Human papillomavirus type 38 E6 and E7 act as tumour promoters during chemically induced skin carcinogenesis

Journal of General Virology

Volumn 94, Issue PART4, 2013, Pages 749-752

  Viarisio, Daniele ^a   Decker, Karin Müller ^a   Aengeneyndt, Birgit ^a   Flechtenmacher, Christa ^b   Gissmann, Lutz ^a,c   Tommasino, Massimo ^d  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^c KING SAUD UNIVERSITY   (Saudi Arabia)

^d INTERNATIONAL AGENCY FOR RESEARCH ON CANCER   (France)

Author keywords

[No Author keywords available]

Indexed keywords

DIMETHYLBENZ[A]ANTHRACENE; PROTEIN E6; PROTEIN E7;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER GROWTH; CANCER INCIDENCE; CELL PROLIFERATION; CHEMICALLY INDUCED DISORDER; CONTROLLED STUDY; DNA DAMAGE; FEMALE; GENE MUTATION; HUMAN PAPILLOMAVIRUS TYPE 38; HYPERKERATOSIS; KERATINIZATION; KERATINOCYTE; MOUSE; NON MELANOMA SKIN CANCER; NONHUMAN; ONCOGENE H RAS; PRIORITY JOURNAL; SKIN CARCINOGENESIS; ULTRAVIOLET RADIATION; VIRUS ONCOGENE; WART VIRUS;

EID: 84875642667     PISSN: 00221317     EISSN: 14652099     Source Type: Journal    
DOI: 10.1099/vir.0.048991-0     Document Type: Article

References (18)

1. Abel, E. L., Angel, J. M., Kiguchi, K. & DiGiovanni, J. (2009). Multi-stage chemical carcinogenesis in mouse skin: fundamentals and applications. Nat Protoc 4, 1350-1362.
2. Accardi, R., Dong, W., Smet, A., Cui, R., Hautefeuille, A., Gabet, A. S., Sylla, B. S., Gissmann, L., Hainaut, P. & Tommasino, M. (2006). Skin human papillomavirus type 38 alters p53 functions by accumulation of DNp73. EMBO Rep 7, 334-340.
3. Accardi, R., Scalise, M., Gheit, T., Hussain, I. S., Yue, J., Carreira, C., Collino, A., Indiveri, C., Gissmann, L. & other authors (2011). IkB kinase beta promotes cell survival by antagonizing p53 functions through DNp73a phosphorylation and stabilization. Mol Cell Biol 31, 2210-2226.
4. Bouvard, V., Gabet, A. S., Accardi, R., Sylla, S. B. & Tommasino, M. (2006). The cutaneous human papillomavirus types and non-melanoma-skin cancer. In Papillomavirus Research: From Natural History to Vaccine and Beyond, pp. 269-277. Edited by M. S. Campo. Norfolk, UK: Caister Academic Press.
5. Caldeira, S., Zehbe, I., Accardi, R., Malanchi, I., Dong, W., Giarrè, M., de Villiers, E. M., Filotico, R., Boukamp, P. & Tommasino, M. (2003). The E6 and E7 proteins of the cutaneous human papillomavirus type 38 display transforming properties. J Virol 77, 2195-2206
6. Dong, W., Kloz, U., Accardi, R., Caldeira, S., Tong, W. M., Wang, Z. Q., Jansen, L., Durst, M., Sylla, B. S. & other authors (2005). Skin hyperproliferation and susceptibility to chemical carcinogenesis in transgenic mice expressing E6 and E7 of human papillomavirus type 38. J Virol 79, 14899-14908.
7. Fujiki, H., Suganuma, M., Yoshizawa, S., Kanazawa, H., Sugimura, T., Manam, S., Kahn, S. M., Jiang, W., Hoshina, S. & Weinstein, I. B. (1989). Codon 61 mutations in the c-Harvey-ras gene in mouse skin tumors induced by 7,12-dimethylbenz[a]anthracene plus okadaic acid class tumor promoters. Mol Carcinog 2, 184-187.
8. Gabet, A. S., Accardi, R., Bellopede, A., Popp, S., Boukamp, P., Sylla, B. S., LondoñO-Vallejo, J. A. & Tommasino, M. (2008). Impairment of the telomere/telomerase system and genomic instability are associated with keratinocyte immortalization induced by the skin human papillomavirus type 38. FASEB J 22, 622-632.
9. Howie, H. L., Koop, J. I., Weese, J., Robinson, K., Wipf, G., Kim, L. & Galloway, D. A. (2011). Beta-HPV 5 and 8 E6 promote p300 degradation by blocking AKT/p300 association. PLoS Pathog 7, e1002211.
10. Michel, A., Kopp-Schneider, A., Zentgraf, H., Gruber, A. D. & de Villiers, E. M. (2006). E6/E7 expression of human papillomavirus type 20 (HPV-20) and HPV-27 influences proliferation and differentiation of the skin in UV-irradiated SKH-hr1 transgenic mice. J Virol 80, 11153-11164.
11. Muench, P., Probst, S., Schuetz, J., Leiprecht, N., Busch, M., Wesselborg, S., Stubenrauch, F. & Iftner, T. (2010). Cutaneous papillomavirus E6 proteins must interact with p300 and block p53-mediated apoptosis for cellular immortalization and tumorigenesis. Cancer Res 70, 6913-6924.
12. Muschik, D., Braspenning-Wesch, I., Stockfleth, E., Rosl, F., Hofmann, T. G. & Nindl, I. (2011). Cutaneous HPV23 E6 prevents p53 phosphorylation through interaction with HIPK2. PLoS ONE 6, e27655.
13. Pfister, H. (2003). Chapter 8: Human papillomavirus and skin cancer. J Natl Cancer Inst Monogr 2003, 52-56.
14. Rundhaug, J. E. & Fischer, S. M. (2010). Molecular mechanisms of mouse skin tumor promotion. Cancers (Basel) 2, 436-482.
15. Schaper, I. D., Marcuzzi, G. P., Weissenborn, S. J., Kasper, H. U., Dries, V., Smyth, N., Fuchs, P. & Pfister, H. (2005). Development of skin tumors in mice transgenic for early genes of human papillomavirus type 8. Cancer Res 65, 1394-1400.
16. Underbrink, M. P., Howie, H. L., Bedard, K. M., Koop, J. I. & Galloway, D. A. (2008). E6 proteins from multiple human betapapillomavirus types degrade Bak and protect keratinocytes from apoptosis after UVB irradiation. J Virol 82, 10408-10417.
17. Viarisio, D., Mueller-Decker, K., Kloz, U., Aengeneyndt, B., Kopp-Schneider, A., Grone, H. J., Gheit, T., Flechtenmacher, C., Gissmann, L. & Tommasino, M. (2011). E6 and E7 from beta HPV38 cooperate with ultraviolet light in the development of actinic keratosis-like lesions and squamous cell carcinoma in mice. PLoS Pathog 7, e1002125.
18. Wallace, N. A., Robinson, K., Howie, H. L. & Galloway, D. A. (2012). HPV 5 and 8 E6 abrogate ATR activity resulting in increased persistence of UVB induced DNA damage. PLoS Pathog 8, e1002807.