Immune surveillance for ERAAP dysfunction

Molecular Immunology

Volumn 55, Issue 2, 2013, Pages 120-122

  Nagarajan, Niranjana A ^a   Shastri, Nilabh ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Antigen processing; CD8+ T cells; Immune surveillance; MHC class I

Indexed keywords

ENDOPLASMIC RETICULUM AMINOPEPTIDASE ASSOCIATED WITH ANTIGEN PROCESSING; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; PEPTIDE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ANTIGEN PRESENTATION; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; IMMUNOSURVEILLANCE; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REVIEW; WILD TYPE;

AMINOPEPTIDASES; ANIMALS; ANTIGEN PRESENTATION; CD8-POSITIVE T-LYMPHOCYTES; CYTOMEGALOVIRUS; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; IMMUNOLOGIC SURVEILLANCE; LEUCYL AMINOPEPTIDASE; MICE;

HUMAN HERPESVIRUS 5; MUS;

EID: 84875625610     PISSN: 01615890     EISSN: 18729142     Source Type: Journal    
DOI: 10.1016/j.molimm.2012.10.006     Document Type: Review

References (5)

1. Blanchard N., Kanaseki T., et al. Endoplasmic reticulum aminopeptidase associated with antigen processing defines the composition and structure of MHC class I peptide repertoire in normal and virus-infected cells. Journal of immunology 2010, 184(6):3033-3042.
2. Blanchard N., Shastri N. Coping with loss of perfection in the MHC class I peptide repertoire. Current Opinion in Immunology 2008, 20:82-88.
3. Hammer G.E., Gonzalez F., et al. In the absence of aminopeptidase ERAAP, MHC class I molecules present many unstable and highly immunogenic peptides. Nature Immunology 2007, 8(1):101-108.
4. Kim S., Lee S., et al. Human cytomegalovirus microRNA miR-US4-1 inhibits CD8(+) T cell responses by targeting the aminopeptidase ERAP1. Nature Immunology 2011, 12(10):984-991.
5. Nagarajan N.A., Gonzalez F., et al. Nonclassical MHC class Ib-restricted cytotoxic T cells monitor antigen processing in the endoplasmic reticulum. Nature Immunology 2012, 13(6):579-586.