Left Ventricular Assist Device Effects on Metabolic Substrates in the Failing Heart

PLoS ONE

Volumn 8, Issue 4, 2013, Pages

  Weitzel, Lindsay B ^a   Ambardekar, Amrut V ^a   Brieke, Andreas ^a   Cleveland, Joseph C ^b   Serkova, Natalie J ^a   Wischmeyer, Paul E ^a   Lowes, Brian D ^c  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF COLORADO   (United States)

^c UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; ALDOSTERONE ANTAGONIST; AROMATIC AMINO ACID; CREATININE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; GLUCOSE; GLUTAMINE; INOTROPIC AGENT; LACTIC ACID; SUCCINIC ACID; VASODILATOR AGENT;

ADULT; AMINO ACID BLOOD LEVEL; ARTICLE; CITRIC ACID CYCLE; CLINICAL ARTICLE; CLINICAL EFFECTIVENESS; CONTROLLED STUDY; CREATININE BLOOD LEVEL; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; HEART FAILURE; HEART INDEX; HEART METABOLIC SUBSTRATE; HEART MUSCLE METABOLISM; HUMAN; IMPLANTATION; LACTATE BLOOD LEVEL; LEFT VENTRICULAR ASSIST DEVICE; MALE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

ADULT; ALANINE; AMINO ACIDS, AROMATIC; CASE-CONTROL STUDIES; CREATINE; FEMALE; GLUCOSE; GLUTAMINE; HEART FAILURE; HEART-ASSIST DEVICES; HUMANS; LACTIC ACID; MALE; MIDDLE AGED; MYOCARDIUM; SUCCINIC ACID;

EID: 84875636542     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0060292     Document Type: Article

References (28)

1. Aquilani R, Opasich C, Verri M, Boschi F, Febo O, et al. (2003) Is nutritional intake adequate in chronic heart failure patients? J Am Coll Cardiol 42: 1218-1223.
2. Sheeran FL, Pepe S, (2006) Energy deficiency in the failing heart: linking increased reactive oxygen species and disruption of oxidative phosphorylation rate. Biochim Biophys Acta 1757: 543-552.
3. Ingwall JS, Weiss RG, (2004) Is the failing heart energy starved? On using chemical energy to support cardiac function. Circ Res 95: 135-145.
4. Katz AM, (1998) Is the Failing Heart Energy Depleted? Cardilogy Clinics 16.
5. Neubauer S, (2007) The failing heart-an engine out of fuel. N Engl J Med 356: 1140-1151.
6. Anker SD, von Haehling S, (2011) The obesity paradox in heart failure: accepting reality and making rational decisions. Clin Pharmacol Ther 90: 188-190.
7. Arcand J, Floras V, Ahmed M, Al-Hesayen A, Ivanov J, et al. (2009) Nutritional inadequacies in patients with stable heart failure. J Am Diet Assoc 109: 1909-1913.
8. Rose EA, Gelijns AC, Moskowitz AJ, Heitjan DF, Stevenson LW, et al. (2001) Long-term use of a left ventricular assist device for end-stage heart failure. N Engl J Med 345: 1435-1443.
9. Maybaum S, Mancini D, Xydas S, Starling RC, Aaronson K, et al. (2007) Cardiac improvement during mechanical circulatory support: a prospective multicenter study of the LVAD Working Group. Circulation 115: 2497-2505.
10. Burkhoff D, Klotz S, Mancini DM, (2006) LVAD-induced reverse remodeling: basic and clinical implications for myocardial recovery. J Card Fail 12: 227-239.
11. Klotz S, Foronjy RF, Dickstein ML, Gu A, Garrelds IM, et al. (2005) Mechanical unloading during left ventricular assist device support increases left ventricular collagen cross-linking and myocardial stiffness. Circulation 112: 364-374.
12. McCarthy PM, Nakatani S, Vargo R, Kottke-Marchant K, Harasaki H, et al. (1995) Structural and left ventricular histologic changes after implantable LVAD insertion. Ann Thorac Surg 59: 609-613.
13. Nakatani S, McCarthy PM, Kottke-Marchant K, Harasaki H, James KB, et al. (1996) Left ventricular echocardiographic and histologic changes: impact of chronic unloading by an implantable ventricular assist device. J Am Coll Cardiol 27: 894-901.
14. Razeghi P, Young ME, Ying J, Depre C, Uray IP, et al. (2002) Downregulation of metabolic gene expression in failing human heart before and after mechanical unloading. Cardiology 97: 203-209.
15. Ambardekar AV, Walker JS, Walker LA, Cleveland JC Jr, Lowes BD, et al. (2011) Incomplete recovery of myocyte contractile function despite improvement of myocardial architecture with left ventricular assist device support. Circ Heart Fail 4: 425-432.
16. Serkova NJ, Glunde K, (2009) Metabolomics of cancer. Methods Mol Biol 520: 273-295.
17. Serkova N, Fuller TF, Klawitter J, Freise CE, Niemann CU, (2005) H-NMR-based metabolic signatures of mild and severe ischemia/reperfusion injury in rat kidney transplants. Kidney Int 67: 1142-1151.
18. Cohen MJ, Serkova NJ, Wiener-Kronish J, Pittet JF, Niemann CU, (2010) 1H-NMR-based metabolic signatures of clinical outcomes in trauma patients-beyond lactate and base deficit. J Trauma 69: 31-40.
19. Stringer KA, Serkova NJ, Karnovsky A, Guire K, Paine R 3rd, et al. (2011) Metabolic consequences of sepsis-induced acute lung injury revealed by plasma (1)H-nuclear magnetic resonance quantitative metabolomics and computational analysis. Am J Physiol Lung Cell Mol Physiol 300: L4-L11.
20. Wischmeyer PE, Vanden Hoek TL, Li C, Shao Z, Ren H, et al. (2003) Glutamine preserves cardiomyocyte viability and enhances recovery of contractile function after ischemia-reperfusion injury. JPEN J Parenter Enteral Nutr 27: 116-122.
21. Wischmeyer PE, Jayakar D, Williams U, Singleton KD, Riehm J, et al. (2003) Single dose of glutamine enhances myocardial tissue metabolism, glutathione content, and improves myocardial function after ischemia-reperfusion injury. JPEN J Parenter Enteral Nutr 27: 396-403.
22. Lomivorotov VV, Efremov SM, Shmirev VA, Ponomarev DN, Lomivorotov VN, et al. (2011) Glutamine Is Cardioprotective in Patients with Ischemic Heart Disease following Cardiopulmonary Bypass. Heart Surg Forum 14: E384-388.
23. Sufit A, Weitzel L, Hamiel C, Queensland K, Dauber I, et al. (2012) Oral Glutamine Reduces Myocardial Injury and Peri-Operative Complications in Patients Undergoind Cardiac Surgery: A Randomized Pilot Trial. Journal of Parenteral and Enteral Nutrition In Press.
24. Rajabi M, Kassiotis C, Razeghi P, Taegtmeyer H, (2007) Return to the fetal gene program protects the stressed heart: a strong hypothesis. Heart Fail Rev 12: 331-343.
25. Khogali SE, Harper AA, Lyall JA, Rennie MJ, (1998) Effects of L-glutamine on post-ischaemic cardiac function: protection and rescue. J Mol Cell Cardiol 30: 819-827.
26. Des Rosiers C, Labarthe F, Lloyd SG, Chatham JC, (2011) Cardiac anaplerosis in health and disease: food for thought. Cardiovasc Res 90: 210-219.
27. Qanud K, Mamdani M, Pepe M, Khairallah RJ, Gravel J, et al. (2008) Reverse changes in cardiac substrate oxidation in dogs recovering from heart failure. Am J Physiol Heart Circ Physiol 295: H2098-2105.
28. Cheng S, Rhee EP, Larson MG, Lewis GD, McCabe EL, et al. (2012) Metabolite profiling identifies pathways associated with metabolic risk in humans. Circulation 125: 2222-2231.