetal chlorpyrifos exposure: adverse effects on brain cell development and cholinergic biomarkers emerge postnatally and continue into adolescence and adulthood. Environ Health Perspect 2003, 111(4):536-544.
222. Qiao D., Seidler F.J., et al. Chlorpyrifos exposure during neurulation: cholinergic synaptic dysfunction and cellular alterations in brain regions at adolescence and adulthood. Brain Res Dev Brain Res 2004, 148(1):43-52.
223. Qin M., Entezam A., et al. A mouse model of the fragile X premutation: effects on behavior, dendrite morphology, and regional rates of cerebral protein synthesis. Neurobiol Dis 2011, 42(1):85-98.
224. Radyushkin K., Hammerschmidt K., et al. Neuroligin-3-deficient mice: model of a monogenic heritable form of autism with an olfactory deficit. Genes Brain Behav 2009, 8(4):416-425.
225. Ratra G.S., Kamita S.G., et al. Role of human GABA(A) receptor beta3 subunit in insecticide toxicity. Toxicol Appl Pharmacol 2001, 172(3):233-240.
226. Rauh V.A., Garfinkel R., et al. Impact of prenatal chlorpyrifos exposure on neurodevelopment in the first 3years of life among inner-city children. Pediatrics 2006, 118(6):e1845-e1859.
227. Ray D.E., Fry J.R. A reassessment of the neurotoxicity of pyrethroid insecticides. Pharmacol Ther 2006, 111(1):174-193.
228. Rett A. A cerebral atrophic syndrome in hypoammoniemia. Monatsschr Kinderheilkd 1968, 116(6):310-311.
229. Ricceri L., Markina N., et al. Developmental exposure to chlorpyrifos alters reactivity to environmental and social cues in adolescent mice. Toxicol Appl Pharmacol 2003, 191(3):189-201.
230. Ricceri L., Venerosi A., et al. Developmental neurotoxicity of organophosphorous pesticides: fetal and neonatal exposure to chlorpyrifos alters sex-specific behaviors at adulthood in mice. Toxicol Sci 2006, 93(1):105-113.
231. Rice D.C. Lead-induced behavioral impairment on a spatial discrimination reversal task in monkeys exposed during different periods of development. Toxicol Appl Pharmacol 1990, 106(2):327-333.
232. Richardson J.R., Miller G.W. Acute exposure to aroclor 1016 or 1260 differentially affects dopamine transporter and vesicular monoamine transporter 2 levels. Toxicol Lett 2004, 148(1-2):29-40.
233. Richter C.A., Birnbaum L.S., et al. In vivo effects of bisphenol A in laboratory rodent studies. Reprod Toxicol 2007, 24(2):199-224.
234. Ropero A.B., Alonso-Magdalena P., et al. Rapid endocrine disruption: environmental estrogen actions triggered outside the nucleus. J Steroid Biochem Mol Biol 2006, 102(1-5):163-169.
235. Rosner D., Markowitz G. The politics of lead toxicology and the devastating consequences for children. Am J Ind Med 2007, 50(10):740-756.
236. Rossignol E. Genetics and function of neocortical GABAergic interneurons in neurodevelopmental disorders. Neural Plast 2011, 2011:649325.
237. Rotschafer S.E., Trujillo M.S., et al. Minocycline treatment reverses ultrasonic vocalization production deficit in a mouse model of fragile X syndrome. Brain Res 2012, 1439:7-14.
238. Roullet F.I., Crawley J.N. Mouse models of autism: testing hypotheses about molecular mechanisms. Curr Top Behav Neurosci 2011, 7:187-212.
239. Routledge E.J., White R., et al. Differential effects of xenoestrogens on coactivator recruitment by estrogen receptor (ER) alpha and ERbeta. J Biol Chem 2000, 275(46):35986-35993.
240. Roy T.S., Andrews J.E., et al. Chlorpyrifos elicits mitotic abnormalities and apoptosis in neuroepithelium of cultured rat embryos. Teratology 1998, 58(2):62-68.
241. Rubin B.S., Lenkowski J.R., et al. Evidence of altered brain sexual differentiation in mice exposed perinatally to low, environmentally relevant levels of bisphenol A. Endocrinology 2006, 147(8):3681-3691.
242. Rusiecki J.A., Baccarelli A., et al. Global DNA hypomethylation is associated with high serum-persistent organic pollutants in Greenlandic Inuit. Environ Health Perspect 2008, 116(11):1547-1552.
243. Salinas J.A., Huff N.C. Lead and conditioned fear to contextual and discrete cues. Neurotoxicol Teratol 2002, 24(4):541-550.
244. Sargis R.M., Johnson D.N., et al. Environmental endocrine disruptors promote adipogenesis in the 3T3-L1 cell line through glucocorticoid receptor activation. Obesity 2010, 18(7):1283-1288.
245. Scattoni M.L., Gandhy S.U., et al. Unusual repertoire of vocalizations in the BTBR T+tf/J mouse model of autism. PLoS One 2008, 3(8):e3067.
246. Scattoni M.L., Ricceri L., et al. Unusual repertoire of vocalizations in adult BTBR T+tf/J mice during three types of social encounters. Genes Brain Behav 2011, 10(1):44-56.
247. Schantz S.L. Developmental neurotoxicity of PCBs in humans: what do we know and where do we go from here?. Neurotoxicol Teratol 1996, 18(3):217-227. discussion 229-276.
248. Scheiffele P., Beg A.A. Neuroscience: Angelman syndrome connections. Nature 2010, 468(7326):907-908.
249. Schieve L.A., Baio J., et al. Risk for cognitive deficit in a population-based sample of U.S. children with autism spectrum disorders: variation by perinatal health factors. Disabil Health J 2010, 3(3):202-212.
250. Seegal R.F., Bush B., et al. Polychlorinated biphenyls induce regional changes in brain norepinephrine concentrations in adult rats. Neurotoxicology 1985, 6(3):13-23.
251. Seegal R.F., Bush B., et al. Lightly chlorinated ortho-substituted PCB congeners decrease dopamine in nonhuman primate brain and in tissue culture. Toxicol Appl Pharmacol 1990, 106(1):136-144.
252. Seegal R.F., Bush B., et al. Sub-chronic exposure of the adult rat to Aroclor 1254 yields regionally-specific changes in central dopaminergic function. Neurotoxicology 1991, 12(1):55-65.
253. Shah P.E., Dalton R., Boris N.W. Pervasive developmental disorders and childhood psychosis. Nelson Textbook of Pediatrics 2007, Saunders Elsevier, Philadelphia, Pa, [chapter 29]. 18th ed. R.M. Kliegman, R.E. Behrman, H.B. Jenson, B.F. Stanton (Eds.).
254. Shafer T.J., Atchison W.D. Block of 45Ca uptake into synaptosomes by methylmercury: Ca++- and Na+-dependence. J Pharmacol Exp Ther 1989, 248(2):696-702.
255. Shafer T.J., Meyer D.A., et al. Developmental neurotoxicity of pyrethroid insecticides: critical review and future research needs. Environ Health Perspect 2005, 113(2):123-136.
256. Shim S.H., Hwangbo Y., et al. Increased levels of plasma brain-derived neurotrophic factor (BDNF) in children with attention deficit-hyperactivity disorder (ADHD). Prog Neuropsychopharmacol Biol Psychiatry 2008, 32(8):1824-1828.
257. Sidhu P., Nehru B. Relationship between lead-induced biochemical and behavioral changes with trace element concentrations in rat brain. Biol Trace Elem Res 2003, 92(3):245-256.
258. Sidiropoulou E., Sachana M., et al. Fipronil interferes with the differentiation of mouse N2a neuroblastoma cells. Toxicol Lett 2011, 201(1):86-91.
259. Silva M.J., Reidy J.A., et al. Detection of phthalate metabolites in human amniotic fluid. Bull Environ Contam Toxicol 2004, 72(6):1226-1231.
260. Silverman J.L., Yang M., et al. Behavioural phenotyping assays for mouse models of autism. Nat Rev Neurosci 2010, 11(7):490-502.
261. Silverman J.L., Smith D.G., et al. Negative allosteric modulation of the mGluR5 receptor reduces repetitive behaviors and rescues social deficits in mouse models of autism. Sci Transl Med 2012, 4(131):131-151.
262. Slotkin T.A. Cholinergic systems in brain development and disruption by neurotoxicants: nicotine, environmental tobacco smoke, organophosphates. Toxicol Appl Pharmacol 2004, 198(2):132-151.
263. Smialowicz R.J., Andrews J.E., et al. Evaluation of the immunotoxicity of low level PCB exposure in the rat. Toxicology 1989, 56(2):197-211.
264. Spencer C.M., Graham D.F., et al. Social behavior in Fmr1 knockout mice carrying a human FMR1 transgene. Behav Neurosci 2008, 122(3):710-715.
265. Spencer C.M., Alekseyenko O., et al. Modifying behavioral phenotypes in Fmr1KO mice: genetic background differences reveal autistic-like responses. Autism Res 2011, 4(1):40-56.
266. Splawski I., Timothy K.W., et al. Ca(V)1.2 calcium channel dysfunction causes a multisystem disorder including arrhythmia and autism. Cell 2004, 119(1):19-31.
267. Stehr C.M., Linbo T.L., et al. The developmental neurotoxicity of fipronil: notochord degeneration and locomotor defects in zebrafish embryos and larvae. Toxicol Sci 2006, 92(1):270-278.
268. Svensson B.G., Hallberg T., et al. Parameters of immunological competence in subjects with high consumption of fish contaminated with persistent organochlorine compounds. Int Arch Occup Environ Health 1994, 65(6):351-358.
269. Szatmari P., Paterson A.D., et al. Mapping autism risk loci using genetic linkage and chromosomal rearrangements. Nat Genet 2007, 39(3):319-328.
270. Szyf M. Epigenetics, DNA methylation, and chromatin modifying drugs. Annu Rev Pharmacol Toxicol 2009, 49:243-263.
271. Ta T.A., Koenig C.M., et al. Bioaccumulation and behavioral effects of 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) in perinatally exposed mice. Neurotoxicol Teratol 2011, 33(3):393-404.
272. Takumi T. The neurobiology of mouse models syntenic to human chromosome 15q. J Neurodev Disord 2011, 3(3):270-281.
273. Talts U., Fredriksson A., et al. Changes in behavior and muscarinic receptor density after neonatal and adult exposure to bioallethrin. Neurobiol Aging 1998, 19(6):545-552.
274. Tate P., Skarnes W., et al. The methyl-CpG binding protein MeCP2 is essential for embryonic development in the mouse. Nat Genet 1996, 12(2):205-208.
275. Tayebati S.K., Di Tullio M.A., et al. Influence of dermal exposure to the pyrethroid insecticide deltamethrin on rat brain microanatomy and cholinergic/dopaminergic neurochemistry. Brain Res 2009, 1301:180-188.
276. Thomas P., Dong J. Binding and activation of the seven-transmembrane estrogen receptor GPR30 by environmental estrogens: a potential novel mechanism of endocrine disruption. J Steroid Biochem Mol Biol 2006, 102(1-5):175-179.
277. Thomas A.M., Bui N., et al. Group I metabotropic glutamate receptor antagonists alter select behaviors in a mouse model for fragile X syndrome. Psychopharmacology (Berl) 2012, 219(1):47-58.
278. Tilson H.A., Kodavanti P.R. The neurotoxicity of polychlorinated biphenyls. Neurotoxicology 1998, 19(4-5):517-525.
279. Toran-Allerand C.D. On the genesis of sexual differentiation of the general nervous system: morphogenetic consequences of steroidal exposure and possible role of alpha-fetoprotein. Prog Brain Res 1984, 61:63-98.
280. Toscano C.D., Guilarte T.R. Lead neurotoxicity: from exposure to molecular effects. Brain Res Brain Res Rev 2005, 49(3):529-554.
281. Toscano C.D., Hashemzadeh-Gargari H., et al. Developmental Pb2+ exposure alters NMDAR subtypes and reduces CREB phosphorylation in the rat brain. Brain Res Dev Brain Res 2002, 139(2):217-226.
282. Tran V., Hoffman N., et al. Bifenthrin inhibits neurite outgrowth in differentiating PC12 cells. Med Sci Monit 2006, 12(2):BR57-62.
283. Turyk M.E., Persky V.W., et al. Hormone disruption by PBDEs in adult male sport fish consumers. Environ Health Perspect 2008, 116(12):1635-1641.
284. Uchino S., Wada H., et al. Direct interaction of post-synaptic density-95/Dlg/ZO-1 domain-containing synaptic molecule Shank3 with GluR1 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor. J Neurochem 2006, 97(4):1203-1214.
285. Utari A., Chonchaiya W., et al. Side effects of minocycline treatment in patients with fragile X syndrome and exploration of outcome measures. Am J Intellect Dev Disabil 2010, 115(5):433-443.
286. Van Birgelen A.P., Smit E.A., et al. Subchronic effects of 2,3,7,8-TCDD or PCBs on thyroid hormone metabolism: use in risk assessment. Eur J Pharmacol 1995, 293(1):77-85.
287. Van Den Berg M., Birnbaum L.S., et al. The 2005 World Health Organization reevaluation of human and mammalian toxic equivalency factors for dioxins and dioxin-like compounds. Toxicol Sci 2006, 93(2):223-241.
288. Vandenberg L.N., Hauser R., et al. Human exposure to bisphenol A (BPA). Reprod Toxicol 2007, 24(2):139-177.
289. Vandenberg L.N., Chahoud I., et al. Urinary, circulating, and tissue biomonitoring studies indicate widespread exposure to bisphenol A. Ciencia & saude coletiva 2012, 17(2):407-434.
290. Veenstra-Vanderweele J., Christian S.L., et al. Autism as a paradigmatic complex genetic disorder. Annu Rev Genomics Hum Genet 2004, 5:379-405.
291. Verkerk A.J., Pieretti M., et al. Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome. Cell 1991, 65(5):905-914.
292. Verpelli C., Dvoretskova E., et al. Importance of Shank3 protein in regulating metabotropic glutamate receptor 5 (mGluR5) expression and signaling at synapses. J Biol Chem 2011, 286(40):34839-34850.
293. Vogel S.A. The politics of plastics: the making and unmaking of bisphenol a "safety". Am J Public Health 2009, 99(Suppl. 3):S559-S566.
294. Voineagu I., Wang X., et al. Transcriptomic analysis of autistic brain reveals convergent molecular pathology. Nature 2011, 474(7351):380-384.
295. Volk H.E., Hertz-Picciotto I., et al. Residential proximity to freeways and autism in the CHARGE study. Environ Health Perspect 2011, 119(6):873-877.
296. Vorstman J.A., Staal W.G., et al. Identification of novel autism candidate regions through analysis of reported cytogenetic abnormalities associated with autism. Mol Psychiatry 2006, 11(1):18-28. 1.
297. Wahl M., Guenther R., et al. Polybrominated diphenyl ethers and arylhydrocarbon receptor agonists: different toxicity and target gene expression. Toxicol Lett 2010, 198(2):119-126.
298. Wahlsten D., Metten P., et al. Survey of 21 inbred mouse strains in two laboratories reveals that BTBR T/+ tf/tf has severely reduced hippocampal commissure and absent corpus callosum. Brain Res 2003, 971(1):47-54.
299. Walz N.C. Parent report of stereotyped behaviors, social interaction, and developmental disturbances in individuals with Angelman syndrome. J Autism Dev Disord 2007, 37(5):940-947.
300. Wang X., McCoy P.A., et al. Synaptic dysfunction and abnormal behaviors in mice lacking major isoforms of Shank3. Hum Mol Genet 2011, 20(15):3093-3108.
301. Watson C.S., Bulayeva N.N., et al. Signaling from the membrane via membrane estrogen receptor-alpha: estrogens, xenoestrogens, and phytoestrogens. Steroids 2005, 70(5-7):364-371.
302. Weisglas-Kuperus N., Vreugdenhil H.J., et al. Immunological effects of environmental exposure to polychlorinated biphenyls and dioxins in Dutch school children. Toxicol Lett 2004, 149(1-3):281-285.
303. Wiegers T.C., Davis A.P., et al. Text mining and manual curation of chemical-gene-disease networks for the comparative toxicogenomics database (CTD). BMC Bioinformatics 2009, 10:326.
304. Willemsen R., Hoogeveen-Westerveld M., et al. The FMR1 CGG repeat mouse displays ubiquitin-positive intranuclear neuronal inclusions; implications for the cerebellar tremor/ataxia syndrome. Hum Mol Genet 2003, 12(9):949-959.
305. Winneke G., Walkowiak J., et al. PCB-induced neurodevelopmental toxicity in human infants and its potential mediation by endocrine dysfunction. Toxicology 2002, 181-182:161-165.
306. Wohr M., Roullet F.I., et al. Reduced scent marking and ultrasonic vocalizations in the BTBR T+tf/J mouse model of autism. Genes Brain Behav 2011, 10(1):35-43.
307. Woods R., Vallero R.O., et al. Long-lived epigenetic interactions between perinatal PBDE exposure and Mecp2308 mutation. Hum Mol Genet 2012, 21(11):2399-2411.
308. Xing T., Chen L., et al. Effects of decabrominated diphenyl ether (PBDE 209) exposure at different developmental periods on synaptic plasticity in the dentate gyrus of adult rats in vivo. Toxicol Sci 2009, 110(2):401-410.
309. Yang M., Clarke A.M., et al. Postnatal lesion evidence against a primary role for the corpus callosum in mouse sociability. Eur J Neurosci 2009, 29(8):1663-1677.
310. Yang M., Bozdagi O., et al. Reduced excitatory neurotransmission and mild autism-relevant phenotypes in adolescent Shank3 null mutant mice. J Neurosci 2012, 32(19):6525-6541.
311. Yaoi T., Itoh K., et al. Genome-wide analysis of epigenomic alterations in fetal mouse forebrain after exposure to low doses of bisphenol A. Biochem Biophys Res Commun 2008, 376(3):563-567.
312. Ye H., Liu J., et al. Cell adhesion molecules and their involvement in autism spectrum disorder. Neurosignals 2010, 18(2):62-71.
313. Yin Z., Milatovic D., et al. Methylmercury induces oxidative injury, alterations in permeability and glutamine transport in cultured astrocytes. Brain Res 2007, 1131(1):1-10.
314. Yorifuji T., Tsuda T., et al. Total mercury content in hair and neurologic signs: historic data from Minamata. Epidemiology 2009, 20(2):188-193.
315. Young J.G., Eskenazi B., et al. Association between in utero organophosphate pesticide exposure and abnormal reflexes in neonates. Neurotoxicology 2005, 26(2):199-209.
316. Yu K., He Y., et al. DE-71-induced apoptosis involving intracellular calcium and the Bax-mitochondria-caspase protease pathway in human neuroblastoma cells in vitro. Toxicol Sci 2008, 104(2):341-351.
317. Yuan Y., Atchison W.D. Disruption by methylmercury of membrane excitability and synaptic transmission of CA1 neurons in hippocampal slices of the rat. Toxicol Appl Pharmacol 1993, 120(2):203-215.
318. Zhang X.Y., Liu A.P., et al. Effect of developmental lead exposure on the expression of specific NMDA receptor subunit mRNAs in the hippocampus of neonatal rats by digoxigenin-labeled in situ hybridization histochemistry. Neurotoxicol Teratol 2002, 24(2):149-160.
319. Zhang C., Liu X., et al. Role of brominated diphenyl ether-209 in the differentiation of neural stem cells in vitro. Int J Dev Neurosci 2010, 28(6):497-502.
320. Zoeller R.T. Environmental chemicals as thyroid hormone analogues: new studies indicate that thyroid hormone receptors are targets of industrial chemicals?. Mol Cell Endocrinol 2005, 242(1-2):10-15.
321. Zoeller R.T., Bansal R., et al. Bisphenol-A, an environmental contaminant that acts as a thyroid hormone receptor antagonist in vitro, increases serum thyroxine, and alters RC3/neurogranin expression in the developing rat brain. Endocrinology 2005, 146(2):607-612.
322. Zoghbi H.Y. Postnatal neurodevelopmental disorders: meeting at the synapse?. Science 2003, 302(5646):826-830.
323. Zsarnovszky A., Le H.H., et al. Ontogeny of rapid estrogen-mediated extracellular signal-regulated kinase signaling in the rat cerebellar cortex: potent nongenomic agonist and endocrine disrupting activity of the xenoestrogen bisphenol A. Endocrinology 2005, 146(12):5388-5396.